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301 - 350 of 1596 citations for cis 3 2 3 Bromophenyl 2 oxoethyl cyclohexane 1 carboxylic acid since 2020

• Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells

  Yuka Sakata, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 2 μM SU-5402 (Tocris), and 10 μM DAPT (Tocris) ...
• HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum

  Braulio Munoz, et al., bioRxiv - Neuroscience 2022

  Quote: ... and Torin 2 (4248, Tocris). Other reagents used for making solutions were purchased from Sigma-Aldrich or Fisher Scientific.
• An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

  Kathleen C. Keough, et al., bioRxiv - Developmental Biology 2021

  Quote: ... SB-505124 (2 μM; Tocris) and FGF2 (20 ng/mL ...
• Single cell trajectory analysis of human pluripotent stem cells differentiating towards lung and hepatocyte progenitors

  Chaido Ori, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 2 μM dorsomorphin (DSM; Tocris) and 10 μM SB431542 (Miltenyi Biotec) ...
• Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytes

  Claudia Raggi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... 4 μM IWP-2 (Tocris), and 1 μM A83-01 (Tocris ...
• Cell-type specific innate immune responses shape rabies virus tropism

  Lena Feige, et al., bioRxiv - Microbiology 2021

  Quote: ... 2 μM CHIR99021 (4423, TOCRIS) induced mesoderm specification of human iPSC colonies (XCL-1 ...
• Translation of dipeptide repeat proteins in C9ORF72-ALS/FTD through unique and redundant AUG initiation codons

  Yoshifumi Sonobe, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 2 µM DMH1 (Tocris Bioscience), and 2 µM SB431542 (Stemgent ...
• Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons

  Simon Chamberland, et al., bioRxiv - Neuroscience 2022

  Quote: ... CGP-55845 (2 μM, Tocris) dendrotoxin-K (50 nM ...
• An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x,
• Synapse specific and plasticity-regulated AMPAR mobility tunes synaptic integration

  Agata Nowacka, et al., bioRxiv - Neuroscience 2024

  Quote: ... 0.002 2-chloroadenosine (Tocris, #3136). High Pr conditions aCSF contained 1 mM MgCl2 and 4 mM CaCl2 ...
• LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

  Riccardo Sirtori, et al., bioRxiv - Neuroscience 2024

  Quote: ... and SB431542 (2 μM, Tocris). On day 7 and 13 ...
• SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

  Eline J.H. van Hugte, et al., bioRxiv - Neuroscience 2023

  Quote: ... Levetiracetam (Tocris, #102767-28-2), Topiramate (Tocris ...
• The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

  Federica Raguseo, et al., bioRxiv - Biochemistry 2023

  Quote: ... 2 μM SB431542 (Tocris Bioscience), and 3.3 μM CHIR99021 (Tocris Bioscience) ...
• Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids

  Zongyong Ai, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM Gö6983 (TOCRIS, 2285) and 10 ng/ml recombinant human LIF (Peprotech ...
• Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

  Cheng-Guo Wu, et al., bioRxiv - Biochemistry 2023

  Quote: ... and 2 μM rolipram (Tocris) to activate adenylyl cyclase and inhibit cAMP phosphodiesterase 4 (PDE4 ...
• Recording morphogen signals reveals origins of gastruloid symmetry breaking

  Harold M. McNamara, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM PD0325901 (Tocris, 4192), and 3 μM CHIR99021 (Tocris ...
• APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

  Meghan E. Wynne, et al., bioRxiv - Cell Biology 2022

  Quote: ... 2 μM dorsomorphin (Tocris, 3093) and 2 μM A-83 (Tocris ...
• Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

  Evan J. Underhill, Jared E. Toettcher, bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM PD0325901 (Tocris, 4192), and 3 μM CHIR99021 (Tocris ...
• Actin polymerization drives lumen formation in a human epiblast model

  Dhiraj Indana, et al., bioRxiv - Developmental Biology 2023

  Quote: ... ML-141 (2 µM; Tocris Bioscience 4266 ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... valinomycin (Tocris, 3373, 2 μM), sorafenib (Selleckchem ...
• Reuniens thalamus recruits recurrent excitation in medial prefrontal cortex

  Gil Vantomme, et al., bioRxiv - Neuroscience 2024

  Quote: ... 2 QX314-Cl (Tocris, 2313), pH 7.3 ...
• Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• Stepwise developmental mimicry generates proximal-biased kidney organoids

  Jack Schnell, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 2 µM DAPT (Tocris 2634), or both ...
• Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity

  Nanna Møller Jensen, et al., bioRxiv - Neuroscience 2024

  Quote: ... 2 µM LM22A4 (Tocris Bioscience), 2.5 µM DAPT (Tocris Bioscience) ...
• The Parkinson’s Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

  Katy R. McCarron, et al., bioRxiv - Cell Biology 2024

  Quote: ... MLi-2 (Tocris Bioscience; 5756), nigericin sodium salt (Sigma-Aldrich ...
• Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2

  Nicolai D. Raig, et al., bioRxiv - Cell Biology 2024

  Quote: ... 500 nM MLi-2 (Tocris), or various concentrations of RN277 or RN341 for 4 h at 37 °C and 5 % CO2 ...
• Differential inhibition of GABA release from mouse hippocampal interneuron subtypes by the volatile anesthetic isoflurane

  Iris A. Speigel, Hugh C. Hemmings Jr, bioRxiv - Neuroscience 2020

  Quote: ... containing 10 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 50 μM D,L-2-amino-5-phosphonovaleric acid (AP5) to block glutamatergic signaling (both from Tocris, Bristol, UK). Experiments involving tetrodotoxin (TTX ...
• Group I p21-activated kinases in leukemia cell adhesion to fibronectin

  Kateřina Kuželová, et al., bioRxiv - Cell Biology 2020

  Quote: ... IPA-3 (#3622) and PIR3.5 (#4212) were purchased from Tocris Bioscience and dissolved in sterile dimethylsulfoxide (DMSO ...
• A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates

  Ryan J. Geusz, et al., bioRxiv - Genomics 2020

  Quote: ... consisting of cSFDM base supplemented with 3 µm CHIR99021 (Tocris), 10 ng/mL rhKGF (R&D Systems) ...
• PAK1 and PAK2 in cell metabolism regulation

  Tereza Kořánová, et al., bioRxiv - Cell Biology 2021

  Quote: IPA-3 (#3622) and PIR3.5 (#4212) were purchased from Tocris Bioscience and dissolved in sterile dimethylsulfoxide (DMSO ...
• An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age

  S. Kragness, et al., bioRxiv - Neuroscience 2022

  Quote: ... and 3) bath application of 1µM DCG-IV (0975, Tocris) at the end of LTP recording significantly reduced the evoked fEPSPs ...
• A Pluripotent Developmental State Confers a Low Fidelity of Chromosome Segregation

  Chenhui Deng, et al., bioRxiv - Cell Biology 2022

  Quote: ... 3 µM or 6 µM proTAME (Tocris #I-440-01M) and mounted in modified rose chambers ...
• SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

  Jessie Huang, et al., bioRxiv - Molecular Biology 2020

  Quote: ... “CBRa” media consists of cSFDM containing 3 μm CHIR99021 (Tocris), 10 ng/mL recombinant human BMP4 (rhBMP4 ...
• Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

  Matthew Wind, et al., bioRxiv - Developmental Biology 2020

  Quote: ... day 3 hPSC-derived NMP-like cells were dissociated using Accutase and re-plated at a density of 37,500-86,000 cells /cm2 on Geltrex (Thermo Fisher)-coated plates directly in N2B27 containing CHIR99021 (3 µM, Tocris) and FGF2 (100 ng/ml ...
• Single-molecule imaging of telomerase RNA reveals a Recruitment – Retention model for telomere elongation

  Hadrien Laprade, et al., bioRxiv - Molecular Biology 2020

  Quote: ... cells were treated with 3 µM of KU60019 (Tocris Bioscience) for 24 hours ...
• Dopamine modulates adaptive forgetting in medial prefrontal cortex

  Francisco Tomás Gallo, et al., bioRxiv - Animal Behavior and Cognition 2021

  Quote: ... SCH 23389 (3 mg/ml in saline, Tocris #0925/10) and SKF 38393 (8.41 mg/ml in saline ...
• Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses

  Chong Guo, et al., bioRxiv - Neuroscience 2020

  Quote: ... mGluR2/3 antagonist (1μM LY341495, Tocris Bio-Techne, Minneapolis, MN) and DGK inhibitor II (100 μM R59949 ...
• The genetic basis of tail-loss evolution in humans and apes

  Bo Xia, et al., bioRxiv - Evolutionary Biology 2021

  Quote: ... and 3 µM GSK3 inhibitor CHIR99021 (Tocris, Cat. No. 4423). mESC medium was made from Knockout DMEM (Gibco ...
• A PTER-dependent pathway of taurine metabolism linked to energy balance

  Wei Wei, et al., bioRxiv - Biochemistry 2024

  Quote: ... Exendin-3 (9-39) amide (2081) was purchased from Tocris. Recombinant GDF15 (957-GD ...
• A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

  Changwen Wang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 3 μM of CHIR99021 (Tocris Bioscience, Minneapolis, USA, Cat#4423) and 1 μM of PD0325901 (Selleckchem ...
• Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors

  Fay Cooper, et al., bioRxiv - Developmental Biology 2023

  Quote: ... The N2B27 medium was supplemented with CHIR (3 μM, Tocris), FGF2 (20 ng/ml ...
• Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2

  Kyla Mace, et al., bioRxiv - Neuroscience 2024

  Quote: Peptide YY (3-36) (PYY) was obtained from Tocris (#1618) and dissolved in water to achieve a 100µM stock solution ...
• Development of LRRK2 designed ankyrin-repeat proteins

  Verena Dederer, et al., bioRxiv - Biochemistry 2023

  Quote: ... the cells were incubated at 37 °C with DMSO or MLi-2 (Tocris; 2 μM) for 2 hours ...
• Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development

  Cantaut-Belarif Yasmine, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and paralyzed by injecting 1-2 nL of 500 μM alphabungarotoxin (Tocris, 2133) in the caudal muscles of the trunk ...
• Hypertrophic cardiomyopathy ß-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state

  Alison Schroer Vander Roest, et al., bioRxiv - Biophysics 2020

  Quote: ... the cells were treated with either Akt inhibitor (Akti 1/2, Tocris: 5μM) or and ERK inhibitor (SCH772984 ...
• Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis

  Yusuke Hirata, et al., bioRxiv - Cell Biology 2022

  Quote: ... Yoda 1 (catalog #5586) and 2-aminoethoxydiphenyl borate (catalog #1224) were from Tocris Bioscience (Bristol ...
• SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides

  Andrea Loreto, et al., bioRxiv - Neuroscience 2024

  Quote: ... and split 1:2 with 10 µM ROCK inhibitor (Y-27632) (Tocris Bioscience). Cells were differentiated into dopamine neurons using on a modified Krik’s protocol43 ...
• KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons

  Irune Guerra San Juan, et al., bioRxiv - Neuroscience 2024

  Quote: ... retinoic Acid (RA, 1 µM, Tocris) and smoothened agonist (SAG ...