Labshake search

101 - 150 of 1006 citations for 5 2 Chloronicotinoyl 2 furoic acid since 2020

• Ca²⁺-sensing receptor regulates neuronal excitability via Kv7 channel and G_i/o protein signalling

  Nontawat Chuinsiri, et al., bioRxiv - Physiology 2023

  Quote: ... 2 μM PD0332991 (Tocris), 10 ng/ml human BDNF (Miltenyi Biotec) ...
• NOTCH3 signalling controls human trophoblast stem cell expansion and differentiation

  Bianca Dietrich, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 µM CHIR99021 (Tocris) and 5µM Y27632 (Santa Cruz) ...
• CDKN1B (p27^kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors

  Elad Horwitz, et al., bioRxiv - Cancer Biology 2024

  Quote: ... AKTi-1/2 (Tocris), MK-2206 (VWR) ...
• LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

  Riccardo Sirtori, et al., bioRxiv - Neuroscience 2024

  Quote: ... DMH1 (2 μM, Tocris) and SB431542 (2 μM ...
• An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

  Leonard Yoon, et al., bioRxiv - Cell Biology 2023

  Quote: ... 2 µM Dorsomorphin (Tocris), 10 µM SB-431542 (Tocris) ...
• Genetically edited human placental organoids cast new light on the role of ACE2 in placental development

  Anya L. Arthurs, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 2 µM CHIR99021 (Tocris) and 5 µM Y27632 (Santa Cruz).
• A trimeric USP11/USP7/TCEAL1 complex stabilizes RNAPII during early transcription to sustain oncogenic gene expression

  Markus Dehmer, et al., bioRxiv - Cancer Biology 2024

  Quote: ... NVP-2 (Tocris Biosciences), Flavopiridol (Sigma-Aldrich) ...
• Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic network oscillations

  Adam C Lu, et al., bioRxiv - Neuroscience 2020

  Quote: ... The GAT1 blocker NO-711 [(1,2,5,6-tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride] and GAT3 blocker SNAP-5114 [1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid] were purchased from Tocris Bioscience (Minneapolis ...
• Enhanced food motivation in obese mice is controlled by D1R expressing spiny projection neurons in the nucleus accumbens

  Bridget A Matikainen-Ankney, et al., bioRxiv - Neuroscience 2022

  Quote: ... the AMPA/NMDA receptor agonist kynurenic acid (2 mM) and the GABA-A receptor antagonist picrotoxin (PTX; 100 uM, Tocris) were present ...
• Hypoxia-induced Complement Component 3 Promotes Aggressive Tumor Growth in the Glioblastoma Microenvironment

  Rebecca Rosberg, et al., bioRxiv - Cancer Biology 2024

  Quote: ... mice were randomized into groups and treated daily (5 days on, 2 days off) with 1mg/kg SB290157 trifluoroacetate (Tocris, 6860/5) intra-peritoneally ...
• Short chain fatty acids enhance expression and activity of the umami taste receptor in enteroendocrine cells via a Gα_i/o pathway

  Matilda Shackley, et al., bioRxiv - Cell Biology 2020

  Quote: ... 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4-CMTB; Tocris) was used as a FFAR2-specific agonist and AR420626 (Cayman ...
• Revival of light-evoked neuronal signals in the post-mortem mouse and human retina

  Fatima Abbas, et al., bioRxiv - Neuroscience 2020

  Quote: ... to isolate inner retinal signaling (B-waves) and DL-2-Amino-4-phosphonobutyric acid (DL-AP4, 40µM, Tocris Bioscience, Bristol, U.K.) to isolate the photoreceptor component of the ERG signal (A-wave) ...
• The ketone body acetoacetate activates human neutrophils through FFA2R

  Jonas Mårtensson, et al., bioRxiv - Cell Biology 2022

  Quote: ... The FFA2R antagonist CATPB ((S)-3-(2-(3-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)-phenyl) butanoic acid) was from Tocris (Britsol, UK).
• TRPM8-dependent shaking in mammals and birds

  Tudor Selescu, et al., bioRxiv - Physiology 2024

  Quote: ... 1-(2-hydroxyphenyl)-4-(V3-nitrophenyl)-l,2,3,6-tetrahydropyrimidine-2-one (icilin, Tocris #1531) 10 mM in DMSO ...
• Neuromesodermal Progenitors Advance Network Formation of Spinal Neurons and Support Cells in Neural Ribbons In Vitro and Unprotected Survival in a Rat Subacute Contusion Model

  Zachary T. Olmsted, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2 μM CHIR99021 (Tocris Bioscience), 10 μM DAPT (Millipore Sigma) ...
• The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

  E. Werner, et al., bioRxiv - Cell Biology 2022

  Quote: ... 2 μM dorsomorphin (Tocris, 3093) and 2 μM A-83 (Tocris ...
• Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis

  Vukasin M. Jovanovic, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 2 µM forskolin (1099, Tocris), 200 nM phorbol-12 myristate-13 acetate (1201 ...
• A cell-based platform for oxidative stress monitoring in motor neurons using genetically encoded biosensors of H₂O₂

  Elizaveta I. Ustyantseva, et al., bioRxiv - Cell Biology 2021

  Quote: ... and 2 μM DMH1 (Tocris) for 6 days ...
• TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons

  Ki Bum Um, et al., bioRxiv - Neuroscience 2021

  Quote: ... 2-APB (Tocris, Cat.#: 1224), CPP (Tocris ...
• Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure

  Patricia Rueda, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... 2’Me-CCPA (Tocris, 2281), MRS1754 (Tocris ...
• Identification and Characterization of Stem Cells in Mammalian Esophageal Stratified Squamous Epithelia

  Yanan Yang, et al., bioRxiv - Cell Biology 2021

  Quote: ... Wnt inhibitor IWP-2(TOCRIS) and Srfp-2(R&D Systems ...
• Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomes

  Jillian H. Kluss, et al., bioRxiv - Cell Biology 2021

  Quote: ... MLi-2 (Tocris, cat #5756) was used at 1 μM in DMSO for 90 min ...
• A peptidergic amygdala microcircuit modulates sexually dimorphic contextual fear

  AK Rajbhandari, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2 mg/ml biocytin (Tocris) was dissolved in the intracellular solution and cells were dialyzed for 20 minutes ...
• Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex

  Stephen D. Glasgow, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 2-Aminoethoxydiphenylborane (1224, Tocris) in DMSO ...
• Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

  Gaël Moquin-Beaudry, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 4 μM IWP-2 (Tocris), and 1 μM A83-01 (Tocris) ...
• Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells

  Yuka Sakata, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 2 μM SU-5402 (Tocris), and 10 μM DAPT (Tocris) ...
• HCN1 channels mediate mu opioid receptor long-term depression at insular cortex inputs to the dorsal striatum

  Braulio Munoz, et al., bioRxiv - Neuroscience 2022

  Quote: ... and Torin 2 (4248, Tocris). Other reagents used for making solutions were purchased from Sigma-Aldrich or Fisher Scientific.
• An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

  Kathleen C. Keough, et al., bioRxiv - Developmental Biology 2021

  Quote: ... SB-505124 (2 μM; Tocris) and FGF2 (20 ng/mL ...
• Single cell trajectory analysis of human pluripotent stem cells differentiating towards lung and hepatocyte progenitors

  Chaido Ori, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 2 μM dorsomorphin (DSM; Tocris) and 10 μM SB431542 (Miltenyi Biotec) ...
• Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytes

  Claudia Raggi, et al., bioRxiv - Developmental Biology 2020

  Quote: ... 4 μM IWP-2 (Tocris), and 1 μM A83-01 (Tocris ...
• Cell-type specific innate immune responses shape rabies virus tropism

  Lena Feige, et al., bioRxiv - Microbiology 2021

  Quote: ... 2 μM CHIR99021 (4423, TOCRIS) induced mesoderm specification of human iPSC colonies (XCL-1 ...
• SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

  Eline J.H. van Hugte, et al., bioRxiv - Neuroscience 2023

  Quote: ... Levetiracetam (Tocris, #102767-28-2), Topiramate (Tocris ...
• Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids

  Zongyong Ai, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM Gö6983 (TOCRIS, 2285) and 10 ng/ml recombinant human LIF (Peprotech ...
• The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

  Federica Raguseo, et al., bioRxiv - Biochemistry 2023

  Quote: ... 2 μM SB431542 (Tocris Bioscience), and 3.3 μM CHIR99021 (Tocris Bioscience) ...
• Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

  Cheng-Guo Wu, et al., bioRxiv - Biochemistry 2023

  Quote: ... and 2 μM rolipram (Tocris) to activate adenylyl cyclase and inhibit cAMP phosphodiesterase 4 (PDE4 ...
• Recording morphogen signals reveals origins of gastruloid symmetry breaking

  Harold M. McNamara, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM PD0325901 (Tocris, 4192), and 3 μM CHIR99021 (Tocris ...
• Synapse specific and plasticity-regulated AMPAR mobility tunes synaptic integration

  Agata Nowacka, et al., bioRxiv - Neuroscience 2024

  Quote: ... 0.002 2-chloroadenosine (Tocris, #3136). High Pr conditions aCSF contained 1 mM MgCl2 and 4 mM CaCl2 ...
• An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x,
• An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal and neural cells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

  Riccardo Sirtori, et al., bioRxiv - Neuroscience 2024

  Quote: ... and SB431542 (2 μM, Tocris). On day 7 and 13 ...
• Translation of dipeptide repeat proteins in C9ORF72-ALS/FTD through unique and redundant AUG initiation codons

  Yoshifumi Sonobe, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 2 µM DMH1 (Tocris Bioscience), and 2 µM SB431542 (Stemgent ...
• Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons

  Simon Chamberland, et al., bioRxiv - Neuroscience 2022

  Quote: ... CGP-55845 (2 μM, Tocris) dendrotoxin-K (50 nM ...
• APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

  Meghan E. Wynne, et al., bioRxiv - Cell Biology 2022

  Quote: ... 2 μM dorsomorphin (Tocris, 3093) and 2 μM A-83 (Tocris ...
• Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

  Evan J. Underhill, Jared E. Toettcher, bioRxiv - Developmental Biology 2023

  Quote: ... 2 μM PD0325901 (Tocris, 4192), and 3 μM CHIR99021 (Tocris ...
• Actin polymerization drives lumen formation in a human epiblast model

  Dhiraj Indana, et al., bioRxiv - Developmental Biology 2023

  Quote: ... ML-141 (2 µM; Tocris Bioscience 4266 ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... valinomycin (Tocris, 3373, 2 μM), sorafenib (Selleckchem ...
• Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...
• Stepwise developmental mimicry generates proximal-biased kidney organoids

  Jack Schnell, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 2 µM DAPT (Tocris 2634), or both ...
• The Parkinson’s Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

  Katy R. McCarron, et al., bioRxiv - Cell Biology 2024

  Quote: ... MLi-2 (Tocris Bioscience; 5756), nigericin sodium salt (Sigma-Aldrich ...
• Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

  Renée Moerkens, et al., bioRxiv - Cell Biology 2024

  Quote: ... CHIR99021 (2 μM, Tocris, #4423), B27 (1x ...