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2601 - 2650 of 10000+ citations for 4' Trifluoromethoxy 5 trifluoromethyl 1 1' biphenyl 3 carboxylic acid since 2020

• Maintaining intact parathyroid glands throughout life requires Dicer and microRNA-mediated mTORC1 signaling

  Alia Hassan, et al., bioRxiv - Developmental Biology 2023

  Quote: ... CASPASE 3 (Cell Signaling Technologies 9661S), both of which were diluted at 1:200 and DAPI nuclear staining.
• Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems

  Alessandra Tammaro, et al., bioRxiv - Pathology 2023

  Quote: ... total Histone 3 (Cell signaling #9715), acetylated Histone H4 (Lys8 ...
• IRE1 RNase controls CD95-mediated cell death

  D Pelizzari-Raymundo, et al., bioRxiv - Cell Biology 2022

  Quote: ... Cleaved caspase-3 (Cell signaling, 9661), FADD (Cell signaling ...
• Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism

  Akihiro Yamashita, et al., bioRxiv - Cell Biology 2023

  Quote: ... Cleaved Caspase-3 (Cell Signaling, 9661), Cleaved Caspase-7 (Cell Signaling ...
• Development of novel cytoprotective small compounds inhibiting mitochondria-dependent apoptosis

  Mieko Matsuyama, et al., bioRxiv - Cell Biology 2023

  Quote: ... Caspase-3 (Cell Signaling, 9662, 1000X), and anti-beta actin (Sigma Aldrich ...
• Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

  Marine Berquez, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-cleaved caspase 3 (Cell signaling), 9662 ...
• Personalized models of breast cancer desmoplasia reveal biomechanical determinants of drug penetration

  Giovanni S. Offeddu, et al., bioRxiv - Bioengineering 2023

  Quote: ... Caspase-3 (#9661S, Cell Signaling Technology), COL-1 (#AF6220-SP ...
• Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems

  Alessandra Tammaro, et al., bioRxiv - Pathology 2023

  Quote: ... total Histone 3 (Cell signaling #9715), acetylated Histone H4 (Lys8 ...
• HDL regulates TGFß-receptor lipid raft partitioning, restoring contractile features of cholesterol-loaded vascular smooth muscle cells

  Prashanth Thevkar Nagesh, et al., bioRxiv - Molecular Biology 2023

  Quote: ... SMAD2/3 (Cell Signaling, Cat. #8685); TUBA (Sigma ...
• A Novel Interaction Between Aquaporin 1 and Caspase-3 in Pulmonary Arterial Smooth Muscle Cells

  Shannon Niedermeyer, et al., bioRxiv - Cell Biology 2023

  Quote: ... total caspase 3 (Cell Signaling 9662S); and cleaved caspase 3 (Cell Signaling 9664S) ...
• RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability

  Vincent E. Provasek, et al., bioRxiv - Biochemistry 2024

  Quote: ... cleaved-caspase-3 (Cell Signaling #9664), and PARP-1 (Cell Signaling #9542).
• Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis

  Gabriela Pessenda, et al., bioRxiv - Immunology 2024

  Quote: ... cleaved caspase 3 (5A1E, Cell Signaling) 1:100 ...
• Epstein-Barr Virus Latent Membrane Protein 1 Subverts IMPDH pathways to drive B-cell oncometabolism

  Eric M. Burton, et al., bioRxiv - Microbiology 2024

  Quote: ... Caspase 3 (Cell Signaling Technology, #9662), EBNA1 (a gift from Jaap Middledorp) ...
• Cytoplasmic expression of the cell cycle regulator cyclin D1 in radial glial progenitor cells modulates brain cortex development

  Neus Pedraza, et al., bioRxiv - Neuroscience 2024

  Quote: ... α-cleaved caspase-3 (Cell Signaling, 9661) or α-HA (Sigma ...
• TBK1 and IKKε protect target cells from IFNγ-mediated T cell killing via an inflammatory apoptotic mechanism

  Nicholas D. Sun, et al., bioRxiv - Immunology 2024

  Quote: ... cleaved caspase 3 (Cell Signaling, 9661S), cleaved PARP (Cell Signaling ...
• Role of Arginine and its Metabolism in TGF-β-Induced Activation of Lung Fibroblasts

  Robert B Hamanaka, et al., bioRxiv - Cell Biology 2024

  Quote: ... Phospho-SMAD2/3 (Cell Signaling, 9520), SMAD2/3 (Cell Signaling ...
• Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoids

  Kaja Nicole Wächtershäuser, et al., bioRxiv - Cancer Biology 2024

  Quote: ... α-caspase-3 (9662S, Cell Signaling Technologies), α-cleaved-caspase-3 (9661 ...
• Endothelial Rho kinase controls blood vessel integrity and angiogenesis

  Martin Lange, et al., bioRxiv - Developmental Biology 2024

  Quote: ... PAK1/2/3 (Cell Signaling, # 2604S), pLIMK1/2 (Cell Signaling ...
• Enhanced in vivo gene knockout with undetectable off-targets using multiplexed Cas12a sgRNAs

  Fillip Port, et al., bioRxiv - Genetics 2024

  Quote: ... anti-phosphorylated Histone 3 (Cell Signaling) and anti-Smoothened (DSHB ...
• Interferon-Gamma Signaling Promotes Melanoma Progression and Metastasis

  Bo Zhou, et al., bioRxiv - Cancer Biology 2021

  Quote: ... IRF1 (D5E4, 1:1,000; Cell Signaling Technology). The secondary antibodies used for detection were horseradish peroxidase (HRP)–conjugated goat anti-mouse and goat anti-rabbit IgG (1:5,000 ...
• Interferon-Gamma Signaling Promotes Melanoma Progression and Metastasis

  Bo Zhou, et al., bioRxiv - Cancer Biology 2021

  Quote: ... STAT3 (124H6, 1:1,000; Cell Signaling Technology), pSTAT3 (Y705 ...
• Inhibition of Metastatic Uveal Melanoma Cell Proliferation by the Histone Deacetylase 6 Inhibitor, Ricolinostat, is Linked to Altered Microphthalmia-associated Transcription Factor and Phospho-ERK Expression

  Husvinee Sundaramurthi, et al., bioRxiv - Cancer Biology 2021

  Quote: ... GAPDH (1:1000; #2118, Cell Signaling Technology) and β-actin (1:1000 ...
• ASO-based PKM Splice-switching Therapy Inhibits Hepatocellular Carcinoma Cell Growth

  Wai Kit Ma, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rb-E-cadherin (1:1,000; Cell Signaling), rb-Vimentin (1:1,000 ...
• Haploinsufficient tumour suppressor PRP4K is negatively regulated during epithelial-to-mesenchymal transition

  Livia E. Clarke, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and anti-Zo-1 (Cell Signaling, 8193) (1:1000) ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... 4E-BP1 (1:1000, Cell Signaling Technology), HIF-1α (1:1000 Novus Biologicals) ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Cleaved PARP (1:1000, Cell Signaling Technology), Caspase 3 (1:1000 ...
• A subset of CB002 xanthine analogues bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

  Liz J. Hernández Borrero, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pH3 (#3377) (1:1,000; Cell Signaling Technology) and β-actin (1:10000 ...
• Loss of the H4 lysine methyltransferase KMT5B drives tumorigenic phenotypes by depleting H3K27me3 at loci otherwise retained in H3K27M mutant DIPG cells

  Ketty Kessler, et al., bioRxiv - Cancer Biology 2021

  Quote: ... H3K27me3 at 1/500 (#9735, Cell Signaling), H3 at 1/2000 (#9715 ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p53 (Cell Signaling Technology, #2527, 1:1000), CDK4 (Cell Signaling Technology ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... RB (Cell Signaling Technology, #9313, 1:1000), p-CREB (Cell Signaling Technology ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CDK4 (Cell Signaling Technology, #12790, 1:1000), P-ERK (Cell Signaling Technology ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CREB (Cell Signaling Technology, #9104, 1:1000), tyrosinase (Abcam ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... AKT (Cell Signaling Technology, #9272, 1:1000) CHRM1 (Invitrogen ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... FoxM1 (Cell Signaling Technology, #5436, 1:1000). After incubation with the appropriate secondary antibody ...
• Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors

  Angela M. Carter, et al., bioRxiv - Cancer Biology 2021

  Quote: ... GFP (Cell Signaling Technology 2956; 1:2000), SSTR2 (Santa Cruz sc-365502 ...
• Dissection of N-, O- and glycosphingolipid glycosylation changes in PaTu-S pancreatic adenocarcinoma cells upon TGF-β challenge

  Jing Zhang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Slug 1:1000 (IB: 9585, Cell Signaling), SOX4 1:1000 (IB ...
• NMNAT promotes glioma growth through regulating post-translational modifications of p53 to inhibit apoptosis

  Jiaqi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-SIRT1 (1:1000, Cell Signaling, 2492), anti-acetyl-p53 (1:1000 ...
• Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma

  Marc A. Vittoria, et al., bioRxiv - Cancer Biology 2021

  Quote: ... secondary antibodies (1:5000, Cell Signaling Technology) for 1 h ...
• Deregulation of the histone H3K9 di-methylation landscape suppresses canonical Wnt signaling in embryonal rhabdomyosarcoma

  Ananya Pal, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-H3K9me2 (#9753S, 1:1000, Cell Signaling), anti-ß-actin (#A2228 ...
• BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

  Tianyi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... β-actin (Cell Signaling Technology, 3700S, 1:2000), ERK1/2 (Cell Signaling Technology ...
• BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

  Tianyi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... BRAF (Cell Signaling Technology, 9433, 1:500), CRAF (Cell Signaling Technology ...
• BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

  Tianyi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... CRAF (Cell Signaling Technology, 9422, 1:500), Akt1 (Abcam ...
• Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD⁺ signaling

  Mustafa N. Okur, et al., bioRxiv - Cell Biology 2020

  Quote: ... p-DRP-1 (S616, Cell signaling, #3455), Beclin-1 (Cell signaling ...
• Boron induces osteogenesis by stimulating NaBC1 in cooperation with BMPR1A

  Patricia Rico, et al., bioRxiv - Cell Biology 2020

  Quote: ... pMLC-intracellular tension (Cell Signaling, 1:200), integrin α5 (abcam ...
• Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

  Chen Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... NGFR (1:1000) (Cell Signaling Technology, #8238), SOX10 (1:1000 ...
• Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

  Chen Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... GAPDH (1:2000) (Cell Signaling Technology, #5174), ATF4 (1:200 ...
• Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

  Chen Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... AXL (1:200) (Cell Signaling Technology, #8661), MITF (1:100 ...
• Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

  Chen Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... ATF4 (1:200) (Cell Signaling Technology, #11815S), phospho-Rb S780 (1:1500 ...
• Rapidly induced drug adaptation mediates escape from BRAF inhibition in single melanoma cells

  Chen Yang, et al., bioRxiv - Cell Biology 2020

  Quote: ... γ-H2AX (1:400) (Cell Signaling Technology, #9718), and MCM2 (1:200 ...
• Gain-of-function mutations amplify cytotoxic FAM111 protease activity in human genetic disorders

  Saskia Hoffmann, et al., bioRxiv - Cell Biology 2020

  Quote: ... histone H2AX (2595, Cell Signaling (1:1,000)) ...