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2751 - 2800 of 10000+ citations for 7 Methyl 1 5 dioxo 1 2 3 5 tetrahydro indolizine 6 carbonitrile since 2019

• The novel linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse embryonic development

  Sung-Eun Kim, et al., bioRxiv - Genetics 2024

  Quote: ... GFP (Cell signaling #2956; 1:1000), HA (Cell signaling #3724 ...
• The novel linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse embryonic development

  Sung-Eun Kim, et al., bioRxiv - Genetics 2024

  Quote: ... Gli1 (Cell signaling #2534; 1:500), GAPDH (Cell signaling #2118 ...
• Systemic Dosing of Virus-derived Serpin Improves Survival and Immunothrombotic Damage in Murine Colitis

  Liqiang Zhang, et al., bioRxiv - Molecular Biology 2024

  Quote: ... M2 macrophage arginase-1 (Cell Signaling, 93668 ...
• Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in syndrome caused by mutated trappc9

  Yan Li, et al., bioRxiv - Neuroscience 2024

  Quote: ... PSD95 (1:1000, Cell Signaling, 2507S), Dlg2 (1:200 ...
• Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

  Dong Wang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... S6 (Cell Signaling, 2217T, 1:1000), Phosphor-S6 (Cell Signaling ...
• Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

  Dong Wang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... MYC (Cell signaling, 13987S, 1:50), Pol II (Cell signaling ...
• Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

  Dong Wang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... H3K27me3 (Cell signaling, 9733s, 1:50), and IgG (EpiCypher ...
• Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

  Dong Wang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... BRD4 (Cell signaling, 13440S, 1:50), H3K27ac (Active motif ...
• Metastatic site influences driver gene function in pancreatic cancer

  Kaloyan M. Tsanov, et al., bioRxiv - Cancer Biology 2024

  Quote: ... RUNX1 (Cell Signaling #8529, 1:1000), and Actin-HRP (Sigma #A3854 ...
• Human MX1 orchestrates the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs

  Joe McKellar, et al., bioRxiv - Microbiology 2024

  Quote: ... Rab11 (Cell Signaling, 5589 1/50), Rab11a (Proteintech ...
• Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration

  Ligia B. Schmitd, et al., bioRxiv - Neuroscience 2024

  Quote: ... α-p75NTR (Cell Signaling #8238, 1:1000), α-c-Jun (Cell Signaling #9165 ...
• Profound seizure suppression and disease modification by targeting JAK1, a key driver of a pro-epileptogenic gene network

  Olivia R. Hoffman, et al., bioRxiv - Neuroscience 2023

  Quote: ... STAT1 (1:1000, #14994 Cell Signaling), pS727-STAT1 (1:1000 ...
• Profound seizure suppression and disease modification by targeting JAK1, a key driver of a pro-epileptogenic gene network

  Olivia R. Hoffman, et al., bioRxiv - Neuroscience 2023

  Quote: ... STAT2 (1:1000, #72604 Cell Signaling), pY1007/08-JAK2 (1:500 ...
• Impaired 26S proteasome causes learning and memory deficiency and induces neuroinflammation mediated by NF-κB in mice

  Christa C. Huber, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-PSD95 (1:1000, Cell Signaling), anti-NF-κB (1:1000 ...
• Impaired 26S proteasome causes learning and memory deficiency and induces neuroinflammation mediated by NF-κB in mice

  Christa C. Huber, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-Trem2 (1:1000, Cell Signaling), anti-Actin (1:1000 ...
• Small-molecule degraders reduce Aβ production through CAPRIN1-mediated lysosomal degradation of APP in Alzheimer’s iPSC-derived neurons

  Sunghan Jung, et al., bioRxiv - Neuroscience 2023

  Quote: ... Presenilin 1 (Cell Signaling Technology, 5643), Presenilin 2 (Cell Signaling Technology ...
• A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

  Maritza Puray-Chavez, et al., bioRxiv - Microbiology 2024

  Quote: ... STAT1 (Cell Signaling #14994, 1:1000), MX1 (Cell Signaling #37849 ...
• A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

  Maritza Puray-Chavez, et al., bioRxiv - Microbiology 2024

  Quote: ... IFIT1 (Cell Signaling #14769, 1:1000), STING (Cell Signaling #13647S ...
• A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

  Maritza Puray-Chavez, et al., bioRxiv - Microbiology 2024

  Quote: ... IRF3 (Cell Signaling #4302S, 1:1000), SARS-CoV-2 Nucleocapsid (Sino Biological # 40588-T62 ...
• A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

  Maritza Puray-Chavez, et al., bioRxiv - Microbiology 2024

  Quote: ... TBK1 (Cell Signaling #38066S, 1:1000), IRF3 (Cell Signaling #4302S ...
• A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

  Maritza Puray-Chavez, et al., bioRxiv - Microbiology 2024

  Quote: ... cGAS (Cell Signaling #15102S, 1:1000), TBK1 (Cell Signaling #38066S ...
• A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

  Maritza Puray-Chavez, et al., bioRxiv - Microbiology 2024

  Quote: ... MX1 (Cell Signaling #37849, 1:1000), IFIT1 (Cell Signaling #14769 ...
• A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

  Maritza Puray-Chavez, et al., bioRxiv - Microbiology 2024

  Quote: ... STING (Cell Signaling #13647S, 1:1000), cGAS (Cell Signaling #15102S ...
• Exploiting a metabolic vulnerability in brain tumour stem cells using a brain-penetrant drug with safe profile

  Audrey Burban, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Notch1 (1:1000, Cell Signaling, #CST3608), Olig2 (1:2000 ...
• RNA G-quadruplex dynamic steers the crosstalk between protein synthesis and energy metabolism

  Leïla Dumas, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Tubulin (1:1000, Cell Signaling CS2146), Lamin A (1:1000 ...
• Co-Essentiality Analysis Identifies PRR12 as a Regulator of Cohesin and Genome Integrity

  Alexandra L. Nguyen, et al., bioRxiv - Cell Biology 2024

  Quote: ... SMC4 (1:500, Cell Signaling; D14E2), H3S10p (1:250 ...
• Microbial Metabolite Trimethylamine N-Oxide Promotes Campylobacter jejuni Infection by Escalating Intestinal Inflammation, Epithelial Damage, and Barrier Disruption

  Caitlyn B. Smith, et al., bioRxiv - Microbiology 2024

  Quote: ... zonula occludens-1 (Cell Signaling Technologies), zonula occludens-2 (ZO-2 ...
• Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation

  Tanusri Roy, et al., bioRxiv - Cell Biology 2024

  Quote: ... γ-H2AX (1:500, Cell signaling Technologies), Lamin A/C (1:400 ...
• Dual agonism of sodium iodide symporter function in vivo

  Katie Brookes, et al., bioRxiv - Cancer Biology 2024

  Quote: ... VCP (1:1000; Cell Signaling Technology) and β-actin (1:10000 ...
• Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

  Dong Wang, et al., bioRxiv - Cancer Biology 2024

  Quote: ... 4EBP1 (Cell Signaling, 9644S, 1:1000), Phosphor-4EBP1 (Cell Signaling ...
• Co-Essentiality Analysis Identifies PRR12 as a Regulator of Cohesin and Genome Integrity

  Alexandra L. Nguyen, et al., bioRxiv - Cell Biology 2024

  Quote: ... CTCF (1:500, Cell Signaling; D31H2), SMC4 (1:500 ...
• Macrophage epigenetic memories of early life injury drive neonatal nociceptive priming

  Adam J. Dourson, et al., bioRxiv - Neuroscience 2023

  Quote: ... p75NTR 1:1000 (Cell Signaling 82385); F4/80 1:500 (Abcam ab6640) ...
• Chronic activation of tubulin tyrosination in HCM mice and in human iPSC-engineered heart tissues improves heart function

  Niels Pietsch, et al., bioRxiv - Physiology 2024

  Quote: ... α-tubulin (1:1,000, Cell Signaling), dTyr-tub (1:1,000 ...
• Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

  Brian T. Do, et al., bioRxiv - Cancer Biology 2024

  Quote: ... PU.1 (Cell Signaling Technologies #2258), and vinculin (Cell Signaling Technologies #13901) ...
• Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

  Devon E. Mason, et al., bioRxiv - Cell Biology 2024

  Quote: ... pMLC (1:200, Cell signaling, 3675). Primary antibodies were detected secondaries antibodies diluted in PBS with 1% goat serum ...
• Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

  Devon E. Mason, et al., bioRxiv - Cell Biology 2024

  Quote: ... TAZ (1:250, Cell Signaling, 4883), Vinculin (1:100 ...
• Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

  Devon E. Mason, et al., bioRxiv - Cell Biology 2024

  Quote: ... TAZ (1:1000, Cell Signaling, 4883), pMLC (1:1000 ...
• Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

  Devon E. Mason, et al., bioRxiv - Cell Biology 2024

  Quote: ... GAPDH (1:3000, Cell Signaling, 5174) were incubated overnight in blocking buffer with .2% tween-20 (Fisher Scientific) ...
• Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma

  Moriah R. Arnold, et al., bioRxiv - Cell Biology 2024

  Quote: ... γH2AX (Cell Signaling #9718, 1:500), Treacle (Sigma-Aldrich #GW22821 ...
• Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma

  Moriah R. Arnold, et al., bioRxiv - Cell Biology 2024

  Quote: ... or γH2AX (1:1,000; Cell Signaling) and 1 hour at RT with IRDye 680CW Goat anti-mouse (1:10,000 ...
• The novel linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse embryonic development

  Sung-Eun Kim, et al., bioRxiv - Genetics 2024

  Quote: ... HA (Cell signaling #3724; 1:1000), Flag (Sigma F1804 ...
• Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy

  Nipun Verma, et al., bioRxiv - Genetics 2024

  Quote: ... IRF3 (Cell Signaling # 11904, 1:1000), GAPDH (ThermoFisher # MA1-16757 ...
• Nephronophthisis-associated FBW7 mediates cyst-dependent decline of renal function in ADPKD

  Maulin Mukeshchandra Patel, et al., bioRxiv - Genetics 2024

  Quote: ... VIMENTIN (1:200, Cell Signaling 5741), α-SMOOTH MUSCLE ACTIN (1:200 ...
• Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy

  Nipun Verma, et al., bioRxiv - Genetics 2024

  Quote: ... TBK1 (Cell Signaling # 3504, 1:1000), IRF3 (Cell Signaling # 11904 ...
• Microbial Metabolite Trimethylamine N-Oxide Promotes Campylobacter jejuni Infection by Escalating Intestinal Inflammation, Epithelial Damage, and Barrier Disruption

  Caitlyn B. Smith, et al., bioRxiv - Microbiology 2024

  Quote: ... zonula occludens-1 (Cell Signaling Technologies), zonula occludens-2 (ZO-2 ...
• LRRK2 G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3

  Ningbo Zheng, et al., bioRxiv - Immunology 2024

  Quote: ... (1:4000, #7076, Cell Signaling Technology).
• Chitinase 3-like-1 (CHI3L1) Inhibits Innate Anti-Tumor and Tissue Remodeling Immune Responses by Regulating CD47-SIRPα and CD24-Siglec10-Mediated Phagocytosis

  Bing Ma, et al., bioRxiv - Immunology 2024

  Quote: ... SHP-1 (Cell Signaling Technology, C14H6), and SHP-2 (Cell Signaling Technology ...
• Profound seizure suppression and disease modification by targeting JAK1, a key driver of a pro-epileptogenic gene network

  Olivia R. Hoffman, et al., bioRxiv - Neuroscience 2023

  Quote: ... JAK2 (1:1000, #3230 Cell Signaling), JAK1 (1:1000 ...
• Profound seizure suppression and disease modification by targeting JAK1, a key driver of a pro-epileptogenic gene network

  Olivia R. Hoffman, et al., bioRxiv - Neuroscience 2023

  Quote: ... JAK1 (1:1000, #3344S Cell Signaling), STAT1 (1:1000 ...
• Profound seizure suppression and disease modification by targeting JAK1, a key driver of a pro-epileptogenic gene network

  Olivia R. Hoffman, et al., bioRxiv - Neuroscience 2023

  Quote: ... STAT3 (1:1000, #12640 Cell Signaling), JAK2 (1:1000 ...