Labshake search

1851 - 1900 of 3119 citations for 7 Chloro 1H pyrrolo 2 3 c pyridine since 2019

• Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency

  Daisuke Ariyasu, et al., bioRxiv - Genetics 2019

  Quote: ... 2) anti-PERK rabbit monoclonal antibody C33E10 (Cell Signaling Technology, 3192) (dilution 1:1000) ...
• A live-cell screen for altered Erk dynamics reveals principles of proliferative control

  Alexander G. Goglia, et al., bioRxiv - Cell Biology 2019

  Quote: ... and anti-total-Erk1/2 mouse monoclonal antibody (Cell Signaling 4696). The next day ...
• TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Brain

  Huynh TH Nguyen, et al., bioRxiv - Neuroscience 2019

  Quote: ... p44/42 MAPK (ERK1/2, 1:1000, #9102 Cell Signaling Technologies) and phosphorylated ERK1/2 (pERK1/2 ...
• BAP31 regulated polarization of macrophages through C/EBP β in cutaneous wound healing

  Qing Yuan, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-Cox-2 were from Cell Signaling Technology (Danvers, MA, USA); anti-Ym1 was from STEM CELL (STEM CELL ...
• A developmental stage- and Kidins220/ARMS-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor

  Fanny Jaudon, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit monoclonal anti-phosphorylated MAPK1/2 (Thr202/Tyr204, #4377, Cell signaling), rabbit polyclonal anti-MAPK1/2 (#06-182 ...
• Endothelial cell polarity and extracellular matrix production rely on functional ATP6AP2 during developmental and pathological angiogenesis

  NR Patel, A Blanks, Y Li, MC Prieto, SM Meadows, bioRxiv - Molecular Biology 2021

  Quote: ... anti-p44/42 MAPK (Erk1/2) (Cell signaling, 4695, 1:1000), anti-phospho-p44/42 MAPK (pErk1/2 ...
• Limited inhibition of multiple nodes in a driver network blocks metastasis

  Ali E. Yesilkanal, et al., bioRxiv - Cancer Biology 2020

  Quote: Phopsho-p44/42 MAPK (ERK1/2)(Thr202/Tyr204) (Cell Signaling, 9101)
• Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor

  Jie Li, Jiayi Wu, Xiao-chen Bai, Eunhee Choi, bioRxiv - Cell Biology 2022

  Quote: ... anti-pERK1/2 (WB, 1:000; 197G2, Cat. #4377, Cell Signaling); anti-IR (WB ...
• In vivo KRAS G12D/V degradation mediated by CANDDY using a modified proteasome inhibitor

  Satoshi Imanishi, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... Erk1/2 (p44/42 MAPK) (1:1000, #4695; Cell Signaling Technology), p-Akt (1:2000 ...
• BCAA catabolism drives adipogenesis via an intermediate metabolite and promotes subcutaneous adipose tissue expansion during obesity

  Jing Shao, et al., bioRxiv - Physiology 2022

  Quote: ... anti-Erk1/2 (#9102) antibodies were purchased from Cell Signaling Technology. Anti-C/EBPα (ab18336) ...
• P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway

  Zhijia Wang, et al., bioRxiv - Biochemistry 2022

  Quote: ... anti-p44/42 MAPK (Erk1/2) (Cell Signaling Technology, 1:4000). Manufacturers provide validation for all antibodies.
• ACE1 knockout in neurons selectively dysregulates the hippocampal renin angiotensin system and causes vascular loss

  Sohee Jeon, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-p44/42 (Erk1/2) (#CS 137F5, Cell Signaling Technology), rabbit anti-angiotensinogen (#79299 ...
• Prenatal Arsenite Exposure Alters Maternal Cardiac Remodeling During Late Pregnancy

  Nicole Taube, et al., bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... p44/42 MAPK (ERK1/2) (1:1000, Rabbit mAb, Cell Signaling), and p-p44/42 MAPK (T202/Y204 ...
• Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function

  Chao Chang, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-pERK1/2 (Thr202/Tyr204; Cell Signaling Technology, #9101; RRID:AB_331646), rabbit anti-ERK1/2 (Cell Signaling Technology ...
• Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target

  Lucas Caldi Gomes, et al., bioRxiv - Neuroscience 2024

  Quote: ... and rabbit anti Phospho-MEK1/2 (Ser217/221) (Cell Signaling Technology, Danvers ...
• Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target

  Lucas Caldi Gomes, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti Phospho-p44/42 MAPK(ERK1/2) (Cell Signaling Technology, Danvers ...
• Insulin Receptor Loss Impairs Mammary Tumorigenesis in Mice

  Lauren Podmore, et al., bioRxiv - Cancer Biology 2023

  Quote: ... phospho-p44/42 MAPK (Erk1/2) (T202/Y204) (Cell Signaling #9101), S6 (Cell Signaling #2217) ...
• EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

  Joaquin Olmedo-Pelayo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... extracts were incubated with 2 µl Micrococcal Nuclease (Cell Signaling, 10011) and sonicated in a Bioruptor (Diagenode ...
• CRIPTO promotes extracellular vesicle uptake and activation of cancer associated fibroblasts

  David W. Freeman, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-ERK1/2 (Thr202/204) (Clone D13.144E, Cell Signaling, 1:1000), ERK1/2 (L34F12 ...
• A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane

  Jofre Font-Mateu, et al., bioRxiv - Genomics 2023

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling #9106S), HP1 gamma (Millipore 05-690).
• NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma

  Claudia Cirotti, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho-ERK 1/2 (Thr202/Tyr204) (D13.14.4E) (Cell Signaling Technology), anti-Ubiquitin (P4D1 ...
• Inhibition of Cellular MEK/ERK Signaling Suppresses Murine Papillomavirus Type 1 Replicative Activities and Promotes Tumor Regression

  Adrian J. Luna, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Immunohistochemical detection of p-ERK1/2 (Cell Signaling #4370; 1:500) required the tyramide signal amplification (TSA ...
• Actomyosin-II Proactively Shields Axons of the Central Nervous System from Mild Mechanical Stress

  Xiaorong Pan, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-Phospho-Myosin Light Chain 2 (Thr18/Ser19) (Cell Signaling, #3674); anti-Myosin Light Chain 2 (Cell Signaling ...
• In Silico Transcriptome-based Screens Identify Epidermal Growth Factor Receptor Inhibitors as Therapeutics for Noise-induced Hearing Loss

  Sarath Vijayakumar, et al., bioRxiv - Neuroscience 2023

  Quote: ... phospho forms (AKT-S473 and ERK1/2-T202/Y204, Cell Signaling) and β-actin (Sigma A3854).
• Anti-apoptotic and anti-inflammatory properties of grapefruit IntegroPectin on human microglial HMC3 cell line

  Miriana Scordino, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-p-ERK1/2 (1:1000, 9101 Cell Signaling Technology), rabbit anti-p-Akt (1:1000 ...
• Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

  Jayne Aiken, Erika L. F. Holzbaur, bioRxiv - Cell Biology 2023

  Quote: ... and Synaptobrevin-2 (anti-rabbit; Cell Signaling; 13508; 1:250 dilution). Following three washes with PBS ...
• Secreted soluble factors from tumor-activated mesenchymal stromal cells confer platinum chemoresistance to ovarian cancer cells

  Yifat Koren Carmi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-phospho-ERK1/2 (Thr202/Tyr204) (D13.14.4E, Cell Signaling Technology) as per the manufacturers’ instructions ...
• EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

  Sukanya Chakraborty, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho-ERK1/2-Thr202/Tyr204 (#9101) from Cell Signaling Technology; and anti-beta-actin (#A5441 ...
• Oncogenic Kras^G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8⁺ T cells dependent manner

  Krishnan K. Mahadevan, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Cell Signaling 4376S, 1:1000) and Vinculin (Abcam ab129002 ...
• Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function

  Rajan K C, et al., bioRxiv - Molecular Biology 2023

  Quote: ... p44/42 MAPK (ERK1/2) (Cell Signaling Technology, 4695S, 1:1,000), p-p44/42 MAPK (pERK1/2 ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... mouse anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-phospho myosin light chain 2 (Cell signaling ...
• Spatiotemporal Proteomics Deciphers Functional Selectivity of EGFR ligands

  Akihiro Eguchi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... mouse anti-phospho-Erk1/2 (T202/T204) (#9106; Cell Signaling Technology), rabbit anti-Clint1 (ab251892 ...
• Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2

  Iqra Nazish, et al., bioRxiv - Neuroscience 2023

  Quote: ... and anti-4′,6-diamidino-2-phenylindole (DAPI) (Cell Signaling #4083). The primary microglial yield was approximately 5 × 105 cells/flask with minimal astrocyte contamination ...
• HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

  Hongbo Ling, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho-ERK1/2 (Thr202/Tyr204) (Cell Signaling Technology, #9101, RRID:AB_331646), anti-ERK1/2 (Cell Signaling Technology ...
• Ascites in malignant ovarian cancer confer ovarian cancer cells chemoresistance to platinum. Combination treatment with crizotinib and 2-hydroxyestradiol restores platinum sensitivity

  Yifat Koren Carmi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-phospho-ERK1/2 (Thr202/Tyr204) (D13.14.4E, Cell Signaling Technology) according to the manufacturers’ instructions ...
• Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

  Anagha Inguva Sheth, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Primary antibodies used include BCL-2 (Cell Signaling Technologies, no.15071), SERCA3 (Biorad ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-cofilin (Abcam ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-cofilin (Abcam ...
• FGF9, a potent mitogen, is a new ligand for integrin αvβ3, and the FGF9 mutant defective in integrin binding acts as an antagonist

  Chih-Chieh Chang, et al., bioRxiv - Biochemistry 2023

  Quote: ... rabbit anti-p44/42 MAPK (ERK1/2) (Cell Signaling Technology, USA), anti-phospho-p44/42 MAPK (p-ERK1/2 ...
• FDA-Approved MEK1/2 Inhibitor, Trametinib, Protects Mice from Cisplatin and Noise-Induced Hearing Loss

  Richard D. Lutze, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-pERK1/2 (Thr202/Tyr204, 9101S, Cell Signaling Technologies, 1:1000) and anti-GAPDH (ab181602 ...
• Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions

  Yan Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... P-ERK1/2 (Thr202/Tyr204) (1:1000, #9101, Cell Signaling Technology), β-actin (1:1000 ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-phospho-MAPKAPK-2 (Thr222) (1:1000, Cell Signaling 3316), rabbit anti-p38 MAPK (1:1000 ...
• Distinct Mechanisms of Type 3 Secretion System Recognition Control LTB₄ Synthesis in Neutrophils versus Macrophages

  Amanda Brady, et al., bioRxiv - Immunology 2024

  Quote: ... anti-p-p44/42 (ERK1/2) (Cell Signaling; Cat. No. 9101s), anti-p44/42 (Cell Signaling ...
• Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation

  Qin Ni, et al., bioRxiv - Biophysics 2024

  Quote: ... anti-p44/42 MAPK (ERK1/2; Cell Signaling; 4695; 1:1000). GAPDH was used as a loading control (Cell Signaling ...
• Inhibitory effects of Akt on neuronal FoxO4 activation after subarachnoid hemorrhage in vivo and in vitro

  Min Qi, et al., bioRxiv - Neuroscience 2020

  Quote: ... SOD2 and apoptosis-related proteins Cleaved-Caspase 3 were purchased from Cell Signaling Technology (Beverly, MA, USA). After the membranes were washed three times for 10 minutes each in PBST ...
• Cell cycle progression requires repression by Groucho during S-phase and its relief at G2-phase

  Shaked Bar-Cohen, Ze’ev Paroush, bioRxiv - Developmental Biology 2022

  Quote: Primary antibodies used in this study were: rabbit anti-phospho-Histone 3 (1:100; Cell Signaling #9701); mouse anti-phospho-Histone 3 (1:100 ...
• NatB modulates Rb mutant cell death and tumor growth by regulating EGFR/MAPK signaling through the N-end rule pathways

  Zhentao Sheng, Wei Du, bioRxiv - Cell Biology 2019

  Quote: ... Primary antibodies used in this study: rabbit anti-activated Caspase-3 (C3, 1:400 from Cell Signaling), rabbit anti dpErk (1:400 ...
• Measurement and models accounting for cell death capture hidden variation in compound response

  Song Yi Bae, et al., bioRxiv - Cancer Biology 2019

  Quote: ... Each membrane was incubated overnight with antibody against cleaved caspase 3 (Cell Signaling Technology, Danvers, MA, #9664) or 1.5 hrs with HRP conjugated β-actin antibody (Cell Signaling Technology ...
• Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors

  Yasuaki Anami, et al., bioRxiv - Bioengineering 2021

  Quote: ... rabbit anti-cleaved caspase 3 antibody (9661S) and rabbit anti-EGFR antibody (4267S) from Cell Signaling Technology) ...
• Septins disruption controls tumor growth and enhances efficacy of Herceptin

  Rakesh K Singh, et al., bioRxiv - Cancer Biology 2020

  Quote: ... STAT-3 (catalog number: 4904) and GAPDH antibodies (catalog number: 2118s) were purchased from Cell Signaling Technology Inc ...