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251 - 300 of 677 citations for 4 2 Trimethylsilyl Ethyl Aniline since 2020

• Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

  Zheng Liao, et al., bioRxiv - Cell Biology 2024

  Quote: ... 0.3 μm WH-4-023 (Tocris, cat. no. 5413), 2 μm Minocycline hydrochloride (Santa Cruz Biotech-nology ...
• Effect of Positive Allosteric Modulation and Orthosteric Agonism of Dopamine D2 Receptors on Respiration in Mouse Models of Rett Syndrome

  Sebastian N. Maletz, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: PAOPA ((3R)-2-Oxo-3-[[(2S)-2-Pyrrolidinylcarbonyl]amino]-1-pyrrolidineacetamide) was acquired from Tocris (Minneapolis, MN). (-)Quinpirole HCl and dopamine HCl were acquired from Sigma-Aldrich (St ...
• Inhibition of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner

  Jessica L Hoffman, et al., bioRxiv - Neuroscience 2022

  Quote: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one (JNJ-5; Tocris, Minneapolis, MN) is a high affinity ...
• TRPM8-dependent shaking in mammals and birds

  Tudor Selescu, et al., bioRxiv - Physiology 2024

  Quote: ... N-(3-aminopropyl)-2-{[(3-methylphenyl)methyl]oxy}-N-(2-thienylmethyl)benzamide hydrochloride salt (AMTB, Tocris #3989) 10 mM in H2O ...
• Bassoon controls synaptic vesicle pools via regulation of presynaptic phosphorylation and cAMP homeostasis

  Carolina Montenegro-Venegas, et al., bioRxiv - Neuroscience 2021

  Quote: ... and (+)-Bicuculline (CAS #485-49-4) were purchased from Tocris. H-89 (CAS #130964-39-5) ...
• Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish

  Ester Antón-Galindo, et al., bioRxiv - Neuroscience 2021

  Quote: ... Quinpirole 0.25-4 mg/L diluted in H2O (Tocris #1061) was administered by immersion for 1 hour.
• Sertraline modulates hippocampal plasticity and learning via sigma 1 receptors, cellular stress and neurosteroids

  Yukitoshi Izumi, et al., bioRxiv - Neuroscience 2024

  Quote: ... NE-100 (CAS#:149409-57-4) was purchased from Tocris Bioscience (Ellisville MO) ...
• Distinct subtypes of grey matter heterotopia show subtype-specific morpho-electric neuronal properties and dynamics of epileptiform activity in mice

  Jean-Christophe Vermoyal, et al., bioRxiv - Neuroscience 2023

  Quote: ... 0,2 4-methoxy-7-nitroindolinyl (MNI)-caged glutamate (Tocris Bioscience), 0,005 CPP [()-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid] (NMDA receptors antagonist ...
• Homeostatic Synaptic Plasticity Rescues Neural Coding Reliability

  Eyal Rozenfeld, et al., bioRxiv - Neuroscience 2022

  Quote: ... 100 μM of CGP 54626 (Tocris, CAS: 149184-21-4) and 250 μM of picrotoxin (Sigma-Aldrich ...
• A distinct hypothalamus-habenula circuit governs risk preference

  Dominik Groos, et al., bioRxiv - Neuroscience 2024

  Quote: ... 4-AP (100 µM, Tocris, 0940, CAS: 504-24-5), CNQX (20 µM ...
• Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

  Richard Drexler, et al., bioRxiv - Neuroscience 2024

  Quote: ... EdU (4 μM) with or without VU 0255035 (10μM, Tocris) or 4-DAMP (10μM ...
• Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis

  Chloé Berland, et al., bioRxiv - Neuroscience 2021

  Quote: ... d-amphetamine sulphate (2 mg/kg, Tocris), JZL184 (8 mg/kg ...
• The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

  E. Werner, et al., bioRxiv - Cell Biology 2022

  Quote: ... and 2 μM A-83 (Tocris, 692), in non-treated polystyrene plates for 7 days with a daily medium change ...
• Derivation of macaque trophoblast stem cells

  Jenna Kropp Schmidt, et al., bioRxiv - Developmental Biology 2020

  Quote: ... 2 µM CHIR99021 (Tocris, cat no: 4423), 0.5 µM A83-01 (Tocris ...
• Deletion of the mitochondrial matrix protein cyclophilin-D prevents parvalbumin interneuron dysfunction and cognitive deficits in a mouse model of NMDA hypofunction

  Aarron Phensy, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 2 QX-314 bromide (Tocris Bioscience). Theta-glass pipettes (Warner Instruments ...
• ASH1L REGULATES THE STRUCTURAL DEVELOPMENT OF NEURONAL CIRCUITRY BY MODULATING BDNF/TrkB SIGNALING IN HUMAN NEURONS

  Seon Hye Cheon, et al., bioRxiv - Neuroscience 2020

  Quote: ... Y27632 dihydrochloride (Tocris Catalog #129830-23-2), to ensure the survival of singly dissociated stem cells ...
• Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export

  Lauren Duan, et al., bioRxiv - Cell Biology 2021

  Quote: ... or NVP-2 (Tocris Bioscience, in DMSO) at doses/times indicated in the figure legends ...
• NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve pluripotent stem cells

  Katsiaryna Maskalenka, et al., bioRxiv - Developmental Biology 2022

  Quote: ... supplemented either with 2 μM Gö6983 (Tocris), 1 μM PD0325901 ...
• A new mutant mouse model lacking mitochondrial-associated CB₁ receptor

  Antonio C. Pagano Zottola, et al., bioRxiv - Neuroscience 2020

  Quote: ... WIN 55,212-2 was purchased from Tocris Bioscience (Bristol ...
• Neural-specific alterations in glycosphingolipid biosynthesis and cell signaling associated with two human ganglioside GM3 Synthase Deficiency variants

  Michelle Dookwah, et al., bioRxiv - Neuroscience 2021

  Quote: ... 2 µM GSK3 inhibitor IX (BIO) (Tocris), and 20 µM SB431542 (Tocris) ...
• Impaired migration and premature differentiation underlie the neurological phenotype associated with PCDH12 loss of function

  Jennifer Rakotomamonjy, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2 mM of A83-01 (Tocris, 2939), and kept shaking at 95 rpm for 7 days ...
• ERBB-activated myofibroblastic cancer-associated fibroblasts promote local metastasis of pancreatic cancer

  Gianluca Mucciolo, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 2 μM A83-01 (2939; Tocris Bioscience), 10 ng/mL murine EGF (PMG8043 ...
• Establishment of Bovine Trophoblast Stem Cells

  Yinjuan Wang, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 2 μM Dimethinedene maleate (DiM) (Tocris, 1425) and 2 μM Minocycline hydrochloride (MiH ...
• Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signaling

  Yiming Fang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 10uM IWP-2 (Tocris, Cat. No. 3533) dissolved in DMSO ...
• Multidimensional super-resolution microscopy unveils nanoscale surface aggregates in the aging of FUS condensates

  Changdong He, Chun Ying Wu, Wan Li, Ke Xu, bioRxiv - Biophysics 2023

  Quote: ... 10 μM of CRANAD-2 (4803, Tocris), and 5 nM of Cy3B hydrolyzed from Cy3B-NHS ester (PA63101 ...
• Transgene directed induction of a stem cell-derived human embryo model

  Bailey AT Weatherbee, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 8nM β-estradiol (50-28-2, Tocris) and 200ng/mL progesterone (P0130 ...
• Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

  Kizito-Tshitoko Tshilenge, et al., bioRxiv - Neuroscience 2022

  Quote: ... ascorbic acid (2 mM, Tocris Bioscience, 4055). Medium was passed through a 0.22-µm filter ...
• Activity of Salmonella SPI-1 inhibits the TLR4-dependent transcriptional but not translational response during macrophage infection

  George Wood, et al., bioRxiv - Molecular Biology 2024

  Quote: ... TLR1/2 was stimulated with Pam3CSK4 (Tocris). Mock stimulations were conducted with vehicle only ...
• Vagus nerve stimulation (VNS) modulates synaptic plasticity in the rat infralimbic cortex via Trk-B receptor activation to reduce drug-seeking

  Christopher M. Driskill, et al., bioRxiv - Neuroscience 2024

  Quote: ... and 2 QX-314 bromide (Tocris Bioscience). Theta-glass pipettes (Warner Instruments ...
• VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction

  Harris E. Blankenship, et al., bioRxiv - Neuroscience 2023

  Quote: ... SGC-CK-2 was purchased from Tocris. All additional chemicals were purchased from Sigma-Aldrich.
• Allosteric Competition and Inhibition in AMPA Receptors

  W. Dylan Hale, et al., bioRxiv - Biophysics 2023

  Quote: ... and 2 µM ZK 20075 (Tocris, 2345) and moved into a 30 ˚C ...
• Biomimetic fractal topography enhances podocyte maturation in vitro

  Chuan Liu, et al., bioRxiv - Bioengineering 2024

  Quote: ... Verteporfin (1 or 2 μg/ml, Tocris) was added to the culture media 24 hours post seeding ...
• Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer’s disease and aging

  Bidur Paudel, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2 μM XAV939 (Tocris Bioscience, Bristol, UK), and 3 μg/ml doxycycline (Sigma) ...
• Non-invasive quantification of contractile dynamics in cardiac cells, spheroids and organs-on-a-chip using high frequency ultrasound

  Eric M. Strohm, et al., bioRxiv - Bioengineering 2022

  Quote: ... the Wnt inhibitor IWP2 (2□uM, TOCRIS) and rhVEGF (10□ng/mL ...
• Actin contraction controls nuclear blebbing and rupture independent of actin confinement

  Mai Pho, et al., bioRxiv - Cell Biology 2022

  Quote: ... 10 μM Y27632 (129830-38-2, Tocris), 10 nM of Rho Activator II CN03 (Cytoskeleton ...
• APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

  Meghan E. Wynne, et al., bioRxiv - Cell Biology 2022

  Quote: ... and 2 μM A-83 (Tocris, 692). After 7 days ...
• Lesion-specific suppression of YAP/TAZ by biomimetic nanodrug ameliorates atherosclerosis development

  Hui-Chun Huang, et al., bioRxiv - Bioengineering 2023

  Quote: ... or 2 mg of VP (Tocris Bioscience) was dissolved in 1 mL of DCM containing PLGA ...
• Epigenetic memory of Lateral Ganglionic Eminence derived hiPSCs cannot overcome barriers in authentic MSN differentiation

  O. J. M. Bartley, et al., bioRxiv - Cell Biology 2024

  Quote: ... and 2 μM XAV-939 (Xav; Tocris). From day 6 ...
• Memantine Inhibits Calcium-Permeable AMPA Receptors

  Elisa Carrillo, et al., bioRxiv - Biophysics 2024

  Quote: ... and 2 µM ZK 20075 (Tocris, 2345) were added to cells 12 – 24 hours post-induction ...
• Longitudinal multi-omics reveals pathogenic TSC2 variants disrupt developmental trajectories of human cortical organoids derived from Tuberous Sclerosis Complex

  Weibo Niu, et al., bioRxiv - Neuroscience 2024

  Quote: ... and 2 μM Dorsomorphin dihydrochloride (Tocris/fisher). On day 6 ...
• Vcam1+ Fibro-adipogenic Progenitors Mark Fatty Infiltration in Chronic Limb Threatening Ischemia

  Qunsheng Dai, et al., bioRxiv - Genomics 2024

  Quote: ... 2 uM Way-316606 hydrochloride (Tocris, 4767) or vehicle control (DMSO) ...
• Axonal transport of Hrs is activity-dependent and rate limiting for synaptic vesicle protein degradation

  Veronica Birdsall, et al., bioRxiv - Neuroscience 2021

  Quote: ... 4- aminopyridine (Tocris Bioscience, 50 µM, 5 min-2hrs or 20hrs), AP5 (Tocris Bioscience ...
• Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci

  Ákos Menyhárt, et al., bioRxiv - Neuroscience 2020

  Quote: ... and the aquaporin-4 channel inhibitor TGN-020 (Tocris; 100 μM) were co-applied (n=16) ...
• LRH-1/NR5A2 regulates the PTGS2-PGE₂-PTGER1 signalling axis contributing to islet survival and antidiabetic actions of the agonist BL001

  Eugenia Martin Vázquez, et al., bioRxiv - Physiology 2021

  Quote: ... and/or 4) 100 nM ONO-8130 (Tocris Bioscience, Bristol, UK). In the latter two conditions ...
• A blue-shifted genetically encoded Ca²⁺ indicator with enhanced two-photon absorption

  Abhi Aggarwal, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 1 mM (S)-α-methyl-4-carboxyphenylglycine ((S)-MCPG) (Tocris). Neurons were field stimulated with 1 ...
• Sensory neuron population expansion enhances odor tracking without sensitizing projection neurons

  Suguru Takagi, et al., bioRxiv - Neuroscience 2024

  Quote: ... 50 µM CGP54626 hydrochloride (1088/10, TOCRIS, CAS 149184-21-4), 200 µM (low dose ...
• Spinal cerebrospinal fluid contacting neurons are a conserved sensory neuronal population along the mouse spinal cord

  Crozat Elysa, et al., bioRxiv - Neuroscience 2024

  Quote: ... α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA, Tocris Bioscience), Kainate and N-methyl-D-aspartate acid (NMDA ...
• Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate Culture

  Vinod Kumar Reddy Lekkala, et al., bioRxiv - Bioengineering 2024

  Quote: ... 25 ng/mL bone morphogenetic protein 4 (BMP4; Tocris; 314-BP), 1% GlutaMAXTM (Gibco ...
• G protein-Coupled Receptor Associated Sorting Protein GASP1 mediated trafficking of the Glucagon Like Peptide-1 Receptor contributes to the development of tolerance to incretin drugs

  Anirudh Gaur, et al., bioRxiv - Cell Biology 2024

  Quote: ... high glucose (11mM) or high glucose + 100nM Ex-4 (Tocris, 1933). After an hour ...
• Comparative chromatin accessibility upon BDNF-induced neuronal activity delineates neuronal regulatory elements

  Ignacio L. Ibarra, et al., bioRxiv - Genomics 2021

  Quote: ... neurons were made quiescent for 2 hours with 100 μM D-2- amino-5-phosphonopentanoic acid (D-AP5; Tocris #0106) and 1 μM tetrodotoxin (TTX ...