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101 - 150 of 653 citations for Benzyl carbamic acid prop 2 ynyl ester since 2020

• Substrate-specific regulation of mTORC1 activity by G protein-coupled receptors

  Samuel J. Atkinson, et al., bioRxiv - Cell Biology 2024

  Quote: All cell lines were washed with PBS then starved of amino acids or FBS for 2 hours before treatment with the GPCR antagonists at 1 µM: CNO (Tocris/bio-techne 6329), Isoprenaline/Carvedilol (Sigma/Merck I6504 ...
• Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2

  Linda Pesonen, et al., bioRxiv - Cell Biology 2021

  Quote: ... gambogic acid (GB, 3590, Tocris Bioscience) or gambogenic acid (GBA ...
• Optical analysis of the action range of glutamate in the neuropil

  E.A. Matthews, et al., bioRxiv - Neuroscience 2021

  Quote: ... 70 nl kainic acid (20mM, Tocris) was injected above the left hippocampal CA1 region (−2AP −1.4ML −1.1DV ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: ... and Ascorbic Acid (200 μM, Tocris) for 2 weeks ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: ... and Ascorbic Acid (200 μM, Tocris) and maintained in suspension in ULA T-175 flasks ...
• Mechanisms Controlling Hemolymph Circulation Under Resting Conditions In The Chagas Disease Vector Rhodnius Prolixus (Stål)

  María José Villalobos Sambucaro, et al., bioRxiv - Physiology 2023

  Quote: ... N‘-tetra-acetic acid (Tocris Bioscience) -300 µM and 400 µM- ...
• Stem cells tightly regulate dead cell clearance to maintain tissue fitness

  Katherine S Stewart, et al., bioRxiv - Cell Biology 2023

  Quote: ... and arachidonic acid (all Tocris Bioscience) were each dissolved in 100% ethanol and stored like the retinoids ...
• Patho-transcriptomic analysis of invasive mucinous adenocarcinoma of the lung (IMA): comparison with lung adenocarcinoma with signet ring cell features (SRCC)

  William D. Stuart, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Mycophenolic acid/MPA (cat# 1505, Tocris) or Sorafenib (cat# 6814 ...
• KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons

  Irune Guerra San Juan, et al., bioRxiv - Neuroscience 2024

  Quote: ... retinoic Acid (RA, 1 µM, Tocris) and smoothened agonist (SAG ...
• Novel Mouse Model of Alternating Hemiplegia of Childhood Exhibits Prominent Motor and Seizure Phenotypes

  Nicole A. Hawkins, et al., bioRxiv - Neuroscience 2024

  Quote: Kainic acid (KA, Tocris, Bristol, UK) was administered intraperitoneally at 25 mg/kg to 16-22 mice per genotype which were then video recorded for 2 hours ...
• Recombinant B3 clade enterovirus D68 strains are efficiently rescued in 293T cells and infect human spinal cord organoids

  Jennifer E. Jones, et al., bioRxiv - Microbiology 2024

  Quote: ... and 100 nM retinoic acid (Tocris).
• Interictal spikes during spatial working memory carry helpful or distracting representations of space and have opposing impacts on performance

  Justin D. Yi, et al., bioRxiv - Neuroscience 2024

  Quote: Kainic Acid (Tocris Bioscience, ItemNo: 0222:) was prepared by combining 50mg of KA powder with a 40mM Sodium hydroxylate solution to get a stock solution of 40mM Kainate ...
• Prenatal Methadone Exposure Disrupts Behavioral Development and Alters Motor Neuron Intrinsic Properties and Local Circuitry

  Gregory G. Grecco, et al., bioRxiv - Neuroscience 2020

  Quote: ... The bath solution for recordings contained elevated concentrations of divalent cations [4 mM Ca2+ and 4 mM Mg2+] and NMDA receptor antagonist 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) [5 mM] (Tocris biosciences, 126453-07-4). Slices were used 1.5–4.5 hours after preparation ...
• CXCL17 is an endogenous inhibitor of CXCR4 via a novel mechanism of action

  Carl W. White, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... N,N’-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride (IT1t) was purchased from Tocris (United Kingdom). Bovine serum albumin ...
• Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis

  Vukasin M. Jovanovic, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 200 µM ascorbic acid (4055, Tocris).
• Long-range GABAergic inhibition modulates spatiotemporal dynamics of the output neurons in the olfactory bulb

  Pablo S. Villar, Ruilong Hu, Ricardo C. Araneda, bioRxiv - Neuroscience 2020

  Quote: ... kynurenic acid sodium salt (Catalog #3694, Tocris).
• TASK-3 Two-Pore Potassium Channels drive neuronal excitability of the circadian clock and entrainment to challenging light environments

  Aiste Steponenaite, et al., bioRxiv - Neuroscience 2020

  Quote: L-Glutamic acid was purchased from Tocris Bioscience ...
• Interleukin-33 coordinates a microglial phagocytic response and limits corticothalamic excitability and seizure susceptibility

  Rafael T. Han, et al., bioRxiv - Neuroscience 2021

  Quote: ... and Kainic acid (KA; Tocris, United Kingdom) were dissolved in normal saline and freshly prepared ...
• The hippocampus and dorso-lateral striatum link distinct types of memories through time and space, respectively

  Janina Ferbinteanu, bioRxiv - Neuroscience 2020

  Quote: ... or a solution of quinolinic acid (Tocris; 25mg/ml in phosphate buffer titrated with sodium hydroxide to pH 7.4 ...
• Cortical and raphe GABA_A, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine

  Thu Ha Pham, et al., bioRxiv - Neuroscience 2020

  Quote: ... dihyrokainic acid (DHK, Tocris Bioscience, Lille, France) was dissolved in the aCSF and perfused at 5 mM for 2.5 hours according to Gasull-Camos et al. ...
• Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

  Matthew Wind, et al., bioRxiv - Developmental Biology 2020

  Quote: ... all trans retinoic acid (0.1 µM, Tocris), BDNF (20ng/ml ...
• Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

  Matthew Wind, et al., bioRxiv - Developmental Biology 2020

  Quote: ... all trans retinoic acid (0.1 µM, Tocris), and ROCK inhibitor Y-27632 (10 µM ...
• Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

  Matthew Wind, et al., bioRxiv - Developmental Biology 2020

  Quote: ... all trans retinoic acid (0.1 µM, Tocris), and ROCK inhibitor Y-27632 (10 µM ...
• Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

  Matthew Wind, et al., bioRxiv - Developmental Biology 2020

  Quote: ... all trans retinoic acid (0.1 µM, Tocris), BDNF (20ng/ml ...
• Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

  Matthew Wind, et al., bioRxiv - Developmental Biology 2020

  Quote: ... all-trans retinoic acid (0.1 µM, Tocris), LDN-193189 (100 nM ...
• A generic binding pocket for small molecule I_Ks activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

  Magnus Chan, et al., bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... Mefenamic acid (Tocris Bioscience, Oakville, ON, Canada) was used to activate IKs at concentrations of 100 μM and 1 mM.
• Structure-guided engineering of a fast genetically encoded sensor for real-time H₂O₂ monitoring

  Justin Daho Lee, et al., bioRxiv - Bioengineering 2024

  Quote: ... Stock solution of Cyclopiazonic Acid (Tocris, 1235) was prepared in 100% DMSO at 20mM ...
• Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

  Laurène Adam, et al., bioRxiv - Biophysics 2023

  Quote: ... Kainic acid (KA) was obtained from Tocris Bioscience (Bristol ...
• Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALS

  Delfina Larrea, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 100 nM retinoic acid (RA) (Tocris 1254) and 500 nM Smoothened Agonist (SAG Stemcell Technologies 73414) ...
• Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis

  Célia Alecki, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and 0.5 mM valproic acid (Tocris, #2815)) on Matrigel-coated plates ...
• Interictal spikes during spatial working memory carry helpful or distracting representations of space and have opposing impacts on performance

  Justin D. Yi, et al., bioRxiv - Neuroscience 2024

  Quote: ... 70nL of 20mM Kainate Acid (Tocris Bioscience) or saline was injected unilaterally into cortex above right hippocampus (M/L =1.5mm ...
• Tuba1a is uniquely important for axon guidance through midline commissural structures

  Georgia Buscaglia, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and 1mM kynurenic acid (Tocris Bioscience, Bristol, UK). Meninges were removed and cortices were dissected and cut into approximately 1mm pieces ...
• Synapse development is regulated by microglial THIK-1 K⁺ channels

  Pablo Izquierdo, et al., bioRxiv - Neuroscience 2021

  Quote: ... or kainic acid (Tocris, 1 μM; Tocris 0222) were bath-applied sequentially (ensuring that holding current returned to the original control level before subsequent drug application ...
• Synapse development is regulated by microglial THIK-1 K⁺ channels

  Pablo Izquierdo, et al., bioRxiv - Neuroscience 2021

  Quote: ... or kainic acid (Tocris, 1 μM; Tocris 0222) were bath-applied sequentially (ensuring that holding current returned to the original control level before subsequent drug application ...
• Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening

  Caroline E. Strong, et al., bioRxiv - Bioengineering 2022

  Quote: ... and 20 nM ascorbic acid (Tocris, cat# 4055). A stock solution consisting of all materials except cAMP and ascorbic acid was prepared in advance ...
• Reduced Hippocampal Inhibition and Enhanced Autism-Epilepsy Comorbidity in Mice Lacking Neuropilin 2

  Carol Eisenberg, et al., bioRxiv - Neuroscience 2021

  Quote: ... kynurenic acid (3 mM KyA, Tocris, Ellisville, MO) in the recording aCSF ...
• The cell wall polymer initiates plasma membrane partitioning in mycobacteria

  Takehiro Kado, et al., bioRxiv - Molecular Biology 2022

  Quote: ... a TAMRA-based fluorescent D-amino acid (TOCRIS), 1 µM RADA was added to the culture upon back dilution ...
• Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion

  Jana Slováková, et al., bioRxiv - Cell Biology 2020

  Quote: ... and 1-Oleoyl lysophosphatidic acid (LPA, Tocris Bioscience) were used at the indicated concentrations (1 nM ...
• A transient decrease in mitochondrial activity is required to establish the ganglion cell fate in retina adapted for high acuity vision

  Laurent Brodier, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Retinas treated with all-trans retinoic acid (Tocris) were electroporated with reporter plasmids and were kept for 36h in culture with 25 nM ...
• BDNF-induced BDNF release mediates presynaptic LTP and is regulated by cannabinoids

  Coralie Berthoux, et al., bioRxiv - Neuroscience 2021

  Quote: ... cyclopiazonic acid and picrotoxin were purchased from Tocris Bioscience ...
• Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

  Marisol Sampedro-Castañeda, et al., bioRxiv - Neuroscience 2023

  Quote: ... low dose 5mg/kg kainic acid (Tocris Bioscience) dissolved in sterile saline was administrated intraperitoneally every 30 minutes to assess brain susceptibility to increasing dosage of chemo convulsant ...
• Altered metabolic function induced by amyloid-beta oligomers and PSEN1-mutations in iPSC-derived astrocytes

  R. J. Elsworthy, et al., bioRxiv - Neuroscience 2023

  Quote: ... and DL-threob-benzyloxyaspartic acid (TBOA) (Tocris, UK).
• Preventing Jacob-induced transcriptional inactivation of CREB protects synapses from β-amyloid in Alzheimer’s Disease

  Katarzyna M. Grochowska, et al., bioRxiv - Neuroscience 2022

  Quote: ... For the experiment with okadaic acid (OA, Tocris) cells were treated for 20 min with 2 µM OA 1 day post transfection ...
• A one-track model for spatiotemporal coordination of Bacillus subtilis septal cell wall synthesis

  Kevin D. Whitley, et al., bioRxiv - Microbiology 2023

  Quote: ... the red fluorescent D-amino acid TADA33 (Tocris) was added to a final concentration of 0.5 mM ...
• Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative diseases

  Li-Pao Fang, et al., bioRxiv - Neuroscience 2024

  Quote: ... 70 nl of 20 mM kainic acid (Tocris) in saline solution were injected into the right hemisphere of anesthetized mice ...
• Aberrant splicing exonizes C9ORF72 repeat expansion in ALS/FTD

  Suzhou Yang, et al., bioRxiv - Neuroscience 2023

  Quote: ... and ascorbic acid (10 µM, Tocris, 4055/50). At days 2 and 4 ...
• Female-Specific Pituitary Hypersensitivity to Gonadotropin-Releasing Hormone in a Mouse Model of Chronic Temporal Lobe Epilepsy

  Cathryn A. Cutia, et al., bioRxiv - Neuroscience 2022

  Quote: ... mice underwent unilateral injection of kainic acid (Tocris Bioscience ...
• Newly synthesized mRNA escapes translational repression during the acute phase of the mammalian unfolded protein response

  Mohammed R. Alzahrani, et al., bioRxiv - Molecular Biology 2022

  Quote: ... or 100 µM Cyclopiazonic acid (CPA) (Tocris Bioscience) for the indicated durations ...
• β-barrel proteins dictate the effect of core oligosaccharide composition on outer membrane mechanics

  Dylan Fitzmaurice, et al., bioRxiv - Biophysics 2024

  Quote: ... the fluorescent D-amino acid HADA (Tocris Bioscience), MitoTracker Orange CM-H2TMRos (Invitrogen) ...
• Activation and signaling characteristics of the hydroxy-carboxylic acid 3 receptor identified in human neutrophils through a microfluidic flow cell technique

  Huamei Forsman, et al., bioRxiv - Immunology 2024

  Quote: ... The HCA3R agonists IBC 293 (1-(1-Methylethyl)-1H-benzotriazole-5-carboxylic acid) and 3-hydroxy-octanoic acid (3-OH-C8) were from Tocris (Bristol, UK) and Cayman Chemical (Michigan ...