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1001 - 1050 of 2174 citations for 2' Methyl 3 phenylpropiophenone since 2020

• Engineered small extracellular vesicles as a FGL1/PD-L1 dual-targeting delivery system for alleviating immune rejection

  Hsiang-i Tsai, et al., bioRxiv - Bioengineering 2021

  Quote: ... Human LAG-3 and Na+K+ATPase antibodies were purchased from Cell Signaling Technology and Santa Cruz Biotechnology Inc ...
• Disbalance of the intestinal epithelial cell turnover and apoptosis in a rat model of sporadic Alzheimer’s disease

  Jan Homolak, et al., bioRxiv - Neuroscience 2021

  Quote: ... and incubated with 1:500 anti-caspase-3 antibody (#9662S, Cell Signaling Technologies, USA) overnight at 4 °C in-between polyvinyl chloride (PVC ...
• Disbalance of the intestinal epithelial cell turnover and apoptosis in a rat model of sporadic Alzheimer’s disease

  Jan Homolak, et al., bioRxiv - Neuroscience 2021

  Quote: ... Sections were incubated in anti-caspase-3 primary antibody (#9662S, Cell Signaling Technologies, USA) diluted 1:500 in 1% NGS in PBST overnight at 4 °C under PVC coverslips ...
• Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo

  Maxinne Watchon, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-acetylated histone 3 and 4 (acetylated H3K9 and H4K5 antibodies, Cell Signaling), rabbit anti-MT-ND5 (Abcam) ...
• The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer

  Rhona Millar, et al., bioRxiv - Cancer Biology 2020

  Quote: ... was purchased from Abcam and anti-Caspase 3 (clone Asp-175; 1:500) was purchased from Cell Signaling. Quantitative analysis of positive staining was performed by counting cells in at least 3 high-power fields of view (×40 ...
• The Nerve Growth Factor IB-like Receptor Nurr1 (NR4A2) Recruits CoREST Transcription Repressor Complexes to Silence HIV Following Proviral Reactivation in Microglial Cells

  Fengchun Ye, et al., bioRxiv - Microbiology 2021

  Quote: ... a rabbit polyclonal anti-acetylated histone 3 (Ac-H3) antibody (Cell Signaling, Cat#9677S), a rabbit polyclonal anti-H3K27me3 antibody (EDM Millipore ...
• BAX is necessary for neuronal death following exposure to isoflurane during the neonatal period

  Andrew M. Slupe, Laura Villasana, Kevin M. Wright, bioRxiv - Neuroscience 2020

  Quote: ... followed by antibody staining with 1:1000 anti-cleaved caspase-3 (Cell Signaling Technology) and subsequently 1:1000 anti-rabbit Alexa 568 (ThermoFisher ...
• EMC is required for biogenesis and membrane insertion of Xport-A, an essential chaperone of rhodopsin-1 and the TRP channel

  Catarina J. Gaspar, et al., bioRxiv - Cell Biology 2021

  Quote: ... testis were incubated with rabbit anti-cleaved caspase 3 (1:200) (Asp175, Cell Signaling) diluted in 0.1% PBT ...
• Cancer cells induce hepatocytes apoptosis in co-opted colorectal cancer liver metastatic lesions

  Miran Rada, et al., bioRxiv - Cancer Biology 2021

  Quote: The following primary antibodies were used: cleaved caspase-3 1:100 (Cell signaling, # 9664S) and cleaved PARP-1 1:50 (Cell signaling ...
• String/Cdc25 phosphatase is a suppressor of Tau-associated neurodegeneration

  Andreia C. Oliveira, et al., bioRxiv - Neuroscience 2022

  Quote: ... Incubation with primary antibodies anti-Cleaved caspase 3 (Asp 175) (1:50, Cell Signaling) and anti-ELAV (1:400 ...
• miR-17∼92 exerts stage-specific effects in adult V-SVZ neural stem cell lineages

  Fabrizio Favaloro, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-cleaved caspase 3 (rabbit polyclonal, 1:100, Cell Signaling, Cat# 9661, RRID: AB_2341188); anti-DLX2 (mouse polyclonal ...
• The early endosomal protein Rab21 is critical for enterocyte functions and intestinal homeostasis

  Sonya Nassari, et al., bioRxiv - Cell Biology 2020

  Quote: ... rabbit anti-cleaved caspase 3 (#9661, Cell Signaling Technology, Danvers, MA, USA; 1/500), rabbit anti-ref(2)p (ab178440 ...
• eyes absent in the cockroach panoistic ovaries regulates proliferation and differentiation through ecdysone signalling

  S. Ramos, et al., bioRxiv - Developmental Biology 2020

  Quote: ... rabbit antibody anti-cleaved Caspase-3 (Asp-175, Cell Signaling Tech; dilution 1:50), and mouse antibody anti-Eya ...
• BAM15 treats mouse sepsis and sepsis-AKI, linking circulating mitochondrial DNA and tubule reactive oxygen species

  Naoko Tsuji, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... Immunohistochemical staining was performed with anti- caspase 3 antibody (Cell Signaling Technology, Danvers, MA) as a primary antibody and polyclonal goat anti-rabbit Immunoglobulins conjugated with HRP (Agilent Dako ...
• FLASH irradiation enhances the therapeutic index of abdominal radiotherapy for the treatment of ovarian cancer

  Karen Levy, et al., bioRxiv - Cancer Biology 2020

  Quote: ... sections were incubated in cleaved caspase-3 (Asp175) antibody (1:300; Cell Signaling Technology) at 4°C overnight in a humidified chamber ...
• PFKFB3 Depletion Activates β-Cell Replication by Cell Competitive Culling of Compromised β-Cells Under Stress

  Jie Min, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-cleaved caspase-3 (Cell Signaling Technology 9664S, Danvers, MA, USA, 1:400); ...
• The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice

  Ke Xu, et al., bioRxiv - Developmental Biology 2022

  Quote: ... rabbit anti-Cleaved Caspase-3 monoclonal antibody (1:1,000 dilution, 9664, Cell Signaling Technology), rabbit anti-B-cell lymphoma-2 (BCL-2 ...
• Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control

  Lukas-Adrian Gurzeler, et al., bioRxiv - Molecular Biology 2023

  Quote: ... and cells were lysed with 3 µl cold Lysis buffer (Cell Signaling, Cat. 9803) at 4°C under shaking ...
• Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner

  Aleksandra Janusz-Kamińska, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-caspase 3 antibody (Cell Signaling, catalog no. 9662; 1:1000 for WB), rabbit anti-phospho-GluA1 (Ser845 ...
• Targeting tumour-intrinsic neural vulnerabilities of glioblastoma

  Sohyon Lee, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Alexa Fluor® 555 anti-Cleaved Caspase-3 (1:500, Cell Signaling Technology, #9604S), Alexa Fluor® 546 anti-HOMER (1:300 ...
• Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity

  Renata L.S. Goncalves, et al., bioRxiv - Biochemistry 2023

  Quote: ... washed 3 times and then incubated with HRP-conjugated secondary antibody (Cell Signaling Technologies) for 1h at RT ...
• Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential

  Lisa D.J. Schiffelers, et al., bioRxiv - Immunology 2023

  Quote: ... rabbit anti-cleaved caspase-3 (Asp175) clone 5A1E (Cell Signaling Technology Cat#9664S, RRID:AB_2070042), rabbit anti-caspase-7 clone D2Q3L (Cell Signaling Technology Cat#12827T ...
• Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose limitation

  Matthew H. Raymonda, et al., bioRxiv - Microbiology 2023

  Quote: ... The following antibodies were used for immunoblot analysis: Cleaved Caspase 3 (Cell Signaling, 9661), Vinculin (Cell Signaling ...
• ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer

  Harald Schuhwerk, et al., bioRxiv - Cancer Biology 2023

  Quote: ... IHC or IF staining as described previously 21 (cl. Casp. 3: Cell Signaling Technology, 9661S ...
• The efficacy of CB-103, a first-in-class transcriptional Notch inhibitor, in preclinical models of breast cancer

  Michele Vigolo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and a rabbit polyclonal anti-Cleaved Caspase 3 (Cell Signaling, Asp175, 1:500 dilution). After rinsing in PBS ...
• ATF4 Dependent Increase in Mitochondrial-Endoplasmic Reticulum Tethering Following OPA1 Deletion in Skeletal Muscle

  Antentor Hinton Jr., et al., bioRxiv - Biophysics 2023

  Quote: ... glyceraldehyde 3-phosphate dehydrogenase (GAPDH; 1:5,000; Cell Signaling Technology: Danvers, MA, USA; #2118), MFN1 (1:1,000 ...
• Cdc25A phosphatase is activated and mediates neuronal cell death by PUMA via pRB/E2F1 pathway in a model of Parkinson’s disease

  Anoy Kumar Das, Subhas C Biswas, bioRxiv - Neuroscience 2024

  Quote: ... anti-cleaved Caspase 3 (D175) (cat no. 9661S) were purchased from Cell Signaling Technology. Anti-TH antibodies (cat no ...
• Altered liver metabolism post-wean abolishes efficacy of vitamin D for breast cancer prevention in a mouse model

  Sarah M Bernhardt, et al., bioRxiv - Cancer Biology 2024

  Quote: ... or Cleaved Caspase-3 (CC3; Cell Signaling, 1:150, 1 h at room temperature). Slides were washed thrice in TBST prior to incubation with a pre-diluted HRP-conjugated secondary antibody (Nacalai USA Histofine) ...
• An shRNA screen in primary human beta cells identifies the serotonin 1F receptor as a negative regulator of survival during transplant

  Rebecca A. Lee, et al., bioRxiv - Cell Biology 2024

  Quote: ... The primary antibodies were rabbit anti-cleaved caspase-3 (Cell Signaling; 9661; 1:100), chicken anti-GFP (Aves Labs ...
• Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity

  Shilpa Singh, et al., bioRxiv - Cancer Biology 2024

  Quote: ... The primary antibodies were: rabbit anti-Histone 3 DH12 (Cell Signaling #4499, 1:5000) and rabbit anti-phospho Histone H2A.X Ser 139 (Cell signaling #2577 ...
• Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene program in bat wing development

  Magdalena Schindler, et al., bioRxiv - Evolutionary Biology 2024

  Quote: ... Anti-Cleaved-Caspase-3 (D175) Antibody (rabbit polyclonal, Cell Signaling Technology, #9661, Lot 47) was diluted in blocking solution (1:400 ...
• A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy

  Darshika Tomer, et al., bioRxiv - Cell Biology 2022

  Quote: ... pH 8.8 (20 mM Tris-Cl, 2 mM EDTA, 2% w/v sodium deoxycholate, 1X protease inhibitor cocktail (Cell Signaling Technology, 5871). Extracts were carefully transferred to Eppendorf tubes containing 1 μl (250 units ...
• Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction

  Reina E. Ito, Chitose Oneyama, Kazuhiro Aoki, bioRxiv - Cancer Biology 2020

  Quote: ... The antibodies used for western blot and immunofluorescence analyses are as follows: phospho-anti-Erk1/2 (Thr202/Tyr204) (E10) and anti-Erk1/2 (137F5) were from Cell Signaling Technology; anti-KRAS (clone 3B10-2F2 ...
• GREM1 is epigenetically reprogrammed in muscle cells after exercise training and controls myogenesis and metabolism

  Odile Fabre, et al., bioRxiv - Cell Biology 2020

  Quote: ... phospho-Ampkα1/2 (Thr172, #2535), Ampkα1/2 (#2532), phospho-Akt (Ser473, #4060), Akt (#4691) or β-Actin (D6A8, #8457) (all fivefrom Cell Signaling Technology) antibodies ...
• MAPK Pathway Inhibition as A Rational Therapeutic Strategy for MiR-138-5p/PAQR3 Dysregulation-mediated Epirubicin Resistance in Triple-negative Breast Cancer

  Jianbo Huang, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK1/2 (#9102, Rabbit, WB 1:1000) and MEK1/2 (#4694, Mouse, WB 1:1000) antibodies were purchased from Cell Signaling Technology, MA ...
• Constitutive signal bias mediated by the human GHRHR splice variant 1

  Zhaotong Cong, et al., bioRxiv - Molecular Biology 2021

  Quote: ... The membranes were blocked with 5% BSA in TBST buffer for 2 h at RT and incubated overnight at 4°C with primary antibodies against ERK1/2 (1:1000; 9102s, Cell Signaling Technology), pERK1/2 (1:1000 ...
• TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

  Engin Demirdizen, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rabbit anti-Tensin-2 (Cell Signaling #11990, 1:1000); rabbit anti-FAK (Cell Signaling #3285 ...
• PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity

  Florian Wiede, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-ERK1/2 (Cell Signaling Technology Cat# 4376, RRID:AB_331772), LCK (Cell Signaling Technology Cat# 2752 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK1/2 (Thr202/Tyr204) (1:500 Cell Signaling Technology), phospho-eEF2 (Thr56 ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK (Cell Signaling Technology, p44/42 MAPK (Erk1/2) (137F5 ...
• Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth

  Elena Vasileva, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p44/42 MAPK (Erk1/2) (137F5) (4695S, Cell signaling) at 1:2000 ...
• Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

  Jill E. Hunter, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK 1/2 (phospho T202, Y204) (9101 Cell Signaling), ERK 1/2 (9102 Cell Signaling) ...
• HDAC and MAPK/ERK Inhibitors Cooperate to Reduce Viability and Stemness in Medulloblastoma

  Mariane da Cunha Jaeger, et al., bioRxiv - Cancer Biology 2020

  Quote: ... p44/42 MAPK (Erk1/2, 1:1000; Cell Signaling) and β-actin (1:2000 ...
• BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

  Tianyi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-ERK1/2 (Cell Signaling Technology, 4370, 1:2000), periostin (Invitrogen ...
• Wnt-dependent activation of ERK mediates repression of chondrocyte fate during calvarial development

  Beatriz Ibarra, Cody Machen, Radhika P. Atit, bioRxiv - Developmental Biology 2021

  Quote: ... rabbit-anti-Erk1/2 (1:500, Cell Signaling 9102), rabbit-anti-Lef1 (1:500 ...
• Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS Mutations

  Andreas Damianou, et al., bioRxiv - Molecular Biology 2021

  Quote: ... p44/42 MAPK (Erk1/2) (Cell Signaling Technology, 9107), Phospho-p44/42 MAPK (Erk1/2 ...
• Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1

  Amanda M. Rampersaud, et al., bioRxiv - Developmental Biology 2020

  Quote: ... phosphorylated ERK1/2 (E10, 1:2000, Cell Signaling Technology), focal adhesion kinase (FAK ...
• A BTB-Domain Transcription factor Recruits Chromatin Remodelers and a Histone Chaperone during the exit from Pluripotency

  Daniel Olivieri, et al., bioRxiv - Molecular Biology 2020

  Quote: ... or Phospho-Erk1/2 antibody (Cell Signaling Technology, #9101) 1/1000 in PBST-5% BSA.
• An integrative oncogene-dependency map identifies unique vulnerabilities of oncogenic EGFR, KRAS, and RIT1 in lung cancer

  Athea Vichas, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Phospho-MEK1/2 (Ser217/221) (Cell Signaling Technology, 9154), MEK1 (Cell Signaling Technology ...
• An integrative oncogene-dependency map identifies unique vulnerabilities of oncogenic EGFR, KRAS, and RIT1 in lung cancer

  Athea Vichas, et al., bioRxiv - Cancer Biology 2020

  Quote: ... p44/42 MAPK (Erk1/2) (Cell Signaling Technology, 9107), Phospho-MEK1/2 (Ser217/221 ...