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1351 - 1359 of 1359 citations for 1 6 Chloropyridazin 3 yl piperidine 4 carboxamide since 2020

• Substrate-specific regulation of mTORC1 activity by G protein-coupled receptors

  Samuel J. Atkinson, et al., bioRxiv - Cell Biology 2024

  Quote: All cell lines were washed with PBS then starved of amino acids or FBS for 2 hours before treatment with the GPCR antagonists at 1 µM: CNO (Tocris/bio-techne 6329), Isoprenaline/Carvedilol (Sigma/Merck I6504 ...
• Synaptic signaling networks encode experience by assuming stimulus-specific and brain-region-specific states

  Jonathan D. Lautz, et al., bioRxiv - Neuroscience 2021

  Quote: ... was dissolved in HEPES-aCSF in the presence of non-mGluR glutamate receptor blockers (CNQX, Tocris, 0190, 40 μM; Nimodipine, Tocris, 0600, 1 μM; D(-)-2-Amino-5 phosphonopentanoic acid (APV) ...
• Species-specific sensitivity to TGFβ signaling and changes to the Mmp13 promoter underlie avian jaw development and evolution

  Spenser S. Smith, et al., bioRxiv - Developmental Biology 2020

  Quote: ... cells were treated with 1 µM SB431542 (S4317, MilliporeSigma, Burlington, MA, USA) to inhibit TGFβR1 activity or 3µM SIS3 (5291, Tocris/R&D Systems, Minneapolis, MN, USA) to inhibit SMAD3 solubilized in 50 mM DMSO ...
• Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells

  Saeko Akiyama, et al., bioRxiv - Cell Biology 2023

  Quote: ... 20 μM forskolin (solvent: DMSO, 063-02193, Fujifilm Wako Pure Chemicals, Osaka, Japan) and 1 μM LDN193189 (solvent: DMSO, 6053-10, Tocris Bioscience Bristol United Kingdom), with an induction period of 10 days.
• SRC family kinase inhibition rescues molecular and behavioral phenotypes, but not protein interaction network dynamics, in a mouse model of Fragile X syndrome

  Vera Stamenkovic, et al., bioRxiv - Neuroscience 2023

  Quote: ... was dissolved in HEPES-aCSF in the presence of non-mGluR glutamate receptor blockers (CNQX, Tocris, 0190, 40 µM; Nimodipine, Tocris, 0600, 1 µM; D(-)-2-Amino-5 phosphonopentanoic acid (APV) ...
• FAST-STEM: A Human pluripotent stem cell engineering toolkit for rapid design-build-test-learn development of human cell-based therapeutic devices

  Aaron H. Rosenstein, et al., bioRxiv - Bioengineering 2024

  Quote: ... FAST-STEM hiPSCs grown to 80% confluency were dissociated into single cells using TypLE for 5 minutes and seeded into the Aggrewell at a density of 1.2×105 cells per-well in 1 mL of mTesR Plus with 10 μg/mL ROCK Inhibitor Y-27632 (Tocris Bioscience, Bristol, UK; 1254) and 1% Penicillin-Streptomycin (Life Technologies ...
• Hierarchy of prediction errors shapes the learning of context-dependent sensory representations

  Matthias C. Tsai, et al., bioRxiv - Neuroscience 2024

  Quote: ... hM4Di was activated via intraperitoneal (i. p.) injection of the ligand clozapine N-oxide (CNO dihydrochloride, 1–5 mg/kg, Tocris Bioscience, Catalog number 4936) 25-30 minutes before each training session.
• Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature

  Charlie J. Childs, et al., bioRxiv - Bioengineering 2024

  Quote: ... was obtained through the administration of exponential doses with concentrations of 1 nM to 10 mM at 2 min intervals before the administration of 10 μM scopolamine (Tocris Bioscience Cat#1414/1G). After another equilibrium period ...
• TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons

  Ki Bum Um, et al., bioRxiv - Neuroscience 2021

  Quote: ... glutamate and GABA receptor blockers (10 μM NBQX, Tocris, UK, 1044; 5 μM CPP, Tocris, 0247; 5 μM SR-95531, Tocris, 1262; 1 μM CGP-55845, Tocris, 1248) were included in the recording solutions.