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101 - 150 of 517 citations for Bis 3 acetyl 4 hydroxyphenyl methane since 2020

• Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis

  Chloé Berland, et al., bioRxiv - Neuroscience 2021

  Quote: ... AM251 (3 mg/kg, Tocris), AM6545 (10 mg/kg ...
• A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

  Kunimichi Suzuki, et al., bioRxiv - Neuroscience 2020

  Quote: ... CGP 55845 (3 μM, Tocris), and tetrodotoxin (Tocris ...
• Multi-layered regulation of neuroectoderm differentiation by retinoic acid in a primitive streak-like context

  Luigi Russo, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 3 μM CHIR99021 (Tocris) or 50 ng/ml Activin A (Peprotech) ...
• Kinetochores respond to subtle changes in the stability of microtubule attachments

  Jessica D. Warren, et al., bioRxiv - Cell Biology 2021

  Quote: ... ZM447439 (3 μM; Tocris Bioscience), Okadaic Acid (100 nM ...
• C9ORF72 dipeptide repeat proteins disrupt formation of GEM bodies and induce aberrant accumulation of survival of motor neuron protein

  Yuma Kato, et al., bioRxiv - Neuroscience 2021

  Quote: ... 3 μM SB431542 (Tocris, UK), and 3 μM CHIR99021 (Focus Biomolecules ...
• Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord

  Kalaimakan Hervé Arulkandarajah, et al., bioRxiv - Neuroscience 2020

  Quote: ... gabazine (3 μM, Tocris, USA), CNQX Disodium (20 μM ...
• LTD at amygdalocortical synapses as a novel mechanism for hedonic learning

  Melissa S. Haley, et al., bioRxiv - Neuroscience 2020

  Quote: ... 3 QX-314 (Tocris Bioscience), 0.2% biocytin (Vrev [Cl−1] = −49.3mV) ...
• Altered Thalamocortical Signaling in a Mouse Model of Parkinson’s Disease

  Olivia K. Swanson, David Richard, Arianna Maffei, bioRxiv - Neuroscience 2020

  Quote: ... 3 QX-314 (Tocris Bioscience), 0.2% biocytin (Erev[Cl−] = −49.8mV)) ...
• CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cells development

  Young Sun Hwang, M. Andrés Blanco, Kotaro Sasaki, bioRxiv - Developmental Biology 2022

  Quote: ... 3 μM CHIR99021 (Tocris Bioscience) and 10 μM of a ROCK inhibitor ...
• Robust three-dimensional expansion of human adult alveolar stem cells and SARS-CoV-2 infection

  Jeonghwan Youk, et al., bioRxiv - Cell Biology 2020

  Quote: ... and 3 μM CHIR99021 (Tocris)) was added to each lower chamber ...
• Inhibitory gating of thalamocortical inputs onto rat gustatory insular cortex

  Melissa S. Haley, et al., bioRxiv - Neuroscience 2022

  Quote: ... 3 QX-314 (Tocris Bioscience), 0.2% biocytin (Vrev [Cl−1] = −49.3mV) ...
• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... 3 μM CHIR-99021 (Tocris), 200 μM L-ascorbic acid (Merck) ...
• Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence

  Giovanni Pietrogrande, et al., bioRxiv - Neuroscience 2023

  Quote: ... CHIR99021 3 μM (4423, Tocris), holo-transferrin 10 μg/ml (T0665 Sigma) ...
• Design, implementation, and functional validation of a new generation of microneedle 3D high-density CMOS multi-electrode array for brain tissue and spheroids

  Lisa Mapelli, et al., bioRxiv - Neuroscience 2022

  Quote: ... 3 μM TTX (tetrodotoxin, Tocris) was added to the Krebs solution ...
• An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (3 μM, Tocris, #4423) and defined FBS (2% vol/vol ...
• A Spatiotemporal and Machine-Learning Platform Accelerates the Manufacturing of hPSC-derived Esophageal Mucosa

  Ying Yang, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 3 μM CHIR99021 (Tocris). In base control strategy #14 ...
• MRCK controls myosin II activation in the polarized cortex of mouse oocytes and promotes spindle rotation and male pronucleus centration

  Anne Bourdais, Benoit Dehapiot, Guillaume Halet, bioRxiv - Cell Biology 2022

  Quote: ... IPA-3 (1 μM; Tocris), BDP-9066 (1 μM ...
• Translation of dipeptide repeat proteins in C9ORF72-ALS/FTD through unique and redundant AUG initiation codons

  Yoshifumi Sonobe, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 3 µM CHIR99021 (Tocris Bioscience), 2 µM DMH1 (Tocris Bioscience) ...
• Electron microscopic analysis of the influence of iPSC-derived motor neurons on bioengineered human skeletal muscle tissues

  Christine T. Nguyen, et al., bioRxiv - Cell Biology 2023

  Quote: ... 3 μM CHIR99021 (Tocris 4423) and 200 μM ascorbic acid (Sigma-Aldrich ...
• Tissue-intrinsic Wnt signals antagonize Nodal-driven AVE differentiation

  Sina Schumacher, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 3 µM CHIR99021 (Tocris), referred to as 2i + LIF.33 N2B27 was prepared as a 1:1 mixture of DMEM/F12 and Neuropan Basal Medium (both from PAN Biotech) ...
• Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (3 μM, Tocris, #4423) and defined FBS (2% vol/vol ...
• Modulation of sweet preference by neurosteroid-sensitive, δ-GABA_A receptors in adult mouse gustatory insular cortex

  Priscilla E Yevoo, et al., bioRxiv - Neuroscience 2024

  Quote: ... 3 QX-314 (Tocris Bioscience), 0.2% biocytin (reversal potential (Vrev)[Cations] = 10mV) ...
• Patho-transcriptomic analysis of invasive mucinous adenocarcinoma of the lung (IMA): comparison with lung adenocarcinoma with signet ring cell features (SRCC)

  William D. Stuart, et al., bioRxiv - Cancer Biology 2024

  Quote: ... H2122 cells were infected with lentivirus carrying HNF4A and treated with BI 6015 (cat# 4641, Tocris, Minneapolis, MN), Mycophenolic acid/MPA (cat# 1505 ...
• A “double-edged” role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs

  Serena Notartomaso, et al., bioRxiv - Neuroscience 2024

  Quote: ... VU0360172 [N-cyclobutyl-6-(2-(3-fluorophenyl)ethynyl) pyridine-3-carboxamide] was purchased from Tocris Bioscience (Bristol ...
• Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions

  Anna Bodzęta, et al., bioRxiv - Neuroscience 2021

  Quote: ... The following chemical reagents were used: 4-aminopyridine (4-AP, TOCRIS, #940), ADX 71743 (TOCRIS ...
• Somatic Depolarization Enhances Hippocampal CA1 Dendritic Spike Propagation and Distal Input Driven Synaptic Plasticity

  Tobias Bock, Steven A. Siegelbaum, bioRxiv - Neuroscience 2021

  Quote: ... 4-AP (Tocris, UK) was stored as a stock solution of 100 mM in ACSF at -20°C and applied to the bath at 5 mM ...
• An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

  Kathleen C. Keough, et al., bioRxiv - Developmental Biology 2021

  Quote: ... CHIR99021 (4 μM; Tocris), FGF2 (20 ng/mL ...
• Macrophage Migration Inhibitory Factor on Apoptotic Extracellular Vesicles Regulates Compensatory Proliferation

  Safia A. Essien, et al., bioRxiv - Cell Biology 2023

  Quote: ... 4-IPP (Tocris, 3429), and Brefeldin A (Millipore-Sigma ...
• ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis

  Kathryn M. Yammine, et al., bioRxiv - Genetics 2024

  Quote: ... 4 μM CHIR99021 (Tocris), 20 ng/mL FGF2 (PeproTech ...
• Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

  Richard Drexler, et al., bioRxiv - Neuroscience 2024

  Quote: ... 4-DAMP (10μM, Tocris) and vehicle (DMSO ...
• Human cartilage model of the precocious osteoarthritis-inducing COL2A1 p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II

  Kathryn M. Yammine, et al., bioRxiv - Cell Biology 2024

  Quote: ... 4 μM CHIR99021 (Tocris), 20 ng/mL FGF2 (PeproTech ...
• Regulation of Interorganellar Ca²⁺ Transfer and NFAT Activation by the Mitochondrial Ca²⁺ Uniporter

  Ryan E. Yoast, et al., bioRxiv - Cell Biology 2021

  Quote: ... and 6-O-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-2,3-O-(1-methylethylidene)-D-myo-Inositol 1,4,5-tris[bis[(1-oxopropoxy)methyl]phosphate] (ci-IP3/PM; 1 μM, Tocris #6210) in imaging buffer with 0.01 % BSA in dark at room temperature ...
• SARS-CoV-2 Beta Variant Substitutions Alter Spike Glycoprotein Receptor Binding Domain Structure and Stability

  Daniel L. Moss, Jay Rappaport, bioRxiv - Biochemistry 2021

  Quote: Guanine unfolding experiments were performed by fluorescent dye assay using bis-ANS (4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid, Tocris, Bristol, UK) as described previously(21 ...
• Experience Shapes Chandelier Cell Function and Structure in the Visual Cortex

  Koen Seignette, et al., bioRxiv - Neuroscience 2023

  Quote: ... in combination with potassium channel blocker 4-aminopyridine (4-AP, 1 mM, Tocris) to facilitate transmitter release at monosynaptic connections from RSC to ChC and recorded the PSP amplitudes (Figure 1H) ...
• Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells

  Jose Ernesto Canton-Josh, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 μM Pyr-3 (Tocris,3753), 1 mM MNI-caged-L-glutamate ...
• Single-cell profiling of transcriptome and histone modifications with EpiDamID

  Franka J. Rang, et al., bioRxiv - Genomics 2021

  Quote: ... 3 μM CHIR99021 (Tocris, SML1046-5MG), 1000 U/mL ESGRO mLIF ...
• 3D genome organization around nuclear speckles drives mRNA splicing efficiency

  Prashant Bhat, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 3 μM CHIR 99021 (Tocris, 4423), and 50 nM PI 103 (Tocris ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... IPA-3 (Tocris, 3622, 5 μM), CK666 (Tocris ...
• Defective Schwann cell lipid metabolism alters plasma membrane dynamics in Charcot-Marie-Tooth disease 1A

  Robert Prior, et al., bioRxiv - Neuroscience 2023

  Quote: ... 3 mM CHIR-99021 (Tocris Biosciences), and 20 µM SB 431542 (Tocris Biosciences) ...
• Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence

  Giovanni Pietrogrande, et al., bioRxiv - Neuroscience 2023

  Quote: ... and CHIR99021 3 μM (4423, Tocris). After 3 days ...
• Recording morphogen signals reveals origins of gastruloid symmetry breaking

  Harold M. McNamara, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and 3 μM CHIR99021 (Tocris, 4423).
• Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

  Kizito-Tshitoko Tshilenge, et al., bioRxiv - Neuroscience 2022

  Quote: ... GABA (3 mM, Tocris Bioscience, 0344), CaCl2 (1.8 mM ...
• Identification of the main barriers to Ku accumulation in chromatin

  Madeleine Bossaert, et al., bioRxiv - Molecular Biology 2024

  Quote: ... or NU-7441 (3 µM, Tocris) were added when specified 1 h prior to irradiation ...
• Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway

  Artemis Koumoundourou, et al., bioRxiv - Neuroscience 2023

  Quote: ... 3 μM DCG-IV (Tocris Bioscience) was applied after each experiment ...
• Human neuron subtype programming through combinatorial patterning with scRNA-seq readouts

  Hsiu-Chuan Lin, et al., bioRxiv - Bioengineering 2023

  Quote: ... and 3 µM CHIR99021 (Tocris Bioscience).
• Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

  Evan J. Underhill, Jared E. Toettcher, bioRxiv - Developmental Biology 2023

  Quote: ... and 3 μM CHIR99021 (Tocris, 4423).
• Elevated ENO2 Disrupts VSMCs Homeostasis Facilitating the Development of Aortic Dissection

  Weixing Cai, et al., bioRxiv - Molecular Biology 2023

  Quote: ... Ang II (4474-91-3, Tocris) was injected subcutaneously at a total dose of 1 ...
• Engineering fluorescent reporters in human pluripotent cells and strategies for live imaging human neurogenesis

  Alwyn Dady, et al., bioRxiv - Developmental Biology 2024

  Quote: ... supplemented with 3 µM Chiron99021 (Tocris) and 20 ng/ml bFGF (PeproTech ...
• GluN2B-mediated regulation of silent synapses for receptor specification and addiction memory

  Hyun Jin Kim, et al., bioRxiv - Neuroscience 2024

  Quote: ... Ifenprodil hemitartrate (3 μM, #0545, Tocris) and PPDA (0.1 μM ...
• Excitatory Cortical Neurons from CDKL5 Deficiency Disorder Patient-Derived Organoids Show Early Hyperexcitability Not Identified in Neurogenin2 Induced Neurons

  Madison R. Glass, et al., bioRxiv - Neuroscience 2024

  Quote: ... 3 μM CHIR99021 (Tocris Bioscience # 4423) and the MEK inhibitor ...