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1401 - 1450 of 7257 citations since 2019

• IL-13 promotes sensory-sympathetic neurons crosstalk in asthma

  Théo Crosson, et al., bioRxiv - Neuroscience 2023

  Quote: ... These voltage and current clamp experiments were performed before and 10 mins post-addition with a pipette of external solution (vehicle) or Leu31Pro34NPY (250 nM; Tocris, #1176). Current amplitudes ...
• IL-13 promotes sensory-sympathetic neurons crosstalk in asthma

  Théo Crosson, et al., bioRxiv - Neuroscience 2023

  Quote: ... 100 nM and 300 nM (Tocris, #0462) or JT010 10 μM and 50 μM (Sigma ...
• Investigation of adenosine A1 receptor mediated β-arrestin 2 recruitment using a split-luciferase assay

  Luisa Saecker, Hanns Häberlein, Sebastian Franken, bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX; Tocris, 102146-07-6), 4-[2-[[6-amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino] ethyl]-benzenepropanoic acid ...
• The Multidrug Resistance Transporter P-glycoprotein Confers Resistance to Ferroptosis Inducers

  William J. E. Frye, et al., bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... RSL3 was purchased from Tocris (Minneapolis, MN). Fumitremorgin C (FTC ...
• 3D genome organization around nuclear speckles drives mRNA splicing efficiency

  Prashant Bhat, et al., bioRxiv - Molecular Biology 2023

  Quote: ... pelleted and resuspended in mTeSR1 supplemented with 1uM Y27632 (Tocris, 1254). Cells were seeded onto a 6 well coated plate with Growth Factor Reduced Matrigel ...
• Reduction of aggressive behaviour following hypothalamic deep brain stimulation: involvement of 5-HT_1A and testosterone

  Flavia Venetucci Gouveia, et al., bioRxiv - Neuroscience 2023

  Quote: WAY-100635 maleate (2.5 mg/kg SC; Tocris) was diluted in saline and administered to the animals 30 minutes before stimulation onset on each behavioural testing day ...
• 3D genome organization around nuclear speckles drives mRNA splicing efficiency

  Prashant Bhat, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and 50 nM PI 103 (Tocris, 2930) and incubated for 24hrs ...
• 3D genome organization around nuclear speckles drives mRNA splicing efficiency

  Prashant Bhat, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 3 μM CHIR 99021 (Tocris, 4423), and 50 nM PI 103 (Tocris ...
• 5-iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling

  Chanchal Chauhan, et al., bioRxiv - Cell Biology 2023

  Quote: ... MK2 inhibitor PF3644022 (#4279, Tocris, 5μM), RIPK1 inhibitor Nec-1 (#BML-AP309-0020 ...
• Establishment and characterization of a new Pseudomonas aeruginosa infection model using 2D airway organoids and dual RNA sequencing

  Cayetano Pleguezuelos-Manzano, et al., bioRxiv - Microbiology 2023

  Quote: ... 500□nM A83-01 (Tocris; 2939), 5□μM Y-27632 (Abmole ...
• Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via CASM

  Jake Cross, et al., bioRxiv - Cell Biology 2023

  Quote: ... PP242 (4257, Tocris), Monensin (M5273 ...
• Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via CASM

  Jake Cross, et al., bioRxiv - Cell Biology 2023

  Quote: ... BafA1 (1334, Tocris), PP242 (4257 ...
• Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase

  Paul Batty, et al., bioRxiv - Cell Biology 2023

  Quote: ... 1 µM dTAG-7 (Tocris, 6912) was added 14 h after the release from the final aphidicolin block ...
• The psychosis risk factor RBM12 encodes a novel repressor of GPCR/cAMP signal transduction

  Khairunnisa M. Semesta, et al., bioRxiv - Cell Biology 2023

  Quote: ... DAMGO was purchased from Tocris (Cat. #1171), dissolved in DMSO to 10 mM stock ...
• Generation of human alveolar epithelial type I cells from pluripotent stem cells

  Claire L Burgess, et al., bioRxiv - Cell Biology 2023

  Quote: iPSCs were first differentiated into iAT2s and passaged as above in 3D cultures in iAT2 medium (CK+DCI) supplemented for the first 3 days after passaging with 10 uM Y-27632 (Tocris). To generate iAT1s ...
• Generation of human alveolar epithelial type I cells from pluripotent stem cells

  Claire L Burgess, et al., bioRxiv - Cell Biology 2023

  Quote: ... 10 uM Y-27632 (Tocris)] with Live/dead stain [Calcein blue (Life technologies ...
• Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signaling

  Yiming Fang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 10uM IWP-2 (Tocris, Cat. No. 3533) dissolved in DMSO ...
• GolpHCat (TMEM87A): a unique voltage-gated and pH-sensitive cation channel in the Golgi

  Hyunji Kang, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and ZD7288 (100 μM, TOCRIS, 1000). The IC50 values was estimated by non-linear regression analysis ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... GW5074 (Tocris, 1381, 5 μM), ZM336372 (Tocris ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and BAM7 (Tocris, 4810, 20 μM). Chloramphenicol was dissolved in 70% ethanol ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... CK666 (Tocris, 3950, 25 μM), obatoclax (Selleckchem ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... Rhosin (Tocris, 5003, 50 μM), BAY-293 (Tocris ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... RGDS peptide (Tocris, 3498, 10 μg/ml), NSC23766 (Tocris ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... BAY-293 (Tocris, 6857, 1 μM), LY294002 (Sigma‒Aldrich ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... IPA-3 (Tocris, 3622, 5 μM), CK666 (Tocris ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... ZCL278 (Tocris, 4794, 100 μM), Rhosin (Tocris ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... ZM336372 (Tocris, 1321, 10 μM), venetoclax (Selleckchem ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... NSC23766 (Tocris, 2161, 200 μM), ZCL278 (Tocris ...
• Cytotrophoblast cells are selectively permissive and favor Zika virus, but no other related flavivirus, invasion to the placental stroma

  Mercedes Viettri, et al., bioRxiv - Microbiology 2023

  Quote: Rapamycin (Tocris-Bioscience®: 53123-88-9), was used to inhibit the mTORC1 pathway ...
• Serotonin in the orbitofrontal cortex enhances cognitive flexibility

  Jung Ho Hyun, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4-methoxy-7-nitroindolinyl-glutamate (MNI-caged glutamate, Tocris) was dissolved in Mg2+-free ACSF (4 mM Ca2+ ...
• Long-read sequencing and profiling of RNA-binding proteins reveals the pathogenic mechanism of aberrant splicing of an SCN1A poison exon in epilepsy

  Hannah C Happ, et al., bioRxiv - Genetics 2023

  Quote: ... LDN-193189 (100 nM, Tocris), doxycycline (2 ug/ml) ...
• The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

  Liang Liu, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 20 µM final concentration of JTE-607 (Tocris) in neat DMSO was added to the cell culture media and incubated at 37°C for 4 hours.
• The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

  Liang Liu, et al., bioRxiv - Molecular Biology 2023

  Quote: HepG2 cells were treated with DMSO or 20 µM JTE-607 (Tocris) for 3 hours at 37°C ...
• Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington's disease

  Doo Eun Choi, et al., bioRxiv - Genetics 2023

  Quote: ... cells were supplemented with SB431542 (10 µM; Tocris), LDN-193189 (100 nM ...
• Serotonergic Modulation of the BNST-CeA Circuit Promotes Sex Differences in Fear Learning

  Rebecca Ravenelle, et al., bioRxiv - Neuroscience 2023

  Quote: ... The selective 5-HT2C receptor antagonist RS102221 (Tocris Bioscience, #1050, Minneapolis, MN) was dissolved in a 50% aCSF and 50% sterile saline solution and infused bilaterally into the aBNST at a dose of 0.5 µg per side [14][14] ...
• Serotonergic Modulation of the BNST-CeA Circuit Promotes Sex Differences in Fear Learning

  Rebecca Ravenelle, et al., bioRxiv - Neuroscience 2023

  Quote: ... dissolved in artificial cerebrospinal fluid (aCSF) (Tocris Bioscience, #3525, Minneapolis, MN) was infused bilaterally into the adBNST at a dose of 1mM per side ...
• Growth Signaling Autonomy in Circulating Tumor Cells Aids Metastatic Seeding

  Saptarshi Sinha, et al., bioRxiv - Cancer Biology 2023

  Quote: ... we washed cells once with PBS and then added various concentrations of drugs (tamoxifen, fulvenstrant, or 18albociclib; all purchased from Tocris) in phenol red free DMEM (ThermoFisher Scientific ...
• Beta-catenin mediates growth defects induced by centrosome loss in APC mutant colorectal cancer independently of p53

  Mohamed Bourmoum, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 0.5 μM TGFb type I Receptor inhibitor A83-01 (Tocris #2939). In addition ...
• Beta-catenin mediates growth defects induced by centrosome loss in APC mutant colorectal cancer independently of p53

  Mohamed Bourmoum, et al., bioRxiv - Cancer Biology 2023

  Quote: ... 2.5 μM CHIR 99021 (Tocris #4423) and 10 μM p38 MAPK inhibitor ...
• Genetic and pharmacological reduction of CDK14 mitigates α-synuclein pathology in human neurons and in rodent models of Parkinson’s disease

  Jean-Louis A. Parmasad, et al., bioRxiv - Neuroscience 2023

  Quote: ... 10 µM SB431542 (Tocris, 1614, Bristol, UK) and 500 nM LDN- 193189 (Stemgent 04-0074 ...
• Genetic and pharmacological reduction of CDK14 mitigates α-synuclein pathology in human neurons and in rodent models of Parkinson’s disease

  Jean-Louis A. Parmasad, et al., bioRxiv - Neuroscience 2023

  Quote: ... differentiated NPCs were treated with Y-27632 (Tocris, 1254) for 4 hours ...
• Beta-catenin mediates growth defects induced by centrosome loss in APC mutant colorectal cancer independently of p53

  Mohamed Bourmoum, et al., bioRxiv - Cancer Biology 2023

  Quote: Centrinone B (Tocris Bioscience #5690/10), Alexa Fluor™ 488 Phalloidin (Invitrogen #A12379) ...
• The AMPK-TORC1 signalling axis regulates caffeine-mediated DNA damage checkpoint override and cell cycle effects in fission yeast

  John. P. Alao, Charalampos Rallis, bioRxiv - Cell Biology 2023

  Quote: ... Torin1 (Tocris, Abingdon, United Kingdom) was dissolved in DMSO (3.3 mM ...
• Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala

  Jessica L. Zhou, et al., bioRxiv - Genomics 2023

  Quote: ... and APV (Tocris #189), and the GABA-B receptor antagonist CGP55845 (Tocris #1246) ...
• Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala

  Jessica L. Zhou, et al., bioRxiv - Genomics 2023

  Quote: ... and the GABA-B receptor antagonist CGP55845 (Tocris #1246). Experiments with a series resistance of >15 MΩ or >20% change in series resistance were excluded from the final dataset ...
• Centripetal integration of past events by hippocampal astrocytes and its regulation by the locus coeruleus

  Peter Rupprecht, et al., bioRxiv - Neuroscience 2023

  Quote: Prazosin (Tocris, Cat No. 0623) was dissolved in distilled water (10 mg in 100 mL millipore ...
• GATA1 knockout in human pluripotent stem cells generates enhanced neutrophils to investigate extracellular trap formation

  Thomas C. Harper, et al., bioRxiv - Immunology 2023

  Quote: ... and 2 μM CHIR99021 (Tocris, 4423). Cells were incubated for two days ...
• GATA1 knockout in human pluripotent stem cells generates enhanced neutrophils to investigate extracellular trap formation

  Thomas C. Harper, et al., bioRxiv - Immunology 2023

  Quote: ... coated 6 cm dishes in mTeSR Plus media with 10 μM Y-27632 (Tocris, 1254). On Day 0 ...
• 3D model of mouse embryonic pancreas and endocrine compartment using stem cell-derived mesoderm and pancreatic progenitors

  Shlomit Edri, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 1 µM DAPT (γ-secretase and Notch signalling pathway inhibitor, Tocris 2634) or 1 µM XXI (Compound E ...
• FMRP-Regulated Alternative Splicing is Multifactorial and Resembles Splicing Control by MBNL1

  Suna Jung, et al., bioRxiv - Cell Biology 2023

  Quote: ... After 72h of incubation, cells were treated with 10 μM MG132 (MilliporeSigma, 474790) or Lactacystine (Tocris, 2267) and harvested at different time points.