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1101 - 1150 of 2191 citations for 6 Chloro 3 fluoro 2 formylpyridine since 2019

• Addressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation

  Xiaotong Zhu, et al., bioRxiv - Biochemistry 2021

  Quote: ... anti-Erk1/2 (Cell signaling technology, cat. no. 4695).
• Hydroxylation of Actin Impairs Cell Motility Through Blocking its’ Histidine Methylation

  Zhenzhen Zi, et al., bioRxiv - Biochemistry 2021

  Quote: ... PHD-2/Egln1 (D31E11) Rabbit mAb (Cell Signaling, 4835s), EGLN3/PHD3 Antibody (Novus Biologicals ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-ERK1/2 (Cell Signaling 4695, 1:2000), rabbit anti-phospho-PAK1 (S199/S204 ...
• SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes

  Yen K. Lieu, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-p-MAPKAPK-2 (MK2; T334) (Cell Signaling, 9595T), anti-α-Tubulin (Cell Signaling ...
• Zfp36l1 and Zfp36l2 balances proliferation and differentiation in the developing retina

  Fuguo Wu, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and rabbit anti-Zfp36l1/2 (Cell signaling 2119,1:100). Secondary antibodies were purchased from Life Sciences.
• Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

  Honglin Jiang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Erk1/2 (Cell Signaling Technology, 4696, Dilution: 1:1000); GAPDH (Cell Signaling Technology ...
• The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

  Elisa Avolio, et al., bioRxiv - Cell Biology 2021

  Quote: ... P-ERK1/2 Thr202/Tyr204 (Cell Signaling Technology #4370), 1:2000 ...
• Androgen Receptor promotes renal cell carcinoma (RCC) vasculogenic mimicry (VM) via altering TWIST1 nonsense-mediated decay through lncRNA-TANAR

  Bosen You, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Argonaute-2 (Ago2) (Cell Signaling Technology, #2897, Danvers, MA), IgG (Santa Cruz ...
• Copper chelation inhibits TGF-β pathways and suppresses epithelial-mesenchymal transition in cancer

  E. M. Poursani, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p44/42 MAPK (ERK1/2) (9102S, Cell Signaling Technology), MMP-9 (D6O3H ...
• Adipocytes reprogram glucose metabolism in cancer cells promoting metastasis

  Abir Mukherjee, et al., bioRxiv - Cancer Biology 2022

  Quote: ... HK-2 (Cell Signaling Technology, cat# 2867, 1:1000), p-STAT3 Tyr 708 (Cell Signaling Technology ...
• Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

  Yueyang Wang, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-phospho Myosin Light Chain 2 (Cell Signaling 3671) and secondary antibody anti-rabbit AlexaFluor 488 (Invitrogen A-21441) ...
• Acquired and intrinsic resistance to vemurafenib in BRAF^V600E-driven melanoma brain metastases

  Ping Zhang, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... phospho-ERK1/2 (1:200; 4370; Cell Signaling Technology), phospho-AKT (1:8,000 ...
• The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids

  Jennifer Rynne, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Antibodies used were: BRF1/2 (Cell Signaling Technology #2119), GR (Cell Signaling Technology #3660 ...
• Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

  Eleftheria Koropouli, et al., bioRxiv - Neuroscience 2022

  Quote: ... Neuropilin-2 (rabbit polyclonal, Cell Signaling, Cat no. 3366S); Neuropilin-2 (goat polyclonal ...
• PKC-alpha promotes phosphorylation of KRAS suppressing its oncogenic properties

  Tejashree Joglekar, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-p44/42 MAPK (Erk1/2) (Cell Signaling #4696); anti-KRAS (Sigma #WH0003845M1) ...
• PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

  Maria B. Campaña, et al., bioRxiv - Cell Biology 2023

  Quote: ... ERK1/2 (1:1000; 9102; Cell Signaling Technology, Inc.); phospho-AKT (Ser473 ...
• Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function

  Chao Chang, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-ERK1/2 (Cell Signaling Technology, #9102; RRID:AB_330744), goat polyclonal anti-EPHB2 (R&D Systems ...
• Diacylglycerol kinase-ε is S-palmitoylated on cysteine in the cytoplasmic end of its N-terminal transmembrane fragment

  Gabriela Traczyk, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-flotillin-2 (Cell Signaling, cat. No. 3436), donkey anti-sheep IgG-HRP (Jackson ImmunoResearch ...
• Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

  Mingrong Zuo, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-ERK1/2(Thr202/Tyr204) (Cell Signaling Technology #4370S), total-ERK1/2 (Cell Signaling Technology #4696) ...
• Repurposing of the antibiotic nitroxoline for the treatment of mpox

  Denisa Bojkova, et al., bioRxiv - Microbiology 2022

  Quote: ... MEK1/2 (Cell Signaling 1:1000, #9122, 1:1000), phospho-MEK1/2 S217/221 (Cell Signaling ...
• Rewiring of the TCR signalosome in natural intestinal Intraepithelial T lymphocytes drives non-deletional tolerance

  Harriet J. Watt, et al., bioRxiv - Immunology 2023

  Quote: ... SHP-1 or SHP-2 (all Cell Signaling Technology) followed by anti-rabbit Dylight649 (1:500 ...
• Competitive, connective and allosteric Nanobodies that modulate the SOS1•RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design

  Baptiste Fischer, et al., bioRxiv - Bioengineering 2023

  Quote: ... rabbit monoclonal ERK1/2 (1:50, Cell Signaling #4696), and mouse monoclonal Flag antibody (clone M2 ...
• Peripheral extracellular vesicle-derived miR-150-3p exacerbates acute kidney injury following acute pancreatitis by promoting ferroptosis through FTH1 signaling

  Ji-tao Cui, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-Cox-2 (1:1,000, 9461, Cell Signaling Technology), anti-β-actin (1:2,000 ...
• Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2

  Ding-Chin Lee, et al., bioRxiv - Evolutionary Biology 2023

  Quote: ... rabbit anti-SARS-CoV-2 envelope (Cell signaling, #74698), rabbit anti-GAPDH (Genetex ...
• Phencyclidine disrupts neural coordination and cognitive control by dysregulating translation

  Eun Hye Park, et al., bioRxiv - Neuroscience 2023

  Quote: ... ERK1/2 (Cell Signaling Technology, Cat.No.9102S, 1:1000), phospho-4EBP1 (Cell Signaling Technology ...
• Actin polymerization drives lumen formation in a human epiblast model

  Dhiraj Indana, et al., bioRxiv - Developmental Biology 2023

  Quote: ... phospho- myosin light chain 2 (Cell Signaling Technology #3674), Arp2/3 complex (Sigma-Aldrich MABT95) ...
• Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

  Tiantian Zhang, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Mek1/2 (1:1,000, Cell Signaling Technology, Cat# 9122), alpha-tubulin (Sigma ...
• Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1

  Niraj Nag, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti Bcl-2 antibody (Cell Signaling Technology Cat# 15071), anti-caspase 8 antibody (Cell Signaling Technology Cat# 9746) ...
• Neural stem cells protect blood-brain barrier integrity via the p38, JNK, and ERK1/2 pathways following intracerebral hemorrhage in rats

  Jing Sun, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-ERK1/2 (Cell Signaling, USA, 1:1000 dilution), anti-p38 (Cell Signaling ...
• Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

  Marco Di Gioia, et al., bioRxiv - Immunology 2023

  Quote: ... ERK1/2 (1:1000, Cell Signaling Technology, Cat# 9102), phospho-p38 (Thr180/Tyr182 ...
• Ellagic acid ameliorates atherosclerosis by targeting the epidermal growth factor receptor

  Ye-Wei Huang, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-ERK1/2 (4696S, Cell Signaling Technology, MA, USA), anti-phospho-ERK1/2 (4370S ...
• Serine arginine-rich splicing factor (SRSF7) cooperates with the histone methyltransferase KMT5a to promote the type I interferon response via transcriptional activation of IRF7

  Haley M. Scott, et al., bioRxiv - Immunology 2023

  Quote: ... or 2 µg of isotype control (IgG, Cell Signaling), 5ul Y701 STAT1 (Cell Signaling) ...
• Braf-mutant Schwann cells divert to a repair phenotype to induce congenital demyelinating neuropathy

  Elise Marechal, et al., bioRxiv - Developmental Biology 2024

  Quote: ... rabbit polyclonal anti-Erk1/2 (#9102; Cell Signaling Technology), rabbit monoclonal anti-Jun (60A8 ...
• Multifunctional molecular hybrid for targeted colorectal cancer cells: Integrating doxorubicin, AS1411 aptamer, and T9/U4 ASO

  Kanpitcha Jiramitmongkon, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Bcl–2 (1:1000; 25 – 28 kDa, Cell signaling), and Bax (1:1000 ...
• Reorganization of innate immune cell lipid profiles by bioinspired meroterpenoids to limit inflammation

  Lorenz Waltl, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... rabbit anti-MEK1/2 (1:1000; # 9122; Cell Signaling), rabbit anti-phospho-MEK1/2 (1:1000 ...
• Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

  Giuliana Giamundo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-MAPKAPK-2 (1:1000, Cell Signaling 3042), rabbit anti-phospho-MAPKAPK-2 (Thr222 ...
• Synthetic G protein-coupled receptors for programmable sensing and control of cell behavior

  Nicholas A. Kalogriopoulos, et al., bioRxiv - Synthetic Biology 2024

  Quote: ... p44/42 MAPK (Erk1/2; Cell Signaling Technology #9107), and β-Tubulin (Cell Signaling Technology #86298).
• Viral Insulin/IGF-like Peptides Selectively Activate Host Insulin/IGF Signaling pathways during Grouper Iridovirus Infection

  Aurelien Chuard, et al., bioRxiv - Microbiology 2024

  Quote: ... p44/42 MAPK (Erk1/2) Antibody (Cell Signaling #9102); β-Actin (D6A8 ...
• Potassium starvation induces autophagy in yeast

  Nambirajan Rangarajan, et al., bioRxiv - Biochemistry 2020

  Quote: ... at 1:1,000 dilution in blocking buffer or glucose 6-phosphate dehydrogenase (G6PDH) antibodies (8866, Cell Signaling Technology, 1:1,000). Immunoreactive species were detected with antibodies conjugated with horseradish peroxidase (715-035-150 ...
• The E2F4/p130 repressor complex cooperates with oncogenic ΔNp73α to promote cell survival in human papillomavirus 38 E6/E7-transformed keratinocytes and in cancer cells

  Valerio Taverniti, et al., bioRxiv - Cancer Biology 2022

  Quote: Senescence was assessed using the Senescence β-Galactosidase Staining Kit at pH 6 following the manufacturer’s instructions (Cell Signaling Technology). For SAHF staining ...
• ERK1/2 Inhibition Alleviates Noise-Induced Hearing Loss While Tempering Down the Immune Response

  Richard D. Lutze, et al., bioRxiv - Neuroscience 2023

  Quote: ... Mice were sacrificed 6 days after noise exposure and whole cochlear lysates were prepared in lysis buffer (9803; Cell Signaling) after adding protease (cOmplete ULTRA Tablets 05892791001 ...
• Neuromodulation of Behavioral Specialization: Tachykinin Signaling Inhibits Task-specific Behavioral Responsiveness in Honeybee Workers

  Bin Han, et al., bioRxiv - Evolutionary Biology 2021

  Quote: ... The membranes were blocked for 2 hours at room temperature and then incubated with rabbit monoclonal anti-pERK1/2 antibody (Cell Signaling Technology, USA) and anti-rabbit horseradish peroxidase-conjugated secondary antibody (Cell Signaling Technology ...
• Using rat operant delayed match-to-sample task to identify neural substrates recruited with increased working memory load

  Christina Gobin, Lizhen Wu, Marek Schwendt, bioRxiv - Neuroscience 2020

  Quote: ... PKC substrate antibody selectively detects proteins with phosphorylated PKC consensus sites (phosphorylated Ser residues surrounded by Arg or Lys at the –2 and +2 positions and a hydrophobic residue at the +1 position, Cell Signaling, Danvers, MA). Next ...
• The protein phosphatases MoPtc1 and MoPtc2 are induced during pathogen-host interactions and play synergistic roles in regulating MAPK pathways in Magnaporthe oryzae

  Wilfred M. Anjago, et al., bioRxiv - Molecular Biology 2022

  Quote: ... phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (D13.14.4E) Rabbit mAb and p44/42 MAPK (Erk1/2) antibodies (Cell Signaling Technology, Beverly, MA, USA) and affinity purified goat anti-rabbit & mouse antibody conjugated to horseradish peroxidase (Abmart ...
• Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral and signaling plasticity in vivo

  Mohamed R. Ahmed, et al., bioRxiv - Neuroscience 2023

  Quote: ... Doubly phosphorylated (active) ERK1/2 was detected with a phospho-ERK-specific [phosphor-ERK1/2(Thr202/Tyr204)] mouse monoclonal antibody (Cell Signaling, cat.# 9106) at 1:2,000 dilution ...
• Inhibiting BCKDK in triple negative breast cancer suppress protein translation, impair mitochondrial function, and potentiate doxorubicin cytotoxicity

  Dipsikha Biswas, et al., bioRxiv - Cancer Biology 2021

  Quote: Caspase activity assay (Caspase-3 Activity Assay Kit #5723, Cell Signaling Technology, Danvers, MA, USA) was performed according the manufacturer’s instructions ...
• Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution

  Bortolin-Cavaillé Marie-Line, et al., bioRxiv - Molecular Biology 2021

  Quote: ... embryos were incubated with antibodies directed against either cleaved Caspase-3 (Asp175) (Cell Signaling Technology), or HuC/D (Molecular Probes) ...
• Surface-associated antigen induces B-cell permeabilization and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

  Fernando Y. Maeda, et al., bioRxiv - Cell Biology 2021

  Quote: ... Cells were then incubated with antibodies specific for cleaved caspase-3 (Asp175) (Cell Signaling Technology) followed by AF488 donkey-anti-rabbit IgG (Life Technologies ...
• High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage

  Fabien Aubry, et al., bioRxiv - Microbiology 2020

  Quote: ... The primary antibodies were rabbit anti-cleaved caspase 3 (1:300, #9661, Cell Signaling Technologies), mouse anti-flavivirus group antigen (1:800 ...
• SF3B1 promotes tumor malignancy through splicing-independent activation of HIF1α

  Patrik T. Simmler, et al., bioRxiv - Cell Biology 2021

  Quote: ... cleaved caspase 3 (rabbit monoclonal, clone number D3E9, Cell Signaling, Cell Signaling, #9579, 1:400) and CD31 (rabbit polyclonal ...