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1151 - 1200 of 10000+ citations for 3 Hydrazino 5 methyl 4H 1 2 4 triazol 4 ylamine hydrochloride since 2020

• Patient-derived tumor organoids from resected non-small cell lung cancers for high-throughput response testing with approved and repurposed drugs

  Kanve N. Suvilesh, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and apoptosis marker cleaved caspase-3 (Rabbit, 9664, 1:100; Cell Signaling Technologies). Percentages of Ki67 and or cleaved caspase-3 positive expression in PDTOs were calculated by a pathologist blinded to the study ...
• Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

  Caiqi Zhao, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-Cleaved Caspase-3 (Asp175) (1:100, Cat# 9661, Cell Signaling Technology), and rabbit anti-SARS-CoV nucleocapsid protein (N ...
• Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

  Caiqi Zhao, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-Cleaved Caspase-3 (Asp175) (1:100, Cat# 9661, Cell Signaling Technology), rabbit anti-phospho-RIP (Ser166 ...
• HuD (ELAVL4) gain-of-function impairs neuromuscular junctions and induces apoptosis in in vitro and in vivo models of amyotrophic lateral sclerosis

  Beatrice Silvestri, et al., bioRxiv - Neuroscience 2024

  Quote: ... fixed cells were incubated with anti-CC-3 (1:400, 9661, Cell signaling) overnight ...
• Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

  Caiqi Zhao, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-Cleaved Caspase-3 (Asp175) (1:1000, Cat#9661S, Cell Signaling Technology), and mouse anti-β-actin (1:2000 ...
• The selective autophagy receptor p62 and the heat shock protein HSP27 facilitate lysophagy via the formation of phase-separated condensates

  Elizabeth R. Gallagher, Erika L.F. Holzbaur, bioRxiv - Cell Biology 2022

  Quote: ... rabbit monoclonal anti-GABARAP (E1J4E) (Cell Signaling, 13733, Lot: 3, WB: 1:1000); rabbit monoclonal anti-GABARAP+GABARAPL1+GABARAPL2 (Abcam ...
• Epitranscriptomics m⁶A analyses reveal distinct m⁶A marks under tumor necrosis factor α (TNF-α)-induced apoptotic conditions in HeLa cells

  Azime Akçaöz-Alasar, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-cleaved-caspase-3 (1:200, 5A1E, Cell Signaling Technology, MA, USA), in PBS/0.1% Triton at 4 °C overnight ...
• Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival

  Jongkyun Kang, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-cleaved caspases-3 (1:150, 9661, Cell Signaling Technology, RRID: AB_2341188), or rabbit anti-Iba1 (1:500 ...
• Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity

  Shilpa Singh, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and Cleaved Caspase-3 (1:400, rabbit monoclonal antibody, Cell Signaling Cat# 9664). The immunostained slides were scanned at (40X ...
• AUTS2, a causative gene for microcephaly, regulates division of intermediate progenitor cells and production of upper-layer neurons

  Kazumi Shimaoka, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-cleaved caspase-3 (1:400; 9661S; Cell Signaling Technology, Danvers, MA), rabbit anti-PAX6 (1:500 ...
• MEK1/2 and ERK1/2 mediated lung endothelial injury and altered hemostasis promote diffuse alveolar hemorrhage in murine lupus

  Haoyang Zhuang, et al., bioRxiv - Immunology 2024

  Quote: ... Primary antibodies anti-cleaved caspase-3 (1:100 Cell Signaling Technology, Danvers, MA), anti-CD31/Pecam1 (R&D Systems 1:200 ...
• DNA replication fork speed Acts as an Engine in Cortical Neurogenesis

  Jianhong Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... Rabbit polyclonal anti-Cleaved Caspase-3 (Asp175) ( 1:500, Cell Signaling Technology, 9661S); Rabbit polyclonal anti-Phospho-KAP-1(Ser824 ...
• Enhancer adoption by an LTR retrotransposon generates viral-like particles causing developmental limb phenotypes

  Juliane Glaser, et al., bioRxiv - Developmental Biology 2024

  Quote: ... Invitrogen #A11008).α-Cleaved-Caspase 3 (rabbit polyclonal, Cell Signaling Technology Cat#9661, Asp175, 1:400) was used with donkey anti-rabbit Alexa-fluorophore 568 (1:1000 ...
• Microbial Metabolite Trimethylamine N-Oxide Promotes Campylobacter jejuni Infection by Escalating Intestinal Inflammation, Epithelial Damage, and Barrier Disruption

  Caitlyn B. Smith, et al., bioRxiv - Microbiology 2024

  Quote: ... and zonula occludens-3 (ZO-3) (Cell Signaling Technologies).
• Missense and nonsense mutations of the zebrafish hcfc1a gene result in contrasting mTor and radial glial phenotypes

  Victoria L. Castro, et al., bioRxiv - Developmental Biology 2022

  Quote: ... 14-3-3-beta/alpha (Cell Signaling Cat # 9636S) (anti-rabbit ...
• S-Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Cardiac Hypertrophy

  Matthew J. Brody, et al., bioRxiv - Molecular Biology 2021

  Quote: ... p-extracellular signal-regulated kinase (ERK) 1/2 (Cell Signaling Technology, #4370, 1:500), ERK1/2 (Cell Signaling Technology ...
• Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

  Alexa C. Cannon, et al., bioRxiv - Cancer Biology 2023

  Quote: ... phospho-ERK 1/2 Y202/204 1:2000 (Cell Signaling Technology Cat# 4370, RRID:AB_2315112), ERK 1:1000 (Cell Signaling Technology Cat# 4695 ...
• Identification of SIRT4 as a novel paralog-specific interactor and candidate suppressor of C-RAF kinase in MAPK signaling

  Mehrnaz Mehrabipour, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-p-ERK(1/2) (1:1000; #4370, Cell Signaling, Frankfurt am Main, Germany); anti-KRAS (1:1000 ...
• Synthesis of ionizable lipopolymers using split-Ugi reaction for pulmonary delivery of various size RNAs and gene editing

  K. Yu. Vlasova, et al., bioRxiv - Bioengineering 2024

  Quote: ... cycle 2 Rabbit E-Cadherin (Cell Signaling, 24E10 #3195, dilution 1:200, 1 h), cycle 3 Rabbit CD31 (Abcam ...
• Ascitic fluid protects against ferroptosis and enables the peritoneal spread of ovarian cancer

  Yasaman Setayeshpour, et al., bioRxiv - Cancer Biology 2024

  Quote: ... followed by 3 5-minute washes by 1x TBST and probing with horseradish peroxidase conjugated secondary antibodies (Cell Signaling, 7074, 7076) for 1-1.5 hours at 25°C ...
• Regulation of early growth response-1 (Egr-1) gene expression by Stat1-independent type I interferon signaling and respiratory viruses

  Chilakamarti V. Ramana, bioRxiv - Genomics 2020

  Quote: ... and subjected to immunoblotting with the antibodies for phosphorylated Erk-1/2 (Thr202/Tyr 204) or total Erk-1/2 from Cell Signaling Technology (Beverly, MA). Blots were visualized by enhanced chemiluminescence western detection system (Pierce ...
• Syndecan-4^-/- mice have smaller muscle fibers, increased Akt/mTOR/S6K1 and Notch/HES-1 pathways, and alterations in extracellular matrix components

  Sissel Beate Rønning, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-pSer240/244-RPS6 (1:1000, 5% BSA, #5364 Cell Signaling), anti-pSer473-Akt (1:500 ...
• Neuron-radial glial cell communication via BMP/Id1 signaling maintains the regenerative capacity of the adult zebrafish telencephalon

  Gaoqun Zhang, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-Phospho Smad1/5/9 (1:200, Cell Signaling Technology) and rabbit anti-RFP (1:500 ...
• Stress-induced vascular remodeling: novel insight into the role of omega-3 fatty acid metabolite, 4-oxoDHA

  Makoto Nishimori, et al., bioRxiv - Biochemistry 2023

  Quote: ... Antibodies against rabbit anti-5-lipoxygenase (1:1000, Cell Signaling, #C49G1), rabbit anti-NRF2 (1:500 ...
• The anatomy of transcriptionally active chromatin loops in Drosophila primary spermatocytes using super-resolution microscopy

  Madeleine L. Ball, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 1:500 and rabbit anti-RPol-PSer2/5 (47355, Cell Signaling); 1:500 ...
• Essential role of the amino-terminal region of Drosha for the Microprocessor function

  Amit Prabhakar, et al., bioRxiv - Molecular Biology 2022

  Quote: ... phospho-Smad1/5/8 (1:100 dilution, Cell signaling Technology, 9511), anti-β-actin (1:5000 dilution ...
• Targeting of MMP-13 prevents aortic aneurysm formation in Marfan mice

  Laura-Marie A. Zimmermann, et al., bioRxiv - Biochemistry 2022

  Quote: ... anti-phospho-SMAD1/5/8 (#9511, Cell Signaling, WB: 1:1000), anti-BMP-7 GF (#500-P198 B ...
• Dopamine-driven Increase in IL-1β in Myeloid Cells is Mediated by Differential Dopamine Receptor Expression and Exacerbated by HIV

  Stephanie M. Matt, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-NLRC4 antibody (12421, 1:1000 in 5% BSA, Cell Signaling) or anti-AIM2 antibody (MA5-38442 ...
• Construction of an embryonic caudal organizer by BMP4

  Yan-Yi Xing, et al., bioRxiv - Developmental Biology 2024

  Quote: ... Anti-pSmad1/5/9 antibody (13820, Cell Signaling Technologies, 1:800), anti-SOX2 antibody (AF2018 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... phospho-ERK1/2 (Thr202/Tyr204) (1:500 Cell Signaling Technology), ERK1/2 (Thr202/Tyr204 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... phospho-MEK1/2 (Ser217/221) (1:500 Cell Signaling Technology), MEK1/2 (1:500 Cell Signaling Technology) ...
• HDAC and MAPK/ERK Inhibitors Cooperate to Reduce Viability and Stemness in Medulloblastoma

  Mariane da Cunha Jaeger, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Phospho-p44/42 MAPK (pErk1/2, 1:2000; Cell Signaling), p44/42 MAPK (Erk1/2 ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... p-ERK1/2 T202/Y204 (#4370S, 1:1000, Cell Signaling), ERK1/2 (#4695S ...
• Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

  Ayan Rajgarhia, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and ERK 1/2 (Cell Signaling Technology, Danvers, MA, USA)
• Wnt-dependent activation of ERK mediates repression of chondrocyte fate during calvarial development

  Beatriz Ibarra, Cody Machen, Radhika P. Atit, bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-phospho-ERK1/2 (1:1250, Cell Signaling 4370). Wide-field images were captured at 20X and 40X using the Leica DMi8 inverted microscope using the Leica Application Suite X (LASX ...
• Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors

  Xiaoyan Wei, et al., bioRxiv - Cell Biology 2021

  Quote: ... Rabbit anti-pErk1/2 (Cell Signaling Technology # 9101; 1:1000), Rabbit anti-Erk1/2 (Cell Signaling Technology # 9102 ...
• Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors

  Xiaoyan Wei, et al., bioRxiv - Cell Biology 2021

  Quote: ... Rabbit anti-Erk1/2 (Cell Signaling Technology # 9102; 1:1000), Mouse anti-ß-Actin (Cell Signaling Technology # 58169 ...
• Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of juvenile myogenic progenitors

  Xiaoyan Wei, et al., bioRxiv - Cell Biology 2021

  Quote: ... Rabbit anti-pErk1/2 (Cell Signaling Technology # 9101; 1:300), Rabbit anti-phosphor (s235/236)-S6 (Cell Signaling Technology # 4858 ...
• The Peroxiredoxin 6 gene plays a critical role in the homeostatic regulation of fear response

  Sarayut Phasuk, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-total ERK1/2 (1:1000; Cell Signaling, Danvers, MA), anti-PSD95 (1:2000 ...
• The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma

  Muzhou Wu, et al., bioRxiv - Cancer Biology 2020

  Quote: ... p44/42 MAPK (Erk1/2) (Cell Signaling, 9102s, 1:1000), MITF (Cell Signaling ...
• Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages

  Kevin Christian M. Gulay, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-ERK1/2 antibody (1:1000; Cell Signaling Technology, 4695S), anti-H2AK119Ub1 antibody (1:2000 ...
• A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes corpus luteum regression

  Dianrong Li, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-Phospho-MEK1/2 (9154S, Cell Signaling; WB, 1:1000), anti-MEK1/2 (ab178876 ...
• Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

  Lilija Wehling, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and pLATS1/2 (1:500, Cell Signaling Technology, #8654, RRID:AB_10971635) and Cytochrome P450 2E1 (1:500 ...
• Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

  Yian Guan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-pERK1/2 (1:5000, Cat#9101, Cell Signaling Technology), anti-PTPN12 (1:500 ...
• Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

  Yian Guan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-ERK1/2 (1:3000, Cat#4695, Cell Signaling Technology), anti-pERK1/2 (1:5000 ...
• Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress

  Laura Virtanen, et al., bioRxiv - Molecular Biology 2022

  Quote: ... rabbit monoclonal pERK1/2 (1:1000, D13.14.4E, Cell Signaling Technologies), rabbit monoclonal cleaved PARP-1 (1:1000 ...
• IFT20 is critical for early chondrogenesis during endochondral ossification

  Hiroyuki Yamaguchi, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-phospho ERK1/2 (Cell Signaling technology; #4376, 1:1,000), anti-ERK1/2 (Cell Signaling technology ...
• A noble TGFβ biogenesis inhibitor exhibits both potent anti-fibrotic and anti-inflammatory capabilities

  Han-Soo Kim, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... ERK 1/2 from Cell Signaling Technology (Danver, MA, USA). All antibodies were diluted to 1:1000 v/v in 5% BSA in DPBS (Welgene).
• Sortilin exhibits tumor suppressor-like activity by limiting EGFR transducing function

  E. Lapeyronnie, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pERK1/2 (Thr202/Thr204, #4370, 1:1000 dilution, Cell Signaling), ERK1/2 (#9102 ...
• Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer

  Laura K. Godfrey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p-ERK1/2 (#4376, RRID:AB_331772, Cell Signaling Technology, 1:15), Vinculin (#13901 ...