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6151 - 6200 of 7257 citations since 2019

• Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice

  Elisa M Nabel, et al., bioRxiv - Neuroscience 2020

  Quote: Clozipine-N-Oxide dihydrochloride (CAS2250025-93-3, Tocris Biosciences) was injected intraperitoneally (i.p. ...
• Development of a genetically-encoded oxytocin sensor

  Neymi Mignocchi, et al., bioRxiv - Neuroscience 2020

  Quote: ... and/or L-371,257 (Tocris, Cat #: 2410) were added to the neuronal cultures and illuminated with blue light using the same time intervals and equipment described above for varying periods of time (5 min ...
• Development of a genetically-encoded oxytocin sensor

  Neymi Mignocchi, et al., bioRxiv - Neuroscience 2020

  Quote: ... varying concentrations of OXT (Tocris, Cat #: 1910) and/or L-371,257 (Tocris ...
• The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch

  Tayler D. Sheahan, et al., bioRxiv - Neuroscience 2020

  Quote: ... 632 (40 ng, Tocris, 1669), gastrin-releasing peptide (GRP ...
• The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch

  Tayler D. Sheahan, et al., bioRxiv - Neuroscience 2020

  Quote: ... clozapine N-oxide hydrochloride (CNO, Tocris, Cat No. 6329), which was dissolved in sterile saline and delivered at 5 mg/kg ...
• The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch

  Tayler D. Sheahan, et al., bioRxiv - Neuroscience 2020

  Quote: ... NK1R antagonist CP 99994 (18 μg, Tocris, 3417). Sterile saline was delivered as a vehicle control.
• Atomoxetine modulates the contribution of high- and low-level signals during free viewing of natural images in rhesus monkeys

  Amélie J. Reynaud, et al., bioRxiv - Neuroscience 2020

  Quote: ... atomoxetine (ATX, Tocris Bioscience, Ellisville, MO) and saline (control ...
• Optical measurement of physiological sodium currents in the axon initial segment

  Luiza Filipis, Marco Canepari, bioRxiv - Neuroscience 2020

  Quote: ... Tetrodotoxin (TTX, purchased from Tocris, Bristol, UK) and huwentoxin-IV (HwTx-IV ...
• Ketamine restores escape behavior by re-engaging dopamine systems to drive cortical spinogenesis

  M Wu, et al., bioRxiv - Neuroscience 2020

  Quote: ... SKF 81297 hydrobromide (SKF 81297, 1 μM, Tocris), and H-89 dihydrochloride (H-89 ...
• Ketamine restores escape behavior by re-engaging dopamine systems to drive cortical spinogenesis

  M Wu, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2.5 mM MNI-caged-L-glutamate (Tocris) was perfused into the slice chamber ...
• Ketamine restores escape behavior by re-engaging dopamine systems to drive cortical spinogenesis

  M Wu, et al., bioRxiv - Neuroscience 2020

  Quote: ... SR 95531 hydrobromide (gabazine, 10 μM, Tocris), SKF 81297 hydrobromide (SKF 81297 ...
• Ketamine restores escape behavior by re-engaging dopamine systems to drive cortical spinogenesis

  M Wu, et al., bioRxiv - Neuroscience 2020

  Quote: ... and H-89 dihydrochloride (H-89, 10 μM, Tocris) were used in acute slice experiments ...
• Ketamine restores escape behavior by re-engaging dopamine systems to drive cortical spinogenesis

  M Wu, et al., bioRxiv - Neuroscience 2020

  Quote: ... SKF 83566 (10 mg/kg, Tocris), Clozapine N-oxide (3 mg/kg in vivo ...
• Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical circuit assembly

  Yajun Xie, et al., bioRxiv - Neuroscience 2020

  Quote: ... mEPSCs were recorded for 5min in the presence of 1 μM tetrodotoxin (Tocris) and 10 μM gabazine (Tocris ...
• Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical circuit assembly

  Yajun Xie, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 10 μM gabazine (Tocris) at a holding potential of –70 mV ...
• Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex

  Stephen D. Glasgow, et al., bioRxiv - Neuroscience 2020

  Quote: ... nifedipine (1075, Tocris), and 2-Aminoethoxydiphenylborane (1224 ...
• Ontogeny of the VIP+ interneuron sensory-motor circuit prior to active whisking

  Cristiana Vagnoni, et al., bioRxiv - Neuroscience 2020

  Quote: ... containing 100µM of 4-Methoxy-7-nitroindolinyl-caged-L-glutamate (MNI glutamate, Tocris Bioscience).
• Single-cell sequencing of human iPSC-derived cerebellar organoids shows recapitulation of cerebellar development

  Samuel Nayler, et al., bioRxiv - Neuroscience 2020

  Quote: ... 50 μM Y-27562 (Tocris) and 10 μM SB431542 (Muguruma et al. ...
• Correlating cell function and morphology by performing fluorescent immunocytochemical staining on the light-microscope stage

  Hiroyuki Kawano, et al., bioRxiv - Neuroscience 2020

  Quote: ... by transferal of the coverslip into a culture dish filled with dye-free Tyrode’s solution containing 1 μM of the voltage-gated Na+ channel blocker tetrodotoxin (tetrodotoxin citrate, TTX, 1069; Tocris Bioscience ...
• Single-cell sequencing of human iPSC-derived cerebellar organoids shows recapitulation of cerebellar development

  Samuel Nayler, et al., bioRxiv - Neuroscience 2020

  Quote: ... hiPSC were passaged upon reaching approximately 80% confluence using EDTA at 37°C for three to five minutes and plated in mTESR1 with 10 μM Y-27562 (Tocris, UK). Media without Y-27562 was supplemented the day following.
• Revival of light-evoked neuronal signals in the post-mortem mouse and human retina

  Fatima Abbas, et al., bioRxiv - Neuroscience 2020

  Quote: ... to isolate inner retinal signaling (B-waves) and DL-2-Amino-4-phosphonobutyric acid (DL-AP4, 40µM, Tocris Bioscience, Bristol, U.K.) to isolate the photoreceptor component of the ERG signal (A-wave) ...
• Mild membrane depolarization in neurons induces immediate early gene transcription and acutely subdues responses to successive stimulus

  Kira D. A. Rienecker, et al., bioRxiv - Neuroscience 2020

  Quote: FK506: FK506 aka FK (Tocris, #3631) treatments (1µM ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: Ectoderm differentiation was induced using Essential 6 (E6) medium supplemented with LDN-193189 (100 nM, Tocris) and A83-01 (2 μM ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: ... and A83-01 (2 μM, Tocris). Cells were plated at a density of 5E5 cells/cm2 on VTN-coated T75 flasks in 15 mL of E8 media supplemented with CEPT cocktail and allowed to reach 70% confluency ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: ... cyclic-AMP (50 μM, Tocris) and Ascorbic Acid (200 μM ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: ... and Y-27632 (10 μM, Tocris). After confirming the superiority of the CEPT cocktail ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: ... cyclic-AMP (50 μM, Tocris) and Ascorbic Acid (200 μM ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: ... Biolamina)-coated 384-well plates in 30 μL of E8 media supplemented with CEPT cocktail or Y-27632 (10 μM, Tocris). After 24 h ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: ... and Ascorbic Acid (200 μM, Tocris) for 2 weeks ...
• Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

  Carlos A. Tristan, et al., bioRxiv - Bioengineering 2020

  Quote: ... and 0.7 μM Trans-ISRIB (#5284; Tocris).
• Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABA_A receptors

  Meredith Lodge, et al., bioRxiv - Neuroscience 2020

  Quote: ... NBQX (20 mM; Tocris), and the α5-NAM RO4938581 (10 mM ...
• Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABA_A receptors

  Meredith Lodge, et al., bioRxiv - Neuroscience 2020

  Quote: ... QX314 (5mM, Tocris) was dissolved in the internal pipette solution ...
• Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABA_A receptors

  Meredith Lodge, et al., bioRxiv - Neuroscience 2020

  Quote: ... and SR95531 (0.2μM and 10μM, Tocris) were dissolved in water ...
• Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABA_A receptors

  Meredith Lodge, et al., bioRxiv - Neuroscience 2020

  Quote: ... CGP54626 hydrochloride (10 mM; Tocris), NBQX (20 mM ...
• Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex

  Stephen D. Glasgow, et al., bioRxiv - Neuroscience 2020

  Quote: ... flufenamic acid (4522, Tocris), nifedipine (1075 ...
• Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABA_A receptors

  Meredith Lodge, et al., bioRxiv - Neuroscience 2020

  Quote: D-AP5 (50 mM; Tocris) and SR95531 (0.2μM and 10μM ...
• DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity

  Daniel J. Wilcock, et al., bioRxiv - Cancer Biology 2020

  Quote: Compounds were used at the following concentrations unless otherwise noted 50 μM AZD3988 (Tocris), 30 μM A922500 (Stratech ...
• DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity

  Daniel J. Wilcock, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 5 μM Ebselen (Tocris), 1 mM Tempol ...
• FUS gene is dual-coding with both proteins united in FUS-mediated toxicity

  Marie A Brunet, et al., bioRxiv - Genetics 2020

  Quote: ... 2µM SB431542 (Tocris Bioscience), and 3.3µM CHIR99021 (Miltenyi Biotec) ...
• Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity

  Ian A. Mellis, et al., bioRxiv - Systems Biology 2020

  Quote: ... On Day 3 we changed the medium to RPMI + 2% B-27 (minus insulin) + 1uM Xav 939 (Tocris Bioscience, cat. 3748) and incubated the cells for 48 hours ...
• XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition

  Abhishek B. Sharma, et al., bioRxiv - Molecular Biology 2020

  Quote: ... The ATMi KU-55933 (Tocris Biosciences) was used as described in experiments with CPT [44] ...
• Identification of compounds producing non-visual photosensation via TRPA1 in zebrafish

  Darya Cheng, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... Optovin was obtained from Tocris (4901), DMSO from Sigma Aldrich ...
• A novel luminescence-based β-arrestin membrane recruitment assay for unmodified GPCRs

  Maria Hauge Pedersen, et al., bioRxiv - Cell Biology 2020

  Quote: ... WN552122 (#1038) and rimonabant hydrochloride (#0923) from Tocris (Bristol, UK); DAMGO (#024-10 ...
• Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics

  David E. Buchholz, et al., bioRxiv - Developmental Biology 2020

  Quote: ... On day 101 baseline recordings were made to confirm activity before adding 300nM tetrodotoxin (Tocris, 1078). Recordings were made from 10 cells from 3 separate culture dishes ...
• Multistable and dynamic CRISPRi-based synthetic circuits

  Javier Santos-Moreno, et al., bioRxiv - Synthetic Biology 2020

  Quote: ... 40 µM DFHB1-1T (Tocris Bioscience) were added to the medium ...
• Abuse liability, antinociceptive, and discriminative stimulus properties of IBNtxA

  Ariful Islam, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... and SNC 162 were purchased from Tocris (Minneapolis, MN).
• Abuse liability, antinociceptive, and discriminative stimulus properties of IBNtxA

  Ariful Islam, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... IBNtxA was synthesized using commercial naltrexone (Tocris) converted into naltrexamine ...
• Pathogenic LRRK2 regulates ciliation probability upstream of Tau Tubulin kinase 2

  Yuriko Sobu, et al., bioRxiv - Cell Biology 2020

  Quote: ... MLi-2 was obtained from Tocris Biosciences (Cat no 5756 ...
• Immobilised collagen prevents shedding and induces sustained GPVI clustering and signalling in platelets

  Chiara Pallini, et al., bioRxiv - Cell Biology 2020

  Quote: ... The Src-family kinases inhibitor PP2 and Syk inhibitor PRT-060318 were purchased from TOCRIS (Abingdon, UK) and Caltag Medsystems (Buckingham ...
• Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion

  Jana Slováková, et al., bioRxiv - Cell Biology 2020

  Quote: ... Pharmacological inhibitors were used at the following concentrations: 10 μM active (−) or inactive Blebbistatin (+) (Tocris Bioscience), 0.3 μM Latrunculin-B (Sigma-Aldrich) ...