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3501 - 3550 of 10000+ citations for 7 CHLORO 1 METHYL 1H PYRAZOLO 4 3 B PYRIDINE since 2019

• PIKfyve deficiency in myeloid cells impairs lysosomal homeostasis in macrophages and promotes systemic inflammation in mice

  Sang Hee Min, et al., bioRxiv - Cell Biology 2019

  Quote: ... Phospho 4EBP1 (Cell Signaling Technology; 1:1000), 4EBP1 (Cell Signaling Technology ...
• PIKfyve deficiency in myeloid cells impairs lysosomal homeostasis in macrophages and promotes systemic inflammation in mice

  Sang Hee Min, et al., bioRxiv - Cell Biology 2019

  Quote: ... anti-rabbit (Cell Signaling Technology; 1:1000), anti-rat (Santa Cruz Biotechnology ...
• Osteocytes remodel bone by TGF-β-induced YAP/TAZ signaling

  Christopher D. Kegelman, et al., bioRxiv - Cell Biology 2019

  Quote: ... anti-YAP (1:200, 14074; Cell Signaling), and anti-TAZ (1:200 NB110-58359 ...
• mDia2 formin selectively interacts with catenins and not E-cadherin to regulate Adherens Junction formation

  Yuqi Zhang, et al., bioRxiv - Cell Biology 2019

  Quote: ... and 1:100 E-cadherin (Cell Signaling), or 1:100 αE-catenin (Genetex (Irvine ...
• Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

  Nathalie Tisch, et al., bioRxiv - Developmental Biology 2019

  Quote: ... RIPK3 (1:1000, ref.13526, Cell Signaling), Casp-8 (1:1000 ...
• Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

  Nathalie Tisch, et al., bioRxiv - Developmental Biology 2019

  Quote: ... ERK (1:1000, ref.9102, Cell Signaling), RIPK3 (1:1000 ...
• Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

  Nathalie Tisch, et al., bioRxiv - Developmental Biology 2019

  Quote: ... FAK (1:1000, ref.3285, Cell Signaling), p-ERK p44/42 (1:1000 ...
• Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

  Nathalie Tisch, et al., bioRxiv - Developmental Biology 2019

  Quote: ... Akt (1:1000, ref.9272, Cell Signaling), p-FAK Tyr397 (1:1000 ...
• Caspase-8 Modulates Angiogenesis By Regulating A Cell Death Independent Pathway In Endothelial Cells

  Nathalie Tisch, et al., bioRxiv - Developmental Biology 2019

  Quote: ... p38 (1:1000, ref.9228, Cell Signaling), p-Akt Ser473 (1:1000 ...
• Generation of inducible SMARCAL1 knock-down iPSC to model severe Schimke immune-osseous dysplasia reveals a link between replication stress and altered expression of master differentiation genes

  Giusj Monia Pugliese, et al., bioRxiv - Cell Biology 2019

  Quote: ... anti p-ATM (1:800; Cell Signaling), anti-pATM (IF 1:300 ...
• HMGB1 orchestrates uterine macrophage trafficking to safeguard embryo implantation

  Shizu Aikawa, et al., bioRxiv - Developmental Biology 2019

  Quote: ... α-Tubulin (1:1000, 2144, Cell Signaling Technology) and Lamin A/C (1:1000 ...
• HMGB1 orchestrates uterine macrophage trafficking to safeguard embryo implantation

  Shizu Aikawa, et al., bioRxiv - Developmental Biology 2019

  Quote: ... PR (1:300, 8757; Cell Signaling technology), FOXA2 (1:300 ...
• MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure

  Zhihao Wu, et al., bioRxiv - Cell Biology 2019

  Quote: ... mouse anti-RpS6 (1:500, Cell Signaling), and rabbit anti-RpL3 (1:500 ...
• Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments

  Anne-Sophie Hafner, et al., bioRxiv - Neuroscience 2019

  Quote: ... rabbit anti-biotin (Cell Signaling, 1:1000), chicken anti-GFP (Aves ...
• Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice

  Latha Muniappan, et al., bioRxiv - Pathology 2020

  Quote: ... ILK-1 (Cell Signaling, catalog No:3862), FAK (Cell Signaling ...
• VHL Synthetic Lethality Signatures Uncovered by Genotype-specific CRISPR-Cas9 Screens

  Ning Sun, et al., bioRxiv - Cancer Biology 2019

  Quote: ... anti-pVHL (1:500, Cell Signaling Technology), and anti-αTubulin (1:10,000 ...
• Positive allosteric modulation of metabotropic glutamate receptor 5 modulates Akt and GSK3β signaling in vivo

  Kari A Johnson, P. Jeffrey Conn, bioRxiv - Neuroscience 2019

  Quote: ... total Akt (Cell Signaling #2920, 1:1000), phospho-GSK3β Ser9 (Cell Signaling #9322 ...
• Connexin 43 impacts the chick premigratory cranial neural crest cell population without affecting the neural crest cell epithelial-to-mesenchymal transition

  Karyn Jourdeuil, Lisa A. Taneyhill, bioRxiv - Developmental Biology 2019

  Quote: ... Snail2 (1:100; Cell Signaling Technology, C1967), Phospho-histone H3 (pHH3 ...
• OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis

  Lien Verboom, et al., bioRxiv - Cancer Biology 2019

  Quote: ... phospho-IκBα (1:1000, Cell Signaling Technology), HOIL-1 (1:2000 ...
• OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis

  Lien Verboom, et al., bioRxiv - Cancer Biology 2019

  Quote: ... or anti-Ki67 (1:1000, Cell Signaling). Next ...
• Glutamine Synthetase-1 induces autophagy-lysosomal degradation of huntingtin aggregates and ameliorates animal motility in a Drosophila model for Huntington’s disease

  Luisa Vernizzi, et al., bioRxiv - Cell Biology 2019

  Quote: ... ULK1/ATG1 (1:500 Cell Signaling #D8H5), or ATG5 (1:500 Thermo Fisher #OSA00026W).
• EML4-ALK V3 drives cell migration through NEK9 and NEK7 kinases in non-small-cell lung cancer

  Laura O’Regan, et al., bioRxiv - Cancer Biology 2019

  Quote: ... myc (1:1000, mouse, Cell Signaling Technologies) or GFP (0.2 µg/ml ...
• Antibody Targeting of B7-H4 Enhances the Immune Response in Urothelial Carcinoma

  Joseph R. Podojil, et al., bioRxiv - Cancer Biology 2019

  Quote: ... and FoxP3 (1:400, #12653, Cell Signaling). IHC was performed using a Dako Autostainer Plus instrument (Dako ...
• Regenerative capacity in Drosophila imaginal discs is controlled by damage-responsive, maturity-silenced enhancers

  Robin E. Harris, et al., bioRxiv - Developmental Biology 2019

  Quote: ... rabbit anti-HA (1:1000, Cell Signaling). Secondary antibodies used were from Cell Signaling ...
• Regenerative capacity in Drosophila imaginal discs is controlled by damage-responsive, maturity-silenced enhancers

  Robin E. Harris, et al., bioRxiv - Developmental Biology 2019

  Quote: ... rabbit anti-DCP1 (1:1000, Cell Signaling), rabbit anti-TDF/apt (1:1000 ...
• Inhibiting TG2 sensitizes lung cancer to radiotherapy through interfering TOPOIIα-mediated DNA repair

  Xiao Lei, et al., bioRxiv - Cancer Biology 2019

  Quote: ... E-cadherin (1:200; Cell Signaling Tech.), Vimentin (1:200 ...
• Altered m⁶A modification of specific cellular transcripts affects Flaviviridae infection

  Nandan S. Gokhale, et al., bioRxiv - Molecular Biology 2019

  Quote: ... anti-phospho-eIF2α (Cell Signaling, 1:1000), anti-GADD34 (Proteintech ...
• The impact of gut microbiota on depressive-like behaviors and adult hippocampal neurogenesis requires the endocannabinoid system

  Grégoire Chevalier, et al., bioRxiv - Neuroscience 2019

  Quote: ... HRP-linked antibody (1:3000, Cell Signaling) for 1 hour at room temperature before being revealed using ECL Prime detection reagent (GE Healthcare ...
• Duo-activation of PKA and PKG by PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against proteinopathy

  Hanming Zhang, et al., bioRxiv - Cell Biology 2019

  Quote: ... anti-HA (#3724, Cell Signaling; 1:1000), anti-GFP (SC-9996 ...
• Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence

  Jacob P Matson, et al., bioRxiv - Cell Biology 2019

  Quote: ... p21 (Cell Signaling Technology, #2947S, 1:6,000) Cdc6 (Santa Cruz Biotechnology ...
• Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling

  Jiuzhi Xu, et al., bioRxiv - Cancer Biology 2019

  Quote: ... anti-Sox9 (1:1,000, Cell Signaling Technology), anti-CD45 (1:200 ...
• Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling

  Jiuzhi Xu, et al., bioRxiv - Cancer Biology 2019

  Quote: ... anti-Ets1 (1:800, Cell Signaling Technology), anti-Sox9 (1:1,000 ...
• Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling

  Jiuzhi Xu, et al., bioRxiv - Cancer Biology 2019

  Quote: ... anti-Yap (1:500, Cell Signaling Technology), anti-Mucin2 (1:100 ...
• Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

  Christina M. Bebber, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Anti-GAPDH (Cell signaling, 97166S, 1:2,000).
• Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

  Christina M. Bebber, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Anti-Txn1 (Cell signaling, 2429S, 1:1,000), Anti-GAPDH (Cell signaling ...
• Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

  Christina M. Bebber, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Anti-Txnrd2 (Cell signaling, 12029, 1:1,000), Anti-Acsl4 (Santa Cruz Biotechnology ...
• Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

  Christina M. Bebber, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Anti-Txnrd1 (Cell signaling, 15140S, 1:1,000), Anti-Txnrd2 (Cell signaling ...
• Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

  Christina M. Bebber, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Anti-Cas9 (Cell signaling, 14697, 1:1,000,), Anti-ß-actin (Sigma ...
• Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBM

  A Bohm, et al., bioRxiv - Cancer Biology 2019

  Quote: ... anti-NG2 (1:1000; Cell Signaling 4235); anti-GFAP (1:1000 ...
• Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBM

  A Bohm, et al., bioRxiv - Cancer Biology 2019

  Quote: ... anti-EGFR (1:2000; Cell Signaling 4267); anti-Olig2 (1:2000 ...
• Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence

  Alberto Granzotto, et al., bioRxiv - Neuroscience 2019

  Quote: ... rabbit p-Akt 1:1000 (Cell Signaling); Erk1,2 1:200 (Santa Cruz) ...
• The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGF-beta; signaling in triple-negative breast cancer

  Zane A Gibbs, et al., bioRxiv - Cancer Biology 2020

  Quote: ... TRIM27 (15099; 1:1000; Cell Signaling Technology). The following antibodies were used for proximity ligation assays ...
• The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGF-beta; signaling in triple-negative breast cancer

  Zane A Gibbs, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Tubulin (2128; 1:1000; Cell Signaling Technology), ZNF446 (16218-1-AP ...
• MCL-1 inhibition by selective BH3 mimetics disrupts mitochondrial dynamics in iPSC-derived cardiomyocytes

  Megan L. Rasmussen, et al., bioRxiv - Cell Biology 2019

  Quote: ... pDRP-1 S616 (Cell Signaling Technologies #4494), OPA1 (Cell Signaling Technologies #67589S) ...
• Functional Profiling of Single CRISPR/Cas9-Edited Human Long-Term Hematopoietic Stem Cells

  Elvin Wagenblast, et al., bioRxiv - Genetics 2019

  Quote: ... anti-GATA-1 antibody (Cell Signaling D24E4) was titrated prior to use on a lysate from CD34+ cord blood and 1:5 dilution was used in the samples.
• ETV4 is necessary for estrogen signaling and growth in endometrial cancer cells

  Adriana C. Rodriguez, et al., bioRxiv - Molecular Biology 2020

  Quote: ... GR (Cell Signaling D6H2L; 1:1000 dilution), Lamin (Abcam 16048 ...
• NatB modulates Rb mutant cell death and tumor growth by regulating EGFR/MAPK signaling through the N-end rule pathways

  Zhentao Sheng, Wei Du, bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti-MAPK (1:500, Cell signaling), mouse anti-PP2AC (1:400 ...
• NatB modulates Rb mutant cell death and tumor growth by regulating EGFR/MAPK signaling through the N-end rule pathways

  Zhentao Sheng, Wei Du, bioRxiv - Cell Biology 2019

  Quote: ... rabbit anti dpErk (1:400, Cell signaling), rabbit anti-MAPK (1:500 ...
• Microenvironment-contextual cell signaling is attenuated with age

  Henriette C. Ertsås, et al., bioRxiv - Cell Biology 2019

  Quote: ... anti-pAKT (1/200, Cell Signaling #4060), anti-pY1494 ITGβ4 (1/100 ...
• Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability

  Dina Simkin, et al., bioRxiv - Neuroscience 2019

  Quote: ... synapsin (Cell signaling #5297, AB_2616578, 1:200), Map2 (Millipore MAB3418 ...