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251 - 300 of 2138 citations for 6 Methyl 5 4 phenyl 1 3 thiazol 2 yl 2 trifluoromethyl nicotinic acid since 2020

• Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

  Cheng-Guo Wu, et al., bioRxiv - Biochemistry 2023

  Quote: ... and 2 μM rolipram (Tocris) to activate adenylyl cyclase and inhibit cAMP phosphodiesterase 4 (PDE4 ...
• Recording morphogen signals reveals origins of gastruloid symmetry breaking

  Harold M. McNamara, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM PD0325901 (Tocris, 4192), and 3 μM CHIR99021 (Tocris ...
• Synapse specific and plasticity-regulated AMPAR mobility tunes synaptic integration

  Agata Nowacka, et al., bioRxiv - Neuroscience 2024

  Quote: ... 0.002 2-chloroadenosine (Tocris, #3136). High Pr conditions aCSF contained 1 mM MgCl2 and 4 mM CaCl2 ...
• An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x,
• An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

  Riccardo Sirtori, et al., bioRxiv - Neuroscience 2024

  Quote: ... and SB431542 (2 μM, Tocris). On day 7 and 13 ...
• Translation of dipeptide repeat proteins in C9ORF72-ALS/FTD through unique and redundant AUG initiation codons

  Yoshifumi Sonobe, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 2 µM DMH1 (Tocris Bioscience), and 2 µM SB431542 (Stemgent ...
• Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons

  Simon Chamberland, et al., bioRxiv - Neuroscience 2022

  Quote: ... CGP-55845 (2 μM, Tocris) dendrotoxin-K (50 nM ...
• APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

  Meghan E. Wynne, et al., bioRxiv - Cell Biology 2022

  Quote: ... 2 μM dorsomorphin (Tocris, 3093) and 2 μM A-83 (Tocris ...
• Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

  Evan J. Underhill, Jared E. Toettcher, bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM PD0325901 (Tocris, 4192), and 3 μM CHIR99021 (Tocris ...
• Actin polymerization drives lumen formation in a human epiblast model

  Dhiraj Indana, et al., bioRxiv - Developmental Biology 2023

  Quote: ... ML-141 (2 µM; Tocris Bioscience 4266 ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... valinomycin (Tocris, 3373, 2 μM), sorafenib (Selleckchem ...
• Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• Stepwise developmental mimicry generates proximal-biased kidney organoids

  Jack Schnell, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 2 µM DAPT (Tocris 2634), or both ...
• The Parkinson’s Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

  Katy R. McCarron, et al., bioRxiv - Cell Biology 2024

  Quote: ... MLi-2 (Tocris Bioscience; 5756), nigericin sodium salt (Sigma-Aldrich ...
• Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity

  Nanna Møller Jensen, et al., bioRxiv - Neuroscience 2024

  Quote: ... 2 µM LM22A4 (Tocris Bioscience), 2.5 µM DAPT (Tocris Bioscience) ...
• Reuniens thalamus recruits recurrent excitation in medial prefrontal cortex

  Gil Vantomme, et al., bioRxiv - Neuroscience 2024

  Quote: ... 2 QX314-Cl (Tocris, 2313), pH 7.3 ...
• Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2

  Nicolai D. Raig, et al., bioRxiv - Cell Biology 2024

  Quote: ... 500 nM MLi-2 (Tocris), or various concentrations of RN277 or RN341 for 4 h at 37 °C and 5 % CO2 ...
• STK25 inhibits PKA signaling by phosphorylating PRKAR1A

  Xiaokan Zhang, et al., bioRxiv - Physiology 2022

  Quote: ... 50U penicillin and 50U streptomycin) with 3-6 μM CHIR (4423, Tocris). 2 days after initial CHIR addition ...
• Voltage tunes mGlu5 receptor function, impacting synaptic transmission

  Marin Boutonnet, et al., bioRxiv - Neuroscience 2023

  Quote: ... N-Methyl-D-Aspartate (NMDA, Tocris®). 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt ...
• Development of LRRK2 designed ankyrin-repeat proteins

  Verena Dederer, et al., bioRxiv - Biochemistry 2023

  Quote: ... the cells were incubated at 37 °C with DMSO or MLi-2 (Tocris; 2 μM) for 2 hours ...
• Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development

  Cantaut-Belarif Yasmine, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and paralyzed by injecting 1-2 nL of 500 μM alphabungarotoxin (Tocris, 2133) in the caudal muscles of the trunk ...
• Hypertrophic cardiomyopathy ß-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state

  Alison Schroer Vander Roest, et al., bioRxiv - Biophysics 2020

  Quote: ... the cells were treated with either Akt inhibitor (Akti 1/2, Tocris: 5μM) or and ERK inhibitor (SCH772984 ...
• SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides

  Andrea Loreto, et al., bioRxiv - Neuroscience 2024

  Quote: ... and split 1:2 with 10 µM ROCK inhibitor (Y-27632) (Tocris Bioscience). Cells were differentiated into dopamine neurons using on a modified Krik’s protocol43 ...
• Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis

  Yusuke Hirata, et al., bioRxiv - Cell Biology 2022

  Quote: ... Yoda 1 (catalog #5586) and 2-aminoethoxydiphenyl borate (catalog #1224) were from Tocris Bioscience (Bristol ...
• Realistic mossy fiber input patterns to unipolar brush cells evoke a continuum of temporal responses comprised of components mediated by different glutamate receptors

  Vincent Huson, Wade G. Regehr, bioRxiv - Neuroscience 2024

  Quote: Recordings were performed at ∼34°C in ACSF (flow rate 2–4 ml / min) containing inhibitory receptor blockers picrotoxin (20µM; Tocris), CGP 55845 (1µM ...
• High Mobility Group Box 1 enhances ADP-mediated platelet activation by increasing platelet surface P2Y₁₂ localization

  Deirdre Nolfi-Donegan, et al., bioRxiv - Cell Biology 2021

  Quote: ... interleukin-1 receptor-associated kinase 1 and 4 (IRAK 1/4; IRAK 1/4 inhibitor, 0.1 μM; Tocris); TANK-binding kinase 1 (TBK1 ...
• KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons

  Irune Guerra San Juan, et al., bioRxiv - Neuroscience 2024

  Quote: ... retinoic Acid (RA, 1 µM, Tocris) and smoothened agonist (SAG ...
• SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

  Eline J.H. van Hugte, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4-AP (10 μM, Tocris, #504-24-5), Phenytoin (25 μM ...
• Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

  Mehdi Benlarbi, et al., bioRxiv - Microbiology 2022

  Quote: ... E64d and MMP-2/MMP-9 Inhibitor II were from MilliporeSigma and TAPI-2 from Tocris.
• Transcriptional networks predating cognition-associated pyramidal lineages are restructured by erythropoietin

  Manvendra Singh, et al., bioRxiv - Neuroscience 2023

  Quote: ... mIPSC were pharmacologically isolated by blocking glutamatergic EPSCs (2 µM NBQX and 2 µM CPP, Tocris) and were recorded using an internal solution consisting of (in mM ...
• Extracellular matrix stiffness regulates degradation of the Hippo kinase MST2 via SCF ^βTrCP

  Ana Paula Zen Petisco Fiore, et al., bioRxiv - Cell Biology 2021

  Quote: ... AKT (20 μM MK2206, Cayman Biochemicals #1032350-13-2) and myosin ATPase activity inhibitor (5 μM Blebbistatin, Tocris #1852).
• Defining totipotency using criteria of increasing stringency

  Eszter Posfai, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2 µM Dimethindene maleate (Tocris #1425); and 2 µM Minocycline Hydrochloride (Santa Cruz #sc-203339) ...
• Diversity of excitatory release sites

  Maria Rita Karlocai, et al., bioRxiv - Neuroscience 2021

  Quote: ... and 2 µM AM251 (Tocris; #1117). All drugs were applied using a recirculating system with a peristaltic pump (3-5 ml/min) ...
• Axonal CB1 receptors mediate inhibitory bouton formation via cAMP increase

  Jian Liang, et al., bioRxiv - Neuroscience 2021

  Quote: ... 100 µM 2-AG (Tocris Bioscience), 25 µM forskolin (Abcam) ...
• Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutation

  Michael X. Henderson, et al., bioRxiv - Neuroscience 2020

  Quote: ... MLi-2 was obtained from Tocris Bioscience (Cat#5756) ...
• The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

  E. Werner, et al., bioRxiv - Cell Biology 2022

  Quote: ... and 2 μM cyclopamine (Tocris, 1623). The floating EBs were then transferred to Matrigel-coated 6-well plates at day 7 to form neural tube-like rosettes ...
• RNA-Targeting CRISPR/Cas13d System Eliminates Disease-Related Phenotypes in Pre-clinical Models of Huntington’s Disease

  Kathryn H. Morelli, et al., bioRxiv - Neuroscience 2022

  Quote: ... 2 μM PD 0332991 (all Tocris), to 1.8 mM CaCl2 ...
• Generation of Vascularized Brain Organoids to Study Neurovascular Interactions

  Xin-Yao Sun, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and 2 μM A83-01 (Tocris)) ...
• An epigenetic barrier sets the timing of human neuronal maturation

  Gabriele Ciceri, et al., bioRxiv - Developmental Biology 2022

  Quote: ... and 2 μM XAV939 (#3748, Tocris) to induce anterior neuroectodermal patterning ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: ... and A83-01 (2 μM, Tocris). Cells were plated at a density of 5E5 cells/cm2 on VTN-coated T75 flasks in 15 mL of E8 media supplemented with CEPT cocktail and allowed to reach 70% confluency ...
• CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons

  Gong-Her Wu, et al., bioRxiv - Neuroscience 2022

  Quote: ... 2 µM PD 0332991 (all Tocris), to 1.8 mM CaCl2 ...
• Pathogenic LRRK2 regulates ciliation probability upstream of Tau Tubulin kinase 2

  Yuriko Sobu, et al., bioRxiv - Cell Biology 2020

  Quote: ... MLi-2 was obtained from Tocris Biosciences (Cat no 5756 ...
• Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocation

  Miha Modic, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 2 μM IWP2 (3533, Tocris) to suppress spontaneous differentiation ...
• Computer Designed PRC2 Inhibitor, EBdCas9, Reveals Functional TATA boxes in Distal Promoter Regions

  Shiri Levy, et al., bioRxiv - Molecular Biology 2020

  Quote: ... (S)-(+)-Dimethindene maleate (2 μM; Tocris), Minocycline hydrochloride (2 μM ...
• Calcium-independent astrocytic lipid release modulates neuronal excitability

  Fushun Wang, et al., bioRxiv - Neuroscience 2021

  Quote: ... calmidazolium chloride (CMZ, 2 µM, Tocris); methyl arachidonyl fluorophosphonate (MAFP ...
• Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension

  Luke Grundy, et al., bioRxiv - Neuroscience 2020

  Quote: ... BAM8-22 (2 μM; Tocris, #1763) and NPFF (5 μM ...
• IL-31 uncouples skin inflammation from itch sensation in allergic dermatitis

  Marlys S. Fassett, et al., bioRxiv - Immunology 2021

  Quote: ... or BAM8-22 (2 μM; Tocris), then capsaicin (1 μM ...
• SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet pro-coagulant activity

  Ambra Cappelletto, et al., bioRxiv - Pathology 2021

  Quote: ... and prostacyclin (PGI2; 2 μM, Tocris) followed by resuspension of the platelet pellet in modified Tyrode’s HEPES buffer (134 mmol/L NaCl ...