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• Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors

  Chuankai Chen, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p-ERK1/2 (Cell Signaling, #4376), ERK1/2 (Santa Cruz ...
• Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors

  Chuankai Chen, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p-MEK1/2 (Cell Signaling, #9121), MEK1 (Cell Signaling ...
• Prohibitin 2 is a Key Regulator of T Cell Proliferation and Effector Functions

  Johannes F. Vogt, et al., bioRxiv - Immunology 2024

  Quote: ... p-Erk1/2 (Cell Signaling #9106), a-tubulin (Cell Signaling #2144) ...
• Acrylic Acid Modified Poly-ethylene Glycol Microparticles for Affinity-Based release of Insulin-Like Growth Factor-1 in Neural Applications

  Pablo Ramos Ferrer, Shelly Sakiyama-Elbert, bioRxiv - Bioengineering 2024

  Quote: ... Primary antibodies for Erk1/2 and p-ERK1/2 (Cell Signaling Technology), were used at a 1:1000 dilution ...
• DOK1 and DOK2 regulate CD8⁺ T cell signaling and memory formation without affecting tumor cell killing

  V. Laletin, et al., bioRxiv - Immunology 2021

  Quote: ... p-Erk1/2 (Cell Signaling Technology #4377), Erk-1/2 (Cell Signaling Technology #9102 ...
• Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis

  Benjamin Ng, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-p-ERK1/2 (4370, Cell Signaling), anti-ERK1/2s (4695 ...
• Human cytomegalovirus UL7, miR-US5-1 and miR-UL112-3p inactivation of FOXO3a protects CD34⁺ hematopoietic progenitor cells from apoptosis

  Meaghan H. Hancock, et al., bioRxiv - Microbiology 2020

  Quote: ... P-ERK1/2 (Thr202/Tyr204, Cell Signaling), PARP (Cell Signaling) ...
• MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer

  Olaf Klingbeil, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p-LATS1/2 (T1079/T1041) (Cell Signaling, D57D3 ...
• Signaling modality within gp130 receptor enhances tissue regeneration

  Ruzanna Shkhyan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... p-ERK 1/2 (cat #9106, Cell Signaling), p-Y416-SRC (cat #1246F ...
• F-domain valency determines outcome of signaling through the angiopoietin pathway

  Yan Ting Zhao, et al., bioRxiv - Biochemistry 2020

  Quote: ... p-ERK1/2 p44/42 (Cell signaling, USA) at 1:10,000 dilution ...
• β-Catenin-NFκB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

  Shikai Hu, et al., bioRxiv - Pathology 2021

  Quote: ... p-Erk1/2 (Cell Signaling, 4370, 1:100), F4/80 (BioRad ...
• AMPK-dependent phosphorylation is required for transcriptional activation of TFEB/TFE3

  Mathieu Paquette, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-ACC1/2 (S79) (Cell Signaling Technology, 3661), 4EBP1 (Cell Signaling Technology ...
• NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

  Carolina Marques, et al., bioRxiv - Cancer Biology 2020

  Quote: ... p-ERK1/2 (T202/Y204) (Cell Signaling Technology, #9101 ...
• Aberrant localization of CDC42 C-terminal variants to the Golgi apparatus drives pyrin inflammasome-dependent autoinflammation

  Masahiko Nishitani-Isa, et al., bioRxiv - Immunology 2021

  Quote: ... anti-p-ERK1/2 (Cell Signaling, 1:1000), anti-p65 (Cell Signaling ...
• CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

  Chunge Zhong, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p-ERK1/2 (Cell Signaling Technology, Cat# 4370S), ERK1/2 (Cell Signaling Technology ...
• Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome

  Rosalba Olga Proce, et al., bioRxiv - Neuroscience 2024

  Quote: ... p-ERK1/2 (Cell Signaling, #4370, 1:500), ERK1/2 (Cell Signaling ...
• ACE1 knockout in neurons selectively dysregulates the hippocampal renin angiotensin system and causes vascular loss

  Sohee Jeon, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-p-p44/42 MAPK (p-Erk1/2) (#CS9101, Cell Signaling Technology), rabbit anti-p44/42 (Erk1/2 ...
• PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity

  Florian Wiede, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-ERK1/2 (Cell Signaling Technology Cat# 4376, RRID:AB_331772), LCK (Cell Signaling Technology Cat# 2752 ...
• BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

  Tianyi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-ERK1/2 (Cell Signaling Technology, 4370, 1:2000), periostin (Invitrogen ...
• MEKK3-TGFβ crosstalk regulates inward arterial remodeling

  Hanqiang Deng, et al., bioRxiv - Pathology 2021

  Quote: ... p-ERK1/2 (Cell Signaling 4370; IB 1:1000).
• SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes

  Yen K. Lieu, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-p-MAPKAPK-2 (MK2; T334) (Cell Signaling, 9595T), anti-α-Tubulin (Cell Signaling ...
• The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

  Elisa Avolio, et al., bioRxiv - Cell Biology 2021

  Quote: ... P-ERK1/2 Thr202/Tyr204 (Cell Signaling Technology #4370), 1:2000 ...
• Development of an automated high-content immuno-fluorescence assay of pSmads quantification: proof-of-concept with drugs inhibiting the BMP/TGFβ pathways

  Valia Khodr, et al., bioRxiv - Bioengineering 2023

  Quote: ... anti-pSmad 1/5/9 (ref: 13820S) and anti-pSmad 2 (ref: 18338S) antibodies were obtained from Cell signaling. The secondary antibody conjugated to Alexa555 or Alexa488 were purchased from Invitrogen ...
• Ubiquitin specific protease 1 expression and function in T cell immunity

  Kyla D Omilusik, et al., bioRxiv - Immunology 2021

  Quote: ... Id2 (1:1000; 9-2-8, CalBioeagents or D39E8, Cell Signaling), Id3 (1:1000 ...
• Missense and nonsense mutations of the zebrafish hcfc1a gene result in contrasting mTor and radial glial phenotypes

  Victoria L. Castro, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 14-3-3-beta/alpha (Cell Signaling Cat # 9636S) (anti-rabbit ...
• Calcium-Mediated Modulation of Blood-Brain Barrier Permeability by Laser Stimulation of Endothelial-Targeted Nanoparticles

  Xiaoqing Li, et al., bioRxiv - Bioengineering 2022

  Quote: ... P-p44/42 ERK1/2 and p44/42 ERK1/2 were purchased from Cell Signaling Technology. Gold (III ...
• PAK1 and PAK2 in cell metabolism regulation

  Tereza Kořánová, et al., bioRxiv - Cell Biology 2021

  Quote: ... PAK1/2/3 (Cell Signaling, #2604), and β-actin (Sigma–Aldrich ...
• Endothelial Rho kinase controls blood vessel integrity and angiogenesis

  Martin Lange, et al., bioRxiv - Developmental Biology 2024

  Quote: ... PAK1/2/3 (Cell Signaling, # 2604S), pLIMK1/2 (Cell Signaling ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... p-ERK1/2 T202/Y204 (#4370S, 1:1000, Cell Signaling), ERK1/2 (#4695S ...
• Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer

  Laura K. Godfrey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p-ERK1/2 (#4376, RRID:AB_331772, Cell Signaling Technology, 1:15), Vinculin (#13901 ...
• The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

  Leila Revollo, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti p-Erk1/2(T202/Y204) (Cell Signaling Technology, #4370), anti Erk1/2(Cell Signaling Technology ...
• Activation of proneuronal transcription factor Ascl1 in maternal liver ensures a healthy pregnancy

  Joonyong Lee, et al., bioRxiv - Physiology 2021

  Quote: ... p-ERK1/2 (T202/Y204, Cell Signaling, 4377, 1:2,000), GAPDH (Cell Signaling ...
• SCARF1-induced efferocytosis plays an immunomodulatory role in humans, and autoantibodies targeting SCARF1 are produced in patients with systemic lupus erythematosus

  April M. Jorge, et al., bioRxiv - Immunology 2021

  Quote: ... Erk1/ 2 p-44/42-Alexa488 (Cell Signaling clone 137F5), and MAPK p38-Alexa488 (Thr180/Tyr182 ...
• Neural stem cells protect blood-brain barrier integrity via the p38, JNK, and ERK1/2 pathways following intracerebral hemorrhage in rats

  Jing Sun, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-p-ERK1/2 (Cell Signaling, USA, 1:500 dilution), anti-p-p38 (Cell Signaling ...
• Lethal giant larvae gene family (Llgl1 and Llgl2) functions as a tumor suppressor in mouse skin epidermis

  Victor M. Bii, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-p-LATS1/2 (1:500, Cell Signaling, #9159), mouse anti-p-AKT (1:1000 ...
• Astrocyte-derived PEA116 increases adult hippocampal neurogenesis and confers stress resilience

  Carron Charline, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-p-ERK1/2 (1:500, Cell Signaling 9101S), rabbit anti-RFP (1:500 ...
• KSR1 knockout mouse model demonstrates MAPK pathway’s key role in cisplatin- and noise-induced hearing loss

  Matthew A. Ingersoll, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-p-ERK1/2 (Thr202/Tyr204, 9101S), anti-MEK1/2 (9122S), and anti-p-MEK1/2 (Ser217/221, 41G9S) were obtained from Cell Signaling Technologies, and anti-α Tubulin (T9026 ...
• NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency

  Jaroslaw Cendrowski, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-P-S6 (Cat# 2211) and anti-P-JNK1/2 (Cat# 9255) from Cell Signaling Technologies; anit-IDH1 (Cat# GT1521 ...
• Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity

  Shilpa Singh, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 6’-diamidino-2-phenylindole (DAPI) (Cell Signaling #4083) for 15 minutes at room temperature ...
• Atheroprone Flow Activates SMAD-FOXO1 to drive Endothelial-to-Mesenchymal Transition and Atherosclerosis

  Paul-Lennard Mendez, et al., bioRxiv - Genomics 2024

  Quote: ... SMAD2/3 (SMAD 2/3 XP, Cell Signaling Technology 8685) or isotype control (Rabbit IgG XP ...
• Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton

  Wenqing Zhou, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-Rac1/2/3 (Cell Signaling 2465S) and secondary antibodies anti-rabbit (ThermoFisher SA5-35571) ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... P-ERK (Cell Signaling Technology, Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204 ...
• Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages

  Kevin Christian M. Gulay, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-p-ERK1/2 antibody (1:1000; Cell Signaling Technology, 4370S), anti-ERK1/2 antibody (1:1000 ...
• ZIP9 is a Druggable Determinant of Sex Differences in Melanoma

  Cristina Aguirre-Portolés, et al., bioRxiv - Cancer Biology 2021

  Quote: ... P-ERK (Cell Signaling Technology, Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204 ...
• Anti-apoptotic and anti-inflammatory properties of grapefruit IntegroPectin on human microglial HMC3 cell line

  Miriana Scordino, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-p-ERK1/2 (1:1000, 9101 Cell Signaling Technology), rabbit anti-p-Akt (1:1000 ...
• Inhibition of Cellular MEK/ERK Signaling Suppresses Murine Papillomavirus Type 1 Replicative Activities and Promotes Tumor Regression

  Adrian J. Luna, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Immunohistochemical detection of p-ERK1/2 (Cell Signaling #4370; 1:500) required the tyramide signal amplification (TSA ...
• Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions

  Yan Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... P-ERK1/2 (Thr202/Tyr204) (1:1000, #9101, Cell Signaling Technology), β-actin (1:1000 ...
• Distinct Mechanisms of Type 3 Secretion System Recognition Control LTB₄ Synthesis in Neutrophils versus Macrophages

  Amanda Brady, et al., bioRxiv - Immunology 2024

  Quote: ... anti-p-p44/42 (ERK1/2) (Cell Signaling; Cat. No. 9101s), anti-p44/42 (Cell Signaling ...
• Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid

  Min Pan, et al., bioRxiv - Cancer Biology 2024

  Quote: ... pSMAD1/5/9 (Cell Signaling, # 13820S), ACVR1 (Abcam ...
• Secreted exosomes induce filopodia formation

  Caitlin McAtee, et al., bioRxiv - Cell Biology 2024

  Quote: ... pSmad1/5/9 (Cell Signaling #13820) and Smad1 (Cell Signaling #6944 ...