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251 - 300 of 806 citations for 4 Nitro n propan 2 yl aniline since 2020

• Non-canonical Hedgehog signaling through L-type voltage gated Ca²⁺ channels controls CD8⁺ T cell killing

  Joachim Hanna, et al., bioRxiv - Immunology 2021

  Quote: In vitro tamoxifen was given as 4-hydroxytamoxifen (4-OH-Tamoxifen or OHT) (TOCRIS, Cat no. 3412) solubilized in DMSO (Life Technologies ...
• Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity

  Sascha R.A. Alles, et al., bioRxiv - Neuroscience 2020

  Quote: ... and N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide (IEM-1460, Tocris) were prepared as 10 mM stocks dissolved in distilled water ...
• The MS remyelinating drug bexarotene (an RXR agonist) promotes induction of human Tregs and suppresses Th17 differentiation in vitro

  Christof Gaunt, et al., bioRxiv - Immunology 2021

  Quote: ... and 2 ng/ml IL-2 (carrier-free; Tocris R&D Systems). Cells treated with only these functioned as the mock control ...
• GLUT1 ablation in astrocytes paradoxically improves central and peripheral glucose metabolism via enhanced insulin-stimulated ATP release

  Carlos G. Ardanaz, et al., bioRxiv - Neuroscience 2022

  Quote: ... or 20 μM 2-methylthyo-adenosine-5’-triphosphate (2-MeSATP, Tocris, 1062) over a 5-min period ...
• Association of a Common Genetic Variant with Parkinson’s Disease is Propagated through Microglia

  R. G. Langston, et al., bioRxiv - Neuroscience 2021

  Quote: ... MLi-2 (Tocris #5756) was reconstituted in DMSO to a stock concentration of 10mM ...
• HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum

  Braulio Munoz, et al., bioRxiv - Neuroscience 2022

  Quote: ... WIN55,212-2 (1038, Tocris), and Torin 2 (4248 ...
• LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

  Luis Bonet-Ponce, et al., bioRxiv - Cell Biology 2020

  Quote: ... MLi-2 (Tocris, 5756) was used at 1 µM ...
• Cannabis sativa Terpenes are Cannabimimetic and Provide Support for the Entourage Effect Hypothesis

  Justin E. LaVigne, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: WIN55,212-2 (Tocris, #1038), α-Humulene (Sigma Aldrich ...
• Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38

  Ceryl Tan, et al., bioRxiv - Cell Biology 2020

  Quote: ... Torin-2 (Tocris 4248), rapamycin (CalBiochem 553211) ...
• LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

  Riccardo Sirtori, et al., bioRxiv - Neuroscience 2024

  Quote: ... DMH1 (2 μM, Tocris) and SB431542 (2 μM ...
• CDKN1B (p27^kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors

  Elad Horwitz, et al., bioRxiv - Cancer Biology 2024

  Quote: ... AKTi-1/2 (Tocris), MK-2206 (VWR) ...
• Proteostasis and lysosomal quality control deficits in Alzheimer’s disease neurons

  Ching-Chieh Chou, et al., bioRxiv - Cell Biology 2023

  Quote: ... 2 µM Dorsomorphin (TOCRIS) and 2 µM XAV939 (Stemgent) ...
• NOTCH3 signalling controls human trophoblast stem cell expansion and differentiation

  Bianca Dietrich, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 µM CHIR99021 (Tocris) and 5µM Y27632 (Santa Cruz) ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... 2 μM PD0332991 (Tocris), 10 ng/ml human BDNF (Miltenyi Biotec) ...
• An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

  Leonard Yoon, et al., bioRxiv - Cell Biology 2023

  Quote: ... 2 µM Dorsomorphin (Tocris), 10 µM SB-431542 (Tocris) ...
• Genetically edited human placental organoids cast new light on the role of ACE2 in placental development

  Anya L. Arthurs, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 2 µM CHIR99021 (Tocris) and 5 µM Y27632 (Santa Cruz).
• A trimeric USP11/USP7/TCEAL1 complex stabilizes RNAPII during early transcription to sustain oncogenic gene expression

  Markus Dehmer, et al., bioRxiv - Cancer Biology 2024

  Quote: ... NVP-2 (Tocris Biosciences), Flavopiridol (Sigma-Aldrich) ...
• Lipogenesis and innate immunity in hepatocellular carcinoma cells reprogrammed by an isoenzyme switch of hexokinases

  Laure Perrin-Cocon, et al., bioRxiv - Cancer Biology 2020

  Quote: ... cells were stained with the 4,4-difluoro-1,3,5,7,8-Pentamethy-4-Bora-3a,4a-Diaza-s-indacene (BODIPY) 493/503 dye (Tocris Bio-Techne).
• OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

  Hugo Sepulveda, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Ogt deletion was induced by exposing Ogt iKO mESC to 1 μM 4-hydroxytamoxifen (4-OHT) (TOCRIS, 3412). At the time points used in this study (6 days after 4-OHT treatment) ...
• Defining totipotency using criteria of increasing stringency

  Eszter Posfai, et al., bioRxiv - Cell Biology 2020

  Quote: ... 4 µM TCS JNK 60 (Tocris 3222); 5 µM XAV939 (Sigma-Aldrich X3004) ...
• VTA-projecting cerebellar neurons mediate stress-dependent depression-like behavior

  Soo Ji Baek, et al., bioRxiv - Neuroscience 2021

  Quote: ... and 4-AP (1 mM, Tocris Bioscience), as was done previously (Carta et al. ...
• Microglia-neuron communication at nodes of Ranvier depends on neuronal activity through potassium release and contributes to myelin repair

  R. Ronzano, et al., bioRxiv - Neuroscience 2020

  Quote: ... or MRS2211 (4 hours, 50 μM, Tocris) were used to inhibit the microglial purinergic receptors P2Y12R and P2Y12R/P2Y13R respectively ...
• Cortical ChAT⁺ neurons co-transmit acetylcholine and GABA in a target- and brain-region specific manner

  Adam J Granger, et al., bioRxiv - Neuroscience 2020

  Quote: ... followed by 100 µM 4-aminopyridine (Tocris). To rule out contributions from other low latency excitatory receptors ...
• Itaconate and its derivatives repress C2C12 myogenesis

  Tae Seok Oh, et al., bioRxiv - Cell Biology 2021

  Quote: ... and 4-octyl itaconate (Tocris Bioscience, 6662).
• Novel genetically encoded tools for imaging or silencing neuropeptide release from presynaptic terminals in vivo

  Dong-Il Kim, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 50 µM 4-AP (Tocris Bioscience). All solutions were continuously bubbled with 95% O2-5% CO2 with pH 7.3-7.4 and 300-310 mOsm ...
• PI3 kinase inhibitor PI828 uncouples aminergic GPCRs and Ca²⁺ mobilization irrespectively of its primary target

  Polina D. Kotova, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... and 4-DAMP were purchased from Tocris Bioscience ...
• Motor cortex directly excites the output nucleus of the basal ganglia, the substantia nigra pars reticulata

  William Scott Thompson, et al., bioRxiv - Neuroscience 2024

  Quote: ... and 4-aminopyridine (100 μM; Tocris, U.K.) to isolate monosynaptic responses ...
• The L27 Domain of MPP7 enhances TAZ-YY1 Cooperation to Renew Muscle Stem Cells

  Anwen Shao, Joseph L. Kissil, Chen-Ming Fan, bioRxiv - Developmental Biology 2023

  Quote: ... 1 µM 4-OH-TMX (Tocris Bioscience) was added to sustain knockout efficiency ...
• Multimodal mechanisms of human centriole engagement and disengagement

  Kei K Ito, et al., bioRxiv - Cell Biology 2024

  Quote: ... Taxol (Tocris, 33069-62-4, 100 nM), and GSK461364 (MedChem Express ...
• Scalable Hypothalamic Arcuate Neuron Differentiation from Human Pluripotent Stem Cells Suitable for Modeling Metabolic and Reproductive Disorders

  Vukasin M. Jovanovic, et al., bioRxiv - Developmental Biology 2024

  Quote: ... Exendin-4 at 10 nM (Tocris, 1933), Forskolin (Tocris ...
• Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

  Kevin Wilhelmsen, et al., bioRxiv - Immunology 2024

  Quote: ... or 4 mM ATP (final concentration; TOCRIS) in Opti-Mem medium with the corresponding concentration of test compound was added to the wells for an additional 1 hr ...
• Estradiol Influences Adenosinergic Signaling and NREM Sleep Need in Adult Female Rats

  Philip C. Smith, et al., bioRxiv - Neuroscience 2021

  Quote: ... free microdialysis probes (n=3) were inserted into a solution of 100nM adenosine (Tocris Biosciences, Bristol, U.K.) in Ringer’s Solution ...
• OGT controls mammalian cell viability by regulating the proteasome/mTOR/mitochondrial axis

  Xiang Li, et al., bioRxiv - Cell Biology 2022

  Quote: ... Ogt deletion was then induced by the addition of 1 μM 4-hydroxytamoxifen (4-OHT) (TOCRIS, catalog number: 3412). Mouse ESCs were maintained on mitomycin C-treated mouse embryonic fibroblasts (MEFs ...
• Astrocytes tune neuronal excitability through the Ca²⁺-activated K⁺ current sIAHP

  Sara Expósito, et al., bioRxiv - Neuroscience 2024

  Quote: ... and 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine (CNO) were purchased from Tocris. 8-Cyclopentyl-1,3-dimethylxanthine (CPT) ...
• CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability

  Marina P. Hommersom, et al., bioRxiv - Neuroscience 2024

  Quote: ... CACNA1A+/− networks on MEA at DIV51 were treated with 20 µM 4-aminopyridine (4-AP; Tocris, #504-24-5) and recorded for 30 minutes after the compound was added ...
• Neuromesodermal Progenitors Advance Network Formation of Spinal Neurons and Support Cells in Neural Ribbons In Vitro and Unprotected Survival in a Rat Subacute Contusion Model

  Zachary T. Olmsted, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2 μM CHIR99021 (Tocris Bioscience), 10 μM DAPT (Millipore Sigma) ...
• The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

  E. Werner, et al., bioRxiv - Cell Biology 2022

  Quote: ... 2 μM dorsomorphin (Tocris, 3093) and 2 μM A-83 (Tocris ...
• Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis

  Vukasin M. Jovanovic, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 2 µM forskolin (1099, Tocris), 200 nM phorbol-12 myristate-13 acetate (1201 ...
• A cell-based platform for oxidative stress monitoring in motor neurons using genetically encoded biosensors of H₂O₂

  Elizaveta I. Ustyantseva, et al., bioRxiv - Cell Biology 2021

  Quote: ... and 2 μM DMH1 (Tocris) for 6 days ...
• TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons

  Ki Bum Um, et al., bioRxiv - Neuroscience 2021

  Quote: ... 2-APB (Tocris, Cat.#: 1224), CPP (Tocris ...
• Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure

  Patricia Rueda, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... 2’Me-CCPA (Tocris, 2281), MRS1754 (Tocris ...
• Identification and Characterization of Stem Cells in Mammalian Esophageal Stratified Squamous Epithelia

  Yanan Yang, et al., bioRxiv - Cell Biology 2021

  Quote: ... Wnt inhibitor IWP-2(TOCRIS) and Srfp-2(R&D Systems ...
• Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomes

  Jillian H. Kluss, et al., bioRxiv - Cell Biology 2021

  Quote: ... MLi-2 (Tocris, cat #5756) was used at 1 μM in DMSO for 90 min ...
• A peptidergic amygdala microcircuit modulates sexually dimorphic contextual fear

  AK Rajbhandari, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2 mg/ml biocytin (Tocris) was dissolved in the intracellular solution and cells were dialyzed for 20 minutes ...
• Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex

  Stephen D. Glasgow, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 2-Aminoethoxydiphenylborane (1224, Tocris) in DMSO ...
• Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells

  Yuka Sakata, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 2 μM SU-5402 (Tocris), and 10 μM DAPT (Tocris) ...
• HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum

  Braulio Munoz, et al., bioRxiv - Neuroscience 2022

  Quote: ... and Torin 2 (4248, Tocris). Other reagents used for making solutions were purchased from Sigma-Aldrich or Fisher Scientific.
• An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

  Kathleen C. Keough, et al., bioRxiv - Developmental Biology 2021

  Quote: ... SB-505124 (2 μM; Tocris) and FGF2 (20 ng/mL ...
• Single cell trajectory analysis of human pluripotent stem cells differentiating towards lung and hepatocyte progenitors

  Chaido Ori, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 2 μM dorsomorphin (DSM; Tocris) and 10 μM SB431542 (Miltenyi Biotec) ...
• Cell-type specific innate immune responses shape rabies virus tropism

  Lena Feige, et al., bioRxiv - Microbiology 2021

  Quote: ... 2 μM CHIR99021 (4423, TOCRIS) induced mesoderm specification of human iPSC colonies (XCL-1 ...