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101 - 150 of 10000+ citations for trans 2 2 4 Methoxyphenyl 2 oxoethyl cyclohexane 1 carboxylic acid since 2020

• Wnt-dependent activation of ERK mediates repression of chondrocyte fate during calvarial development

  Beatriz Ibarra, Cody Machen, Radhika P. Atit, bioRxiv - Developmental Biology 2021

  Quote: ... rabbit-anti-Erk1/2 (1:500, Cell Signaling 9102), rabbit-anti-Lef1 (1:500 ...
• Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1

  Amanda M. Rampersaud, et al., bioRxiv - Developmental Biology 2020

  Quote: ... phosphorylated ERK1/2 (E10, 1:2000, Cell Signaling Technology), focal adhesion kinase (FAK ...
• The neocortical progenitor specification program is established through combined modulation of SHH and FGF signaling

  Odessa R. Yabut, et al., bioRxiv - Developmental Biology 2020

  Quote: ... phosphor-Erk1/2 (1:100 dilution, Cell Signaling (#4370)) ...
• The Peroxiredoxin 6 gene plays a critical role in the homeostatic regulation of fear response

  Sarayut Phasuk, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-pERK1/2 (1:1000; Cell Signaling, Danvers, MA), anti-total ERK1/2 (1:1000 ...
• MEKK3-TGFβ crosstalk regulates inward arterial remodeling

  Hanqiang Deng, et al., bioRxiv - Pathology 2021

  Quote: ... p-ERK1/2 (Cell Signaling 4370; IB 1:1000).
• Protective mitochondrial fission induced by stress responsive protein GJA1-20k

  Daisuke Shimura, et al., bioRxiv - Cell Biology 2021

  Quote: ... and anti-MEK1/2 (1:1000, Cell Signaling Technology). After overnight primary antibody incubation at 4 °C ...
• Defective mitochondrial-lysosomal axis promotes extracellular vesicles release of mitochondrial components in Huntington’s Disease

  Margarida Beatriz, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-flotillin-2 (C42A3) (1:500, #3436,Cell Signaling), anti-calnexin (1:500 ...
• Collagen-VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche

  Vasileios Papalazarou, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-ERK1/2 (1:1000; 9102, Cell Signaling Technology), anti-GAPDH (1:1000 ...
• Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

  Antonio Cuevas-Navarro, et al., bioRxiv - Genetics 2022

  Quote: ... MEK1/2 (Cell Signaling Technologies, Cat #4694; 1:1000).
• Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

  Antonio Cuevas-Navarro, et al., bioRxiv - Genetics 2022

  Quote: ... ERK1/2 (Cell Signaling Technologies, Cat #4696; 1:2000), p-MEK (Cell Signaling Technologies ...
• Optimized transcriptional signature for evaluation of MEK/ERK pathway baseline activity and long-term modulations in ovarian cancer

  Mikhail S. Chesnokov, Anil Yadav, Ilana Chefetz, bioRxiv - Cancer Biology 2022

  Quote: ... total ERK1/2 (Cell Signaling Technology, 137F5, 1:1000), pp90RSK1 (R&D Systems ...
• IFT20 is critical for early chondrogenesis during endochondral ossification

  Hiroyuki Yamaguchi, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-ERK1/2 (Cell Signaling technology; #4695, 1:1,000), anti-active β-Catenin (Cell signaling technology ...
• Nicotinamide mononucleotide treatment increases NAD+ levels in an iPSC Model of Parkinson’s Disease

  Brett K. Fulleylove-Krause, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-SIRT 2 (Cell Signaling, 12672, 1:1000), rabbit anti-SIRT 3 (Abgent ...
• Presenilin-deficient neurons and astrocytes display normal mitochondrial phenotypes

  Sabrina Contino, et al., bioRxiv - Neuroscience 2020

  Quote: ... Anti-Presenilin 2 (1:1,000; Cell Signaling, Danvers, USA); Anti-Tubulin (1:3000 ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-ERK1/2 (Cell Signaling 4695, 1:2000), rabbit anti-phospho-PAK1 (S199/S204 ...
• Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

  Honglin Jiang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Erk1/2 (Cell Signaling Technology, 4696, Dilution: 1:1000); GAPDH (Cell Signaling Technology ...
• Adipocytes reprogram glucose metabolism in cancer cells promoting metastasis

  Abir Mukherjee, et al., bioRxiv - Cancer Biology 2022

  Quote: ... HK-2 (Cell Signaling Technology, cat# 2867, 1:1000), p-STAT3 Tyr 708 (Cell Signaling Technology ...
• Acquired and intrinsic resistance to vemurafenib in BRAF^V600E-driven melanoma brain metastases

  Ping Zhang, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... phospho-ERK1/2 (1:200; 4370; Cell Signaling Technology), phospho-AKT (1:8,000 ...
• PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

  Maria B. Campaña, et al., bioRxiv - Cell Biology 2023

  Quote: ... ERK1/2 (1:1000; 9102; Cell Signaling Technology, Inc.); phospho-AKT (Ser473 ...
• Rewiring of the TCR signalosome in natural intestinal Intraepithelial T lymphocytes drives non-deletional tolerance

  Harriet J. Watt, et al., bioRxiv - Immunology 2023

  Quote: ... SHP-1 or SHP-2 (all Cell Signaling Technology) followed by anti-rabbit Dylight649 (1:500 ...
• Competitive, connective and allosteric Nanobodies that modulate the SOS1•RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design

  Baptiste Fischer, et al., bioRxiv - Bioengineering 2023

  Quote: ... rabbit monoclonal ERK1/2 (1:50, Cell Signaling #4696), and mouse monoclonal Flag antibody (clone M2 ...
• Peripheral extracellular vesicle-derived miR-150-3p exacerbates acute kidney injury following acute pancreatitis by promoting ferroptosis through FTH1 signaling

  Ji-tao Cui, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-Cox-2 (1:1,000, 9461, Cell Signaling Technology), anti-β-actin (1:2,000 ...
• Phencyclidine disrupts neural coordination and cognitive control by dysregulating translation

  Eun Hye Park, et al., bioRxiv - Neuroscience 2023

  Quote: ... ERK1/2 (Cell Signaling Technology, Cat.No.9102S, 1:1000), phospho-4EBP1 (Cell Signaling Technology ...
• Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

  Tiantian Zhang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Mek1/2 (1:1,000, Cell Signaling Technology, Cat# 9122), alpha-tubulin (Sigma ...
• Neural stem cells protect blood-brain barrier integrity via the p38, JNK, and ERK1/2 pathways following intracerebral hemorrhage in rats

  Jing Sun, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-ERK1/2 (Cell Signaling, USA, 1:1000 dilution), anti-p38 (Cell Signaling ...
• Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

  Marco Di Gioia, et al., bioRxiv - Immunology 2023

  Quote: ... ERK1/2 (1:1000, Cell Signaling Technology, Cat# 9102), phospho-p38 (Thr180/Tyr182 ...
• Multifunctional molecular hybrid for targeted colorectal cancer cells: Integrating doxorubicin, AS1411 aptamer, and T9/U4 ASO

  Kanpitcha Jiramitmongkon, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Bcl–2 (1:1000; 25 – 28 kDa, Cell signaling), and Bax (1:1000 ...
• Reorganization of innate immune cell lipid profiles by bioinspired meroterpenoids to limit inflammation

  Lorenz Waltl, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... rabbit anti-MEK1/2 (1:1000; # 9122; Cell Signaling), rabbit anti-phospho-MEK1/2 (1:1000 ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-MAPKAPK-2 (1:1000, Cell Signaling 3042), rabbit anti-phospho-MAPKAPK-2 (Thr222 ...
• Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation, and cell cycle progression

  Nathaniel Shannon, et al., bioRxiv - Cell Biology 2024

  Quote: ... total MEK1/2 (1:1000, Cell Signaling Technology #9122), Cofilin (1:1000 ...
• The pro-apoptotic effect of chronic contractile activity-induced extracellular vesicles on Lewis Lung Carcinoma cells

  Patience O. Obi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... rabbit anti-Bcl-2 (3498, Cell Signaling, 1:1000), rabbit anti-Bax (2772 ...
• XPO1 inhibition modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis

  Andrew E. Evans, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-COX-2 (1/300; Cell Signaling, Cat# 12282S), anti-Ki67 (1/200 ...
• XPO1 inhibition modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis

  Andrew E. Evans, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-COX-2 (1/1000; Cell Signaling, Cat # 12282S), anti-Actin (1/5000 ...
• RyR2/IRBIT regulates insulin gene transcription, insulin content, and secretion in the insulinoma cell line INS-1

  Kyle E. Harvey, et al., bioRxiv - Cell Biology 2021

  Quote: ... ERK1/2 and pERK1/2 antibodies were from Cell Signaling Technology (Danvers, MA).
• KSR1 knockout mouse model demonstrates MAPK pathway’s key role in cisplatin- and noise-induced hearing loss

  Matthew A. Ingersoll, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-p-ERK1/2 (Thr202/Tyr204, 9101S), anti-MEK1/2 (9122S), and anti-p-MEK1/2 (Ser217/221, 41G9S) were obtained from Cell Signaling Technologies, and anti-α Tubulin (T9026 ...
• Effects of Emodin, a Plant-Derived Anthraquinone, on TGF-β1-Induced Cardiac Fibroblast Activation and Function

  Wayne Carver, et al., bioRxiv - Cell Biology 2021

  Quote: ... ERK1/2 or pERK1/2 (all from Cell Signaling Technology Inc, Danvers, MA, www.cellsignal.com). Nitrocellulose membranes were rinsed and incubated in horseradish peroxidase- conjugated anti-rabbit or anti-mouse serum as appropriate ...
• Regulation of early growth response-1 (Egr-1) gene expression by Stat1-independent type I interferon signaling and respiratory viruses

  Chilakamarti V. Ramana, bioRxiv - Genomics 2020

  Quote: ... and subjected to immunoblotting with the antibodies for phosphorylated Erk-1/2 (Thr202/Tyr 204) or total Erk-1/2 from Cell Signaling Technology (Beverly, MA). Blots were visualized by enhanced chemiluminescence western detection system (Pierce ...
• “Metabolic dysregulations of cancer cells with metastatic potential”

  Sara Abdul Kader, et al., bioRxiv - Cancer Biology 2021

  Quote: ... MMP-2 (Cell signaling, #40994), Vimentin (Cell signaling ...
• Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

  Anna L Koessinger, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pERK1/2 (Cell Signaling #4370), AKT (Cell Signaling #9272) ...
• Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

  Anna L Koessinger, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK1/2 (Cell Signaling #4695), pERK1/2 (Cell Signaling #4370) ...
• Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

  Anna L Koessinger, et al., bioRxiv - Cancer Biology 2021

  Quote: ... BCL-2 (Cell Signaling #2762), BCL-xL (Cell Signaling #2762) ...
• Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD⁺ signaling

  Mustafa N. Okur, et al., bioRxiv - Cell Biology 2020

  Quote: ... mitofusin 2 (Cell signaling, #9482), total OXHOS rodent cocktail (Abcam ...
• Peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

  Kanji Okumoto, et al., bioRxiv - Cell Biology 2020

  Quote: ... and Erk1/2 (Cell Signaling), mouse monoclonal antibodies to HA (16B12 ...
• Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling

  Brian Czaya, et al., bioRxiv - Cell Biology 2021

  Quote: ... ERK1/2 (4695, Cell Signaling), STAT3 (4904 ...
• Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

  Behnam Nabet, et al., bioRxiv - Cancer Biology 2020

  Quote: ... ERK1/2 (Cell Signaling, #4696), phospho-AKT S473 (Cell Signaling ...
• Peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

  Kanji Okumoto, et al., bioRxiv - Cell Biology 2020

  Quote: ... phospho-Erk1/2 (Cell Signaling), cytochrome P450 reductase (Santa Cruz Biotechnology ...
• LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer

  Donatella Delle Cave, et al., bioRxiv - Cancer Biology 2022

  Quote: ... MMP-2 (4022S, Cell Signaling), Vimentin (3932 ...
• COMBINATION THERAPIES TARGETING ALK-ABERRANT NEUROBLASTOMA IN PRECLINICAL MODELS

  Elizabeth R. Tucker, et al., bioRxiv - Cancer Biology 2022

  Quote: ... ERK1/2 (Cell Signaling #4695), pERK1/2 (Cell Signaling #9101) ...
• Hemodynamic stress activates inflammatory responses and cell death through spectrin-dependent modulation of Store Operated Calcium Entry

  Lance Hsieh, et al., bioRxiv - Cell Biology 2022

  Quote: ... ERK1/2 (4695, Cell Signaling), SPTAN1 (MAB1622 ...
• Apoptosis-induced FGF signalling promotes non-cell autonomous resistance to cell death

  Florian J. Bock, et al., bioRxiv - Cell Biology 2020

  Quote: ... pERK1/2 (4370, Cell Signaling), CASPASE 3 (9662 ...