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651 - 700 of 1385 citations for 4 2 Methylimidazol 1 ylmethyl phenylamine since 2020

• Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion

  Michael J. Seibert, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 μM tetrodotoxin (Tocris) was included in the bath ...
• EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

  Lyra O. Randzavola, et al., bioRxiv - Immunology 2022

  Quote: ... NGI-1 compound (TOCRIS) or tunicamycin (Sigma ...
• Heparan sulfates regulate axonal excitability and context generalization through Ca²⁺/calmodulin-dependent protein kinase II

  Inseon Song, et al., bioRxiv - Neuroscience 2023

  Quote: ... TTX (1 μM, Tocris) were added to ACSF to isolate action potential-independent mIPSCs ...
• PIEZO1-mediated mechanosensing governs NK cell killing efficiency and infiltration in three-dimensional matrices

  Archana K. Yanamandra, et al., bioRxiv - Immunology 2024

  Quote: ... Yoda-1 from Tocris, and Fibricol Collagen solution (10mg/ml Bovine Type I ...
• Neuroblastoma-associated chromosomal aberrations drive cell identity loss in human neural crest via disruption of developmental regulators

  Ingrid M. Saldana-Guerrero, et al., bioRxiv - Cancer Biology 2022

  Quote: ... CHIR99021 (1 μM, Tocris), BMP4 (15ng/ml ...
• IFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS-associated Amyotrophic Lateral Sclerosis

  Amanda Faria Assoni, et al., bioRxiv - Neuroscience 2022

  Quote: ... CHIR99021 (1 μM) (Tocris), retinoic acid (0.1 μM ...
• Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss

  Hsiao-Jou Cortina Chen, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 μM LM22A4 (Tocris), 2 μM CHIR99021 (Cambridge Bioscience) ...
• Macrophage Migration Inhibitory Factor on Apoptotic Extracellular Vesicles Regulates Compensatory Proliferation

  Safia A. Essien, et al., bioRxiv - Cell Biology 2023

  Quote: ... ISO-1 (Tocris, 4288), 4-IPP (Tocris ...
• In vivo long-term voltage imaging by genetically encoded voltage indicator reveals spatiotemporal dynamics of neuronal populations during development

  Asuka Shiraishi, et al., bioRxiv - Neuroscience 2023

  Quote: ... tetrodotoxin (1 μM, TOCRIS) was added to the extracellular solution using a peristaltic pump (World Precision Instruments) ...
• A cortico-subcortical loop for motor control via the pontine reticular formation

  Emília Bősz, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 QX-314 (Tocris), pH 7.35 with CsOH (∼300 mOsm) ...
• Orthogonal analysis of mitochondrial function in Parkinson’s disease patients

  Sander Barnhoorn, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 μM dorsomorphin (Tocris), 3 μM CHIR 99021 (Axon Medchem ...
• TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids

  Soraia Fernandes, et al., bioRxiv - Cancer Biology 2023

  Quote: ... SAG (1 μM, Tocris) and FGF4 (500 ng/mL ...
• Feed-forward metabotropic signaling by Cav1 Ca²⁺ channels supports pacemaking in pedunculopontine cholinergic neurons

  C. Tubert, et al., bioRxiv - Neuroscience 2023

  Quote: ... ionomycin (Tocris, 1 uM) and oligomycin A (Sigma-Aldrich ...
• Neural tube organoids self-organise floorplate through BMP-mediated cluster competition

  Teresa Krammer, et al., bioRxiv - Developmental Biology 2023

  Quote: ... 1 µM PD0325901 (Tocris) and 20 ng/ml murine LIF (Qkine) ...
• The autism-associated gene SYNGAP1 regulates human cortical neurogenesis

  Marcella Birtele, et al., bioRxiv - Developmental Biology 2023

  Quote: ... TTX (Tocris, #1078/1) at a final concentration of 2LµM ...
• Acetylcholine Promotes Directionally Biased Glutamatergic Retinal Waves

  Kathy Zhang, et al., bioRxiv - Neuroscience 2023

  Quote: ... 1 uM MLA (Tocris), 200 uM DHβE (Tocris) ...
• A novel iPSC model reveals selective vulnerability of neurons in Multiple Sulfatase Deficiency

  Vi Pham, et al., bioRxiv - Cell Biology 2023

  Quote: ... LDN193189 (1 μM, Tocris), and endo-IWR1 (1.5 μM ...
• ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis

  Kathryn M. Yammine, et al., bioRxiv - Genetics 2024

  Quote: ... 1 μM A8301 (Tocris) and 0.25 μM LDN193189 (Cayman Chemical ...
• Transfer learning reveals sequence determinants of the quantitative response to transcription factor dosage

  Sahin Naqvi, et al., bioRxiv - Genomics 2024

  Quote: ... dTAGV-1 (Tocris, 6914) at a range of concentrations was added to BCh medium ...
• Reduced SH3RF3 may protect against Alzheimer’s disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling

  Ronak Patel, et al., bioRxiv - Neuroscience 2024

  Quote: ... IKK16 (1 uM; Tocris), and NSC23766 (50 uM ...
• Identification of neuron-glia signaling feedback in human schizophrenia using patient-derived, mix-and-match forebrain assembloids

  Eunjee Kim, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1 μM CHIR99021 (Tocris), and 1 μM SB-431542 (Cellagentech) ...
• Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9

  Joshua D Eaton, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 1µM dTAGv-1 (Tocris) was used for 1-14hrs (see figure legends for timings used in each experiment) ...
• Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model

  Alice E. Stanton, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1 μM SAG (Tocris), and 50 ng/ mL VEGF-A (PeproTech) ...
• A stepwise, modular design of building uniform brain assembloids representing the dynamic cellular interplay between neurons and glial cells

  Eunjee Kim, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1 μM CHIR99021 (Tocris), and 1 μM SB-431542 (Cellagentech) ...
• Human Stem Cell-derived Kidney Collecting Duct Model via Epithelial Microphysiological Analysis Platform: Epi-MAP

  SoonGweon Hong, et al., bioRxiv - Bioengineering 2024

  Quote: ... T3 (1 nM, Tocris) and fetal bovine serum (2% v/v ...
• Human cartilage model of the precocious osteoarthritis-inducing COL2A1 p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II

  Kathryn M. Yammine, et al., bioRxiv - Cell Biology 2024

  Quote: ... 1 μM A8301 (Tocris) and 0.25 μM LDN193189 (Cayman Chemical ...
• Activity-dependent alteration of early myelin ensheathment in a developing sensory circuit

  Zahraa Chorghay, et al., bioRxiv - Neuroscience 2021

  Quote: Bilateral mosaic tadpoles expressing GCaMP6s at stage 48 were immobilized in 2 mM pancuronium dibromide (Cedarlane/Tocris 0693) and embedded in 1% low melting point agarose in a petri dish filled with 0.1X MBSH ...
• PLD2-phosphatidic acid recruit ESCRT-I to late endosomes for exosome biogenesis

  Antonio Luis Egea-Jimenez, et al., bioRxiv - Cell Biology 2020

  Quote: ... cells were treated with 50 nM VU0364739 inhibitor (N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide) (Lavieri et al., 2010) for 16 h (Tocris Bioscience). For lysosomal inhibition ...
• Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

  Pablo J. Lituma, et al., bioRxiv - Neuroscience 2021

  Quote: ... the group 2/3 mGluR agonist (DCG-IV) and MNI-glutamate for uncaging experiments were purchased from Tocris Bioscience ...
• Expression of a modified astrocytic glutamate transporter alleviates Huntington’s hypokinesia, promotes synaptic glutamate clearance and counteracts potentially adverse EAAT2 interactions

  Stefan Hirschberg, et al., bioRxiv - Neuroscience 2021

  Quote: ... the same routine was repeated in the presence of the glutamate transport blocker TFB-TBOA 2 μM (Tocris). For both traces the fluorescence change was calculated from the average of the baseline fluorescence intensities for each ROI as ΔF/F = (FSBFI - FSBFI(baseline)/FSBFI(baseline) ...
• Single cell reconstruction of human basal cell diversity in normal and IPF lung

  Gianni Carraro, et al., bioRxiv - Cell Biology 2020

  Quote: ... the γ-secretase inhibitor (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine1,1-dimethylethyl ester (DAPT) (Tocris) was added at a concentration of 5 μM ...
• Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens

  Ali Mohebi, Val L. Collins, Joshua D. Berke, bioRxiv - Neuroscience 2022

  Quote: Rats were bilaterally infused with either the selective α4β2 nicotinic antagonist DHβE (low dose: 15μg/.5μL/side, high dose 30μg/.5μL/side; Tocris Bioscience, Bristol, UK) the non-selective dopamine receptor antagonist Flupenthixol (15μg/.5μl/side ...
• Subtype-specific single β1 integrin mechanics for activation, mechanotransduction and cytoskeleton remodeling

  Myung Hyun Jo, et al., bioRxiv - Biophysics 2022

  Quote: ... the 2-methylphenylureaphenylacetyl (MUPA) moiety with LDVPAAK peptide (MUPA-LDVPAAK; now commercially available, Tocris, 7020, supplementary Fig. 12) was custom synthesized by Bio-Synthesis and the amine group of its lysine side chain was reacted with the NHS group of sulfo-SMCC ...
• Focal exocytosis of Syntaxin 3 and TRPML1 at pseudopodia of nascent phagosomes

  Deepti Dabral, Geert van Bogaart, bioRxiv - Cell Biology 2022

  Quote: ... LPS was washed off and the macrophages were treated with 2 μM MK6-83 (cat no. 5547, Tocris), 20 μM MLSA-1 (cat ...
• Robust and Versatile Arrayed Libraries for Human Genome-Wide CRISPR Activation, Deletion and Silencing

  Jiang-An Yin, et al., bioRxiv - Genomics 2023

  Quote: ... and seeded at a seeding density of 10,000–25,000 cells/cm2 in mTeSR supplemented with 2 μM ROCK inhibitor Y27632 (Tocris) onto laminin-521 coated plates ...
• Pathogenic MTOR somatic variant causing focal cortical dysplasia drives hyperexcitability via overactivation of neuronal GluN2C NMDA receptors

  Louison Pineau, et al., bioRxiv - Neuroscience 2023

  Quote: All recordings were done in ACSF-2 without or with 10 μM DQP 1105 (Tocris Bio-Techne, France), 10 μM DQP 1105 + 1μM Ro 25-6981 (Tocris Bio-Techne ...
• Identification of a convergent spinal neuron population that encodes itch

  Tayler D. Sheahan, et al., bioRxiv - Neuroscience 2023

  Quote: ... GRP was applied to the spinal cord to evoke Ca2+ oscillations and 2-APB (100 µM, Tocris 1224) 10 min later ...
• Allosteric Competition and Inhibition in AMPA Receptors

  W. Dylan Hale, et al., bioRxiv - Biophysics 2023

  Quote: ... whereas IS-2 sample was made up to 100 µM CTZ and 100 µM GYKI- 52466 (Tocris, 1454) prior to centrifugation (75,000 g ...
• Promoting Human Intestinal Organoid Formation and Stimulation Using Piezoelectric Nanofiber Matrices

  Holly M. Poling, et al., bioRxiv - Bioengineering 2024

  Quote: ... 2% dFCS,) for four days with 100 ng/ml FGF4 (R&D) and 3 µM Chiron 99021 (Tocris) to induce the formation of spheroids ...
• Neuroblastoma-associated chromosomal aberrations drive cell identity loss in human neural crest via disruption of developmental regulators

  Ingrid M. Saldana-Guerrero, et al., bioRxiv - Cancer Biology 2022

  Quote: ... the BMP type-I receptor inhibitor DMH-1 (1 μM, Cat# 4126, Tocris), 10 μM of Rock Inhibitor (Y-27632 ...
• Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

  María Fernández-Casañas, et al., bioRxiv - Cell Biology 2024

  Quote: ... and Protein Phosphatase 1 inhibitor: Tautomycetin (Tocris Bioscience; 2305, 1 or 5 μΜ).
• Peripheral kappa opioid receptor activation drives noxious cold hypersensitivity in mice

  Manish K. Madasu, et al., bioRxiv - Neuroscience 2021

  Quote: ... and nor-Binaltorphimine dihydrochloride (norBNI, KOR antagonist, 10 mg/kg, i.p.) (CAS# 113158-34-2) were obtained from Tocris and dissolved in 0.9% sterile saline ...
• Activation of group II metabotropic receptors attenuates cortical E-I imbalance in a 15q13.3 microdeletion mouse model

  Marzieh Funk, et al., bioRxiv - Neuroscience 2020

  Quote: ... 20 μM 6,7-dinitroquinoxaline-2,3-dione (DNQX) and 20 μM D-(-)-2-amino-5-phosphopentanoic acid (D-AP5) (Tocris Bioscience) to block glycine- ...
• A bifunctional kinase-phosphatase module integrates mitotic checkpoint and error-correction signalling to ensure mitotic fidelity

  Andrea Corno, et al., bioRxiv - Cell Biology 2022

  Quote: To observe chromosome alignment in fixed-cell experiments – with the advantage of taking high resolution images and easily selecting many cells for further analysis - cells were released from thymidine block for 7 hours before being treated for 2 hours with RO-3306 (10μM, Tocris) – to synchronise cells at the G2/M boundary - or with a 3-hour treatment with STLC (10μM ...
• Advected percolation in the actomyosin cortex drives amoeboid cell motility

  Juan Manuel García-Arcos, et al., bioRxiv - Biophysics 2022

  Quote: ... 100 μM 2-APB blocking stretch-activated inositol triphosphate receptors (InsP3Rs) on the ER/nuclear membranes (Tocris Bioscience #1224), 100 μM CK-666 (Tocris Bioscience #3950 ...
• Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice

  Sampurna Chakrabarti, et al., bioRxiv - Neuroscience 2020

  Quote: ... were performed on mice with no knee injections 20 min before and after C21 (2 mg/kg diluted in sterile saline from a stock of 100 mM in ethanol, i.p., Tocris) injection.
• mGluR5 Negative Modulators for Fragile X: Resistance and Persistence

  David C Stoppel, et al., bioRxiv - Neuroscience 2021

  Quote: ... The mGluR5 specific negative allosteric modulator MPEP hydrochloride (2-Methyl-6-(phenylethynyl)pyridine hydrochloride) was purchased from Tocris (1212) and administered to brain slices at 30 μM by bath perfusion ...
• Extracellular matrix stiffness regulates degradation of the Hippo kinase MST2 via SCF ^βTrCP

  Ana Paula Zen Petisco Fiore, et al., bioRxiv - Cell Biology 2021

  Quote: ... AKT (20 μM MK2206, Cayman Biochemicals #1032350-13-2) and myosin ATPase activity inhibitor (5 μM Blebbistatin, Tocris #1852).
• Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration

  Jinwook Choi, et al., bioRxiv - Cell Biology 2021

  Quote: ... organoids cultured for 8 days with airway cell culture medium were followed by inclusion of CHIR99021 (2 µM, Tocris) for additional 10 days with or without DAPT (20 µM) ...
• Glymphatic Inhibition Exacerbates Tau Propagation in an Alzheimer’s Disease Model

  Douglas M Lopes, et al., bioRxiv - Neuroscience 2023

  Quote: Pharmacological inhibition of AQP4 was achieved using TGN-020 (N-1,3,4-thiadiazol-2-yl-3-pyridinecarboxamide, Tocris Bioscience, UK). Unless otherwise stated ...