Labshake search

101 - 150 of 10000+ citations for 2 Chloro 1 1 trifluoromethyl 1 3 4 9 tetrahydro 2H beta carbolin 2 yl ethan 1 one since 2020

• SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

  Brianna R. Daley, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-pMEK1/2 (Cell Signaling 9154; 1:1000), anti-MEK1/2 (Cell Signaling 4694 ...
• SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis

  Patricia L. Theard, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-ERK1/2 (Cell Signaling 4696; 1:1000), anti-pAKT Ser473 [Cell Signaling 4060 ...
• SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis

  Patricia L. Theard, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-pERK1/2 (Cell Signaling 4370; 1:1,000), anti-ERK1/2 (Cell Signaling 4696 ...
• Med12 cooperates with multiple differentiation signals to enhance embryonic stem cell plasticity

  Max Fernkorn, Christian Schröter, bioRxiv - Cell Biology 2024

  Quote: ... anti-pERK1/2 1:1000 (4370S, Cell Signaling), anti-total ERK1/2 1:1000 (ab36991 ...
• SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma

  Brianna R Daley, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-pERK1/2 (Cell Signaling 4370; 1:1,000), anti-ERK1/2 (Cell Signaling 4696 ...
• The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer’s disease

  Felipe C. Ribeiro, et al., bioRxiv - Neuroscience 2023

  Quote: ... 4E-BP1/2 (#2845, 1:1,1000; Cell Signaling), phospho-mTOR Ser2448 (#2971 ...
• SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma

  Brianna R Daley, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-ERK1/2 (Cell Signaling 4696; 1:1000) primary antibodies ...
• Lactoylglutathione promotes inflammatory signaling in macrophages

  Marissa N. Trujillo, et al., bioRxiv - Biochemistry 2023

  Quote: ... COX-2 (1:2000, Cell Signaling Technologies, #3582), H3K18La (1:1000 ...
• Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

  Christina Plattner, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho-ERK1/2 (Cell Signaling, #4377S, 1:1000), phosho-MEK1 (Invitrogen ...
• Population-level antagonism between FGF and BMP signaling steers mesoderm differentiation in embryonic stem cells

  Marina Gattiglio, et al., bioRxiv - Developmental Biology 2023

  Quote: ... anti- pERK1/2 1:1000 (Cell Signaling, 4370S), and anti-total ERK1/2 1:1000 (Abcam ...
• Loss of presenilin-1 in smooth muscle cells ameliorates elastin aortopathy

  Junichi Saito, et al., bioRxiv - Developmental Biology 2023

  Quote: ... PSEN-2 (Cell Signaling Technology, 9979; 1:1000), GAPDH (Cell Signaling Technology ...
• NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma

  Claudia Cirotti, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-ERK 1/2 (137F5) (Cell Signaling Technology), anti-phospho-ERK 1/2 (Thr202/Tyr204 ...
• Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands

  Lei Wang, et al., bioRxiv - Immunology 2024

  Quote: ... phospho-ERK1/2 (4370S, Cell Signaling, 1: 1000), GAPDH (5174S ...
• Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions

  Yan Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... ERK1/2 (1:1000, #9102, Cell Signaling Technology), P-ERK1/2 (Thr202/Tyr204 ...
• Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome

  Rosalba Olga Proce, et al., bioRxiv - Neuroscience 2024

  Quote: ... p-ERK1/2 (Cell Signaling, #4370, 1:500), ERK1/2 (Cell Signaling ...
• Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation, and cell cycle progression

  Nathaniel Shannon, et al., bioRxiv - Cell Biology 2024

  Quote: ... ERK1/2 (1:2000, Cell Signaling Technology #9102), phospho-MEK1/2 (S217/S221 ...
• The phosphorylation of Pak1 by Erk1/2 for cell migration requires Arl4D acting as a scaffolding protein

  Ting-Wei Chang, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-Erk1/2 (1:2000, #4695S, Cell Signaling), anti-pErk1/2 (1:2000 ...
• The phosphorylation of Pak1 by Erk1/2 for cell migration requires Arl4D acting as a scaffolding protein

  Ting-Wei Chang, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-pErk1/2 (1:2000, #4370S, Cell Signaling), anti-Pak1 (1:2000 ...
• Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets

  Jordan A Bairos, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and incubated overnight at 4°C with primary antibody detecting light chain 3 type 1 and 2 (Cell Signaling technology, catalog #3868), SOAT1 (catalog #84476) ...
• S-Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Cardiac Hypertrophy

  Matthew J. Brody, et al., bioRxiv - Molecular Biology 2021

  Quote: ... p-extracellular signal-regulated kinase (ERK) 1/2 (Cell Signaling Technology, #4370, 1:500), ERK1/2 (Cell Signaling Technology ...
• Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

  Alexa C. Cannon, et al., bioRxiv - Cancer Biology 2023

  Quote: ... phospho-ERK 1/2 Y202/204 1:2000 (Cell Signaling Technology Cat# 4370, RRID:AB_2315112), ERK 1:1000 (Cell Signaling Technology Cat# 4695 ...
• Identification of SIRT4 as a novel paralog-specific interactor and candidate suppressor of C-RAF kinase in MAPK signaling

  Mehrnaz Mehrabipour, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-p-ERK(1/2) (1:1000; #4370, Cell Signaling, Frankfurt am Main, Germany); anti-KRAS (1:1000 ...
• Synthesis of ionizable lipopolymers using split-Ugi reaction for pulmonary delivery of various size RNAs and gene editing

  K. Yu. Vlasova, et al., bioRxiv - Bioengineering 2024

  Quote: ... cycle 2 Rabbit E-Cadherin (Cell Signaling, 24E10 #3195, dilution 1:200, 1 h), cycle 3 Rabbit CD31 (Abcam ...
• Poly(ADP-ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation

  M Iqbal Hossain, et al., bioRxiv - Neuroscience 2023

  Quote: ... Bio-Rad),9 anti-HK-1 (Cell Signaling)] overnight at 4ᵒC ...
• Structural basis for BIRC6 to balance apoptosis and autophagy

  Shuo-Shuo Liu, et al., bioRxiv - Cell Biology 2022

  Quote: ... Caspase-9 (1:1000, Cell Signaling Technology, #9508), Cleaved Caspase-3 (1:1000 ...
• Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

  Hui Li, et al., bioRxiv - Neuroscience 2020

  Quote: ... The membranes were blocked with 5% non-fat dry milk for 2 h at RT and incubated overnight at 4°C with rabbit anti-phospho-ERK1/2 (1:2000, Cell Signaling), anti-phospho-Ser473-Akt (1:2000 ...
• A Two-Step Activation Mechanism Enables Mast Cells to Differentiate their Response between Extracellular and Invasive Enterobacterial Infection

  Christopher von Beek, et al., bioRxiv - Immunology 2023

  Quote: ... incubated 2h on RT or overnight at 4°C with antibodies for Akt (1:1000, Cell signaling, #9272) or P-Akt (Phospho-Akt (Ser473 ...
• Dynamic BMP signaling regulates sclerotome induction and lineage diversification in zebrafish

  Linjun Xie, et al., bioRxiv - Developmental Biology 2024

  Quote: ... rabbit polyclonal antibody to phosphoSmad 1/5/9 (1:100, Cell Signaling Technology, 13820), and chick polyclonal antibody to GFP (1:250 ...
• Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1

  Talita C. Conte, et al., bioRxiv - Cell Biology 2022

  Quote: ... and anti-beta-actin (4967S, 1:5,000; Cell Signaling) as primary antibodies ...
• Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

  Michael J. Podolsky, et al., bioRxiv - Cell Biology 2023

  Quote: ... or beta-Actin (1:10,000; Cell Signaling Technology, 13E5) overnight at 4°C ...
• Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

  Alexander G. Sorets, et al., bioRxiv - Bioengineering 2024

  Quote: ... beta-actin (Clone 13E5, Cell signaling 4970, 1:2,000), GFAP (Clone D1F4Q ...
• Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

  Kevin C. Lister, et al., bioRxiv - Neuroscience 2024

  Quote: ... and beta-tubulin (Cell Signaling, Cat# 2146S, 1:1000). Secondary antibodies were anti-Rabbit IgG – Horseradish Peroxidase antibody (GE Healthcare ...
• Differential expression of GABARAPs in GBM renders temozolomide sensitivity in a p53-dependent manner

  Megha Chaudhary, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Mouse monoclonal antibody Beta-actin (1:1000,8H10D10, Cell signaling), Anti-mouse IgG HRP linked antibody (7076P2,1:5000 ...
• Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations

  Wen Yih Aw, et al., bioRxiv - Bioengineering 2024

  Quote: ... anti-Beta-catenin (1:1000, Cell Signaling Technology, #8480), anti-glyceraldehyde-3-phosphate dehydrogenase (1:5000 ...
• Developmental molecular controls over arealization of descending cortical motor pathways

  Philipp Abe, et al., bioRxiv - Neuroscience 2023

  Quote: ... and subsequently incubated for 2 days with cleaved caspase 3 (1:200, Cell signaling 9661, LOT38) primary antibody at 4 °C ...
• MAPK Pathway Inhibition as A Rational Therapeutic Strategy for MiR-138-5p/PAQR3 Dysregulation-mediated Epirubicin Resistance in Triple-negative Breast Cancer

  Jianbo Huang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK1/2 (#9102, Rabbit, WB 1:1000) and MEK1/2 (#4694, Mouse, WB 1:1000) antibodies were purchased from Cell Signaling Technology, MA ...
• Sensitivity to Vγ9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis

  Astrid Cleven, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Rabbit mAb P44/42 MAPK (Erk 1/2) (137F5) (1:1,000; #4695; Cell Signaling Technology), rabbit mAb Phospho-MAPK (Erk 1/2 Thr202/Tyr204 ...
• TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

  Engin Demirdizen, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rabbit anti-Tensin-2 (Cell Signaling #11990, 1:1000); rabbit anti-FAK (Cell Signaling #3285 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK1/2 (Thr202/Tyr204) (1:500 Cell Signaling Technology), phospho-eEF2 (Thr56 ...
• Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

  Jill E. Hunter, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK 1/2 (phospho T202, Y204) (9101 Cell Signaling), ERK 1/2 (9102 Cell Signaling) ...
• HDAC and MAPK/ERK Inhibitors Cooperate to Reduce Viability and Stemness in Medulloblastoma

  Mariane da Cunha Jaeger, et al., bioRxiv - Cancer Biology 2020

  Quote: ... p44/42 MAPK (Erk1/2, 1:1000; Cell Signaling) and β-actin (1:2000 ...
• BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

  Tianyi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-ERK1/2 (Cell Signaling Technology, 4370, 1:2000), periostin (Invitrogen ...
• Wnt-dependent activation of ERK mediates repression of chondrocyte fate during calvarial development

  Beatriz Ibarra, Cody Machen, Radhika P. Atit, bioRxiv - Developmental Biology 2021

  Quote: ... rabbit-anti-Erk1/2 (1:500, Cell Signaling 9102), rabbit-anti-Lef1 (1:500 ...
• Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1

  Amanda M. Rampersaud, et al., bioRxiv - Developmental Biology 2020

  Quote: ... phosphorylated ERK1/2 (E10, 1:2000, Cell Signaling Technology), focal adhesion kinase (FAK ...
• The neocortical progenitor specification program is established through combined modulation of SHH and FGF signaling

  Odessa R. Yabut, et al., bioRxiv - Developmental Biology 2020

  Quote: ... phosphor-Erk1/2 (1:100 dilution, Cell Signaling (#4370)) ...
• The Peroxiredoxin 6 gene plays a critical role in the homeostatic regulation of fear response

  Sarayut Phasuk, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-pERK1/2 (1:1000; Cell Signaling, Danvers, MA), anti-total ERK1/2 (1:1000 ...
• MEKK3-TGFβ crosstalk regulates inward arterial remodeling

  Hanqiang Deng, et al., bioRxiv - Pathology 2021

  Quote: ... p-ERK1/2 (Cell Signaling 4370; IB 1:1000).
• Protective mitochondrial fission induced by stress responsive protein GJA1-20k

  Daisuke Shimura, et al., bioRxiv - Cell Biology 2021

  Quote: ... and anti-MEK1/2 (1:1000, Cell Signaling Technology). After overnight primary antibody incubation at 4 °C ...
• Defective mitochondrial-lysosomal axis promotes extracellular vesicles release of mitochondrial components in Huntington’s Disease

  Margarida Beatriz, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-flotillin-2 (C42A3) (1:500, #3436,Cell Signaling), anti-calnexin (1:500 ...
• Collagen-VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche

  Vasileios Papalazarou, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-ERK1/2 (1:1000; 9102, Cell Signaling Technology), anti-GAPDH (1:1000 ...