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1351 - 1400 of 5290 citations for 6H Pyrazino 1 2 c pyrimidin 6 one octahydro 2 7 dimethyl 9CI since 2019

• Differentiation of ciliated human midbrain-derived LUHMES neurons

  Gilbert Lauter, et al., bioRxiv - Neuroscience 2020

  Quote: ... and IFT88 (rabbit, ProteinTech 13967-1-AP, 1:500). Neuronal differentiation markers were TUBB3 (Tuj1 ...
• MICAL2 acts through Arp3B isoform-specific Arp2/3 complexes to destabilize branched actin networks

  Chiara Galloni, et al., bioRxiv - Cell Biology 2020

  Quote: ... MICAL1 polyclonal (Proteintech, 14818-1-AP, 1:1000 dilution), GFP monoclonal (custom made by CRUK ...
• A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation

  Emma Rusilowicz-Jones, et al., bioRxiv - Cell Biology 2020

  Quote: ... rabbit-anti-actin (ProteinTech,20536-1-AP, 1:10,000), anti-SYNJ2BP (Sigma HPA000866 ...
• CiliaQ – a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images

  Jan Niklas Hansen, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-ARL13B (1:500, Proteintech, 17711-1-AP), mouse anti-ARL13B (Abcam ...
• Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoforms

  Francois Iv, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-SEPT9 (1:1,500, Proteintech, 10769-1-AP), and HRP-conjugated anti-rabbit antibody (1:10,000 ...
• The crosstalk between DNA-PK and cGAS drives tumor immunogenicity

  Clara Taffoni, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-GAPDH (60004-1-Ig, Proteintech Europe, 1:5000), anti-αTUBULIN (66031-1-Ig ...
• The crosstalk between DNA-PK and cGAS drives tumor immunogenicity

  Clara Taffoni, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-αTUBULIN (66031-1-Ig, Proteintech Europe, 1:10000). Membranes were incubated with secondary antibodies (Cell Signaling Technology ...
• Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis

  Vaibhav Sidarala, et al., bioRxiv - Cell Biology 2022

  Quote: ... mt-Cytb (1:500; ProteinTech, Catalog# 55090-1-AP), Opa1 (1:1000 ...
• The BAF A12T mutation reduces BAF affinity to lamin A/C, preventing its recruitment to nuclear ruptures in Nestor Guillermo Progeria Syndrome cells

  A.F.J. Janssen, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-emerin (Proteintech, 10351-1-AP, 1/500), mouse anti-lamin B1 (Santa Cruz ...
• The BAF A12T mutation reduces BAF affinity to lamin A/C, preventing its recruitment to nuclear ruptures in Nestor Guillermo Progeria Syndrome cells

  A.F.J. Janssen, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-emerin (Proteintech, #10351-1-AP, 1/1000), rabbit anti-H3K9me3 (Abcam ...
• Human septins in cells organize as octamer-based filaments mediating actin-membrane anchoring

  Carla Silva Martins, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-SEPT9 (1:200, Proteintech 10769-1-AP), mouse anti-α-tubulin (1:10,000 ...
• Newly raised anti-c-Kit antibody detects interstitial cells of Cajal in the gut of chicken embryos

  Rei Yagasaki, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 1:500 dilution of Tuj1 (Proteintech, 66375-1-Ig) overnight at 4 °C ...
• Develop an efficient and specific AAV based labeling system for Muller glia in mice

  Yanxia Gao, et al., bioRxiv - Neuroscience 2022

  Quote: ... Rabbit-anti-Calbindin (1:200, Proteintech, 14479-1-AP) and mouse-anti-Calretinin (1:200 ...
• Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair

  Justinn Barr, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-Gnb3 (1:200, 10081-1-AP, Proteintech), rabbit anti-POU2F3 (1:500 ...
• Pancreatic tumors activate arginine biosynthesis to adapt to myeloid-driven amino acid stress

  Juan J. Apiz-Saab, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Beta-Actin (Proteintech 660009-1-lg; 1:10000 dilution). The following secondary antibodies ...
• Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

  Yian Guan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-GFP (1:1000, Cat#66002-1-Ig, Proteintech), anti-HA (1:1000 ...
• A conditional null allele of Dync1h1 enables targeted analyses of dynein roles in neuronal length sensing and neurological disorders

  Agostina Di Pizio, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-dync1h1 (Proteintech, 12345-1-AP, 1:500), mouse anti-Importin β1 (monoclonal ...
• A murine Wac model exhibits phenotypes relevant to DeSanto-Shinawi Syndrome

  April M Stafford, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-S100beta (1:500, 15146-1-AP Proteintech), rat anti-SST (1:200 ...
• Develop an efficient and specific AAV based labeling system for Muller glia in mice

  Yanxia Gao, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-Pax6 (1:200, Proteintech, 12323-1-AP). Sections were washed 3x for 10 minutes per wash on the second day ...
• Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer

  Emily S. Bell, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and Lamin B1 (1/1000, Proteintech, #12987-1-AP). Blots validating SILAC results and lamin response to Akt inhibition were conducted as above ...
• Biochemical analysis challenging Western blot analysis as validation step for antibodies intended for ELISA and Immunohistochemistry use

  Yunyun Zhang, et al., bioRxiv - Biochemistry 2022

  Quote: ... anti-PYGL-1 (rabbit polyclonal, 15851-1-AP, Proteintech, RRID ...
• Piezo mechanosensory channels regulate centrosome integrity

  Liron David, et al., bioRxiv - Cell Biology 2022

  Quote: ... GAPDH mouse monoclonal antibody (1:5000, Proteintech 60004-1) at 4 °C ...
• The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic Hedgehog signalling

  Leah Schembs, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-SMO (1:600; Proteintech #20787-1-AP), rabbit anti-SOX2 (1:1000 ...
• The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic Hedgehog signalling

  Leah Schembs, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-TMEM67 (1:200; Proteintech #13975-1-AP), mouse anti-γ TUB (Sigma T6557 ...
• The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic Hedgehog signalling

  Leah Schembs, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-SUFU (1:600; Proteintech #26759-1-AP), rabbit anti-TBR1 (1:400 ...
• The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic Hedgehog signalling

  Leah Schembs, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-TULP3 (1:600; Proteintech #13637-1-AP). Primary antibodies for immunohistochemistry were detected with Alexa- or Cy2/3-conjugated fluorescent secondary antibodies ...
• Self-activation of Wnt signaling in pre-granulosa cells is required for ovarian folliculogenesis

  Okiko Habara, et al., bioRxiv - Developmental Biology 2020

  Quote: ... rabbit anti-Cyp17a1 (1:4,000, 14447-1-AP, Proteintech), rat anti-Pecam1 (1:100 ...
• Hypusinated eIF5A is required for the translation of collagen

  Marina Barba-Aliaga, et al., bioRxiv - Molecular Biology 2021

  Quote: ... α-tubulin (1:5000, Proteintech Cat# 66031-1-Ig, RRID:AB_11042766), or GAPDH (mouse monoclonal anti-GAPDH antibody ...
• A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation

  Emma Rusilowicz-Jones, et al., bioRxiv - Cell Biology 2020

  Quote: ... mouse anti-actin (ProteinTech 66009-1-Ig, 1:10,000), rabbit-anti-actin (ProteinTech,20536-1-AP ...
• Inhibition of arenavirus entry and replication by the cell-intrinsic restriction factor ZMPSTE24 is enhanced by IFITM antiviral activity

  Robert J Stott, Toshana L Foster, bioRxiv - Microbiology 2021

  Quote: ... rabbit anti-IFITM3 (Proteintech, 11714-1-AP, 1:5000), rabbit anti-ZMPSTE24 antibody (Abcam ab38450 ...
• Inhibition of arenavirus entry and replication by the cell-intrinsic restriction factor ZMPSTE24 is enhanced by IFITM antiviral activity

  Robert J Stott, Toshana L Foster, bioRxiv - Microbiology 2021

  Quote: ... rabbit anti-IFITM2 (Proteintech, 12769-1-AP, 1:5000), rabbit anti-IFITM3 (Proteintech ...
• The m⁶A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

  Fugui Niu, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-YTHDF2 (1:1000, Proteintech 24744-1-AP), rabbit anti-YTHDF1 (1:1000 ...
• Stretch Regulates Alveologenesis and Homeostasis Via Mesenchymal G_αq/11-Mediated TGFβ2 Activation

  Amanda T Goodwin, et al., bioRxiv - Developmental Biology 2022

  Quote: ... rabbit anti-TGFβ2 (Proteintech, 19999-1-AP; 1:3000), rabbit anti-elastin (Atlas ...
• Human skeletal muscle ageing atlas

  Veronika R. Kedlian, et al., bioRxiv - Genomics 2022

  Quote: ... anti-SORBS2 (Proteintech, 24643-1-AP, 1:200 dilution), and anti-MYH8 (DSHB ...
• Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy

  Juan Yan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-Lamin B1 (1:2000, Proteintech, #12987-1-AP) and anti-GAPDH (1:3000 ...
• Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy

  Juan Yan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-β-actin (1:5000, Proteintech, #66009-1-Ig), anti-Lamin B1 (1:2000 ...
• YTHDF2 in dentate gyrus is the m⁶A reader mediating m⁶A modification in hippocampus-dependent learning and memory

  Mengru Zhuang, et al., bioRxiv - Neuroscience 2022

  Quote: ... or YTHDF2 antibody (Proteintech, 24744-1-AP, 1:1000).
• Single-cell proteomics reveals downregulation of TMSB4X to drive actin release for stereocilia assembly

  Ying Zhu, et al., bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-AGR3 (1:250, Proteintech, 11967-1-AP); rabbit anti-CRABP1 (1:250 ...
• Single-cell proteomics reveals downregulation of TMSB4X to drive actin release for stereocilia assembly

  Ying Zhu, et al., bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-CRABP1 (1:250, Proteintech, 12588-1-AP); mouse anti-G-actin (1:250 ...
• Vinculin anchors contractile actin to the cardiomyocyte adherens junction

  Chelsea D. Merkel, et al., bioRxiv - Cell Biology 2019

  Quote: ... anti-Connexin-43 (1:100; ProteinTech 15386-1-AP), anti-Plakophilin 2 (1:10 ...
• Pathogenic LRRK2 regulates ciliation probability upstream of Tau Tubulin kinase 2

  Yuriko Sobu, et al., bioRxiv - Cell Biology 2020

  Quote: ... Rabbit anti-CP110 (Proteintech, 12780-1-AP, 1:2000), mouse anti-CEP164 (Santa Cruz ...
• TDP-43 regulates the expression levels of Disc-large in skeletal muscles to promote the assemble of the neuromuscular synapses in Drosophila

  Nina Strah, et al., bioRxiv - Neuroscience 2019

  Quote: ... anti-TDP-43 (#12892-1-AP Proteintech 1:4000), anti-Dlg 2D11 (#SC9961 Santa Cruz 1:1000) ...
• Primary Cilium Disassembly in Mammalian Cells Occurs Predominantly by Whole-Cilium Shedding

  Mariya Mirvis, et al., bioRxiv - Cell Biology 2019

  Quote: ... (1:100-250 IF) (Proteintech Cat#17560-1-AP). Anti-rabbit GFP (1:250 ...
• FOP plays a negative role in ciliogenesis and promotes cell cycle re-entry by facilitating primary cilia disassembly

  Huadong Jiang, et al., bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-Arl13b (Proteintech, 17711-1-AP, 1:1000), and rabbit anti-OFD1 (Sigma ...
• Subtractive CRISPR screen identifies factors involved in non-canonical LC3 lipidation

  Rachel Ulferts, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-ATG4D (16924-1-AP, Proteintech, WB 1:1000), anti-mCherry (NBP1-96752 ...
• The endosome is a master regulator of plasma membrane collagen fibril assembly

  Joan Chang, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit pAb VIPAS (1:50, Proteintech 20771-1-AP), mouse mAb FN1 (1:400 ...
• Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids

  Dina Ivanyuk, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-LONP1 (1:3000, Proteintech #15440-1-AP); mouse anti-tau (1:1000 ...
• Super-resolution microscopy unveils FIP200-scaffolded, cup-shaped organization of mammalian autophagic initiation machinery

  Samuel Kenny, Xuyan Chen, Liang Ge, Ke Xu, bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-FIP200 (Proteintech #17250-1-AP; 1:100), mouse IgG2b anti-Atg12 (Genetex GTX629815 ...
• Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B

  Lauren L. Daniele, et al., bioRxiv - Biochemistry 2019

  Quote: ... rabbit anti-Pex14 (ProteinTech 10594-1-AP, 1/500), mouse anti-PMP70 (Sigma SAB4200181 ...
• Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B

  Lauren L. Daniele, et al., bioRxiv - Biochemistry 2019

  Quote: ... rabbit anti-Pex14 (ProteinTech 10594-1-AP, 1/1000), mouse anti-PMP70 (Sigma SAB4200181 ...