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• Parallel Neurodegenerative Phenotypes in Sporadic Parkinson’s Disease Fibroblasts and Midbrain Dopamine Neurons

  MJ Corenblum, et al., bioRxiv - Neuroscience 2023

  Quote: ... and CHIR 99021 (3μM, Tocris). This is followed by the stimulation of neuronal maturation through the application of ascorbic acid ...
• Parallel Neurodegenerative Phenotypes in Sporadic Parkinson’s Disease Fibroblasts and Midbrain Dopamine Neurons

  MJ Corenblum, et al., bioRxiv - Neuroscience 2023

  Quote: ... This method involves initiating the neural patterning of the iPSCs via inhibitors of the SMAD signaling pathway [LDN 193189 (100nM, Tocris, Minneapolis MN), SB 431542 (10μM ...
• Parallel Neurodegenerative Phenotypes in Sporadic Parkinson’s Disease Fibroblasts and Midbrain Dopamine Neurons

  MJ Corenblum, et al., bioRxiv - Neuroscience 2023

  Quote: ... Purmorphamine (2μM, Tocris), and CHIR 99021 (3μM ...
• Parallel Neurodegenerative Phenotypes in Sporadic Parkinson’s Disease Fibroblasts and Midbrain Dopamine Neurons

  MJ Corenblum, et al., bioRxiv - Neuroscience 2023

  Quote: ... SB 431542 (10μM, Tocris), and specification towards a ventral midbrain DA neuron fate using the morphogens sonic hedgehog (SHH C25II N-Terminus 100ng/mL ...
• Novel genetically encoded tools for imaging or silencing neuropeptide release from presynaptic terminals in vivo

  Dong-Il Kim, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 50 µM 4-AP (Tocris Bioscience). All solutions were continuously bubbled with 95% O2-5% CO2 with pH 7.3-7.4 and 300-310 mOsm ...
• Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons

  Alexandre Kisner, Abigail M. Polter, bioRxiv - Neuroscience 2023

  Quote: ... spermine and tetrodotoxin were purchased from Tocris Biosciences (Bristol ...
• Common roles for serotonin in rats and humans for computations underlying flexible decision-making

  Qiang Luo, et al., bioRxiv - Neuroscience 2023

  Quote: ... of either citalopram hydrobromide (1 mg/kg or 10 mg/kg; Tocris, Bristol, UK). Citalopram ...
• Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease

  Arpit Kumar Pradhan, et al., bioRxiv - Neuroscience 2023

  Quote: ... These 30 µm slices were incubated with methoxy-X04 solution (0.004 mg/ml, Tocris Bioscience, 1:1 ethanol-PBS solution) at room temperature for 30 minutes ...
• Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT_1A and 5-HT_1B receptors in monkeys

  Yukiko Hori, et al., bioRxiv - Neuroscience 2023

  Quote: ... and GR125487 (cat# 1658, Tocris; for 5-HT4R). WAY100635 ...
• Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT_1A and 5-HT_1B receptors in monkeys

  Yukiko Hori, et al., bioRxiv - Neuroscience 2023

  Quote: ... GR55562 (cat# 1054, Tocris; for 5-HT1BR), MDL100907 (M3324 ...
• Delaying the GABA shift indirectly affects membrane properties in the developing hippocampus

  C. Peerboom, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 50 μM DL-APV (Tocris). For recordings of miniature IPSCs (mIPSCs) ...
• Delaying the GABA shift indirectly affects membrane properties in the developing hippocampus

  C. Peerboom, et al., bioRxiv - Neuroscience 2023

  Quote: ... pH adjusted to 7.2 with KOH) and ACSF was supplemented with 20 μM DNQX (Tocris) and 50 μM DL-APV (Tocris) ...
• Insulin signaling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons

  J. Tabitha Hees, Angelika B. Harbauer, bioRxiv - Neuroscience 2023

  Quote: ... and plated at a density of 2.5*106 per 10 cm dish (Falcon) in StemFlex supplemented with 10 µM Y-27632 (Tocris) on day −2 ...
• Pre- and postsynaptic nanostructures increase in size and complexity after LTP induction

  Valérie Clavet-Fournier, et al., bioRxiv - Neuroscience 2023

  Quote: ... All extracellular solutions for mEPSC were continuously infused with tetrodotoxin (TTX) (1 µM, Tocris, # 1078) and 20 μM bicuculline.
• Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis

  LaNisha L. Patterson, et al., bioRxiv - Microbiology 2023

  Quote: ... and Z-LEHD-FMK TFA (S731303; Tocris Bioscience), respectively ...
• Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis

  LaNisha L. Patterson, et al., bioRxiv - Microbiology 2023

  Quote: ... DAPT (GSI-IX) (S2215; Tocris Bioscience, Bristol, UK) and Z-LEHD-FMK TFA (S731303 ...
• ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain

  Jiachen Chu, et al., bioRxiv - Physiology 2023

  Quote: ... W146 (TOCRIS, # 36024), JTE013 (TOCRIS ...
• Neuronal activity-driven O-GlcNAcylation promotes mitochondrial plasticity

  Seungyoon B. Yu, et al., bioRxiv - Neuroscience 2023

  Quote: ... Neuronal activity was manipulated with 6 hours of 50 µM picrotoxin (PTX, Tocris) treatment ...
• Ketamine’s rapid antidepressant effects are mediated by Ca²⁺-permeable AMPA receptors in the hippocampus

  Anastasiya Zaytseva, et al., bioRxiv - Neuroscience 2023

  Quote: ... 5 μM FK506 (Tocris, 3631) was used to inhibit calcineurin activity in cultured hippocampal excitatory neurons ...
• 3D genome organization around nuclear speckles drives mRNA splicing efficiency

  Prashant Bhat, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and 250 nM LDN-193189 (Tocris, 6053). On day 5 ...
• Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion–FAK axis

  Taisei Wakigawa, et al., bioRxiv - Molecular Biology 2023

  Quote: ... BAI1 (Tocris, 2160, 1 μM), BTSA1 (Selleckchem ...
• Behavioral, molecular and neuronal mechanisms involved in recognition memory retrieval under degraded spatial cues in the rat hippocampus

  Magdalena Miranda, et al., bioRxiv - Neuroscience 2023

  Quote: ... Nimodipine (7.5 μg/ 0.5μl, Tocris) or Vehicle (Veh ...
• Heparan sulfates regulate axonal excitability and context generalization through Ca²⁺/calmodulin-dependent protein kinase II

  Inseon Song, et al., bioRxiv - Neuroscience 2023

  Quote: ... Na+ channel blocker tetrodotoxin (TTX, 1 μM, Tocris) were added to ACSF.
• Heparan sulfates regulate axonal excitability and context generalization through Ca²⁺/calmodulin-dependent protein kinase II

  Inseon Song, et al., bioRxiv - Neuroscience 2023

  Quote: ... GABAB receptor antagonist CGP55845 (3 μM, Tocris), Na+ channel blocker tetrodotoxin (TTX ...
• Heparan sulfates regulate axonal excitability and context generalization through Ca²⁺/calmodulin-dependent protein kinase II

  Inseon Song, et al., bioRxiv - Neuroscience 2023

  Quote: ... 5 mM QX314 was added into the intracellular pipette solution while GABAA receptor antagonist picrotoxin (PTX, 50 μM, Tocris), GABAB receptor antagonist CGP55845 (3 μM ...
• Heparan sulfates regulate axonal excitability and context generalization through Ca²⁺/calmodulin-dependent protein kinase II

  Inseon Song, et al., bioRxiv - Neuroscience 2023

  Quote: ... NBQX (25 μM,Tocris), D-APV (50 μM,Tocris) ...
• Heparan sulfates regulate axonal excitability and context generalization through Ca²⁺/calmodulin-dependent protein kinase II

  Inseon Song, et al., bioRxiv - Neuroscience 2023

  Quote: ... TTX (1 μM, Tocris) were added to ACSF to isolate action potential-independent mIPSCs ...
• Heparan sulfates regulate axonal excitability and context generalization through Ca²⁺/calmodulin-dependent protein kinase II

  Inseon Song, et al., bioRxiv - Neuroscience 2023

  Quote: ... D-APV (50 μM,Tocris), TTX (1 μM ...
• LTK and ALK regulate neuronal polarity and cortical migration by modulating IGF1R activity

  Tania Christova, et al., bioRxiv - Neuroscience 2023

  Quote: ... LY 294002 (Tocris), BKM120 (Buparlisib ...
• Pro-myelinating Clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health

  Keying Chen, Franca Cambi, Takashi D.Y. Kozai, bioRxiv - Neuroscience 2023

  Quote: ... were given either Clemastine (dissolved in 10% DMSO/PBS, 10mg/Kg body weight; Tocris Bioscience) or vehicle solution (only 10% DMSO/PBS ...
• A versatile synaptotagmin-1 nanobody provides perturbation-free live synaptic imaging and low linkage-error in super-resolution microscopy

  Karine Queiroz Zetune Villa Real, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 50 μM 2-amino-5-phosphonopentanoic acid (D-AP5; Tocris Bioscience, Cambridge, UK) to avoid spontaneous network activation ...
• Kv12-Encoded K⁺ Channels Drive the Day-Night Switch in the Repetitive Firing Rates of SCN Neurons

  Tracey O. Hermanstyne, et al., bioRxiv - Neuroscience 2023

  Quote: ... Slices were perfused continuously with ACSF containing 20 μM Gabazine (Tocris Bioscience) and saturated with 95% O2/5% CO2 ...
• A versatile synaptotagmin-1 nanobody provides perturbation-free live synaptic imaging and low linkage-error in super-resolution microscopy

  Karine Queiroz Zetune Villa Real, et al., bioRxiv - Neuroscience 2023

  Quote: ... Transduced neurons were placed onto a custom-built live-imaging chamber and imaged in Tyrode’s solution supplemented with 10 μM cyanquixaline (CNQX, Tocris Bioscience, Cambridge, UK) and 50 μM 2-amino-5-phosphonopentanoic acid (D-AP5 ...
• Regulation of parvalbumin interneuron plasticity by neuropeptide-encoding genes

  Martijn Selten, et al., bioRxiv - Neuroscience 2023

  Quote: Mice between P42 and P70 were treated with vehicle or Clozapine N-oxide (CNO, Tocris Cat. No. 4936) as indicated ...
• Histone bivalency regulates the timing of cerebellar granule cell development

  Kärt Mätlik, et al., bioRxiv - Neuroscience 2023

  Quote: ... UNC1999 (Tocris Biosciences ...
• Regulation of parvalbumin interneuron plasticity by neuropeptide-encoding genes

  Martijn Selten, et al., bioRxiv - Neuroscience 2023

  Quote: ... and 100 μM D-(−)-2-Amino-5-phosphonopentanoic acid (D-APV, Tocris, 0106) to block glutamatergic inputs ...
• Regulation of parvalbumin interneuron plasticity by neuropeptide-encoding genes

  Martijn Selten, et al., bioRxiv - Neuroscience 2023

  Quote: ... Miniature excitatory postsynaptic currents (mEPSCs) and miniature inhibitory postsynaptic currents (mIPSCs) were recorded in the presence of 1 μM Tetrodotoxin (Tocris, 1069) at a holding voltage of -60 mV and +10mV ...
• Regulation of parvalbumin interneuron plasticity by neuropeptide-encoding genes

  Martijn Selten, et al., bioRxiv - Neuroscience 2023

  Quote: ... slices were incubated in recording ACSF supplemented with 5 μM 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX, Tocris, 1045) and 100 μM D-(−)-2-Amino-5-phosphonopentanoic acid (D-APV ...
• Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells

  Song-Yi Lee, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and 5 μM TRO19622 (Tocris). Every 3 days after plating ...
• Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

  Alexander C. Jones, et al., bioRxiv - Molecular Biology 2023

  Quote: ... Gö6983 (catalog no. 285) was purchased from Tocris. Bradford reagent (catalog no ...
• Acute psilocybin enhances cognitive flexibility in rats

  Alejandro Torrado Pacheco, et al., bioRxiv - Neuroscience 2023

  Quote: ... and SB242084 (Tocris, cat #2901) were dissolved in 10% DMSO to a concentration of 1 mg/ml ...
• Optogenetic urothelial cell stimulation induces bladder contractions and pelvic nerve afferent firing

  Gabriella L Robilotto, et al., bioRxiv - Physiology 2023

  Quote: ... GSK1016790A (6433, Tocris), and incubated for 15 minutes at room temperature32 ...
• Ketamine’s rapid antidepressant effects are mediated by Ca²⁺-permeable AMPA receptors in the hippocampus

  Anastasiya Zaytseva, et al., bioRxiv - Neuroscience 2023

  Quote: ... 10 mg/kg IEM-1460 (Tocris, 1636/10) was intraperitoneally injected to 3-month-old male and female CD-1 mice to inhibit in vivo CP-AMPAR activity because it is blood-brain barrier (BBB)-permeable (Adotevi et al. ...
• Ketamine’s rapid antidepressant effects are mediated by Ca²⁺-permeable AMPA receptors in the hippocampus

  Anastasiya Zaytseva, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 μM (-)-Bicuculline methochloride (Tocris, 0131) and incubated in glycine buffer (Mg2+ free buffer with 0.2 mM glycine ...
• Ketamine’s rapid antidepressant effects are mediated by Ca²⁺-permeable AMPA receptors in the hippocampus

  Anastasiya Zaytseva, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 μM 4-methoxy-7-nitroindolinyl (MNI)-caged L-glutamate (Tocris, 1490) was added to the culture media for glutamate uncaging ...
• Glucagon-Like Peptide-1 Receptor Activation Stimulates PKA-Mediated Phosphorylation of Raptor and this Contributes to the Weight Loss Effect of Liraglutide

  Thao D. V. Le, et al., bioRxiv - Physiology 2023

  Quote: ... PKA inhibitors H89 (Cat#2910, Tocris Bioscience) or KT5720 (Cat#1288 ...
• Glucagon-Like Peptide-1 Receptor Activation Stimulates PKA-Mediated Phosphorylation of Raptor and this Contributes to the Weight Loss Effect of Liraglutide

  Thao D. V. Le, et al., bioRxiv - Physiology 2023

  Quote: ... or KT5720 (Cat#1288, Tocris Bioscience), or the Akt inhibitor MK-2207 (Cat#S1078 ...
• ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain

  Jiachen Chu, et al., bioRxiv - Physiology 2023

  Quote: ... JTE013 (TOCRIS, # 2392), BAPTA AM (Cayman ...
• ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain

  Jiachen Chu, et al., bioRxiv - Physiology 2023

  Quote: ... ARL 67156 trisodium salt (Tocris, #1283), sphingosine-1-phosphate (Cayman ...
• ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain

  Jiachen Chu, et al., bioRxiv - Physiology 2023

  Quote: ... diphenyleneiodonium (DPI) (TOCRIS, # 0504), ATP (Sigma-Aldrich ...