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401 - 450 of 1151 citations for 6 BENZOFURAN 2 YL 1H INDOLE since 2019

• Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

  Yueyang Wang, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-phospho Myosin Light Chain 2 (Cell Signaling 3671) and secondary antibody anti-rabbit AlexaFluor 488 (Invitrogen A-21441) ...
• Acquired and intrinsic resistance to vemurafenib in BRAF^V600E-driven melanoma brain metastases

  Ping Zhang, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... phospho-ERK1/2 (1:200; 4370; Cell Signaling Technology), phospho-AKT (1:8,000 ...
• The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids

  Jennifer Rynne, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Antibodies used were: BRF1/2 (Cell Signaling Technology #2119), GR (Cell Signaling Technology #3660 ...
• Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

  Eleftheria Koropouli, et al., bioRxiv - Neuroscience 2022

  Quote: ... Neuropilin-2 (rabbit polyclonal, Cell Signaling, Cat no. 3366S); Neuropilin-2 (goat polyclonal ...
• PKC-alpha promotes phosphorylation of KRAS suppressing its oncogenic properties

  Tejashree Joglekar, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-p44/42 MAPK (Erk1/2) (Cell Signaling #4696); anti-KRAS (Sigma #WH0003845M1) ...
• Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling

  Hussam Husanie, et al., bioRxiv - Cancer Biology 2022

  Quote: ... monoclonal pSMAD 2/3 (Cell Signaling; 8828, Massachusetts, USA), monoclonal pSMAD 1/5/9 (Cell Signaling ...
• Repurposing of the antibiotic nitroxoline for the treatment of mpox

  Denisa Bojkova, et al., bioRxiv - Microbiology 2022

  Quote: ... MEK1/2 (Cell Signaling 1:1000, #9122, 1:1000), phospho-MEK1/2 S217/221 (Cell Signaling ...
• Rewiring of the TCR signalosome in natural intestinal Intraepithelial T lymphocytes drives non-deletional tolerance

  Harriet J. Watt, et al., bioRxiv - Immunology 2023

  Quote: ... SHP-1 or SHP-2 (all Cell Signaling Technology) followed by anti-rabbit Dylight649 (1:500 ...
• Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1

  Niraj Nag, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti Bcl-2 antibody (Cell Signaling Technology Cat# 15071), anti-caspase 8 antibody (Cell Signaling Technology Cat# 9746) ...
• Competitive, connective and allosteric Nanobodies that modulate the SOS1•RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design

  Baptiste Fischer, et al., bioRxiv - Bioengineering 2023

  Quote: ... rabbit monoclonal ERK1/2 (1:50, Cell Signaling #4696), and mouse monoclonal Flag antibody (clone M2 ...
• Peripheral extracellular vesicle-derived miR-150-3p exacerbates acute kidney injury following acute pancreatitis by promoting ferroptosis through FTH1 signaling

  Ji-tao Cui, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-Cox-2 (1:1,000, 9461, Cell Signaling Technology), anti-β-actin (1:2,000 ...
• Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2

  Ding-Chin Lee, et al., bioRxiv - Evolutionary Biology 2023

  Quote: ... rabbit anti-SARS-CoV-2 envelope (Cell signaling, #74698), rabbit anti-GAPDH (Genetex ...
• Phencyclidine disrupts neural coordination and cognitive control by dysregulating translation

  Eun Hye Park, et al., bioRxiv - Neuroscience 2023

  Quote: ... ERK1/2 (Cell Signaling Technology, Cat.No.9102S, 1:1000), phospho-4EBP1 (Cell Signaling Technology ...
• Actin polymerization drives lumen formation in a human epiblast model

  Dhiraj Indana, et al., bioRxiv - Developmental Biology 2023

  Quote: ... phospho- myosin light chain 2 (Cell Signaling Technology #3674), Arp2/3 complex (Sigma-Aldrich MABT95) ...
• Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

  Tiantian Zhang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Mek1/2 (1:1,000, Cell Signaling Technology, Cat# 9122), alpha-tubulin (Sigma ...
• PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

  Maria B. Campaña, et al., bioRxiv - Cell Biology 2023

  Quote: ... ERK1/2 (1:1000; 9102; Cell Signaling Technology, Inc.); phospho-AKT (Ser473 ...
• Ellagic acid ameliorates atherosclerosis by targeting the epidermal growth factor receptor

  Ye-Wei Huang, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-ERK1/2 (4696S, Cell Signaling Technology, MA, USA), anti-phospho-ERK1/2 (4370S ...
• Neural stem cells protect blood-brain barrier integrity via the p38, JNK, and ERK1/2 pathways following intracerebral hemorrhage in rats

  Jing Sun, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-ERK1/2 (Cell Signaling, USA, 1:1000 dilution), anti-p38 (Cell Signaling ...
• Serine arginine-rich splicing factor (SRSF7) cooperates with the histone methyltransferase KMT5a to promote the type I interferon response via transcriptional activation of IRF7

  Haley M. Scott, et al., bioRxiv - Immunology 2023

  Quote: ... or 2 µg of isotype control (IgG, Cell Signaling), 5ul Y701 STAT1 (Cell Signaling) ...
• Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

  Marco Di Gioia, et al., bioRxiv - Immunology 2023

  Quote: ... ERK1/2 (1:1000, Cell Signaling Technology, Cat# 9102), phospho-p38 (Thr180/Tyr182 ...
• Diacylglycerol kinase-ε is S-palmitoylated on cysteine in the cytoplasmic end of its N-terminal transmembrane fragment

  Gabriela Traczyk, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-flotillin-2 (Cell Signaling, cat. No. 3436), donkey anti-sheep IgG-HRP (Jackson ImmunoResearch ...
• Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

  Mingrong Zuo, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-ERK1/2(Thr202/Tyr204) (Cell Signaling Technology #4370S), total-ERK1/2 (Cell Signaling Technology #4696) ...
• Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function

  Chao Chang, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-ERK1/2 (Cell Signaling Technology, #9102; RRID:AB_330744), goat polyclonal anti-EPHB2 (R&D Systems ...
• Potassium starvation induces autophagy in yeast

  Nambirajan Rangarajan, et al., bioRxiv - Biochemistry 2020

  Quote: ... at 1:1,000 dilution in blocking buffer or glucose 6-phosphate dehydrogenase (G6PDH) antibodies (8866, Cell Signaling Technology, 1:1,000). Immunoreactive species were detected with antibodies conjugated with horseradish peroxidase (715-035-150 ...
• The E2F4/p130 repressor complex cooperates with oncogenic ΔNp73α to promote cell survival in human papillomavirus 38 E6/E7-transformed keratinocytes and in cancer cells

  Valerio Taverniti, et al., bioRxiv - Cancer Biology 2022

  Quote: Senescence was assessed using the Senescence β-Galactosidase Staining Kit at pH 6 following the manufacturer’s instructions (Cell Signaling Technology). For SAHF staining ...
• ERK1/2 Inhibition Alleviates Noise-Induced Hearing Loss While Tempering Down the Immune Response

  Richard D. Lutze, et al., bioRxiv - Neuroscience 2023

  Quote: ... Mice were sacrificed 6 days after noise exposure and whole cochlear lysates were prepared in lysis buffer (9803; Cell Signaling) after adding protease (cOmplete ULTRA Tablets 05892791001 ...
• Neuromodulation of Behavioral Specialization: Tachykinin Signaling Inhibits Task-specific Behavioral Responsiveness in Honeybee Workers

  Bin Han, et al., bioRxiv - Evolutionary Biology 2021

  Quote: ... The membranes were blocked for 2 hours at room temperature and then incubated with rabbit monoclonal anti-pERK1/2 antibody (Cell Signaling Technology, USA) and anti-rabbit horseradish peroxidase-conjugated secondary antibody (Cell Signaling Technology ...
• Using rat operant delayed match-to-sample task to identify neural substrates recruited with increased working memory load

  Christina Gobin, Lizhen Wu, Marek Schwendt, bioRxiv - Neuroscience 2020

  Quote: ... PKC substrate antibody selectively detects proteins with phosphorylated PKC consensus sites (phosphorylated Ser residues surrounded by Arg or Lys at the –2 and +2 positions and a hydrophobic residue at the +1 position, Cell Signaling, Danvers, MA). Next ...
• The protein phosphatases MoPtc1 and MoPtc2 are induced during pathogen-host interactions and play synergistic roles in regulating MAPK pathways in Magnaporthe oryzae

  Wilfred M. Anjago, et al., bioRxiv - Molecular Biology 2022

  Quote: ... phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (D13.14.4E) Rabbit mAb and p44/42 MAPK (Erk1/2) antibodies (Cell Signaling Technology, Beverly, MA, USA) and affinity purified goat anti-rabbit & mouse antibody conjugated to horseradish peroxidase (Abmart ...
• Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral and signaling plasticity in vivo

  Mohamed R. Ahmed, et al., bioRxiv - Neuroscience 2023

  Quote: ... Doubly phosphorylated (active) ERK1/2 was detected with a phospho-ERK-specific [phosphor-ERK1/2(Thr202/Tyr204)] mouse monoclonal antibody (Cell Signaling, cat.# 9106) at 1:2,000 dilution ...
• Regulation of early growth response-1 (Egr-1) gene expression by Stat1-independent type I interferon signaling and respiratory viruses

  Chilakamarti V. Ramana, bioRxiv - Genomics 2020

  Quote: ... and subjected to immunoblotting with the antibodies for phosphorylated Erk-1/2 (Thr202/Tyr 204) or total Erk-1/2 from Cell Signaling Technology (Beverly, MA). Blots were visualized by enhanced chemiluminescence western detection system (Pierce ...
• Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

  Selin Schamiloglu, et al., bioRxiv - Neuroscience 2022

  Quote: ... blotted with mouse anti-ERK1/2 (p44/42 MAPK) and rabbit anti-phospho-ERK1/2 (p44/42 MAPK) (Cell Signaling Technologies 4696S and 4370S), both at 1:1000 in 2% BSA at room temperature for 2 hours ...
• The long noncoding RNA lnc-FANCI-2 restricts RAS signaling and phosphorylation of Akt and Erk in HPV16-infected cervical cancer cells

  Haibin Liu, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-Erk1/2 (p44/42 MAPK, #4695), anti-phospho-Erk1/2 (#4370), and anti-IGFBP3 (D1U9C, #25864) were from Cell Signaling Technology (Danvers, MA). Anti-VIM (#MA5-11883 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... phospho-ERK1/2 (Thr202/Tyr204) (1:500 Cell Signaling Technology), ERK1/2 (Thr202/Tyr204 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... phospho-MEK1/2 (Ser217/221) (1:500 Cell Signaling Technology), MEK1/2 (1:500 Cell Signaling Technology) ...
• HDAC and MAPK/ERK Inhibitors Cooperate to Reduce Viability and Stemness in Medulloblastoma

  Mariane da Cunha Jaeger, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Phospho-p44/42 MAPK (pErk1/2, 1:2000; Cell Signaling), p44/42 MAPK (Erk1/2 ...
• RAS specific protease Induces Irreversible Growth Arrest via p27 in several KRAS Mutant Colorectal Cancer cell lines

  Caleb K. Stubbs, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-p44/42 MAPK (ERK1/2, Cell Signaling Technology #4696), anti-HB-EGF (R&D Systems ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... p-ERK1/2 T202/Y204 (#4370S, 1:1000, Cell Signaling), ERK1/2 (#4695S ...
• Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

  Ayan Rajgarhia, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and ERK 1/2 (Cell Signaling Technology, Danvers, MA, USA)
• Wnt-dependent activation of ERK mediates repression of chondrocyte fate during calvarial development

  Beatriz Ibarra, Cody Machen, Radhika P. Atit, bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-phospho-ERK1/2 (1:1250, Cell Signaling 4370). Wide-field images were captured at 20X and 40X using the Leica DMi8 inverted microscope using the Leica Application Suite X (LASX ...
• TrkB agonists prevent post-ischemic BDNF-TrkB mediated emergence of refractory neonatal seizures in CD-1 pups

  P.A. Kipnis, et al., bioRxiv - Neuroscience 2019

  Quote: ... rabbit α Erk1/2 (1:1000, Cell Signaling Technology; #4695), rabbit α phospho-Erk1/2 (1:1000 ...
• Epigenomic profiling discovers trans-lineage SOX2 partnerships driving tumor heterogeneity in lung squamous cell carcinoma

  Takashi Sato, et al., bioRxiv - Cancer Biology 2019

  Quote: ... and anti-phospho-Erk1/2 antibody (Cell Signaling Technology, #4370), anti-β-Actin antibody (Sigma) ...
• Functional analysis of KIT gene structural mutations causing porcine dominant white phenotype by using genome edited mouse models

  Guangjie Sun, et al., bioRxiv - Molecular Biology 2019

  Quote: ... and rabbit anti-Phospho-Erk1/2 antibody (#8544; Cell Signaling) were diluting in 1:2000 ...
• Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing

  Fella Tamzalit, et al., bioRxiv - Immunology 2019

  Quote: ... pErk1/2 (Phospho-Thr202/ Tyr204; clone D13.14.4E; Cell Signaling Technology), IκB (Cell Signaling Technology) ...
• Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism

  Sophie Trefely, et al., bioRxiv - Biochemistry 2019

  Quote: ... ACSS2 (Cell Signaling Technology, cat. #3658, clone: D19C6, lot: 2), ACLY (Proteintech ...
• Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia

  L. Martin, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-phosphorylated Erk1-2 (Thr180/Tyr182) (Cell Signaling Technology, #4370), anti-total Erk1-2 (Sigma-Aldrich ...
• Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors

  Xiaoyan Wei, et al., bioRxiv - Cell Biology 2021

  Quote: ... Rabbit anti-pErk1/2 (Cell Signaling Technology # 9101; 1:1000), Rabbit anti-Erk1/2 (Cell Signaling Technology # 9102 ...
• Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors

  Xiaoyan Wei, et al., bioRxiv - Cell Biology 2021

  Quote: ... Rabbit anti-Erk1/2 (Cell Signaling Technology # 9102; 1:1000), Mouse anti-ß-Actin (Cell Signaling Technology # 58169 ...
• Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors

  Xiaoyan Wei, et al., bioRxiv - Cell Biology 2021

  Quote: ... Rabbit anti-pErk1/2 (Cell Signaling Technology # 9101; 1:300), Rabbit anti-phosphor (s235/236)-S6 (Cell Signaling Technology # 4858 ...
• The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer

  Rhona Millar, et al., bioRxiv - Cancer Biology 2020

  Quote: ... lnti-phospho-ERK1/2 (250ng/mL, Cell Signaling Technology, #4370); anti-ERK1/2 (84ng/mL ...