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651 - 659 of 659 citations for 4 Nitrophenyl beta D glucuronic acid sodium salt since 2020

• Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of MAPT Mutation iPSC-derived Neurons

  Lianna D’Brant, et al., bioRxiv - Neuroscience 2024

  Quote: ... The cell suspension was then centrifuged at 1,200 rpm for 4 minutes and resuspended in mTeSR medium supplemented with 10 μM ROCK inhibitor Y-27632 (Tocris Cat # 1254) at a concentration of 10,000 cells per 100 µL or 1 million cells per 10 mL ...
• Allosteric receptor modulation uncovers an FFAR2 antagonist as a positive orthosteric modulator/agonist in disguise

  Simon Lind, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... as well as the P2Y2R antagonist AR-C118925XX (5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide) were obtained from Tocris (Abingdon, UK). Subsequent dilutions of receptor ligand and other reagents were made in Krebs-Ringer Glucose phosphate buffer (KRG ...
• Gallein and isoniazid act synergistically to attenuate Mycobacterium tuberculosis growth in human macrophages

  Ramesh Rijal, Richard H. Gomer, bioRxiv - Microbiology 2024

  Quote: To investigate the impact of gallein (3’,4’,5’,6’-Tetrahydroxyspiro[isobenzofuran-1(3H),9’- (9H)xanthen]-3-one) (Cat#3090, Tocris, Minneapolis, MN) and/or INH on Mtb growth ...
• Cancer-mediated Axonal Guidance of Sensory Neurons in a Microelectrode-based Innervation MPS

  Matthijs van der Moolen, et al., bioRxiv - Neuroscience 2023

  Quote: ... was selected by qualifying the presence of innervated cancer spheroids at various heights within the gel layer before stimulation with either 4 µM Bradykinin (Tocris/Biotechne, #3004) or 1 µM Capsaicin (Tocris/Biotechne ...
• Global mapping of the Chlamydia trachomatis conventional secreted effector – host interactome reveals CebN interacts with nucleoporins and Rae1 to impede STAT1 nuclear translocation

  Brianna Steiert, et al., bioRxiv - Microbiology 2024

  Quote: ... along with 10 µM GSK-3 α and β inhibitor 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea (Tocris) as previously described20 ...
• Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding

  Gabriel Ocana-Santero, et al., bioRxiv - Neuroscience 2024

  Quote: ... ACSF of the same composition as the recording ACSF but with higher concentration (4 mM) of MgCl2 and CaCl2 and MNI-caged glutamate (200 µM; Tocris Bioscience, UK). UV laser pulses (355 nm ...
• Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and rewires the microenvironment toward an immune-suppressive state

  Yan Tang, et al., bioRxiv - Cancer Biology 2022

  Quote: ... the small molecule 3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one (iMDK; TOCRIS Bio-techne, 9mg/kg), rapamycin (Sirolimus A8167 ...
• TRPM8-dependent shaking in mammals and birds

  Tudor Selescu, et al., bioRxiv - Physiology 2024

  Quote: ... Drugs were added from the following stock solutions: (2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide (WS-12, Tocris #3040, Bio-Techne Ltd, Abingdon, UK) 5 mM in ethanol ...
• Astrocyte sensitivity to glymphatic shear stress is amplified by albumin and mediated by the interaction of sphingosine 1 phosphate with Piezo1

  David Ballesteros-Gomez, et al., bioRxiv - Neuroscience 2023

  Quote: ... we tested effects of an inhibitor (the spider toxin GsMTX 4; Tocris #4912 stock 50 μM in DMSO and the Piezo1 channel activator Yoda1 (Tocris 6586 10 and 20 uM, stock 20 mM in DMSO).