Labshake search

1301 - 1350 of 2174 citations for 2' Methyl 3 phenylpropiophenone since 2020

• Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function

  Chao Chang, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-pERK1/2 (Thr202/Tyr204; Cell Signaling Technology, #9101; RRID:AB_331646), rabbit anti-ERK1/2 (Cell Signaling Technology ...
• Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target

  Lucas Caldi Gomes, et al., bioRxiv - Neuroscience 2024

  Quote: ... and rabbit anti Phospho-MEK1/2 (Ser217/221) (Cell Signaling Technology, Danvers ...
• Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target

  Lucas Caldi Gomes, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti Phospho-p44/42 MAPK(ERK1/2) (Cell Signaling Technology, Danvers ...
• Insulin Receptor Loss Impairs Mammary Tumorigenesis in Mice

  Lauren Podmore, et al., bioRxiv - Cancer Biology 2023

  Quote: ... phospho-p44/42 MAPK (Erk1/2) (T202/Y204) (Cell Signaling #9101), S6 (Cell Signaling #2217) ...
• EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

  Joaquin Olmedo-Pelayo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... extracts were incubated with 2 µl Micrococcal Nuclease (Cell Signaling, 10011) and sonicated in a Bioruptor (Diagenode ...
• CRIPTO promotes extracellular vesicle uptake and activation of cancer associated fibroblasts

  David W. Freeman, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-ERK1/2 (Thr202/204) (Clone D13.144E, Cell Signaling, 1:1000), ERK1/2 (L34F12 ...
• A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane

  Jofre Font-Mateu, et al., bioRxiv - Genomics 2023

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling #9106S), HP1 gamma (Millipore 05-690).
• NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma

  Claudia Cirotti, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho-ERK 1/2 (Thr202/Tyr204) (D13.14.4E) (Cell Signaling Technology), anti-Ubiquitin (P4D1 ...
• Inhibition of Cellular MEK/ERK Signaling Suppresses Murine Papillomavirus Type 1 Replicative Activities and Promotes Tumor Regression

  Adrian J. Luna, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Immunohistochemical detection of p-ERK1/2 (Cell Signaling #4370; 1:500) required the tyramide signal amplification (TSA ...
• Actomyosin-II Proactively Shields Axons of the Central Nervous System from Mild Mechanical Stress

  Xiaorong Pan, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-Phospho-Myosin Light Chain 2 (Thr18/Ser19) (Cell Signaling, #3674); anti-Myosin Light Chain 2 (Cell Signaling ...
• In Silico Transcriptome-based Screens Identify Epidermal Growth Factor Receptor Inhibitors as Therapeutics for Noise-induced Hearing Loss

  Sarath Vijayakumar, et al., bioRxiv - Neuroscience 2023

  Quote: ... phospho forms (AKT-S473 and ERK1/2-T202/Y204, Cell Signaling) and β-actin (Sigma A3854).
• Anti-apoptotic and anti-inflammatory properties of grapefruit IntegroPectin on human microglial HMC3 cell line

  Miriana Scordino, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-p-ERK1/2 (1:1000, 9101 Cell Signaling Technology), rabbit anti-p-Akt (1:1000 ...
• Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

  Jayne Aiken, Erika L. F. Holzbaur, bioRxiv - Cell Biology 2023

  Quote: ... and Synaptobrevin-2 (anti-rabbit; Cell Signaling; 13508; 1:250 dilution). Following three washes with PBS ...
• Secreted soluble factors from tumor-activated mesenchymal stromal cells confer platinum chemoresistance to ovarian cancer cells

  Yifat Koren Carmi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-phospho-ERK1/2 (Thr202/Tyr204) (D13.14.4E, Cell Signaling Technology) as per the manufacturers’ instructions ...
• EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

  Sukanya Chakraborty, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho-ERK1/2-Thr202/Tyr204 (#9101) from Cell Signaling Technology; and anti-beta-actin (#A5441 ...
• Oncogenic Kras^G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8⁺ T cells dependent manner

  Krishnan K. Mahadevan, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Cell Signaling 4376S, 1:1000) and Vinculin (Abcam ab129002 ...
• Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function

  Rajan K C, et al., bioRxiv - Molecular Biology 2023

  Quote: ... p44/42 MAPK (ERK1/2) (Cell Signaling Technology, 4695S, 1:1,000), p-p44/42 MAPK (pERK1/2 ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... mouse anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-phospho myosin light chain 2 (Cell signaling ...
• Spatiotemporal Proteomics Deciphers Functional Selectivity of EGFR ligands

  Akihiro Eguchi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... mouse anti-phospho-Erk1/2 (T202/T204) (#9106; Cell Signaling Technology), rabbit anti-Clint1 (ab251892 ...
• Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2

  Iqra Nazish, et al., bioRxiv - Neuroscience 2023

  Quote: ... and anti-4′,6-diamidino-2-phenylindole (DAPI) (Cell Signaling #4083). The primary microglial yield was approximately 5 × 105 cells/flask with minimal astrocyte contamination ...
• HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

  Hongbo Ling, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho-ERK1/2 (Thr202/Tyr204) (Cell Signaling Technology, #9101, RRID:AB_331646), anti-ERK1/2 (Cell Signaling Technology ...
• Ascites in malignant ovarian cancer confer ovarian cancer cells chemoresistance to platinum. Combination treatment with crizotinib and 2-hydroxyestradiol restores platinum sensitivity

  Yifat Koren Carmi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-phospho-ERK1/2 (Thr202/Tyr204) (D13.14.4E, Cell Signaling Technology) according to the manufacturers’ instructions ...
• Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

  Anagha Inguva Sheth, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Primary antibodies used include BCL-2 (Cell Signaling Technologies, no.15071), SERCA3 (Biorad ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-cofilin (Abcam ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-cofilin (Abcam ...
• FGF9, a potent mitogen, is a new ligand for integrin αvβ3, and the FGF9 mutant defective in integrin binding acts as an antagonist

  Chih-Chieh Chang, et al., bioRxiv - Biochemistry 2023

  Quote: ... rabbit anti-p44/42 MAPK (ERK1/2) (Cell Signaling Technology, USA), anti-phospho-p44/42 MAPK (p-ERK1/2 ...
• FDA-Approved MEK1/2 Inhibitor, Trametinib, Protects Mice from Cisplatin and Noise-Induced Hearing Loss

  Richard D. Lutze, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-pERK1/2 (Thr202/Tyr204, 9101S, Cell Signaling Technologies, 1:1000) and anti-GAPDH (ab181602 ...
• Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions

  Yan Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... P-ERK1/2 (Thr202/Tyr204) (1:1000, #9101, Cell Signaling Technology), β-actin (1:1000 ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-phospho-MAPKAPK-2 (Thr222) (1:1000, Cell Signaling 3316), rabbit anti-p38 MAPK (1:1000 ...
• Distinct Mechanisms of Type 3 Secretion System Recognition Control LTB₄ Synthesis in Neutrophils versus Macrophages

  Amanda Brady, et al., bioRxiv - Immunology 2024

  Quote: ... anti-p-p44/42 (ERK1/2) (Cell Signaling; Cat. No. 9101s), anti-p44/42 (Cell Signaling ...
• Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation

  Qin Ni, et al., bioRxiv - Biophysics 2024

  Quote: ... anti-p44/42 MAPK (ERK1/2; Cell Signaling; 4695; 1:1000). GAPDH was used as a loading control (Cell Signaling ...
• PEPITEM Tripeptides and Peptidomimetics: Next-Generation Modulators of Inflammation in Immune-Mediated Conditions

  Anella Saviano, et al., bioRxiv - Immunology 2024

  Quote: ... rabbit monoclonal COX-2 (1:1000; D5H5; both from Cell Signaling) and mouse monoclonal anti-beta-actin (0.01 µg mL−1 ...
• Distinct phenotypic consequences of cholangiocarcinoma-associated FGFR2 alterations depend on biliary epithelial maturity

  E O’Loughlin, et al., bioRxiv - Cancer Biology 2024

  Quote: ... phospho-SHP-2 (1:1000 for immunoblot; Cell Signaling Technology #3751), phospho-MEK (1:1000 for immunoblot ...
• Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation, and cell cycle progression

  Nathaniel Shannon, et al., bioRxiv - Cell Biology 2024

  Quote: ... phospho-MEK1/2 (S217/S221) (1:1000, Cell Signaling Technology #9121), total MEK1/2 (1:1000 ...
• Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells

  Kaitlin P. McCreery, et al., bioRxiv - Cell Biology 2024

  Quote: ... p44/42 MAPK phospho-Erk1/2 (Cell Signaling 4376, 1:2000), p44/42 MAPK Erk1/2 (Cell Signaling 4695 ...
• PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α and lipid metabolism reprogramming

  Lucía Celada, et al., bioRxiv - Cancer Biology 2024

  Quote: ... rabbit anti-p44/42 MAPK (Erk1/2) (#9102 Cell Signaling Technology) at 1:1,000 dilution ...
• Evolutionary origins and innovations sculpting the mammalian PRPS enzyme complex

  Bibek R. Karki, et al., bioRxiv - Biochemistry 2024

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling #4376), p44/42 MAPK (Erk1/2 ...
• Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

  Mary C. Rominger, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p44/42 MAPK 1:1000 (Erk1/2) (Cell Signaling Technology, 9107), Phospho-p44/42 MAPK (Erk1/2 ...
• The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cells

  Shadi Zahedi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p44/42 MAP kinase (Erk1/2) (#9102) (Cell Signaling, Danvers, MA); LC3 (#NB100–2220 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... p44/42 MAPK (Erk1/2) (3A7) Mouse mAb (Cell Signaling Technology), Phospho-p44/42 MAPK (Erk1/2 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology), and Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences).
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... p44/42 MAPK (Erk1/2) (3A7) Mouse mAb (Cell Signaling Technology)/Phospho-p44/42 MAPK (Erk1/2 ...
• Inhibitory effects of Akt on neuronal FoxO4 activation after subarachnoid hemorrhage in vivo and in vitro

  Min Qi, et al., bioRxiv - Neuroscience 2020

  Quote: ... SOD2 and apoptosis-related proteins Cleaved-Caspase 3 were purchased from Cell Signaling Technology (Beverly, MA, USA). After the membranes were washed three times for 10 minutes each in PBST ...
• Cell cycle progression requires repression by Groucho during S-phase and its relief at G2-phase

  Shaked Bar-Cohen, Ze’ev Paroush, bioRxiv - Developmental Biology 2022

  Quote: Primary antibodies used in this study were: rabbit anti-phospho-Histone 3 (1:100; Cell Signaling #9701); mouse anti-phospho-Histone 3 (1:100 ...
• Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors

  Yasuaki Anami, et al., bioRxiv - Bioengineering 2021

  Quote: ... rabbit anti-cleaved caspase 3 antibody (9661S) and rabbit anti-EGFR antibody (4267S) from Cell Signaling Technology) ...
• Septins disruption controls tumor growth and enhances efficacy of Herceptin

  Rakesh K Singh, et al., bioRxiv - Cancer Biology 2020

  Quote: ... STAT-3 (catalog number: 4904) and GAPDH antibodies (catalog number: 2118s) were purchased from Cell Signaling Technology Inc ...
• Transgenic Drosophila lines for LexA-dependent gene and growth regulation

  Kathleen R. Chang, et al., bioRxiv - Genetics 2021

  Quote: ... for a proliferation marker or anti-cleaved caspase-3 (Asp175) antibody (Cell Signaling Technology #9661, 1:1000) for an apoptosis marker ...
• Dexamethasone Inhibits Cytokine-Induced, DUOX2-Related VEGF-A Expression and DNA damage in Human Pancreatic Cancer Cells and Growth of Pancreatic Cancer Xenografts

  Yongzhong Wu, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... The antibody recognizing Cleaved Caspase-3 was from Cell Signaling Technology (#9661, used 1:100 for 60’); this antibody recognizes both murine and human epitopes ...
• Measuring nonapoptotic caspase activity with a transgenic reporter in mice

  P. J. Nicholls, et al., bioRxiv - Neuroscience 2022

  Quote: ... and incubated overnight at 4 C in 1:500 cleaved caspase-3 antibody (Cell Signaling Technology #9661). The following day ...
• Cyclopamine sensitizes Glioblastoma cells to Temozolomide treatment through Sonic Hedgehog pathway

  Gabriela Basile Carballo, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-OCT-4 and anti-caspase 3 antibodies were obtained from Cell Signaling Technology (Danvers, MA, USA). Hybond-P polyvinylidene difluoride (PVDF ...