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1651 - 1700 of 5290 citations for 6H Pyrazino 1 2 c pyrimidin 6 one octahydro 2 7 dimethyl 9CI since 2019

• Otx2 and Oc1 directly regulate the transcriptional program of cone photoreceptor development

  Nicolas Lonfat, et al., bioRxiv - Developmental Biology 2020

  Quote: ... rabbit anti-Otx2 (1:200-400, Proteintech, 13497-1-AP), mouse anti-Rxrg (1:50 ...
• Efficient Generation of Isogenic Primary Human Myeloid Cells using CRISPR-Cas9 Ribonucleoproteins

  Joseph Hiatt, et al., bioRxiv - Genetics 2020

  Quote: ... rabbit polyclonal anti-GNE (1:1000)(Proteintech 25079-1-AP), rabbit polyclonal anti-SAMHD1 (1:1000)(Proteintech 12586-1-AP) ...
• Efficient Generation of Isogenic Primary Human Myeloid Cells using CRISPR-Cas9 Ribonucleoproteins

  Joseph Hiatt, et al., bioRxiv - Genetics 2020

  Quote: ... rabbit polyclonal anti-SAMHD1 (1:1000)(Proteintech 12586-1-AP), rabbit monoclonal anti-β-actin (1:5000)(CST 4970P) ...
• In vivo and in vitro mechanistic characterization of a clinically relevant PolγA mutation

  Pedro Silva-Pinheiro, et al., bioRxiv - Genetics 2020

  Quote: ... anti-LONP1 (1:1000) was from Proteintech (15440-1-AP), anti-HSC70 (1:1000 ...
• c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

  Abigail O. Smith, et al., bioRxiv - Genetics 2021

  Quote: ... glyceraldehyde-3-phosphate dehydrogenase (1:10,000, Proteintech, 60004-1-Ig), SMA (1:1,000 ...
• Clostridium difficile Toxin B activates the NLRP3 inflammasome in human macrophages, demonstrating a novel regulatory mechanism for the Pyrin inflammasome

  Matthew S.J. Mangan, et al., bioRxiv - Immunology 2021

  Quote: ... Pyrin (1:1000, MEFV polyclonal 24280-1-AP) from Proteintech, phospho-Pyrin S241 (1:500 ...
• Therapeutic Reversal of Chemically Induced Parkinson Disease by Converting Astrocytes into Nigral Neurons

  Hao Qian, et al., bioRxiv - Neuroscience 2020

  Quote: ... and Rabbit anti-VMAT2 (Proteintech, 20873-1-AP, 1:500).
• Therapeutic Reversal of Chemically Induced Parkinson Disease by Converting Astrocytes into Nigral Neurons

  Hao Qian, et al., bioRxiv - Neuroscience 2020

  Quote: ... Rabbit anti Calbindin D28K (Proteintech, 14479-1-AP, 1:100) and Mouse anti-RFP (ThermoFisher ...
• Cell Ecosystem and Signaling Pathways of Primary and Metastatic Pediatric Posterior Fossa Ependymoma

  Rachael Aubin, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and rabbit anti-CHI3L1 1:100 (12036-1-AP, Proteintech). Secondary antibodies were incubated for 1 hour at room temperature at the following dilutions ...
• Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

  Na Xiao, et al., bioRxiv - Cell Biology 2021

  Quote: ... and anti-β-actin (1:5,000, 60008-1-Ig, Proteintech). The membranes were then incubated with horseradish peroxidase-conjugated secondary antibodies ...
• ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism

  Bibiana Rius, et al., bioRxiv - Biochemistry 2020

  Quote: ... rabbit PDIA4 (ERP72) antibody (ProteinTech, 14712-1-AP, 1:1000) and mouse PDIA6 antibody (ProteinTech 66669-1-Ig ...
• ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism

  Bibiana Rius, et al., bioRxiv - Biochemistry 2020

  Quote: ... and mouse PDIA6 antibody (ProteinTech 66669-1-Ig, 1:1000).
• Role of PARP1 in oligodendrocyte differentiation during developmental myelination and remyelination after myelin damage

  Yan Wang, et al., bioRxiv - Neuroscience 2021

  Quote: ... MLKL (1:1000, Cat# 66675-1-Ig, RRID: AB_2882029, Proteintech), p-MLKL (S345 ...
• Autophagy is required for midbrain dopaminergic axon development and their responsiveness to guidance cues

  M.S. Profes, A. Saghatelyan, M. Lévesque, bioRxiv - Neuroscience 2020

  Quote: ... and rabbit anti-p62 (1:1000; Proteintech, 18420-1-AP) were diluted in blocking solution ...
• Precise control of microtubule disassembly in living cells

  Grace Y. Liu, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit antibody against Arl13b (1:500; Proteintech, 17711-1-AP), mouse antibody against glutamylated tubulin (1:100 ...
• Targeting subtype-specific metabolic preferences in nucleotide biosynthesis inhibits tumor growth in a breast cancer model

  Martin P. Ogrodzinski, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 1:500 dilution of anti-PPAT (Proteintech 15401-1-AP), 1:1000 dilution of anti-vinculin (Cell Signaling Technology ...
• CRISPR-Cas9-mediated depletion of O-GlcNAc hydrolase and transferase for functional dissection of O-GlcNAcylation in human cells

  Andrii Gorelik, Andrew T. Ferenbach, bioRxiv - Biochemistry 2020

  Quote: ... CTD110.6 (9875, CST, 1:1000) OGA (14711-1-AP, Proteintech 1:1000 – detects the first 350 amino acids of human OGA) ...
• Inferring latent temporal progression and regulatory networks from cross-sectional transcriptomic data of cancer samples

  Xiaoqiang Sun, Ji Zhang, Qing Nie, bioRxiv - Systems Biology 2020

  Quote: ... anti-ACSS1 Rabbit mAb (1:1000, 17138-1-AP, Proteintech), Goat Anti-Rabbit IgG (H+L ...
• Chicoric acid prevents neurodegeneration via microbiota-gut-brain axis in a mouse Parkinson’s disease model

  Ning Wang, et al., bioRxiv - Neuroscience 2021

  Quote: ... and rabbit anti-GAPDH (1:8000, 60,001-1-Ig, Proteintech). Secondary antibodies ...
• Chicoric acid prevents neurodegeneration via microbiota-gut-brain axis in a mouse Parkinson’s disease model

  Ning Wang, et al., bioRxiv - Neuroscience 2021

  Quote: ... mouse anti-β-Actin (1:1000, 10,068-1-AP, Proteintech) and rabbit anti-GAPDH (1:8000 ...
• C9orf72-derived poly-GA DPRs undergo endocytic uptake in iNPC-derived astrocytes and spread to motor neurons

  Paolo M. Marchi, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-AP repeat (1:1000, Proteintech Cat#24493-1-AP). Membranes were then washed three times for 5 min with 1x TBST and incubated with either an anti-mouse IgG- HRP-conjugate (1:5000 ...
• C9orf72-derived poly-GA DPRs undergo endocytic uptake in iNPC-derived astrocytes and spread to motor neurons

  Paolo M. Marchi, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-GA repeat (1:1000, Proteintech Cat#24492-1-AP), anti-AP repeat (1:1000 ...
• WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

  Shangda Yang, et al., bioRxiv - Cell Biology 2021

  Quote: ... α-globin (14537-1-AP, 1:2,000 for WB) from Proteintech; EKLF (OM184222 ...
• Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

  Maxence Le Vasseur, et al., bioRxiv - Cell Biology 2021

  Quote: ... mouse anti-GFP (Proteintech, cat# 66002-1-Ig, 1:2000), mouse anti-β-actin (Proteintech ...
• Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

  Maxence Le Vasseur, et al., bioRxiv - Cell Biology 2021

  Quote: ... mouse anti-COXIV (Proteintech, cat# 66110-1-1g, 1:2000), mouse anti-PHB2 (Proteintech ...
• Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

  Maxence Le Vasseur, et al., bioRxiv - Cell Biology 2021

  Quote: ... mouse anti-OCIAD1 (Proteintech, cat# 66698-1-Ig, 1:5000), rabbit anti-OCIAD2 (Invitrogen ...
• Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

  Maxence Le Vasseur, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-TIM50 (Proteintech, cat# 22229-1-AP, 1:1000), rabbit anti-TOM70 (Proteintech ...
• Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

  Maxence Le Vasseur, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-CYC1 (Proteintech, cat# 10242-1-AP, 1:1000), mouse anti-COXIV (Proteintech ...
• Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

  Maxence Le Vasseur, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-NDUFB8 (Proteintech, cat# 14794-1-AP, 1:2000), mouse anti-SDHA (SantaCruz Biotechnology ...
• Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

  Maxence Le Vasseur, et al., bioRxiv - Cell Biology 2021

  Quote: ... mouse anti-PHB2 (Proteintech, cat# 66424-1-Ig, 1:5000), rabbit anti-TIM50 (Proteintech ...
• Neuropilin-1 is a host factor for SARS-CoV-2 infection

  James L. Daly, et al., bioRxiv - Cell Biology 2020

  Quote: ... mouse anti-ACE2 (Proteintech, 66699-1-Ig, WB 1:1000), mouse anti-GFP (Roche ...
• GC-1 spg cells are most similar to Leydig cells, a testis somatic cell-type, and not germ cells

  Andrew R. Norman, Lauren Byrnes, Jeremy F. Reiter, bioRxiv - Cell Biology 2021

  Quote: ... and rabbit anti-DDX4 (Proteintech, 51042-1-AP, 1/500) were used as primary stains ...
• The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity

  Marlinde J. Smit, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Primary antibodies were: Arl13b (Proteintech, 17711-1-AP, 1:100), mCherry (SICGEN ...
• The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity

  Marlinde J. Smit, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Primary antibodies were: Arl13b (Proteintech, 17711-1-AP, 1:400), PCNA (Abcam ...
• Multiple Ciliary Localization Signals Control INPP5E Ciliary Targeting

  Dario Cilleros-Rodriguez, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-α-tubulin (Proteintech, 66031-1-Ig, WB: 1:1000), anti-EGFP (Proteintech ...
• MOSPD2 a new endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis

  Mehdi Zouiouich, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-GM130 (1:500; 11308-1-AP, ProteinTech, RRID:AB_2115327), mouse anti-Lamp1 H4A3 (1:50 ...
• Mettl3-mediated m⁶A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration

  Fu-Qing Jiang, et al., bioRxiv - Cell Biology 2022

  Quote: ... and anti-β-actin (Proteintech, 60008-1-Ig, 1:2000). Secondary antibodies used are following ...
• Human septins in cells organize as octamer-based filaments mediating actin-membrane anchoring

  Carla Silva Martins, et al., bioRxiv - Cell Biology 2022

  Quote: ... we used mouse anti-SEPT2 (1:7,500, Proteintech 60075-1), rabbit anti-SEPT7 (1:200 ...
• Human septins in cells organize as octamer-based filaments mediating actin-membrane anchoring

  Carla Silva Martins, et al., bioRxiv - Cell Biology 2022

  Quote: ... and rabbit anti-SEPT9 (1:2,000, Proteintech 10769-1-AP). Secondary HRP-conjugated antibodies were either anti-rabbit IgG (1:10,000 ...
• Vimentin intermediate filaments organize organellar architecture in response to ER stress

  Tom Cremer, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-VAP-A (1:100, 15272-1-AP, Proteintech), goat anti-CNX ...
• The Conserved CNOT1 Interaction Motif of Tristetraprolin Regulates ARE-mRNA Decay Independently of the p38 MAPK-MK2 Kinase Pathway

  Alberto Carreño, Jens Lykke-Andersen, bioRxiv - Molecular Biology 2022

  Quote: ... rabbit polyclonal anti-CNOT9 (Proteintech, 22503-1-AP, 1:500), mouse monoclonal anti-GAPDH (Cell Signaling Technology ...
• The Conserved CNOT1 Interaction Motif of Tristetraprolin Regulates ARE-mRNA Decay Independently of the p38 MAPK-MK2 Kinase Pathway

  Alberto Carreño, Jens Lykke-Andersen, bioRxiv - Molecular Biology 2022

  Quote: ... rabbit polyclonal anti-CNOT1 (Proteintech, 14276-1-AP; 1:200), rabbit polyclonal anti-CNOT9 (Proteintech ...
• Stress granules promote chemoresistance by triggering cellular quiescence

  Anthony Khong, et al., bioRxiv - Molecular Biology 2022

  Quote: ... or 1:500 rabbit anti-YBX1 (Proteintech; 20339-1-AP) for 1 hour ...
• Hedgehog signaling is non-cell autonomously activated in the cystic kidney of Arl13b mutant mice

  Chia-Ling Hsieh, et al., bioRxiv - Genetics 2022

  Quote: ... rabbit anti-ARL13b (1:200, Proteintech Group, 17711-1-AP) and mouse anti-acetylated tubulin (1:5000 ...
• Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12

  Zixiang Wang, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and α-Tubulin (1:400 dilution, Proteintech, 66031-1-Ig) overnight at 4°C and then incubated with secondary antibody for 1 h at room temperature in the dark ...
• Pore-forming protein βγ-CAT promptly responses to fasting with capacity to deliver macromolecular nutrients

  Zhi-Hong Shi, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit-derived anti-Flotillin 1 (Proteintech, Cat 15571-1-AP), mouse-derived anti-CD9 (Santa Cruz Biotechnology ...
• Substance P and adenosine signaling pathways regulate exosomal sorting of miR-21 in colonic epithelial cells

  Sameena Wani, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-TUT7/anti-ZCCHC6 (1:500, 25196-1-AP; Proteintech).
• Selection of active defensive behaviors relies on extended amygdala dopamine D2 receptors

  Laia Castell, et al., bioRxiv - Neuroscience 2021

  Quote: ... and rabbit anti-Wfs1 (1:500, Proteintech, 11558-1-AP). The following day ...
• Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Endosomal Sensing by Dendritic Cells in Psoriasis

  Fangzhou Lou, et al., bioRxiv - Immunology 2020

  Quote: ... anti-GAPDH (Proteintech cat. 60004-1-Ig, 1:10000 dilution), anti-Histone H3 (Cell Signaling Technology cat ...
• Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Endosomal Sensing by Dendritic Cells in Psoriasis

  Fangzhou Lou, et al., bioRxiv - Immunology 2020

  Quote: ... anti-COX4I1 (Proteintech cat. 11242-1-AP, 1:100 dilution), anti-ASS1 (Proteintech cat ...