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251 - 300 of 855 citations for Locostatin CAS 90719 30 5 100% since 2020

• Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C^+/- During Development

  Sanam Shafaatalab, et al., bioRxiv - Cell Biology 2023

  Quote: ... followed by 5 mM IWP4 (Tocris) for 2 days without medium change ...
• Functional Recovery from Human Induced Pluripotent Stem Cell-Derived Dopamine Neuron Grafts is Dependent on Neurite Outgrowth

  Rachel Hills, et al., bioRxiv - Neuroscience 2022

  Quote: ... SB431542 (days 1-5, 2μM, Tocris), CHIR99021 (days 3-13 ...
• Opioid receptor expressing neurons of the central amygdala gate behavioral effects of ketamine in mice

  Matthew B. Pomrenze, et al., bioRxiv - Neuroscience 2024

  Quote: ... Naltrexone (5 mg/kg, Tocris, 0677), beta-funaltrexamine (β-FNA ...
• Polycomb Repressive Complex 1.1 Component, BCOR, Promotes Syncytiotrophoblast Differentiation in Mice and Humans

  Danielle Sadowski, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 5 µM A83-01 (Tocris Bioscience), and 2 µM CHIR99021 (Tocris Bioscience) ...
• A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish

  Ugo Coppola, Jennifer Kenney, Joshua S. Waxman, bioRxiv - Developmental Biology 2024

  Quote: ... 5 μM BIO (Tocris, Cat # 3194), 10 μM XAV939 (Tocris ...
• Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state

  Yasuhiro Nakano, et al., bioRxiv - Cell Biology 2023

  Quote: ... supplemented with SB431542 (5 μM) (Tocris), Dorsomorphin dihydrochloride (0.5 μM ...
• Early inflammatory response mediated by Angiotensin II in cardiac arteries of normotensive mice

  Thais Cristina de Souza Oliveira, et al., bioRxiv - Physiology 2023

  Quote: ... 5-PD123.319 (AT2R blocker, ToCris®) and 6-PD+Ang II.
• The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cells

  Shashi P. Singh, et al., bioRxiv - Immunology 2023

  Quote: ... 5 µM SB431542 (Tocris Bioscience, UK) was added ...
• NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

  Hayden T. Pacl, et al., bioRxiv - Microbiology 2022

  Quote: ... GSK 2837808A (5 μM; Tocris, 5189) or the NAMPT inhibitor FK866 (200 μM ...
• Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion

  Michael J. Seibert, et al., bioRxiv - Neuroscience 2022

  Quote: ... 5 mM QX 314 chloride (Tocris) was included in the pipette solutions for all recordings ...
• Linking medicinal cannabis to autotaxin-lysophosphatic acid signaling

  Mathias C. Eymery, et al., bioRxiv - Biochemistry 2022

  Quote: ... 5-DMH-CBD (#1481) from Tocris; CBD (#HB2785 ...
• Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction, progression, and prion-like spread of Alzheimer’s disease pathogenesis

  Yuriy Pomeshchik, et al., bioRxiv - Neuroscience 2023

  Quote: ... and XAV-939 (Tocris, 5 μM). On the tenth day ...
• Re-engineering of TNF_α-NF-_κB signalling dynamics in cancer cells using pathogenic E. coli effectors

  Qiyun Zhong, et al., bioRxiv - Cell Biology 2023

  Quote: ... and 5 μM necrosulfonamide (NSA) (Tocris) were added to the cells 30 min before infection.
• Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity

  Shuhan Huang, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 mM QX314-Cl (Tocris, #2313), 0.4% biocytin (Sigma ...
• CircPVT1 sponges miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer

  Alina Catalina Palcau, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 5 μM A83-01 (Tocris Bioscience), and 500 nM SB202190 (PeproTech ...
• Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism

  Ozan Baytas, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 mM QX-314 (Tocris, 2313) (pH 7.23-7.28 ...
• REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion

  Cosimo Prestigio, et al., bioRxiv - Neuroscience 2021

  Quote: ... networks were acutely exposed to the GABAAR blocker bicuculline (BIC, 30 μM, Tocris Bioscience). After 5 min re-equilibration ...
• EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

  B. van de Kooij, et al., bioRxiv - Molecular Biology 2023

  Quote: ... Cells were then incubated with EdU for 30 minutes and PARGi (Tocris, Bristol, UK) for 20 minutes before collection ...
• Inhibition of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner

  Jessica L Hoffman, et al., bioRxiv - Neuroscience 2022

  Quote: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one (JNJ-5; Tocris, Minneapolis, MN) is a high affinity ...
• Disrupting D2-NMDA receptor heteromerization blocks the rewarding effects of cocaine but preserves natural reward processing

  Andry Andrianarivelo, et al., bioRxiv - Neuroscience 2021

  Quote: ... Cells were then stimulated for 30 min with the indicated concentrations of agonist Quinpirole (Tocris), in the presence of 1 mM IBMX and 10 μM Forskolin (Tocris) ...
• SARS-CoV-2 variant B.1.617 is resistant to Bamlanivimab and evades antibodies induced by infection and vaccination

  Markus Hoffmann, et al., bioRxiv - Molecular Biology 2021

  Quote: ... were pre-incubated for 1 h with medium containing different concentrations (100, 10, 1, 0.1 or 0.01 μM) of Camostat mesylate (prepared from a 100 mM stock; Tocris) or the solvent dimethyl sulfoxide (DMSO ...
• Allosteric Competition and Inhibition in AMPA Receptors

  W. Dylan Hale, et al., bioRxiv - Biophysics 2023

  Quote: ... whereas IS-2 sample was made up to 100 µM CTZ and 100 µM GYKI- 52466 (Tocris, 1454) prior to centrifugation (75,000 g ...
• A high-fat diet changes astrocytic metabolism to enhance synaptic plasticity and promote exploratory behavior

  Alexander Popov, et al., bioRxiv - Neuroscience 2021

  Quote: ... 100 μM DL-TBOA (Tocris Bioscience, UK), an excitatory amino acid transporter (EAATs ...
• Blocking the Rac1-TRPC5 pathway protects human podocytes

  Yiming Zhou, et al., bioRxiv - Cell Biology 2021

  Quote: ... Vitamin D3 (100 nM, Tocris Bioscience, #4156), and Retinoic Acid (100 µM ...
• External light dark cycle shapes gut microbiota through intrinsically photosensitive retinal ganglion cells

  Chi-Chan Lee, et al., bioRxiv - Neuroscience 2020

  Quote: ... 6-OHDA(100 mg/kg, Tocris, UK) was given every 2 d ...
• Astrocytes dystrophy in ageing brain parallels impaired synaptic plasticity

  Alexander Popov, et al., bioRxiv - Neuroscience 2020

  Quote: ... 100 μM DL-TBOA (Tocris Bioscience, UK), an excitatory amino acid transporter (EAATs ...
• LTD at amygdalocortical synapses as a novel mechanism for hedonic learning

  Melissa S. Haley, et al., bioRxiv - Neuroscience 2020

  Quote: ... 100 4-aminopyridine (4-AP) (Tocris Bioscience). To determine possible changes in intrinsic excitability ...
• Dendritic coincidence detection in Purkinje neurons of awake mice

  Christopher J. Roome, Bernd Kuhn, bioRxiv - Neuroscience 2020

  Quote: ... and CNQX disodium salt (100 μM) (Tocris) were used to block Na+ channels and AMPA receptors (excitatory synaptic input ...
• Gating transitions and modulation of a hetero-octameric AMPA glutamate receptor

  Danyang Zhang, et al., bioRxiv - Neuroscience 2020

  Quote: ... 100 μM D-APV (Tocris, Cat #0106) was added to the extracellular solution of both barrels to prevent the contribution of NMDA receptor currents ...
• Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula

  Sarah C. Simmons, et al., bioRxiv - Neuroscience 2020

  Quote: ... GABAAR antagonist picrotoxin (100 μM, Tocris-1128), and NMDAR antagonist D-(-)-2-Amino-5-phosphonopentanoic acid 50 μM ...
• Human Papillomavirus Genome Copy Number Is Maintained by S Phase Amplification, Leakage to the Cytosol during Mitosis and Lysosomal Degradation in G1 Phase

  Malgorzata Bienkowska-Haba, et al., bioRxiv - Microbiology 2022

  Quote: ... and 100 nM bafilomycin A1 (1334, Tocris). After treatment ...
• Advected percolation in the actomyosin cortex drives amoeboid cell motility

  Juan Manuel García-Arcos, et al., bioRxiv - Biophysics 2022

  Quote: ... 100 μM CK-666 (Tocris Bioscience #3950) inhibiting Arp2/3 inhibiting actin polymerization ...
• Cortical ChAT⁺ neurons co-transmit acetylcholine and GABA in a target- and brain-region specific manner

  Adam J Granger, et al., bioRxiv - Neuroscience 2020

  Quote: ... followed by 100 µM 4-aminopyridine (Tocris). To rule out contributions from other low latency excitatory receptors ...
• BiPOLES: a tool for bidirectional dual-color optogenetic control of neurons

  Johannes Vierock, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 100 µM picrotoxin (Tocris, Bristol, UK) were added to the recording solution ...
• Optogenetic silencing of neurotransmitter release with a naturally occurring invertebrate rhodopsin

  Mathias Mahn, et al., bioRxiv - Neuroscience 2021

  Quote: ... and 100 μM picrotoxin (Tocris, Bristol, UK) were added to the recording solution ...
• Functional glycoproteomics by integrated network assembly and partitioning

  Matthew E. Griffin, et al., bioRxiv - Cell Biology 2023

  Quote: ... and 100 μM D-AP5 (Tocris Biosciences), and a subset was also treated with 50 μM Thiamet-G ...
• Anti-TNF-induced IL-27 modulates regulatory T cell responses in patients with IBD that respond to therapy

  Raphael S. Peres, et al., bioRxiv - Immunology 2022

  Quote: ... STAT3 inhibitor (STAT3i, 100 uM, NSC74859, Tocris). For in vitro cell stimulations with anti-TNF agents ...
• Motor cortex directly excites the output nucleus of the basal ganglia, the substantia nigra pars reticulata

  William Scott Thompson, et al., bioRxiv - Neuroscience 2024

  Quote: ... and 4-aminopyridine (100 μM; Tocris, U.K.) to isolate monosynaptic responses ...
• Ca_V2.1 α₁ subunit motifs that control presynaptic Ca_V2.1 subtype abundance are distinct from Ca_V2.1 preference

  Jianing Li, et al., bioRxiv - Neuroscience 2023

  Quote: ... 100 μM 4-aminopyridin (4-AP, Tocris) and 20 mM tetraethylammonium chloride (TEA ...
• Network-level encoding of local neurotransmitters in cortical astrocytes

  Michelle K. Cahill, et al., bioRxiv - Neuroscience 2023

  Quote: ... LY 379268 disodium salt (100 μM, Tocris); Alexa Fluor 594 Hydrazide (0.1–2 μM ...
• Decomposition of retinal ganglion cell electrical images for cell type and functional inference

  Eric G. Wu, et al., bioRxiv - Neuroscience 2023

  Quote: ... and DL-AP5 (100 μM, Tocris 1015), to block photoreceptor-driven responses ...
• Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALS

  Delfina Larrea, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 100 nM retinoic acid (RA) (Tocris 1254) and 500 nM Smoothened Agonist (SAG Stemcell Technologies 73414) ...
• CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer

  Julia M. Houthuijzen, et al., bioRxiv - Cancer Biology 2022

  Quote: ... PK-44 (CD26 inhibitor, Tocris, 100 nM), Marimastat (MMP inhibitor ...
• Kv2 conductances are not required for C-bouton mediated enhancement of motoneuron output

  Calvin C. Smith, Robert M. Brownstone, bioRxiv - Neuroscience 2022

  Quote: ... 100 nM GxTX-1E (Tocris, cat# 5676) in nACSF was perfused through the recording chamber for 10 minutes prior to the 2nd recording (Liu & Bean ...
• Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence

  Laura C. Geben, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 100 nM LDN-193189 (Tocris, 6053). Cells were allowed to aggregate overnight into a sphere while maintained at 37°C and 5% CO2 ...
• Steroid Receptor Coactivator-3 is a Key Modulator of Regulatory T Cell-Mediated Tumor Evasion

  Sang Jun Han, et al., bioRxiv - Cancer Biology 2023

  Quote: Tamoxifen (100 mg, Tocris Cat. No. 6432) was dissolved in 5 mL of corn oil (20 mg/mL) ...
• Multimodal mechanisms of human centriole engagement and disengagement

  Kei K Ito, et al., bioRxiv - Cell Biology 2024

  Quote: ... Taxol (Tocris, 33069-62-4, 100 nM), and GSK461364 (MedChem Express ...
• Reduced SH3RF3 may protect against Alzheimer’s disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling

  Ronak Patel, et al., bioRxiv - Neuroscience 2024

  Quote: ... which included CEP-1347 (100 nM; Tocris), IKK16 (1 uM ...
• Mild focal cooling selectively impacts computations in dendritic trees

  Meisam Habibi Matin, Shulan Xiao, Krishna Jayant, bioRxiv - Neuroscience 2024

  Quote: ... NMDAR blocker (100 mM APV; Tocris Bioscience) and Kv4.2 subunit channel blocker (0.5 mM heteropodatoxin-2 ...
• Growing Macrophages Regulate High Rates of Solute Flux by Pinocytosis

  Biniam M. Tebeje, et al., bioRxiv - Cell Biology 2024

  Quote: ... rapamycin (100 nM final, Tocris/Biotechne #1292), and Torin-1 (1 mM final ...