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Citations for Tocris :
451 - 499 of 499 citations for 2 Iodomethyl tetrahydrofuran since 2020
Citations are collected from bioRxiv only, the total number of publications could be much larger.
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bioRxiv - Neuroscience 2023Quote: Adherent human iPSCs were grown to near confluence before the differentiation to heterogenous spinal/hindbrain neurons was initiated by changing the media for two days to media d1-2 (200 nM LDN193189 [Tocris, 6053], 10 µM SB431542 [Tocris, 1614] ...
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bioRxiv - Cell Biology 2023Quote: ... Cells were cultured in an ad hoc defined generic medium (Supplementary Table 2) supplemented with Rho-kinase inhibitor (ROCKi; Tocris) and Primocin ...
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bioRxiv - Neuroscience 2023Quote: ... and (3-chloro-4-fluoro-N-[(4-([2-(phenylcarbonyl)hydrazino]carbonyl) phenyl)methyl]benzene-sulfonamide) (TCN-201) (Hansen et al., 2012)were obtained from Tocris Bioscience ...
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bioRxiv - Neuroscience 2023Quote: ... 1 MgCl2, and 2 CaCl2 (300-310 mOsm, pH adjusted to 7.4 with NaOH) supplemented by SC79 (5uM, Tocris 4635) or A769662 (1uM ...
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bioRxiv - Biochemistry 2023Quote: ... Washed membranes were incubated in the hypotonic buffer in the presence of 2 mg/ml iodoacetamide and 50 μm SSR149415 (Tocris) for 20 min ...
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bioRxiv - Developmental Biology 2023Quote: 3-((3-((9-(Diethylamino)-5-oxo-5H-benzo[a]phenoxazin-2- yl)oxy)propyl)(dodecyl)(methyl)ammonio)propane-1-sulfonate (NR12S, Cat No 7509, Tocris) was used to measure membrane fluidity ...
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bioRxiv - Microbiology 2023Quote: ... cells were resuspended in 25 µl PBS together with 0.25 µl of 5 mM 3-[[(7-Hydroxy-2-oxo-2H-1-benzopyran-3-yl) carbonyl]amino]-D-alanine hydrocholoride (HADA) (Tocris) dissolved in DMSO ...
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bioRxiv - Pharmacology and Toxicology 2024Quote: ... The slow delayed rectifier potassium current (IKs) was isolated as the current sensitive to 2 µM JNJ303 (Tocris, Bristol, UK). 10 µM nifedipine 5 µM E4031 and 1 µM SEA0400 (all from Sigma-Aldrich ...
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bioRxiv - Neuroscience 2021Quote: ... NMDA receptor (R) dependency was tested by application of an NMDAR antagonist (APV 50 µM, DL-2-Amino-5-phosphonopentanoic acid, Tocris, Germany) in the bath solution ...
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bioRxiv - Pharmacology and Toxicology 2020Quote: ... and a fourth group (DZP) received 2 mg/kg diazepam (CAS #439-14-5; Tocris, 2805; German-Ponciano et al., 2020) as a pharmacological control of anxiolytic activity ...
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bioRxiv - Physiology 2021Quote: ... Picrotoxin (100 µM) was used to block GABAA-receptor-mediated currents and D-2-amino-5-phosphonovalerate (APV; 20 µMm, Tocris Bioscience), and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX ...
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bioRxiv - Neuroscience 2022Quote: ... The medium was then changed to 3N (50:50 DMEM/F12:neurobasal with N2 and B27 supplements) (Shi et al., 2012) without vitamin A with 2 µM DMH1 (Tocris, 4126), 2 µM XAV939 (Cayman Chemical ...
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bioRxiv - Neuroscience 2022Quote: ... containing 10 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 50 μM D,L-2-amino-5-phosphonovaleric acid (AP5) (both from Tocris, Bristol, UK) to block recurrent glutamatergic signaling.
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bioRxiv - Neuroscience 2020Quote: ... to isolate inner retinal signaling (B-waves) and DL-2-Amino-4-phosphonobutyric acid (DL-AP4, 40µM, Tocris Bioscience, Bristol, U.K.) to isolate the photoreceptor component of the ERG signal (A-wave) ...
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bioRxiv - Systems Biology 2020Quote: ... On Day 3 we changed the medium to RPMI + 2% B-27 (minus insulin) + 1uM Xav 939 (Tocris Bioscience, cat. 3748) and incubated the cells for 48 hours ...
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bioRxiv - Cell Biology 2022Quote: ... Inhibitors were resuspended in DMSO and serially diluted in medium to their final working concentration and added on day 0 (Lats1/2 inhibitor Truli40 (CSNpharm, # CSN26140) or the Limk1 inhibitor Damnacanthal41 (Tocris, # 1936)) ...
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bioRxiv - Neuroscience 2022Quote: ... Non-specific binding was measured in the presence of 2 µM of Xanthine Amine Congener (XAC, Tocris Bioscience, Bristol, United Kingdom), and the resulting values were subtracted from those obtained with [3H]DPCPX35 to determine the specific binding and normalized for protein concentration ...
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bioRxiv - Neuroscience 2023Quote: ... 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl) hydrazino]carbonyl]benzyl]benzene-sulfonamide (TCN 201, 3 μM dissolved in DMSO; Tocris Bioscience), (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate (Ro25-6981 ...
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bioRxiv - Neuroscience 2023Quote: ... The following compounds were added to raCSF as indicated in the Results section: D-(-)-2-Amino-5-phosphonopentanoic acid (D-APV, 100 μM dissolved in H2O; Tocris Bioscience), (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate (MK-801 ...
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bioRxiv - Cell Biology 2024Quote: ... + 10 μM Tranylcypromine (2-PCPA) HCl (DMSO; Selleckchem S4246) + 20 μM Forskolin (DMSO; Selleckchem S2449) + 1 μM Ch 55 (DMSO; Tocris 2020) + 5 μM EPZ004777 (DMSO ...
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bioRxiv - Neuroscience 2024Quote: ... Both control and CACNA1A+/− networks at DIV49 were treated acutely with 100 µM D-2-amino-5-phosphonovalerate (D-AP5; Tocris, #0106) for 60 min ...
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bioRxiv - Immunology 2024Quote: ... The following inhibitors were added to the cells for 24 hours before harvesting: the NF-κB inhibitor JSH23 (2 µM, Tocris Bioscience), STING inhibitor H151 (5 µM ...
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bioRxiv - Cell Biology 2024Quote: ... 1.0×105 cells/cm2 for anti-fibrotic condition consisting in FibroGRO 2% FBS supplemented with 75ng/mL of bFGF and 500nM of TGF-β inhibitor (A83-01, Tocris). iPSC-cFbs were maintained for 7 days in culture replacing medium each second day ...
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bioRxiv - Neuroscience 2023Quote: ... the medium was then changed to 3N (50:50 DMEM/F12:neurobasal with N2 and B27 supplements) without vitamin A with 2 µM DMH1 (Tocris, 4126), 2 µM XAV939 (Cayman Chemical ...
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bioRxiv - Cell Biology 2022Quote: ... The FFA2R antagonist CATPB ((S)-3-(2-(3-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)-phenyl) butanoic acid) was from Tocris (Britsol, UK).
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bioRxiv - Physiology 2023Quote: ... the cell medium was replaced with the experimental medium (2 ml/well) consisting of DMEM containing 1 nM of 1,25-dihydroxyvitamin D3 (Tocris; Cat. #2551), as described previously58 ...
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bioRxiv - Neuroscience 2023Quote: iPSCs were replated at a density of 2 x 104 cells/cm2 in mTeSR medium containing 10 µM Rho kinase inhibitor (Y-27632, Tocris #5849), which was removed after 24 hours ...
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bioRxiv - Molecular Biology 2024Quote: ... U2OS cells were extracted 1x PBS containing 0.2% Triton-X100 supplemented with PARP inhibitor (olaparib, 1 μM, Selleckchem #S1060) and PARG inhibitor (PDD 00017273, 1 μM, Tocris #5952) to stabilize ADP-ribosylated species for 5 min on ice prior to fixation with 3% paraformaldehyde/2% sucrose for 15 min at ambient temperature ...
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bioRxiv - Neuroscience 2024Quote: ... The chemogenetic manipulation was carried out 30 minutes after the intraperitoneal injection of CNO at a dosage of 2 mg/kg (TOCRIS Bioscience) or after the administration of saline ...
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bioRxiv - Molecular Biology 2024Quote: ... the cells were either plated on laminin-coated 10 cm plates at 1.2×107 cells per plate for continued differentiation or expanded in motor neuron progenitor MNP medium (1× N2B27 medium supplemented with 3 mM CHIR99021, 2 mM DMH1 (Tocris, #4126), 2 mM SB431542 ...
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bioRxiv - Genetics 2024Quote: ... On Day 3 (after 48 hr) media was replaced with CDM containing 2 μM of the Wnt signaling inhibitor Wnt-C59 (5148, Tocris Bioscience) in CDM ...
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bioRxiv - Bioengineering 2021Quote: ... the medium was switched to N2B27 medium supplemented with 100 ng/mL VEGFA (ProSpec, CYT-116) and 2 μM forskolin (Tocris Bioscience, 1099) for two days ...
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bioRxiv - Neuroscience 2020Quote: ... containing 10 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 50 μM D,L-2-amino-5-phosphonovaleric acid (AP5) to block glutamatergic signaling (both from Tocris, Bristol, UK). Experiments involving tetrodotoxin (TTX ...
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bioRxiv - Cell Biology 2021Quote: ... Calcium-like peptide 2 (CALP2) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W-7) were obtained from Tocris (Minneapolis, MN). CaM kinase II and calcineurin inhibitors ...
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bioRxiv - Neuroscience 2020Quote: ... 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenyl isoquinolinesulfonic acid ester (KN-62; Tocris and HelloBio); D-AP5 (HelloBio) ...
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bioRxiv - Genomics 2020Quote: ... supplemented with SMAD inhibitors (DMH-1 2 μM Tocris, Cat.: #4423; SB431542-10 μM Tocris, Cat.: #1614 and CHIR99021 3 μM, CHIR Tocris, Cat.: #4423).
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bioRxiv - Cancer Biology 2024Quote: ... mice were randomized into groups and treated daily (5 days on, 2 days off) with 1mg/kg SB290157 trifluoroacetate (Tocris, 6860/5) intra-peritoneally ...
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bioRxiv - Immunology 2024Quote: ... Bone marrow-derived macrophages were plated at 2×105 cells/mL and treated with PBS or 500 ng/mL PAM3CSK4 (Tocris Bioscience, 4633) for 6 hours ...
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bioRxiv - Microbiology 2024Quote: ... along with 10 µM GSK-3 α and β inhibitor 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea (Tocris) as previously described20 ...
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bioRxiv - Developmental Biology 2024Quote: ... Between 1.5 × 106 and 3.0 × 106 cells were added to each well in 2 ml mTeSR medium with 10 μM Rho-kinase inhibitor Y-27632 dihydrochloride (Tocris, UK # 1254). To aggregate the cells into the microwells ...
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bioRxiv - Neuroscience 2020Quote: ... slices were equilibrated for 10 minutes while being continuously superfused at room temperature with oxygenated aCSF at 1-2 ml/min containing picrotoxin (50 μM, Tocris Bioscience, MO, USA) to block GABAA receptor-mediated inhibitory responses.
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bioRxiv - Neuroscience 2024Quote: ... a third group of animals were treated as those in group 2 with the addition of CB1 receptor antagonist AM251 (1 µM) (Tocris Bioscience, Bristol, UK). After 8 DIV ...
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bioRxiv - Cell Biology 2024Quote: All cell lines were washed with PBS then starved of amino acids or FBS for 2 hours before treatment with the GPCR antagonists at 1 µM: CNO (Tocris/bio-techne 6329), Isoprenaline/Carvedilol (Sigma/Merck I6504 ...
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bioRxiv - Neuroscience 2020Quote: ... The bath solution for recordings contained elevated concentrations of divalent cations [4 mM Ca2+ and 4 mM Mg2+] and NMDA receptor antagonist 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) [5 mM] (Tocris biosciences, 126453-07-4). Slices were used 1.5–4.5 hours after preparation ...
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bioRxiv - Cell Biology 2024Quote: The PM fluidity of mammalian cells was measured using 3-((3-((9-(Diethylamino)-5-oxo-5H-benzo[a]phenoxazin-2-yl)oxy)propyl)(dodecyl)(methyl)ammonium)propane-1-sulfonate (NR12S; Tocris Bioscience Cat. No. 7509) using a method as exactly mentioned in Wendy S ...
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bioRxiv - Bioengineering 2024Quote: ... FAST-STEM hiPSCs grown to 80% confluency were dissociated into single cells using TypLE for 5 minutes and seeded into the Aggrewell at a density of 1.2×105 cells per-well in 1 mL of mTesR Plus with 10 μg/mL ROCK Inhibitor Y-27632 (Tocris Bioscience, Bristol, UK; 1254) and 1% Penicillin-Streptomycin (Life Technologies ...
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bioRxiv - Bioengineering 2024Quote: ... was obtained through the administration of exponential doses with concentrations of 1 nM to 10 mM at 2 min intervals before the administration of 10 μM scopolamine (Tocris Bioscience Cat#1414/1G). After another equilibrium period ...
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bioRxiv - Neuroscience 2024Quote: Slices from 6-month-old mice were pre-incubated ≥1.5hours and then bath-perfused during dLight recording with LRRK2 kinase inhibitor MLi-2 (500 nM, Tocris 5756, 45% Captisol® in PBS) or vehicle-control (45% Captisol® in PBS 377.6µL/L aCSF) ...
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bioRxiv - Physiology 2024Quote: ... Drugs were added from the following stock solutions: (2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide (WS-12, Tocris #3040, Bio-Techne Ltd, Abingdon, UK) 5 mM in ethanol ...