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201 - 250 of 854 citations for Acetaldehyde 3a 4 5 6 7 7a hexahydro 4 7 methano 1H inden 5 yl oxy since 2020

• Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytes

  Claudia Raggi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... 4 μM IWP-2 (Tocris), and 1 μM A83-01 (Tocris ...
• SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

  Eline J.H. van Hugte, et al., bioRxiv - Neuroscience 2023

  Quote: ... Topiramate (Tocris, #97240-79-4), and Carbamazepine (Tocris ...
• Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation

  Quyen B. Do, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 4 μM XAV (Tocris). On DIV 04 ...
• Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

  Richard Drexler, et al., bioRxiv - Neuroscience 2024

  Quote: ... or 4-DAMP (10μM, Tocris) was added and incubated for a further 24h ...
• Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis

  Célia Alecki, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 4 μM CHIR99021 (Tocris, #4423) and 10 μM Y-27632 hydrochloride (ROCK inhibitor ...
• Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF

  Vladyslava Gorbovytska, et al., bioRxiv - Biochemistry 2021

  Quote: ... neurons at DIV 7 were made quiescent by 1 μM tetrodotoxin (TTX; 1078, Tocris, Minneapolis, MN) overnight ...
• SARS-CoV-2 Viral Replication in a High Throughput Human Primary Epithelial Airway Organ Model

  Christine R. Fisher, et al., bioRxiv - Bioengineering 2021

  Quote: ... + 5 μM ROCKi (Tocris)) and transported on ice to Draper (Cambridge ...
• Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility

  Joshua M. Tworig, Chandler Coate, Marla B. Feller, bioRxiv - Neuroscience 2021

  Quote: ... 5 μM pirenzepine (Tocris), 5 μM gabazine (Tocris) ...
• Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility

  Joshua M. Tworig, Chandler Coate, Marla B. Feller, bioRxiv - Neuroscience 2021

  Quote: ... 5 μM gabazine (Tocris), 25 μM DL-TBOA (Tocris) ...
• High-Throughput Human Primary Cell-Based Airway Model for Evaluating Influenza, Coronavirus, or other Respiratory Viruses in vitro

  A.L. Gard, et al., bioRxiv - Microbiology 2020

  Quote: ... 5 μM ROCKi (Tocris), 1 μM A-83-01 (Tocris) ...
• DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity

  Daniel J. Wilcock, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 5 μM Ebselen (Tocris), 1 mM Tempol ...
• Cortical spheroids display oscillatory network dynamics

  Jessica L. Sevetson, et al., bioRxiv - Neuroscience 2021

  Quote: ... AP-5 (Tocris 0105) was used at a concentration of 50 μM or 5 μM and incubated with the spheroid for 10 minutes prior to imaging ...
• Osteoarthritis: articular chondrocyte inflammatory signaling leads to enhanced gene expression and function of mechanotransduction channel Piezo1 as a pathogenic feed-forward mechanism

  Whasil Lee, et al., bioRxiv - Molecular Biology 2020

  Quote: ... dynasore (5 μM, Tocris), verapamil (0.5 μM ...
• A human primary airway microphysiological system infected with SARS-CoV-2 distinguishes the treatment efficacy between nirmatrelvir and repurposed compounds fluvoxamine and amodiaquine

  Landys Lopez Quezada, et al., bioRxiv - Bioengineering 2023

  Quote: ... 5 μM ROCKi (Tocris), 1 μM A-83-01 (Tocris) ...
• Fatty acid desaturation and lipoxygenase pathways support trained immunity

  Anaísa V. Ferreira, et al., bioRxiv - Immunology 2023

  Quote: ... 5 µM GSK2033 (Tocris), 10 or 100 µM Zileuton (Sigma) ...
• Multi-dimensional profiling of hepatoblastomas and patient-derived tumor organoids uncovers tumor subpopulations with divergent WNT activation profiles and identifies pan-hepatoblastoma drug sensitivities

  Thomas A. Kluiver, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 5 µM A83.01 (Tocris), 10 µM forskolin (Tocris ...
• miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity

  Theresa M. Welle, et al., bioRxiv - Neuroscience 2023

  Quote: ... 5 µM FK506 (Tocris), or 20 µM BAPTA-AM (Tocris ...
• Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

  Richard Drexler, et al., bioRxiv - Neuroscience 2024

  Quote: ... TRO19622 (5 μM; Tocris) and β-mercaptoethanol (Gibco) ...
• The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity

  Andrew C. Fleming, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 μM DAPT (Tocris), and 4 μM SU5402 (DNSK International ...
• Glutamate receptor-dependent cytosolic acidification in hippocampal neurons involves passive flux of protons from the extracellular space

  Sofie E. Pedersen, et al., bioRxiv - Neuroscience 2024

  Quote: ... CCCP (5 µM, Tocris), GABA (50 or 200 µM ...
• Microglial cannabinoid receptor type 1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication

  Yuto Hasegawa, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 10 μM 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide (SR95531; GABAA receptor antagonist, all from Tocris). The resting membrane potential was measured after whole-cell configuration was achieved ...
• Hematopoietic stem cell division is governed by distinct RUNX1 binding partners

  Anne L. Robertson, et al., bioRxiv - Cell Biology 2024

  Quote: ... transgenic embryos were treated in 6-well plates at the indicated time points with 5 μM Ro5-3335 (Tocris) or DMSO (Sigma ...
• The evolutionary ancient MEIS transcription factors actuate lineage-specific transcription to establish cardiac fate

  Zoulfia Darieva, et al., bioRxiv - Developmental Biology 2024

  Quote: ... Monolayers followed the same timing but were cultured in 6-well plates in 3.5 ml of medium and 5 µM XAV939 (Tocris) was included between day 3 and 6.
• ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

  Asmi Chakraborty, et al., bioRxiv - Cancer Biology 2022

  Quote: Pancreatitis was induced by 7 intraperitoneal injections of cerulein (50 μg/kg; Tocris Bioscience, cat#62-641) at hourly intervals on two alternating days ...
• Interneurons that BiTE: Harnessing the migratory capacity of cortical inhibitory interneuron precursors to treat high-grade glioma

  Stephanie N. Brosius, et al., bioRxiv - Cancer Biology 2024

  Quote: From day 2-7 cells were cultured in SRM media supplemented with 0.1 µM LDN193189 (Tocris Biosciences), 10 µM SB431452(Tocris Biosciences) ...
• Mouse exploratory behaviour in the open field with and without NAT-1 EEG device: Effects of MK801 and scopolamine

  Charmaine J.M. Lim, et al., bioRxiv - Neuroscience 2024

  Quote: (+)-MK801 maleate (CAS: 77086-22-7) and scopolamine hydrobromide (CAS: 114-49-8) were obtained from Tocris Bioscience (Bristol ...
• Calcium-permeable AMPA receptors govern PV neuron feature selectivity

  Ingie Hong, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 10 µM 6-imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide (SR95531;GABAA receptor antagonist; all from Tocris Bioscience).
• GLUT1 ablation in astrocytes paradoxically improves central and peripheral glucose metabolism via enhanced insulin-stimulated ATP release

  Carlos G. Ardanaz, et al., bioRxiv - Neuroscience 2022

  Quote: ... was inserted into the guide cannula and a Hamilton Syringe was used to administrate 1 μL of 2 mM pyridoxalphosphate-6-azophenyl-2’,4’-disulfonic acid (PPADS, Tocris, 0625), 1.5 μg/μL S961 (Phoenix Pharmaceuticals ...
• Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis

  Chloé Berland, et al., bioRxiv - Neuroscience 2021

  Quote: ... exendin 4 (10 μg/kg, Tocris), leptin (twice/day for 2 days at 0.25 mg/kg ...
• Type I interferon responses to ischemic injury begin in the bone marrow of mice and humans and depend on Tet2, Nrf2, and Irf3

  David M. Calcagno, et al., bioRxiv - Immunology 2020

  Quote: ... and 4-Octyl-Itaconate (Tocris Bioscience) (100uM ...
• A limbic circuit selectively linking active escape to food suppression

  Estefania P. Azevedo, et al., bioRxiv - Neuroscience 2020

  Quote: ... exendin-4 (Tocris, 1 mg/mL), or y-msh (Tocris ...
• Microglia-neuron communication at nodes of Ranvier depends on neuronal activity through potassium release and contributes to myelin repair

  R. Ronzano, et al., bioRxiv - Neuroscience 2020

  Quote: ... PSB0739 (4 hours, 1 μM, Tocris) or MRS2211 (4 hours ...
• Striatonigrostriatal Circuit Architecture for Disinhibition of Dopamine Signaling

  Priscilla Ambrosi, Talia N. Lerner, bioRxiv - Neuroscience 2021

  Quote: ... 4-AP (100 μM, Tocris Bioscience), and GBZ (10 μM ...
• Dual regulation of spine-specific and synapse-to-nucleus signaling by PKCδ during plasticity

  Lesley A. Colgan, et al., bioRxiv - Neuroscience 2021

  Quote: ... MNI Caged Glu (Tocris, 4 mM), APV (Sigma ...
• Disinhibition of Rab10 gates AMPAR insertion and spine enlargement during long-term potentiation

  Jie Wang, et al., bioRxiv - Neuroscience 2022

  Quote: ... 4 mM MNI-caged glutamate (Tocris) and 1 μM tetrodotoxin (TTX ...
• Engraftment, fate, and function of HoxB8-conditional neutrophil progenitors in the unconditioned murine host

  Joshua T. Cohen, et al., bioRxiv - Immunology 2021

  Quote: ... 100 nM Z-4-hydroxytamoxifen (Tocris), and either puromycin (Sigma-Aldrich ...
• ER stress-mediated BK dysfunction in the DRG underlies pain in a model of multiple sclerosis

  Muhammad Saad Yousuf, et al., bioRxiv - Neuroscience 2020

  Quote: 4-PBA (200mg/kg; Tocris, 2682) was completely dissolved in 1X sterile PBS and injected intraperitoneally (n=6 ...
• SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

  Eline J.H. van Hugte, et al., bioRxiv - Neuroscience 2023

  Quote: ... and Carbamazepine (Tocris, #298-46-4). The working dilution was first diluted into the medium before regular medium change ...
• Integrin-driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration Program

  Menghon Cheah, et al., bioRxiv - Neuroscience 2021

  Quote: ... MLN4924 (5 µM, Tocris Bioscience), MG132 (10 µM ...
• Integrin-driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration Program

  Menghon Cheah, et al., bioRxiv - Neuroscience 2021

  Quote: ... MLN4924 (5 µM, Tocris Bioscience), MG132 (10 µM ...
• Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis

  Chloé Berland, et al., bioRxiv - Neuroscience 2021

  Quote: ... SKF81297 (5 mg/kg, Tocris), haloperidol (0.25 and 0.5 mg/kg ...
• Mutation-specific reporter for the optimization and enrichment of prime editing

  I.F. Schene, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 5 mM A83-01 (Tocris), and 10 mM FSK (Tocris) ...
• Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment

  Le Thi My Le, et al., bioRxiv - Biochemistry 2021

  Quote: ... either 5 mM ATPγS (TOCRIS) or 5 mM orthovanadate and 10 mM MgCl2 ...
• G protein-coupled receptor signaling regulates ER-mitochondria contacts

  Youngshin Lim, et al., bioRxiv - Cell Biology 2021

  Quote: ... U73122 (1268, Tocris, 5 μM), latrunculin (ab144290 ...
• Axonal CB1 receptors mediate inhibitory bouton formation via cAMP increase

  Jian Liang, et al., bioRxiv - Neuroscience 2021

  Quote: ... 5 µM AM251 (Tocris Bioscience). For acute treatments ...
• Impaired p53-mediated DNA damage response contributes to microcephaly in Nijmegen Breakage Syndrome patient-derived cerebral organoids

  Soraia Martins, et al., bioRxiv - Neuroscience 2020

  Quote: ... 5 μM Dorsomorphine (Tocris Bioscience) and 10 μM ROCK inhibitor Y-27632 ...
• Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome

  Zhen Li, et al., bioRxiv - Neuroscience 2022

  Quote: ... 5 μM Dorsopmorphin (Tocris BioScience) and 10 μM SB-431542 (Tocris BioScience) ...
• Organization of cortical and thalamic input to inhibitory neurons in mouse motor cortex

  Sandra U. Okoro, et al., bioRxiv - Neuroscience 2022

  Quote: ... and CPP (5 μM, Tocris) were added to the bath ...
• SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

  Da-Yuan Chen, et al., bioRxiv - Microbiology 2020

  Quote: ... 5 μM IWP4 (Tocris; #5214) was added to the culture medium for 48h to block the WNT signaling ...
• Screening for axon regeneration promoting compounds with human iPSC-derived motor neurons

  Tammy Szu-Yu Ho, et al., bioRxiv - Neuroscience 2021

  Quote: ... and 5 µM DAPT (Tocris). SU-5402 and DAPT specified motor neuron identity.