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501 - 550 of 1142 citations for 3 Ethyl 3 methyloxolane 2 5 dione since 2020

• Genetically edited human placental organoids cast new light on the role of ACE2 in placental development

  Anya L. Arthurs, et al., bioRxiv - Molecular Biology 2024

  Quote: ... 2 µM CHIR99021 (Tocris) and 5 µM Y27632 (Santa Cruz).
• A trimeric USP11/USP7/TCEAL1 complex stabilizes RNAPII during early transcription to sustain oncogenic gene expression

  Markus Dehmer, et al., bioRxiv - Cancer Biology 2024

  Quote: ... NVP-2 (Tocris Biosciences), Flavopiridol (Sigma-Aldrich) ...
• Neural circuitry for maternal oxytocin release induced by infant cries

  Silvana Valtcheva, et al., bioRxiv - Neuroscience 2023

  Quote: ... (S)-2-Amino-2-methyl-4-phosphonobutanoic acid (MAP4; 250 µM; Tocris, Item# 0711), Tetrodotoxin (TTX ...
• uPTI: uniaxial permittivity tensor imaging of intrinsic density and anisotropy

  Li-Hao Yeh, et al., bioRxiv - Biophysics 2021

  Quote: ... and with 5 μM IWP2 (Tocris) for 48 hours on day 3 ...
• Poly(ADP-ribose)-binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions

  Ramhari Kumbhar, et al., bioRxiv - Cell Biology 2020

  Quote: ... 5 μM PARG inhibitor PDD00017273 (Tocris) for 1 h before laser-induced DNA damage.
• G protein-coupled receptor signaling regulates ER-mitochondria contacts

  Youngshin Lim, et al., bioRxiv - Cell Biology 2021

  Quote: ... ESI 09 (4773, Tocris, 5 μM), cAMPS-Rp (13371 ...
• Striatonigrostriatal Circuit Architecture for Disinhibition of Dopamine Signaling

  Priscilla Ambrosi, Talia N. Lerner, bioRxiv - Neuroscience 2021

  Quote: ... NBQX disodium (5 μM, Tocris Bioscience), TTX (1 μM ...
• Molecular mechanism underlying the non-essentiality of Bub1 for the fidelity of chromosome segregation in human cells

  Qinfu Chen, et al., bioRxiv - Cell Biology 2021

  Quote: ... or STLC (5 μM, Tocris Bioscience), or were arrested in metaphase with MG132 (10 μM ...
• Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice

  Lindsey M. Biggs, Elizabeth A.D. Hammock, bioRxiv - Neuroscience 2022

  Quote: ... DNQX (5 μM, #189, Tocris Bioscience); sodium channel blocker ...
• Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

  Kizito-Tshitoko Tshilenge, et al., bioRxiv - Neuroscience 2022

  Quote: ... LM22A4 (5 µM, Tocris Biotec, 4607), forskolin (100 µM ...
• An unconventional GABAergic circuit differently controls pyramidal neuron activity in two visual cortical areas via endocannabinoids

  Martin Montmerle, et al., bioRxiv - Neuroscience 2021

  Quote: ... with Rimonabant (5 mg/kg, TOCRIS) or vehicle (1.25% (vol/vol ...
• Peptidergic modulation of fear responses by the Edinger-Westphal nucleus

  Michael F. Priest, et al., bioRxiv - Neuroscience 2021

  Quote: ... 20 µM PKI (5-24) (Tocris) was added to the internal solution ...
• Cholinergic control of striatal GABAergic microcircuits

  S. Kocaturk, et al., bioRxiv - Neuroscience 2021

  Quote: ... mecamylamine hydrochloride (MEC; 5 μm, Tocris), Atropine (Sigma ...
• Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis

  Amer Jamalpoor, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... 5 μM A83-01 (Tocris Bioscience) and 10 μM Y-27632 was added as “expansion medium” ...
• Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension

  Luke Grundy, et al., bioRxiv - Neuroscience 2020

  Quote: ... and NPFF (5 μM; Tocris, #3137) with changes in intracellular calcium (Ca2+i ...
• Genome-wide Studies Reveal the Essential and Opposite Roles of ARID1A in Controlling Human Cardiogenesis and Neurogenesis from Pluripotent Stem Cells

  Juli Liu, et al., bioRxiv - Cell Biology 2020

  Quote: ... 5 μM XAV-939 (Tocris Bioscience) from day 2 to day 4 ...
• Adhesion-mediated mechanosignaling forces mitohormesis

  Kevin M. Tharp, et al., bioRxiv - Cell Biology 2020

  Quote: ... or 5 μM MitoPy1 (Tocris, 4428) was added to media 1 h prior to imaging ...
• A single cell transcriptional roadmap for human pacemaker cell differentiation

  Alexandra Wiesinger, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 5 μmol/L SB431542 (Tocris, #1614), 250 nmol/L RA (Sigma ...
• A Self-Limiting Circuit Regulates Mammary Cap Cell Plasticity Through TGF-beta Signaling

  Armelle Le Guelte, Ian G. Macara, bioRxiv - Developmental Biology 2021

  Quote: ... Hedgehog inhibitor (Cyclopamine, 5 μM, Tocris), Wnt inhibitor (LGK974 ...
• Liver Organoid and T Cell Coculture Models Cytotoxic T Cell Responses against Hepatitis C Virus

  Vaishaali Natarajan, et al., bioRxiv - Immunology 2021

  Quote: ... 5 μM A83-01 (Tocris Bioscience) and 1:1000 diluted R-spondin-1 conditioned media ...
• Altered GABAergic inhibition in CA1 pyramidal neurons modifies despair-like behavior in mice

  Sang Ho Yoon, et al., bioRxiv - Neuroscience 2021

  Quote: ... AP-5 from Tocris (Bristol, UK).
• NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

  Hayden T. Pacl, et al., bioRxiv - Microbiology 2022

  Quote: ... GSK 2837808A (5 μM; Tocris, 5189) or the NAMPT inhibitor FK866 (200 μM ...
• Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion

  Michael J. Seibert, et al., bioRxiv - Neuroscience 2022

  Quote: ... 5 mM QX 314 chloride (Tocris) was included in the pipette solutions for all recordings ...
• Linking medicinal cannabis to autotaxin-lysophosphatic acid signaling

  Mathias C. Eymery, et al., bioRxiv - Biochemistry 2022

  Quote: ... 5-DMH-CBD (#1481) from Tocris; CBD (#HB2785 ...
• Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction, progression, and prion-like spread of Alzheimer’s disease pathogenesis

  Yuriy Pomeshchik, et al., bioRxiv - Neuroscience 2023

  Quote: ... and XAV-939 (Tocris, 5 μM). On the tenth day ...
• Functional Recovery from Human Induced Pluripotent Stem Cell-Derived Dopamine Neuron Grafts is Dependent on Neurite Outgrowth

  Rachel Hills, et al., bioRxiv - Neuroscience 2022

  Quote: ... SB431542 (days 1-5, 2μM, Tocris), CHIR99021 (days 3-13 ...
• Opioid receptor expressing neurons of the central amygdala gate behavioral effects of ketamine in mice

  Matthew B. Pomrenze, et al., bioRxiv - Neuroscience 2024

  Quote: ... Naltrexone (5 mg/kg, Tocris, 0677), beta-funaltrexamine (β-FNA ...
• Early inflammatory response mediated by Angiotensin II in cardiac arteries of normotensive mice

  Thais Cristina de Souza Oliveira, et al., bioRxiv - Physiology 2023

  Quote: ... 5-PD123.319 (AT2R blocker, ToCris®) and 6-PD+Ang II.
• A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish

  Ugo Coppola, Jennifer Kenney, Joshua S. Waxman, bioRxiv - Developmental Biology 2024

  Quote: ... 5 μM BIO (Tocris, Cat # 3194), 10 μM XAV939 (Tocris ...
• Polycomb Repressive Complex 1.1 Component, BCOR, Promotes Syncytiotrophoblast Differentiation in Mice and Humans

  Danielle Sadowski, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 5 µM A83-01 (Tocris Bioscience), and 2 µM CHIR99021 (Tocris Bioscience) ...
• Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions

  Renhe Luo, et al., bioRxiv - Genetics 2023

  Quote: ... and 5 µM CHIR99021 (TOCRIS; 4423) for the first day.
• Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C^+/- During Development

  Sanam Shafaatalab, et al., bioRxiv - Cell Biology 2023

  Quote: ... followed by 5 mM IWP4 (Tocris) for 2 days without medium change ...
• Re-engineering of TNF_α-NF-_κB signalling dynamics in cancer cells using pathogenic E. coli effectors

  Qiyun Zhong, et al., bioRxiv - Cell Biology 2023

  Quote: ... and 5 μM necrosulfonamide (NSA) (Tocris) were added to the cells 30 min before infection.
• An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCC

  Maroussia M.P. Ganpat, et al., bioRxiv - Cancer Biology 2023

  Quote: ... A83-01 (5 µM, Tocris Bioscience) and Next Generation Surrogate (NGS ...
• Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state

  Yasuhiro Nakano, et al., bioRxiv - Cell Biology 2023

  Quote: ... supplemented with SB431542 (5 μM) (Tocris), Dorsomorphin dihydrochloride (0.5 μM ...
• The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cells

  Shashi P. Singh, et al., bioRxiv - Immunology 2023

  Quote: ... 5 µM SB431542 (Tocris Bioscience, UK) was added ...
• Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity

  Shuhan Huang, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 mM QX314-Cl (Tocris, #2313), 0.4% biocytin (Sigma ...
• Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism

  Ozan Baytas, et al., bioRxiv - Neuroscience 2024

  Quote: ... 5 mM QX-314 (Tocris, 2313) (pH 7.23-7.28 ...
• CircPVT1 sponges miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer

  Alina Catalina Palcau, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 5 μM A83-01 (Tocris Bioscience), and 500 nM SB202190 (PeproTech ...
• TRPM8-dependent shaking in mammals and birds

  Tudor Selescu, et al., bioRxiv - Physiology 2024

  Quote: ... 1-(2-hydroxyphenyl)-4-(V3-nitrophenyl)-l,2,3,6-tetrahydropyrimidine-2-one (icilin, Tocris #1531) 10 mM in DMSO ...
• Neuromesodermal Progenitors Advance Network Formation of Spinal Neurons and Support Cells in Neural Ribbons In Vitro and Unprotected Survival in a Rat Subacute Contusion Model

  Zachary T. Olmsted, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2 μM CHIR99021 (Tocris Bioscience), 10 μM DAPT (Millipore Sigma) ...
• The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

  E. Werner, et al., bioRxiv - Cell Biology 2022

  Quote: ... 2 μM dorsomorphin (Tocris, 3093) and 2 μM A-83 (Tocris ...
• Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis

  Vukasin M. Jovanovic, et al., bioRxiv - Developmental Biology 2021

  Quote: ... 2 µM forskolin (1099, Tocris), 200 nM phorbol-12 myristate-13 acetate (1201 ...
• A cell-based platform for oxidative stress monitoring in motor neurons using genetically encoded biosensors of H₂O₂

  Elizaveta I. Ustyantseva, et al., bioRxiv - Cell Biology 2021

  Quote: ... and 2 μM DMH1 (Tocris) for 6 days ...
• TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons

  Ki Bum Um, et al., bioRxiv - Neuroscience 2021

  Quote: ... 2-APB (Tocris, Cat.#: 1224), CPP (Tocris ...
• Pharmacological insights into safety and efficacy determinants for the development of adenosine receptor biased agonists in the treatment of heart failure

  Patricia Rueda, et al., bioRxiv - Pharmacology and Toxicology 2020

  Quote: ... 2’Me-CCPA (Tocris, 2281), MRS1754 (Tocris ...
• Identification and Characterization of Stem Cells in Mammalian Esophageal Stratified Squamous Epithelia

  Yanan Yang, et al., bioRxiv - Cell Biology 2021

  Quote: ... Wnt inhibitor IWP-2(TOCRIS) and Srfp-2(R&D Systems ...
• Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomes

  Jillian H. Kluss, et al., bioRxiv - Cell Biology 2021

  Quote: ... MLi-2 (Tocris, cat #5756) was used at 1 μM in DMSO for 90 min ...
• A peptidergic amygdala microcircuit modulates sexually dimorphic contextual fear

  AK Rajbhandari, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2 mg/ml biocytin (Tocris) was dissolved in the intracellular solution and cells were dialyzed for 20 minutes ...
• Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex

  Stephen D. Glasgow, et al., bioRxiv - Neuroscience 2020

  Quote: ... and 2-Aminoethoxydiphenylborane (1224, Tocris) in DMSO ...