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1151 - 1200 of 1760 citations for 2 4 Dimethyl 4' 4 methylpiperazinomethyl benzophenone since 2020

• P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway

  Zhijia Wang, et al., bioRxiv - Biochemistry 2022

  Quote: ... anti-p44/42 MAPK (Erk1/2) (Cell Signaling Technology, 1:4000). Manufacturers provide validation for all antibodies.
• Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target

  Lucas Caldi Gomes, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti Phospho-p44/42 MAPK(ERK1/2) (Cell Signaling Technology, Danvers ...
• Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target

  Lucas Caldi Gomes, et al., bioRxiv - Neuroscience 2024

  Quote: ... and rabbit anti Phospho-MEK1/2 (Ser217/221) (Cell Signaling Technology, Danvers ...
• Insulin Receptor Loss Impairs Mammary Tumorigenesis in Mice

  Lauren Podmore, et al., bioRxiv - Cancer Biology 2023

  Quote: ... phospho-p44/42 MAPK (Erk1/2) (T202/Y204) (Cell Signaling #9101), S6 (Cell Signaling #2217) ...
• EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

  Joaquin Olmedo-Pelayo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... extracts were incubated with 2 µl Micrococcal Nuclease (Cell Signaling, 10011) and sonicated in a Bioruptor (Diagenode ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-cofilin (Abcam ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-cofilin (Abcam ...
• Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function

  Chao Chang, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-pERK1/2 (Thr202/Tyr204; Cell Signaling Technology, #9101; RRID:AB_331646), rabbit anti-ERK1/2 (Cell Signaling Technology ...
• ACE1 knockout in neurons selectively dysregulates the hippocampal renin angiotensin system and causes vascular loss

  Sohee Jeon, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-p44/42 (Erk1/2) (#CS 137F5, Cell Signaling Technology), rabbit anti-angiotensinogen (#79299 ...
• Spatiotemporal Proteomics Deciphers Functional Selectivity of EGFR ligands

  Akihiro Eguchi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... mouse anti-phospho-Erk1/2 (T202/T204) (#9106; Cell Signaling Technology), rabbit anti-Clint1 (ab251892 ...
• Ascites in malignant ovarian cancer confer ovarian cancer cells chemoresistance to platinum. Combination treatment with crizotinib and 2-hydroxyestradiol restores platinum sensitivity

  Yifat Koren Carmi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-phospho-ERK1/2 (Thr202/Tyr204) (D13.14.4E, Cell Signaling Technology) according to the manufacturers’ instructions ...
• HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

  Hongbo Ling, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho-ERK1/2 (Thr202/Tyr204) (Cell Signaling Technology, #9101, RRID:AB_331646), anti-ERK1/2 (Cell Signaling Technology ...
• Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

  Anagha Inguva Sheth, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Primary antibodies used include BCL-2 (Cell Signaling Technologies, no.15071), SERCA3 (Biorad ...
• Interneuron migration defects during corticogenesis contribute to Dyrk1a haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

  Maria Victoria Hinckelmann, et al., bioRxiv - Developmental Biology 2023

  Quote: ... mouse anti-phospho myosin light chain 2 (Cell signaling, 1:1000), rabbit anti-phospho myosin light chain 2 (Cell signaling ...
• CRIPTO promotes extracellular vesicle uptake and activation of cancer associated fibroblasts

  David W. Freeman, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-ERK1/2 (Thr202/204) (Clone D13.144E, Cell Signaling, 1:1000), ERK1/2 (L34F12 ...
• Prenatal Arsenite Exposure Alters Maternal Cardiac Remodeling During Late Pregnancy

  Nicole Taube, et al., bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... p44/42 MAPK (ERK1/2) (1:1000, Rabbit mAb, Cell Signaling), and p-p44/42 MAPK (T202/Y204 ...
• FGF9, a potent mitogen, is a new ligand for integrin αvβ3, and the FGF9 mutant defective in integrin binding acts as an antagonist

  Chih-Chieh Chang, et al., bioRxiv - Biochemistry 2023

  Quote: ... rabbit anti-p44/42 MAPK (ERK1/2) (Cell Signaling Technology, USA), anti-phospho-p44/42 MAPK (p-ERK1/2 ...
• Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor

  Jie Li, Jiayi Wu, Xiao-chen Bai, Eunhee Choi, bioRxiv - Cell Biology 2022

  Quote: ... anti-pERK1/2 (WB, 1:000; 197G2, Cat. #4377, Cell Signaling); anti-IR (WB ...
• In vivo KRAS G12D/V degradation mediated by CANDDY using a modified proteasome inhibitor

  Satoshi Imanishi, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... Erk1/2 (p44/42 MAPK) (1:1000, #4695; Cell Signaling Technology), p-Akt (1:2000 ...
• Secreted soluble factors from tumor-activated mesenchymal stromal cells confer platinum chemoresistance to ovarian cancer cells

  Yifat Koren Carmi, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and anti-phospho-ERK1/2 (Thr202/Tyr204) (D13.14.4E, Cell Signaling Technology) as per the manufacturers’ instructions ...
• EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

  Sukanya Chakraborty, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho-ERK1/2-Thr202/Tyr204 (#9101) from Cell Signaling Technology; and anti-beta-actin (#A5441 ...
• Oncogenic Kras^G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8⁺ T cells dependent manner

  Krishnan K. Mahadevan, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Cell Signaling 4376S, 1:1000) and Vinculin (Abcam ab129002 ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-phospho-MAPKAPK-2 (Thr222) (1:1000, Cell Signaling 3316), rabbit anti-p38 MAPK (1:1000 ...
• Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation

  Qin Ni, et al., bioRxiv - Biophysics 2024

  Quote: ... anti-p44/42 MAPK (ERK1/2; Cell Signaling; 4695; 1:1000). GAPDH was used as a loading control (Cell Signaling ...
• PEPITEM Tripeptides and Peptidomimetics: Next-Generation Modulators of Inflammation in Immune-Mediated Conditions

  Anella Saviano, et al., bioRxiv - Immunology 2024

  Quote: ... rabbit monoclonal COX-2 (1:1000; D5H5; both from Cell Signaling) and mouse monoclonal anti-beta-actin (0.01 µg mL−1 ...
• FDA-Approved MEK1/2 Inhibitor, Trametinib, Protects Mice from Cisplatin and Noise-Induced Hearing Loss

  Richard D. Lutze, et al., bioRxiv - Neuroscience 2024

  Quote: ... anti-pERK1/2 (Thr202/Tyr204, 9101S, Cell Signaling Technologies, 1:1000) and anti-GAPDH (ab181602 ...
• Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions

  Yan Wang, et al., bioRxiv - Neuroscience 2024

  Quote: ... P-ERK1/2 (Thr202/Tyr204) (1:1000, #9101, Cell Signaling Technology), β-actin (1:1000 ...
• Distinct Mechanisms of Type 3 Secretion System Recognition Control LTB₄ Synthesis in Neutrophils versus Macrophages

  Amanda Brady, et al., bioRxiv - Immunology 2024

  Quote: ... anti-p-p44/42 (ERK1/2) (Cell Signaling; Cat. No. 9101s), anti-p44/42 (Cell Signaling ...
• Loss of PRICKLE1 in the myometrium leads to reduced fertility, abnormal myometrial architecture, and aberrant extracellular matrix deposition in mice

  Emily R Roberts, et al., bioRxiv - Physiology 2024

  Quote: ... anti-RAC1/2/3 (Cell Signaling Technology, Cat# 2465P, 1:1000), anti-RHOA (Cell Signaling Technology ...
• Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation, and cell cycle progression

  Nathaniel Shannon, et al., bioRxiv - Cell Biology 2024

  Quote: ... phospho-MEK1/2 (S217/S221) (1:1000, Cell Signaling Technology #9121), total MEK1/2 (1:1000 ...
• Distinct phenotypic consequences of cholangiocarcinoma-associated FGFR2 alterations depend on biliary epithelial maturity

  E O’Loughlin, et al., bioRxiv - Cancer Biology 2024

  Quote: ... phospho-SHP-2 (1:1000 for immunoblot; Cell Signaling Technology #3751), phospho-MEK (1:1000 for immunoblot ...
• Evolutionary origins and innovations sculpting the mammalian PRPS enzyme complex

  Bibek R. Karki, et al., bioRxiv - Biochemistry 2024

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling #4376), p44/42 MAPK (Erk1/2 ...
• Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells

  Kaitlin P. McCreery, et al., bioRxiv - Cell Biology 2024

  Quote: ... p44/42 MAPK phospho-Erk1/2 (Cell Signaling 4376, 1:2000), p44/42 MAPK Erk1/2 (Cell Signaling 4695 ...
• PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/HIF2α and lipid metabolism reprogramming

  Lucía Celada, et al., bioRxiv - Cancer Biology 2024

  Quote: ... rabbit anti-p44/42 MAPK (Erk1/2) (#9102 Cell Signaling Technology) at 1:1,000 dilution ...
• The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cells

  Shadi Zahedi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p44/42 MAP kinase (Erk1/2) (#9102) (Cell Signaling, Danvers, MA); LC3 (#NB100–2220 ...
• Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

  Mary C. Rominger, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p44/42 MAPK 1:1000 (Erk1/2) (Cell Signaling Technology, 9107), Phospho-p44/42 MAPK (Erk1/2 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... p44/42 MAPK (Erk1/2) (3A7) Mouse mAb (Cell Signaling Technology), Phospho-p44/42 MAPK (Erk1/2 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology), and Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences).
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... p44/42 MAPK (Erk1/2) (3A7) Mouse mAb (Cell Signaling Technology)/Phospho-p44/42 MAPK (Erk1/2 ...
• Behavioral and Neurostructural changes associated with Chronic Amygdala Hyperactivation

  Keith A. Misquitta, et al., bioRxiv - Neuroscience 2021

  Quote: ... sections were placed overnight at 4°C in a solution containing 2% donkey serum and primary antibodies for post-synaptic density protein 95 (PSD95; rabbit host, 1:100, Cell Signaling Technology, Danvers, MA, product #2507, lot 2), vesicular glutamate transporter 1 (VGLUT1 ...
• Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density

  Keith A. Misquitta, et al., bioRxiv - Neuroscience 2021

  Quote: ... Sections were incubated overnight at 4°C in PBS containing 2% donkey serum and primary antibodies for post-synaptic density protein 95 (PSD95; rabbit host, 1:100, Cell Signaling Technology, Danvers, MA, product #2507, lot 2), and vesicular glutamate transporter 1 (VGLUT1 ...
• Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

  Honglin Jiang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Phospho-Erk1/2 (Thr202/Tyr204) (Cell Signaling Technology, 4370, Dilution: 1:1000); Erk1/2 (Cell Signaling Technology ...
• Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth

  Elena Vasileva, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-Phospho-p44/42 MAPK (Erk1/2) Thr202/Tyr204 (4370S, Cell Signaling) at 1:200 overnight ...
• Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS Mutations

  Andreas Damianou, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology, 4370) GAPDH (Sigma-Aldrich ...
• Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells

  Dhruv Raina, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Primary antibodies used were anti-pERK1/2 1:200 (4370S, Cell Signaling), anti-E-Cad 1:200 (M108 ...
• Endothelial cell polarity and extracellular matrix production rely on functional ATP6AP2 during developmental and pathological angiogenesis

  NR Patel, A Blanks, Y Li, MC Prieto, SM Meadows, bioRxiv - Molecular Biology 2021

  Quote: ... anti-phospho-p44/42 MAPK (pErk1/2) (Cell signaling, 9101, 1:1000), anti-Collagen type III (Abcam ...
• RNA-protein interaction mapping via MS2 or Cas13-based APEX targeting

  Shuo Han, et al., bioRxiv - Molecular Biology 2020

  Quote: ... the other used 2 μL rabbit monoclonal anti-HA antibody (Cell Signaling) as a control IgG for pulldown ...
• The integrated stress response remodels the microtubule organizing center to clear unfolded proteins following proteotoxic stress

  Brian Hurwitz, et al., bioRxiv - Cell Biology 2022

  Quote: ... 1/100 Phospho-Myosin Light Chain 2 (Ser19) (Cell Signaling Technologies, 3675); 1/250 p62/SQSTM (Cell Signaling Technologies ...
• A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis

  Jianting Shi, et al., bioRxiv - Cell Biology 2022

  Quote: ... A pool of 2 μg Rabbit anti-GABARAP (Cell Signaling Technology 13733S) and 2 μg Rabbit anti-GABARAP (N-term ...
• Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome

  Li Zhang, et al., bioRxiv - Genetics 2020

  Quote: ... anti-phospho-p44/42 MAPK(Erk1/2) (Cell Signaling Technologies, catalog #9106), anti-p44/42 MAPK(Erk1/2 ...