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Citations for Tocris :
451 - 500 of 572 citations for 6 Methoxypyridazine 3 Carboxylic Acid since 2019
Citations are collected from bioRxiv only, the total number of publications could be much larger.
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bioRxiv - Neuroscience 2021Quote: ... and GluN2BGC−/− mice (P40 – P60) were stereotactically injected with 50 nl of 20 mM solution of kainic acid (Tocris / Biotechne) in 0.9 % NaCl to the left CA1 area of the dorsal hippocampus (AP −1.8 mm ...
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bioRxiv - Genomics 2021Quote: ... neurons were made quiescent for 2 hours with 100 μM D-2- amino-5-phosphonopentanoic acid (D-AP5; Tocris #0106) and 1 μM tetrodotoxin (TTX ...
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bioRxiv - Neuroscience 2022Quote: ... the AMPA/NMDA receptor agonist kynurenic acid (2 mM) and the GABA-A receptor antagonist picrotoxin (PTX; 100 uM, Tocris) were present ...
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bioRxiv - Neuroscience 2020Quote: ... During BQA experiments the ACSF solution contained the following substances: 10 μM D-(−)-2-Amino-5-phosphonopentanoic acid (D-AP5) (Tocris), 10 μM 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide (NBQX ...
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bioRxiv - Neuroscience 2022Quote: Astrocytes grown in 6-well plates were refreshed with glial maintenance media or glial maintenance media supplemented with 100 μM L-Glutamic Acid (Tocris) for 3 h ...
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bioRxiv - Cell Biology 2023Quote: ... (Optopharma Ltd.) and 20 nM for 1-Oleoyl lysophosphatidic acid sodium salt (LPA) (5 mM stock dissolved in water) (Tocris). As controls ...
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bioRxiv - Neuroscience 2023Quote: ... one day of medium d10 (Medium d3–9 with 200 µM ascorbic acid [Sigma-Aldrich, A4403], 125 µM db-cAMP [Tocris, 1141], 2.5 µM DAPT [Tocris, 2634] ...
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bioRxiv - Neuroscience 2023Quote: ... D-(-)-2-Amino-5-phosphonopentanoic acid (D-AP5) and 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt) were purchased from Tocris Bioscience or from HelloBio (UK) ...
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bioRxiv - Developmental Biology 2021Quote: ... coated 12-well plates at the density of 6×105 cells/well in mTeSR1 medium supplemented with 10 μM ROCK inhibitor (Y-27632, Tocris). The medium was changed daily ...
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bioRxiv - Neuroscience 2021Quote: ... C57BL/6 wild-type mice were daily treated with vehicle or clemastine (#1453 Tocris; 50mg/kg solved in 10% DMSO) by intraperitoneal injections from postnatal day 5 (P5 ...
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bioRxiv - Molecular Biology 2020Quote: ... kin28as strains and their controls were then grown to an OD600 of 0.8 and treated with 6 μM of 1-Naphthyl PP1 (NAPP1; Tocris Bioscience) for 15 min ...
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bioRxiv - Neuroscience 2021Quote: ... 10 μM NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline) and 50 μM AP-5 (Tocris Bioscience, UK) were applied in the bath to block excitatory synaptic responses.
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bioRxiv - Neuroscience 2022Quote: Primary microglia cells from C57Bl/6 J mice cultured in presence of CSF-1 were treated with Formoterol (10 ng/ml, cat # 1448, Tocris) or vehicle for 1 hour ...
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bioRxiv - Neuroscience 2023Quote: ... Neuronal activity was manipulated either with field stimulation (100mA,10 Hz,600 AP) or 6 hours of 50 µM picrotoxin (PTX, Tocris) treatment 65 ...
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bioRxiv - Pharmacology and Toxicology 2023Quote: ... 2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy) phenyl]-2-pyridinyl]thio]-acetamide (BAY 60-6583; Tocris, 910487-58-0), 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide (2-Chloro-IB-MECA ...
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bioRxiv - Cancer Biology 2023Quote: Around 1 x 105 cells were seeded in a 6-well plate for the drug treatment with Brequinar (Tocris, 6196) in a dose-dependent manner for 72 h ...
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bioRxiv - Molecular Biology 2023Quote: ... Male Sprague Dawley (SD) rats (6-10 weeks old) were administered with a single dose of Sugen 5416 (SU) (20mg/kg, Tocris) delivered in CMC vehicle (as previously described)16 or DMSO and placed in hypoxia chambers (10% O2 ...
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bioRxiv - Neuroscience 2021Quote: ... NMDA receptor (R) dependency was tested by application of an NMDAR antagonist (APV 50 µM, DL-2-Amino-5-phosphonopentanoic acid, Tocris, Germany) in the bath solution ...
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bioRxiv - Cell Biology 2021Quote: ... B/D medium was supplemented during submerged culture with 1 nM EC23 (light-stable retinoic acid receptor agonist; Tocris, Abingdon, UK). After confluence was reached ...
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bioRxiv - Neuroscience 2022Quote: ... containing 10 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 50 μM D,L-2-amino-5-phosphonovaleric acid (AP5) (both from Tocris, Bristol, UK) to block recurrent glutamatergic signaling.
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bioRxiv - Neuroscience 2020Quote: ... to isolate inner retinal signaling (B-waves) and DL-2-Amino-4-phosphonobutyric acid (DL-AP4, 40µM, Tocris Bioscience, Bristol, U.K.) to isolate the photoreceptor component of the ERG signal (A-wave) ...
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bioRxiv - Neuroscience 2023Quote: ... The following compounds were added to raCSF as indicated in the Results section: D-(-)-2-Amino-5-phosphonopentanoic acid (D-APV, 100 μM dissolved in H2O; Tocris Bioscience), (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate (MK-801 ...
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bioRxiv - Neuroscience 2023Quote: ... one day of medium d10 (Medium d3–9 with 200 µM ascorbic acid [Sigma-Aldrich, A4403], 125 µM db-cAMP [Tocris, 1141] ...
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bioRxiv - Neuroscience 2023Quote: ... Mice were injected intraperitoneally (i.p.) with 5.0mg/kg synthetic kainic acid (KA) dissolved in 0.9% saline (#7065, Tocris Bioscience, Bristol, United Kingdom). At twenty-minute intervals ...
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bioRxiv - Neuroscience 2021Quote: Varenicline or 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h] [3]benzazepine tartrate (Tocris, UK) was dissolved in sterile 0.9% physiological saline for a final dose of 1 mg/kg free base ...
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bioRxiv - Neuroscience 2020Quote: ... medium was exchanged every 3-4 days with RGC induction media containing: DAPT (3uM, Tocris), 10μM Rock inhibitor (Y27632) ...
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bioRxiv - Neuroscience 2021Quote: ... some slices were incubated at 37°C with 3 µM puromycin (Tocris #40-895-0) at 65-75 minutes post-slicing ...
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bioRxiv - Neuroscience 2022Quote: ... with the addition of either 3 μM or 10 mM GABA (Tocris; Cat. No. 0344). Sylgard 184 (Dow Corning ...
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bioRxiv - Neuroscience 2021Quote: AM251 pharmacology: in experiments using the CB1 antagonist AM251 (3 µM) (Tocris and AdooQ biosciences), the drug (diluted in DMSO ...
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bioRxiv - Neuroscience 2020Quote: ... with either 3 mg/kg clozapine N-oxide (CNO; Tocris, Catalog: 4936, Lot: 13D/233085) in 0.5% DMSO and saline ...
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bioRxiv - Neuroscience 2022Quote: ... mEPSCs were recorded in the presence of 3 μM AMPA receptor antagonist NBQX (Tocris Bioscience) in standard external solution.
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bioRxiv - Cancer Biology 2023Quote: ... N-(1,3,4-thiadiazol-2-yl) pyridine-3-carboxamide dihydrochloride (TGN-020, Tocris Cat No 5425) was used in vitro at 10-100 μM ...
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bioRxiv - Developmental Biology 2023Quote: ... N6,2’-O-Dibutyryladenosine 3’,5’-cyclic monophosphate sodium salt (DB-cAMP, TOCRIS Cat. No.: 1141), 8-(4-Chlorophenylthio)-N6-phenyladenosine-3’,5’-cyclic monophosphate sodium salt (8C6P-cAMP ...
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bioRxiv - Cell Biology 2023Quote: ... the CDBM medium was supplemented with 0.6 U/ml heparin and 3 mM IWP2 (Tocris) for another 3-day incubation with medium refreshed daily ...
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bioRxiv - Neuroscience 2021Quote: ... The bath solution usually contained 6,7-dinitroquinoxaline-2,3-dione (DNQX, 10 µM) and D- aminophosphonovaleric acid (D-APV, 50 µM) to block ionotropic glutamate receptors (Tocris, Abingdon, United Kingdom). Patch electrodes had resistances of 4-6 MΩ when filled with KMeSO4- or CMeSO4-based internal solution (same as used in vivo) ...
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bioRxiv - Neuroscience 2020Quote: ... containing 10 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 50 μM D,L-2-amino-5-phosphonovaleric acid (AP5) to block glutamatergic signaling (both from Tocris, Bristol, UK). Experiments involving tetrodotoxin (TTX ...
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bioRxiv - Immunology 2020Quote: ... These cells were then directed to become proepicardial cells by the addition of retinoic acid and WNT CHIR 99021 followed by TGFβ inhibition (SB431542, Tocris Bioscience 1614). Finally ...
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bioRxiv - Neuroscience 2023Quote: ... and cells were centrifuged at 200 rcf for 5 min and resuspended in N2B27 with the same supplements as on day 0 except for the removal of Y27632 and addition of all-trans retinoic acid (100 nM; Tocris, 0695/50) and SAG (500 nM ...
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Targeted attenuation of elevated histone marks at SNCA alleviates α-synuclein in Parkinson’s diseasebioRxiv - Neuroscience 2020Quote: ... Cells were dissociated into a single-cell suspension using accutase and seeded at a density of 1.0 x 106 cells per well on Matrigel coated 6-well plates in mTeSR1 supplemented with 10 mM ROCK inhibitor Y-27632 (Tocris, 1254).
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bioRxiv - Neuroscience 2022Quote: ... and singularized cells were seeded at a defined density (between 42,000 and 62,000 cells/cm2 depending on the hiPSC line) on matrigel coated 6-well plates in StemMACS iPS-Brew supplemented with 10 µM Y27632 (ROCK inhibitor, Tocris Bioscience). After 24 h (Fig ...
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bioRxiv - Cell Biology 2020Quote: ... hESCs were induced with chemically defined medium (CDM3, containing RPMI/1640, AA and BSA) as the basal medium [30] containing 6 μM CHIR99021 (Tocris Bioscience) from day 0 to day 2 ...
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bioRxiv - Developmental Biology 2021Quote: ... From passage 3 cells were grown NMP differentiation medium supplemented with 5 μM Y-27632 (Tocris). Human iPSCs were found to detach more readily than hESCs ...
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bioRxiv - Developmental Biology 2020Quote: ... short-term serum-free culture was carried out in N2B27 supplemented with 3 μM CHIR99201 (Tocris), 1 μg/ml of Heparin (Sigma ...
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bioRxiv - Developmental Biology 2020Quote: ... mTeSR Plus was replaced with the N2B27 basal medium supplemented with 3 μM CHIR99021 (Tocris Bioscience) and 40 ng/ml basic fibroblast growth factor bFGF/FGF2 (R&D Systems) ...
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bioRxiv - Neuroscience 2020Quote: ... each disk with neurons was transferred into the physiological saline solution containing NBQX (3 μM, Tocris) and bicuculine (30 μM ...
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Safety and efficacy of C9ORF72-repeat RNA nuclear export inhibition in amyotrophic lateral sclerosisbioRxiv - Systems Biology 2021Quote: ... supplemented with SMAD inhibitors (DMH-1 2 µM; SB431542-10 µM and CHIR99021 3 µM [ [Tocris]). The medium was changed every day for 6 days ...
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bioRxiv - Neuroscience 2020Quote: ... Readings were taken before and 3–4 min after application of 20 μM 2-AG (Tocris) to activate CB1R or the eCB sensor.
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bioRxiv - Microbiology 2022Quote: NADA (3-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-alanine hydrochloride) was synthesized by Tocris following the published protocol (31) ...
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bioRxiv - Neuroscience 2021Quote: ... 3-((±)2-carboxypiperazin-4yl) propyl-1-phosphate (CPP, NMDA receptor antagonist, 20 μM; Tocris Bioscience, UK) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX ...
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bioRxiv - Bioengineering 2021Quote: ... Plates were centrifuged at 100xg for 3 minutes in E8 medium containing 10 μM Y27632 (Tocris). The following day ...