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251 - 300 of 1509 citations for 5 Nitro 1H benzo de isoquinoline 1 3 2H dione since 2020

• Fatty acid desaturation and lipoxygenase pathways support trained immunity

  Anaísa V. Ferreira, et al., bioRxiv - Immunology 2023

  Quote: ... 5 µM GSK2033 (Tocris), 10 or 100 µM Zileuton (Sigma) ...
• A human primary airway microphysiological system infected with SARS-CoV-2 distinguishes the treatment efficacy between nirmatrelvir and repurposed compounds fluvoxamine and amodiaquine

  Landys Lopez Quezada, et al., bioRxiv - Bioengineering 2023

  Quote: ... 5 μM ROCKi (Tocris), 1 μM A-83-01 (Tocris) ...
• Multi-dimensional profiling of hepatoblastomas and patient-derived tumor organoids uncovers tumor subpopulations with divergent WNT activation profiles and identifies pan-hepatoblastoma drug sensitivities

  Thomas A. Kluiver, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5 µM A83.01 (Tocris), 10 µM forskolin (Tocris ...
• miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity

  Theresa M. Welle, et al., bioRxiv - Neuroscience 2023

  Quote: ... 5 µM FK506 (Tocris), or 20 µM BAPTA-AM (Tocris ...
• Glutamate receptor-dependent cytosolic acidification in hippocampal neurons involves passive flux of protons from the extracellular space

  Sofie E. Pedersen, et al., bioRxiv - Neuroscience 2024

  Quote: ... CCCP (5 µM, Tocris), GABA (50 or 200 µM ...
• The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity

  Andrew C. Fleming, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 μM DAPT (Tocris), and 4 μM SU5402 (DNSK International ...
• Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

  Richard Drexler, et al., bioRxiv - Neuroscience 2024

  Quote: ... TRO19622 (5 μM; Tocris) and β-mercaptoethanol (Gibco) ...
• Chrna5 is essential for a rapid and protected response to optogenetic release of endogenous acetylcholine in prefrontal cortex

  Sridevi Venkatesan, Evelyn K. Lambe, bioRxiv - Neuroscience 2020

  Quote: ... Dihydro-β-erythroidine (DhβE, 3 μM, Tocris) was used to block β2 containing nicotinic receptors ...
• The mammalian rod synaptic ribbon is essential for Ca_v channel facilitation and ultrafast fusion of the readily releasable pool of vesicles

  Chad Paul Grabner, Tobias Moser, bioRxiv - Biophysics 2020

  Quote: ... at a concentration of 3 μM (TOCRIS). It showed better stability over time ...
• A Pluripotent Developmental State Confers a Low Fidelity of Chromosome Segregation

  Chenhui Deng, et al., bioRxiv - Cell Biology 2022

  Quote: ... 3 µM or 6 µM proTAME (Tocris) and mounted in modified rose chambers ...
• A Pluripotent Developmental State Confers a Low Fidelity of Chromosome Segregation

  Chenhui Deng, et al., bioRxiv - Cell Biology 2022

  Quote: ... 3 µM or 6 µM proTAME (Tocris). For monastrol arrest and release experiments ...
• A Pluripotent Developmental State Confers a Low Fidelity of Chromosome Segregation

  Chenhui Deng, et al., bioRxiv - Cell Biology 2022

  Quote: ... 3 µM or 6 µM proTAME (Tocris).
• Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis

  Haoyuan Jing, et al., bioRxiv - Cell Biology 2022

  Quote: ... 300 mOsm) containing NBQX (3 µM, Tocris) and bicuculine (30 µM ...
• A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

  Jinsoo Seo, et al., bioRxiv - Neuroscience 2020

  Quote: ... 3 μM Wnt-inhibitor (IWRe1, Tocris Biosciences) for 20 days ...
• Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids

  Yasuhiro Umemura, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 3 µM CHIRON99021 (Wako or Tocris Biosciences), and 1 µM PD0325901 (Wako ...
• Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALS

  Delfina Larrea, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 3 µM CHIR 99021 (Tocris 4423/10) and 10 µM ascorbic acid (AA ...
• α₁ adrenergic receptor - PKC - Pyk2 - Src signaling boosts L-type Ca²⁺ channel Ca_v1.2 activity and long-term potentiation in rodents

  Kwun Nok Mimi Man, et al., bioRxiv - Neuroscience 2022

  Quote: ... 3 µM PF-431396 (Tocris Cat#4278), 10 µM PP2 (Sigma-Aldrich Cat#P0042) ...
• Heparan sulfates regulate axonal excitability and context generalization through Ca²⁺/calmodulin-dependent protein kinase II

  Inseon Song, et al., bioRxiv - Neuroscience 2023

  Quote: ... GABAB receptor antagonist CGP55845 (3 μM, Tocris), Na+ channel blocker tetrodotoxin (TTX ...
• Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy

  Homa Majd, et al., bioRxiv - Developmental Biology 2022

  Quote: ... containing CHIR (3 µM, Tocris Bioscience, 4423) and FGF2 (10 ng/ml ...
• Aberrant splicing exonizes C9ORF72 repeat expansion in ALS/FTD

  Suzhou Yang, et al., bioRxiv - Neuroscience 2023

  Quote: ... CHIR 99021 (3 µM; Tocris, 4423/10), and ascorbic acid (10 µM ...
• Stereotyped cell lineage trees support robust development

  Xiaoyu Zhang, et al., bioRxiv - Developmental Biology 2024

  Quote: ... with 3 μm CHIR (Tocris, No.4423), 10 ng/mL rhKGF(R&D ...
• A Shape Sensing Mechanism driven by Arp2/3 and cPLA₂ licenses Dendritic Cells for Migration to Lymph Nodes in Homeostasis

  Zahraa Alraies, et al., bioRxiv - Cell Biology 2023

  Quote: ... CK666 (selective Arp2/3 inhibitor, Tocris #3950), BI605906 (selective IKKβ inhibitor #53001).
• Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization

  Denise Jahn, et al., bioRxiv - Cell Biology 2023

  Quote: ... BIBN 4096 (Tocris #4561, 10-3 M), recombinant mouse Cgrp (Bachem #H-2265 ...
• Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment

  Tyler Ogunmowo, et al., bioRxiv - Neuroscience 2023

  Quote: ... 300 mOsm) containing NBQX (3 µM, Tocris) and bicuculine (30 µM ...
• Species-specific LUBAC-mediated M1 ubiquitination regulates necroptosis by segregating the cellular distribution and fate of activated MLKL

  Nadine Weinelt, et al., bioRxiv - Cell Biology 2022

  Quote: ... and 3 µM Prostaglandin E2 (Tocris Bioscience) (hPO medium).
• Open top multi sample dual view light sheet microscope for live imaging of large multicellular systems

  F. Moos, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 3 uM SB202190 (Catalog no. 1264, Tocris), and 100 μg/ml Primocin (Catalog no ...
• Conservation of neuron-astrocyte coordinated activity among sensory processing centers of the developing brain

  Vered Kellner, et al., bioRxiv - Neuroscience 2024

  Quote: ... or LY341495 hydrochloride (3 mg/kg; Tocris; dissolved in ddH2O and diluted in 0.9% NaCl) ...
• Immune cells promote paralytic disease in mice infected with enterovirus D68

  Mikal A. Woods Acevedo, et al., bioRxiv - Microbiology 2024

  Quote: ... and 3 µM CHIR 99021 (Tocris, 4423). From days 0 to 6 ...
• The exit of naïve pluripotency contains a lipid metabolism-induced checkpoint for genome integrity

  Roshni A. de Souza, et al., bioRxiv - Developmental Biology 2024

  Quote: ... with inhibitors CHIR99021 (3 µM) (Tocris, 4423), PD0325901 (1 µM ...
• Human spinal cord differentiation proceeds rapidly in vitro and only initially maintains differentiation pace in a heterologous environment

  Alwyn Dady, et al., bioRxiv - Developmental Biology 2021

  Quote: ... Cells were then differentiated for 3 days (D) in N2B27 supplemented with 3 µM Chiron99021 (Tocris, Cat. No. 4953) and 20ng/ml bFGF (PeproTech ...
• Activation and signaling characteristics of the hydroxy-carboxylic acid 3 receptor identified in human neutrophils through a microfluidic flow cell technique

  Huamei Forsman, et al., bioRxiv - Immunology 2024

  Quote: ... The FFA2R antagonist CATPB ((S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl) phenyl) butanoic acid) was from Tocris Bioscience (Bristol ...
• Dopamine depletion can be predicted by the aperiodic component of subthalamic local field potentials

  Jinmo Kim, et al., bioRxiv - Neuroscience 2021

  Quote: ... 4 or 8 μl of 6-OHDA (5 μg in 1 μl saline containing 0.1% ascorbic acid; Tocris, Bristol ...
• GRK2/3/5/6 knockout: The impact of individual GRKs on arrestin-binding and GPCR regulation

  J. Drube, et al., bioRxiv - Cell Biology 2021

  Quote: Receptors were stimulated as follows: human Angiotensin 1 receptor (AT1R) with Angiotensin II (AngII; Tocris 4474-91-3, in measuring buffer), human β2 adrenergic receptor (β2ADR ...
• Calcium-permeable AMPA receptors govern PV neuron feature selectivity

  Ingie Hong, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 10 µM 6-imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide (SR95531;GABAA receptor antagonist; all from Tocris Bioscience).
• Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis

  Célia Alecki, et al., bioRxiv - Molecular Biology 2024

  Quote: ... the cells were either plated on laminin-coated 10 cm plates at 1.2×107 cells per plate for continued differentiation or expanded in motor neuron progenitor MNP medium (1× N2B27 medium supplemented with 3 mM CHIR99021, 2 mM DMH1 (Tocris, #4126), 2 mM SB431542 ...
• Defining totipotency using criteria of increasing stringency

  Eszter Posfai, et al., bioRxiv - Cell Biology 2020

  Quote: ... 3 µM CHIR99021 (Tocris 4423, or Axon 1386); 4 µM TCS JNK 60 (Tocris 3222) ...
• Developmental Divergence of Sensory Stimulus Representation in Cortical Interneurons

  Rahel Kastli, et al., bioRxiv - Neuroscience 2020

  Quote: ... In all cases 3 mg/ml biocytin (Tocris) was added in the recording solution and no extra pharmacology was added ...
• Monosodium Urate Crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response

  Isidoro Cobo, et al., bioRxiv - Cell Biology 2021

  Quote: ... p38 MAPK inhibitor SB203580 (3 uM, Tocris, #1202), JNK inhibitor SP600125 (20uM ...
• Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

  Kizito-Tshitoko Tshilenge, et al., bioRxiv - Neuroscience 2022

  Quote: ... GABA (500 µL, 3 mM, Tocris Bioscience, 0344), CaCl2 (370 µL ...
• Reduced Hippocampal Inhibition and Enhanced Autism-Epilepsy Comorbidity in Mice Lacking Neuropilin 2

  Carol Eisenberg, et al., bioRxiv - Neuroscience 2021

  Quote: ... kynurenic acid (3 mM KyA, Tocris, Ellisville, MO) in the recording aCSF ...
• Pump-less, recirculating organ-on-a-chip (rOoC) platform

  M. Busek, et al., bioRxiv - Bioengineering 2022

  Quote: ... 3 μM CHIR99021 (Tocris Bioscience, catalogue no. 4423), 50 nM PI-103 (Tocris Bioscience ...
• Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocation

  Miha Modic, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 3 mM GSK3 inhibitor CHIR99021 (4953/50 Tocris), and 1,000 U/ml LIF (ESGRO ESG1107 ...
• Layer 1 NDNF⁺ Interneurons Control Bilateral Sensory Processing in a Layer-dependent Manner

  Rasmus Vighagen, et al., bioRxiv - Neuroscience 2021

  Quote: ... In some cases 3 mg/ml biocytin (Tocris) was added in the recording solution ...
• Microglial amyloid beta clearance is driven by PIEZO1 channels

  Henna Konttinen, et al., bioRxiv - Neuroscience 2022

  Quote: ... 3) a selective PIEZO1 agonist Yoda1 (5586, Tocris). For pressure pulse stimulation ...
• Rho/ROCK activity tunes cell compartment segregation and differentiation in nephron-forming niches

  John M. Viola, et al., bioRxiv - Bioengineering 2023

  Quote: ... which included 3 µM CHIR 99021 (Tocris, 4423) +/- 10 µM Y27632 (StemCell Technologies ...
• Neural tube organoids self-organise floorplate through BMP-mediated cluster competition

  Teresa Krammer, et al., bioRxiv - Developmental Biology 2023

  Quote: ... N2B27 was supplemented with 3 µM CHIR99021 (Tocris), 1 µM PD0325901 (Tocris ...
• High-speed AFM reveals fluctuations and dimer splitting of the N-terminal domain of GluA2-γ2

  Ayumi Sumino, et al., bioRxiv - Neuroscience 2023

  Quote: ... 3 mM L-glutamate (Glu, #0218, Tocris, UK) and 0.1 mM cyclothiazide (CTZ ...
• Disentangling cell-intrinsic and extrinsic factors underlying gene expression evolution

  Alexander L. Starr, et al., bioRxiv - Evolutionary Biology 2024

  Quote: ... and 3 μM GSK3 inhibitor CHIR99021 (Tocris: 4423). Undifferentiated tdTomato-labelled rat ESCs were maintained in N2B27 medium containing 1 μM MEK inhibitor PD0325901 ...
• Experience instructs the refinement of feature-selectivity in the mouse primary visual thalamus

  Takuma Sonoda, et al., bioRxiv - Neuroscience 2024

  Quote: ... 3 mg/kg clozapine N-oxide (CNO) (Tocris) was injected subcutaneously ...
• The human glucocorticoid receptor variant rs6190 promotes blood cholesterol and atherosclerosis

  Hima Bindu Durumutla, et al., bioRxiv - Physiology 2024

  Quote: ... and 3 µM CHIR99021 (Cat #4423, Tocris Bioscience). Following 24-h treatment ...