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101 - 150 of 1077 citations for 3 1 Phenylethylamino propane 1 thiol since 2020

• Orthogonal analysis of mitochondrial function in Parkinson’s disease patients

  Sander Barnhoorn, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 μM dorsomorphin (Tocris), 3 μM CHIR 99021 (Axon Medchem ...
• Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss

  Hsiao-Jou Cortina Chen, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 μM LM22A4 (Tocris), 2 μM CHIR99021 (Cambridge Bioscience) ...
• CDKN1B (p27^kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors

  Elad Horwitz, et al., bioRxiv - Cancer Biology 2024

  Quote: ... AKTi-1/2 (Tocris), MK-2206 (VWR) ...
• A novel iPSC model reveals selective vulnerability of neurons in Multiple Sulfatase Deficiency

  Vi Pham, et al., bioRxiv - Cell Biology 2023

  Quote: ... LDN193189 (1 μM, Tocris), and endo-IWR1 (1.5 μM ...
• Acetylcholine Promotes Directionally Biased Glutamatergic Retinal Waves

  Kathy Zhang, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 uM MLA (Tocris), 200 uM DHβE (Tocris) ...
• PIEZO1-mediated mechanosensing governs NK cell killing efficiency and infiltration in three-dimensional matrices

  Archana K. Yanamandra, et al., bioRxiv - Immunology 2024

  Quote: ... Yoda-1 from Tocris, and Fibricol Collagen solution (10mg/ml Bovine Type I ...
• The autism-associated gene SYNGAP1 regulates human cortical neurogenesis

  Marcella Birtele, et al., bioRxiv - Developmental Biology 2023

  Quote: ... TTX (Tocris, #1078/1) at a final concentration of 2LµM ...
• Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion

  Michael J. Seibert, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 μM tetrodotoxin (Tocris) was included in the bath ...
• EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

  Lyra O. Randzavola, et al., bioRxiv - Immunology 2022

  Quote: ... NGI-1 compound (TOCRIS) or tunicamycin (Sigma ...
• Heparan sulfates regulate axonal excitability and context generalization through Ca²⁺/calmodulin-dependent protein kinase II

  Inseon Song, et al., bioRxiv - Neuroscience 2023

  Quote: ... TTX (1 μM, Tocris) were added to ACSF to isolate action potential-independent mIPSCs ...
• TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids

  Soraia Fernandes, et al., bioRxiv - Cancer Biology 2023

  Quote: ... SAG (1 μM, Tocris) and FGF4 (500 ng/mL ...
• Feed-forward metabotropic signaling by Cav1 Ca²⁺ channels supports pacemaking in pedunculopontine cholinergic neurons

  C. Tubert, et al., bioRxiv - Neuroscience 2023

  Quote: ... ionomycin (Tocris, 1 uM) and oligomycin A (Sigma-Aldrich ...
• Reduced SH3RF3 may protect against Alzheimer’s disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling

  Ronak Patel, et al., bioRxiv - Neuroscience 2024

  Quote: ... IKK16 (1 uM; Tocris), and NSC23766 (50 uM ...
• Transfer learning reveals sequence determinants of the quantitative response to transcription factor dosage

  Sahin Naqvi, et al., bioRxiv - Genomics 2024

  Quote: ... dTAGV-1 (Tocris, 6914) at a range of concentrations was added to BCh medium ...
• ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis

  Kathryn M. Yammine, et al., bioRxiv - Genetics 2024

  Quote: ... 1 μM A8301 (Tocris) and 0.25 μM LDN193189 (Cayman Chemical ...
• Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model

  Alice E. Stanton, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1 μM SAG (Tocris), and 50 ng/ mL VEGF-A (PeproTech) ...
• Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9

  Joshua D Eaton, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 1µM dTAGv-1 (Tocris) was used for 1-14hrs (see figure legends for timings used in each experiment) ...
• Identification of neuron-glia signaling feedback in human schizophrenia using patient-derived, mix-and-match forebrain assembloids

  Eunjee Kim, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1 μM CHIR99021 (Tocris), and 1 μM SB-431542 (Cellagentech) ...
• Human Stem Cell-derived Kidney Collecting Duct Model via Epithelial Microphysiological Analysis Platform: Epi-MAP

  SoonGweon Hong, et al., bioRxiv - Bioengineering 2024

  Quote: ... T3 (1 nM, Tocris) and fetal bovine serum (2% v/v ...
• A stepwise, modular design of building uniform brain assembloids representing the dynamic cellular interplay between neurons and glial cells

  Eunjee Kim, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1 μM CHIR99021 (Tocris), and 1 μM SB-431542 (Cellagentech) ...
• Human cartilage model of the precocious osteoarthritis-inducing COL2A1 p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II

  Kathryn M. Yammine, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 μM A8301 (Tocris) and 0.25 μM LDN193189 (Cayman Chemical ...
• RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability

  Vincent E. Provasek, et al., bioRxiv - Biochemistry 2024

  Quote: ... and 3 μM GSK-3 inhibitor (CHIR99021, CHIR, from Tocris Bioscience), suspended cell spheres were then incubated with a neuronal basic medium containing 0.1 μM retinoic acid (RA ...
• Neuroblastoma-associated chromosomal aberrations drive cell identity loss in human neural crest via disruption of developmental regulators

  Ingrid M. Saldana-Guerrero, et al., bioRxiv - Cancer Biology 2022

  Quote: ... the BMP type-I receptor inhibitor DMH-1 (1 μM, Cat# 4126, Tocris), 10 μM of Rock Inhibitor (Y-27632 ...
• Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

  María Fernández-Casañas, et al., bioRxiv - Cell Biology 2024

  Quote: ... and Protein Phosphatase 1 inhibitor: Tautomycetin (Tocris Bioscience; 2305, 1 or 5 μΜ).
• Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells

  Jose Ernesto Canton-Josh, et al., bioRxiv - Neuroscience 2022

  Quote: ... Pyr-3 (Tocris,3753), prazosin (Sigma-Aldrich ...
• Synaptic vesicles transiently dock to refill release sites

  Grant F Kusick, et al., bioRxiv - Neuroscience 2020

  Quote: ... NBQX (3 μM; Tocris) and bicuculline (30 μM ...
• Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment

  Matthew Shannon, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 3 µM CHIR99021 (Tocris), and 2 µM Y-27632 (EMD Millipore) ...
• Patient induced pluripotent stem cell-derived hepatostellate organoids establish a basis for liver pathologies in telomeropathies

  Young-Jun Choi, et al., bioRxiv - Cell Biology 2021

  Quote: ... CHIR99021 (3 μM; Tocris), 10058-F4 (25 and 50 μM ...
• Multi-layered regulation of neuroectoderm differentiation by retinoic acid in a primitive streak-like context

  Luigi Russo, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 3 μM CHIR99021 (Tocris) was added to the medium from day 3 onwards ...
• Aging affects K_V7 channels and perivascular-adipose tissue-mediated vascular tone

  Yibin Wang, et al., bioRxiv - Physiology 2021

  Quote: ... 3 µM XE991 (Tocris).
• Single-cell assessment of trophoblast stem cell-based organoids as human placenta-modeling platforms

  Matthew J. Shannon, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 3 μM CHIR99021 (Tocris) and 1 μM Y-27632 (EMD Millipore ...
• Synaptotagmin 7 is enriched at the plasma membrane through γ-secretase processing to promote vesicle docking and control synaptic plasticity in mouse hippocampal neurons

  Jason D. Vevea, et al., bioRxiv - Neuroscience 2021

  Quote: ... NBQX (3 μM; Tocris) and bicuculline (30 μM ...
• An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

  Kathleen C. Keough, et al., bioRxiv - Developmental Biology 2021

  Quote: ... CHIR99021 (3 μM, Tocris), and FGF2 (20 ng/mL ...
• An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

  Kathleen C. Keough, et al., bioRxiv - Developmental Biology 2021

  Quote: ... CHIR99021 (3 µM; Tocris), FGF2 (20 ng/mL ...
• An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

  Kathleen C. Keough, et al., bioRxiv - Developmental Biology 2021

  Quote: ... CHIR99021 (3 μM; Tocris), and A8301 (1 μM ...
• Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

  Matias I. Autio, et al., bioRxiv - Bioengineering 2021

  Quote: ... 3 μM CHIR99021 (Tocris) and 10 μM LY294002 (LC Labs ...
• mSWI/SNF interacts with the ribosome and its inhibition/mutations alter translation and sensitize to mTOR/PI3K inhibitors

  Livia Ulicna, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and PFI-3 (Tocris) inhibitors were used at the indicated concentrations on cells seeded since 24 to 72 hours.
• Heparin protects human neural progenitor cells from Zika Virus-induced cell death and preserves their differentiation into mature neural-glia cells

  Isabel Pagani, et al., bioRxiv - Microbiology 2021

  Quote: ... 3 µM CHIR99021 (Tocris), 10 µM SB-431542 (Miltenyi ...
• IFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS-associated Amyotrophic Lateral Sclerosis

  Amanda Faria Assoni, et al., bioRxiv - Neuroscience 2022

  Quote: ... CHIR99021 (3 μM) (Tocris) and Ascorbic acid (0.1 mM ...
• Medial Prefrontal Cortex Serotonin Input Regulates Cognitive Flexibility in Mice

  Ashlea A. Morgan, et al., bioRxiv - Neuroscience 2023

  Quote: ... bicuculline (3 µM; Tocris) that was used to block GABA receptors ...
• Med12 cooperates with multiple differentiation signals to enhance embryonic stem cell plasticity

  Max Fernkorn, Christian Schröter, bioRxiv - Cell Biology 2024

  Quote: ... 3 μM CHIR99201 (Tocris) and 10 ng/ml LIF (protein chemistry facility ...
• Synapse specific and plasticity-regulated AMPAR mobility tunes synaptic integration

  Agata Nowacka, et al., bioRxiv - Neuroscience 2024

  Quote: ... 3 QX314Cl (Tocris, #2313) and 0.15 spermine (Sima-Aldrich ...
• Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release

  Zhenyong Wu, et al., bioRxiv - Neuroscience 2023

  Quote: ... NBQX (3 μM; Tocris) and bicuculline (30 μM ...
• LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

  Riccardo Sirtori, et al., bioRxiv - Neuroscience 2024

  Quote: ... CHIR99021 (3 μM, Tocris), DMH1 (2 μM ...
• ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis

  Kathryn M. Yammine, et al., bioRxiv - Genetics 2024

  Quote: ... 3 μM C59 (Tocris) and 0.5 μM PD0325901 (Selleck Chemicals) ...
• Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling

  Evan T Hoffman, et al., bioRxiv - Cell Biology 2024

  Quote: ... 3 μM CHIR99021 (Tocris), 1x Insulin-Transferrin-Selenium (ITS ...
• Human cartilage model of the precocious osteoarthritis-inducing COL2A1 p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II

  Kathryn M. Yammine, et al., bioRxiv - Cell Biology 2024

  Quote: ... 3 μM C59 (Tocris) and 0.5 μM PD0325901 (Selleck Chemicals) ...
• WNT-mediating TCF/LEF transcription factor gene expression in early human pluripotency and cell lineages differs from the rodent paradigm

  Connor Ross, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 3 µM CHIR99021 (Tocris) and 10 ng/mL mouse recombinant LIF (Cambridge Stem Cell Institute or Peprotech) ...
• Defining totipotency using criteria of increasing stringency

  Eszter Posfai, et al., bioRxiv - Cell Biology 2020

  Quote: ... N2B27 (1-5% KSR) base media was supplemented with 1 µM PD0325901 (Tocris 4192); 3 µM CHIR99021 (Tocris 4423) ...
• Sensitisation of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity

  Katie H. Barker, et al., bioRxiv - Physiology 2022

  Quote: ... pyridone 6 (1 mM; DMSO) and ruxolitinib (1 mM; DMSO) were purchased from Tocris and stock concentrations made up as described ...