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1 - 50 of 10000+ citations for 2E 4E 2 4 Octadien 1 ol since 2020

• The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer’s disease

  Felipe C. Ribeiro, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4E-BP1/2 (#2845, 1:1,1000; Cell Signaling), phospho-mTOR Ser2448 (#2971 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 4E-BP1 (1:1000, Cell Signaling Technology), HIF-1α (1:1000 Novus Biologicals) ...
• Characterization of early Alzheimer’s-like pathological alterations in non-human primates with aging: a pilot study

  Hannah Jester, et al., bioRxiv - Molecular Biology 2021

  Quote: ... 4E-BP1 (1:1000; Cell Signaling, Cat#), p-eEF2 (1:1000 ...
• mTORC1 and JUN are activated after deletion of Prohibitin 1 in Schwann cells and may link mitochondrial dysfunction to demyelination

  Gustavo Della-Flora Nunes, et al., bioRxiv - Neuroscience 2020

  Quote: ... 4E-BP1 1:500 (Cell signaling #9644), p-S6 1:500 (Cell signaling #4858) ...
• mTORC1 and JUN are activated after deletion of Prohibitin 1 in Schwann cells and may link mitochondrial dysfunction to demyelination

  Gustavo Della-Flora Nunes, et al., bioRxiv - Neuroscience 2020

  Quote: ... p-4E-BP1 1:500 (Cell signaling #2855), 4E-BP1 1:500 (Cell signaling #9644) ...
• A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia

  Victoria da Silva-Diz, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-4E-BP1 (1:1000, 9644S, Cell Signaling), anti-p-4EB-P1 (1:1000 ...
• A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell Leukemia

  Olga Lancho, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-4E-BP1 (1:1000, 9644S, Cell Signaling), anti-p-4EB-P1 (1:1000 ...
• Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt

  Brittany L. Dunkerly-Eyring, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-4E-BP1 (Cell Signaling Technology, 1:1000), anti-phospho-Akt (Ser473 ...
• Non-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

  Heidi H. Pak, et al., bioRxiv - Physiology 2024

  Quote: ... 4E-BP1 (1:1,000; Cell Signaling Technology #9452). Imaging was performed using a GE ImageQuant LAS 4000 imaging station (GE Healthcare) ...
• Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells

  Joseph A. Haight, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 4E-BP1 (Cell Signaling, #9644, 1:1000; RRID:AB_2097841), p-4E-BP1-37/46 (Cell Signaling ...
• Oncogenic signaling in the adult Drosophila prostate-like accessory gland leads to activation of a conserved pro-tumorigenic program, in the absence of proliferation

  S. Jaimian Church, et al., bioRxiv - Developmental Biology 2024

  Quote: ... P-4E-BP 1:200 (Cell Signaling 2855S). Secondary antibodies used in this study are ...
• Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

  Leon Tejwani, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-4E-BP1 (Cell Signaling; #9644, 1:1,000), rabbit anti-phospho-4E-BP1 (Cell Signaling ...
• A chemical screen identifies a link between lipid metabolism and mRNA translation

  Alba Corman, et al., bioRxiv - Molecular Biology 2020

  Quote: ... 4E-BP1 (1:1000, CST Cell Signaling Tech, 9452S), p-eIF2a (phospho S51 ...
• The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer’s disease

  Felipe C. Ribeiro, et al., bioRxiv - Neuroscience 2023

  Quote: ... phospho-4E-BP1 Ser65 (#9451, 1:1,000; Cell Signaling), 4E-BP1/2 (#2845 ...
• Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

  Marine Berquez, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-4E-BP1 (Cell Signaling Technology, 9644, 1:500), anti-phospho-p70 S6 kinase 1 (Thr389 ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-4E-BP1 (1:1000, Cell Signaling 9644), rabbit anti-phospho-4E-BP1 (Ser65 ...
• Nucleus translocation of tRNA synthetase mediates late integrated stress response

  Na Wei, et al., bioRxiv - Molecular Biology 2020

  Quote: ... rabbit monoclonal 4E-BP1 (1:1000, Cell Signaling Technology, #9644), rabbit polyclonal p-eIF2α (1:1000 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... phospho-4E-BP1 (Thr37/46) (1:1000, Cell Signaling Technology), 4E-BP1 (1:1000 ...
• Characterization of early Alzheimer’s-like pathological alterations in non-human primates with aging: a pilot study

  Hannah Jester, et al., bioRxiv - Molecular Biology 2021

  Quote: ... p-4E-BP1 (1:1000; Thr37, Thr46) (Cell Signaling, Cat#), 4E-BP1 (1:1000 ...
• Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration

  Leon Tejwani, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-phospho-4E-BP1 (Cell Signaling; #2855; 1:1,000), rabbit anti- ULK1 (Cell Signaling ...
• LIN28B controls the regenerative capacity of neonatal murine auditory supporting cells through activation of mTOR signaling

  Xiaojun Li, Angelika Doetzlhofer, bioRxiv - Developmental Biology 2020

  Quote: ... rabbit anti-4E-BP1 (Cell Signaling, no. 9644, 1:2000), rabbit anti-human LIN28B (Cell Signaling ...
• Stem cells commit to differentiation following multiple induction events in the Drosophila testis

  Alice C Yuen, Kenzo-Hugo Hillion, Marc Amoyel, bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-phospho-4E-BP1 (1:200, Cell Signaling #2855), rabbit anti-phospho-Akt (1:200 ...
• Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt

  Brittany L. Dunkerly-Eyring, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-phospho-4E-BP1 (Ser65) (Cell Signaling Technology, 1:1000), anti-phospho-ULK1 (Ser757 ...
• FoxO transcription factors actuate the formative pluripotency specific gene expression programme

  Laura Santini, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1:1000 for anti-4E-BP1 (rabbit; Cell Signaling, 9644), 1:1000 for anti-phospho-p70 S6 kinase(Thr389 ...
• The Respiratory Syncytial Virus M2-2 protein is targeted for proteasome degradation and inhibits translation and stress granules assembly

  Orlando Bonito Scudero, et al., bioRxiv - Microbiology 2023

  Quote: ... anti-4E-BP1 rabbit (#9452 – Cell Signaling, 1:1000 WB), anti-Mouse HRP (ab97023 – Abcam ...
• 17α-estradiol Alleviates High-Fat Diet-Induced Inflammatory and Metabolic Dysfunction in Skeletal Muscle of Male and Female Mice

  Matthew P. Bubak, et al., bioRxiv - Physiology 2023

  Quote: ... and 4E-BP1 (1:50, #9452, Cell Signaling, Danvers, MA). Secondary antibodies were included in a WES Master Kit (DM-001 ...
• Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

  Kevin C. Lister, et al., bioRxiv - Neuroscience 2024

  Quote: ... 4E-BP1 (1:200, #2855S, Cell Signaling and Technology Laboratories), Pax2 (1:500 ...
• Targeting the translational machinery in gastrointestinal stromal tumors (GIST) – a new therapeutic vulnerability

  Donna M. Lee, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 4E-BP1 (both Cell Signaling), actin (Santa Cruz) ...
• The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

  Pedro Aguilar-Garrido, et al., bioRxiv - Molecular Biology 2023

  Quote: ... 4E-BP1 (Cell Signaling, #9644), p-4E-BP1(Cell Signaling ...
• SLC25A46 is in contact with lysosomes and plays a role in mitochondrial cholesterol homeostasis

  Jana Schuettpelz, et al., bioRxiv - Cell Biology 2024

  Quote: ... 4E-BP (Cell Signaling; 9644S), Cav1 (BD bioscience ...
• Nucleus translocation of tRNA synthetase mediates late integrated stress response

  Na Wei, et al., bioRxiv - Molecular Biology 2020

  Quote: ... rabbit monoclonal p-4E-BP1 (1:1000, Cell Signaling Technology, #2855), rabbit monoclonal p70 S6K (1:1000 ...
• Setd2 inactivation sensitizes lung adenocarcinoma to inhibitors of oxidative respiration and mTORC1 signaling

  David M. Walter, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p-4E-BP1(T37/46) (Cell Signaling Technology, cs2855, 1:100), mTOR (Cell Signaling Technology ...
• The Respiratory Syncytial Virus M2-2 protein is targeted for proteasome degradation and inhibits translation and stress granules assembly

  Orlando Bonito Scudero, et al., bioRxiv - Microbiology 2023

  Quote: ... anti-Phospho-4E-BP1 rabbit (#2855 – Cell Signaling, 1:1000 WB), anti-4E-BP1 rabbit (#9452 – Cell Signaling ...
• Non-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

  Heidi H. Pak, et al., bioRxiv - Physiology 2024

  Quote: ... p-T37/S46 4E-BP1 (1:1,000; Cell Signaling Technology #2855), 4E-BP1 (1:1,000 ...
• Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

  Marine Berquez, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-phospho‒4E-BP1 (Ser65; Cell signaling technology, 9451, 1:500), anti-4E-BP1 (Cell Signaling Technology ...
• Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells

  Joseph A. Haight, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p-4E-BP1-37/46 (Cell Signaling, #2855, 1:1000; RRID:AB_560835), RRM2 (Santa Cruz Biotechnology ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-phospho-4E-BP1 (Ser65) (1:1000, Cell Signaling 9456), rabbit anti-phospho-4E-BP1 (Thr37/46 ...
• Identification of Hsp90 inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer

  Evelyn M. Mrozek, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 4E-BP1 (9452L, Cell Signaling Technology), p4E-BP1-Ser65 ...
• Estrogen controls mTOR signaling and mitochondrial function via WNT4 in lobular carcinoma cells

  Madeleine T. Shackleford, et al., bioRxiv - Cancer Biology 2020

  Quote: ... 4E-BP1 (Cell Signaling, cat#9452); p4E-BP1-S65 (Cell Signaling ...
• A mitochondrial long-chain fatty acid oxidation defect leads to uncharged tRNA accumulation and activation of the integrated stress response in the mouse heart

  Pablo Ranea-Robles, et al., bioRxiv - Physiology 2021

  Quote: ... anti-4E-BP1 (9644, Cell Signaling), anti-SQSTM1/p62 (5114 ...
• Genetic silencing of AKT induces melanoma cell death

  Gennie L. Parkman, et al., bioRxiv - Cancer Biology 2022

  Quote: ... 4E-BP1 (9644; Cell Signaling Technology); SGK1 (D72C11 ...
• The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

  Pedro Aguilar-Garrido, et al., bioRxiv - Molecular Biology 2023

  Quote: ... p-4E-BP1(Cell Signaling, #2855), Ncl (Abcam ...
• Nutrient Sensing Receptor GPRC6A Regulates mTORC1 Signaling and Tau Biology

  Chao Ma, et al., bioRxiv - Neuroscience 2024

  Quote: ... 4E-BP1 (Cell Signaling Tech, #9644), 4E-BP1 pT37/46 (Cell Signaling Tech ...
• Quantitative mapping of autophagic cargo during nutrient stress reveals YIPF3-YIPF4 as membrane receptors for Golgiphagy

  Kelsey L. Hickey, et al., bioRxiv - Cell Biology 2022

  Quote: ... 4E-BP1 (Cell Signaling Technology 9644), Phospho-4E-BP1 (Thr37/46 ...
• Electron transport chain inhibition increases cellular dependence on purine transport and salvage

  Zheng Wu, et al., bioRxiv - Biochemistry 2023

  Quote: ... 4E-BP1 (Cell Signaling Technology, 9644S), Phospho-4E-BP1 (Ser65 ...
• Absence of postsynaptic activity on developing neurons alters gene expression profiles without preventing the refinement of inputs

  Yumaine Chong, Ellis Cooper, bioRxiv - Neuroscience 2022

  Quote: ... in primary antibodies for 48 hours at 4°C [Rabbit anti-P-4E-BP (1:600; Cell Signaling Technology, Danvers, MA), goat anti-MAP-1A (1:360 ...
• The level of oncogenic Ras controls the malignant transformation of Lkb1 mutant tissue in vivo

  Briana Rackley, et al., bioRxiv - Cancer Biology 2020

  Quote: ... rabbit anti-phospho 4E-BP1 (Thr 37/46) (Cell Signaling, 1:1000), rabbit anti-phospho AKT (Ser 473 ...
• FoxO transcription factors actuate the formative pluripotency specific gene expression programme

  Laura Santini, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 1:1000 for anti-phospho-4E-BP1(Ser65) (rabbit; Cell Signaling, 9451), 1:1000 for anti-4E-BP1 (rabbit ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-phospho-4E-BP1 (Thr37/46) (1:1000, Cell Signaling 2855), rabbit anti-Hamartin/TSC1 (1:1000 ...
• Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor

  Patricia D.B. Tiburcio, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-4E-BP1 (Thr37/46) (Cell Signaling Technology 2855, RRID:AB_560835; 1:1,000), Total P70-S6K1 (Cell Signaling Technology 34475 ...