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51 - 100 of 10000+ citations for 2R 5S 5 4 amino 5 fluoro 2 oxopyrimidin 1 2H yl 1 3 oxathiolan 2 yl methyl butyrate WXC04778 since 2020

• Injury-induced Erk1/2 signaling enhances Ca²⁺ activity and is necessary for regeneration of spinal cord and skeletal muscle

  Jacqueline B. Levin, Laura N. Borodinsky, bioRxiv - Neuroscience 2021

  Quote: ... pERK1/2 1:50 (Cell Signaling 4377s), and Xen1 1:100 (deposited to Developmental Studies Hybridoma Bank (DSHB ...
• DOK1 and DOK2 regulate CD8⁺ T cell signaling and memory formation without affecting tumor cell killing

  V. Laletin, et al., bioRxiv - Immunology 2021

  Quote: ... Erk-1/2 (Cell Signaling Technology #9102) and β-Actin (Cell Signaling Technology #3700) ...
• Extracellular Vesicle-Mediated Purinergic Signaling Contributes to Host Microenvironment Plasticity and Metastasis in Triple Negative Breast Cancer

  Suzann Duan, et al., bioRxiv - Cancer Biology 2020

  Quote: ... COX-2 (1:50, Cell Signaling Technologies), and GAPDH (Cell Signaling Technologies ...
• PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

  Eyleen Corrales, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Erk1/2 (1:1000; L34F12; Cell Signaling), phospho(Ser473)-AKT (1:2000 ...
• PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

  Eyleen Corrales, et al., bioRxiv - Cancer Biology 2022

  Quote: ... MEK1/2 (1:1000; L38C12; Cell Signaling), phospho(Thr44/Tyr42)-ERK1/2 (1:1000 ...
• STAT3 but not STAT5 contributes to the protective effect of electro-acupuncture against myocardial ischemia/reperfusion injury

  Hui-Hui Guo, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Bcl-2 (1:1000, Cell Signaling, #3498), Cyt c (1:1000 ...
• Activation of proneuronal transcription factor Ascl1 in maternal liver ensures a healthy pregnancy

  Joonyong Lee, et al., bioRxiv - Physiology 2021

  Quote: ... ERK1/2 (Cell Signaling, 9102, 1:2,000), p-ERK1/2 (T202/Y204 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... MEK1/2 (1:500 Cell Signaling Technology), phospho-ERK1/2 (Thr202/Tyr204 ...
• The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma

  Muzhou Wu, et al., bioRxiv - Cancer Biology 2020

  Quote: ... MEK1/2 (Cell Signaling, 9122, 1:1000), total H3 (Abcam ...
• Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

  Hui Li, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-ERK1/2 (1:2000, Cell Signaling), and anti-AKT (1:2000 ...
• Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue

  Megan Moruzzi, et al., bioRxiv - Cell Biology 2020

  Quote: ... ERK1/2 1:1000 (Cell Signaling, #9102S), α-tubulin (Sigma Aldrich ...
• Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

  Alice Laschuk Herlinger, et al., bioRxiv - Cancer Biology 2023

  Quote: ... pERK1/2 (1:1,000; Cell Signaling, #9101), ERK1/2 (1:1,000 ...
• Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

  Alice Laschuk Herlinger, et al., bioRxiv - Cancer Biology 2023

  Quote: ... ERK1/2 (1:1,000; Cell Signaling, #4695), pAKT (Thr308 ...
• Nuclear inhibitor of protein phosphatase 1 (NIPP1) regulates CNS tau phosphorylation and myelination during development

  Cody McKee, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-pERK1/2 (1:1000, Cell Signaling), anti-MBP (1:1000 ...
• Nuclear inhibitor of protein phosphatase 1 (NIPP1) regulates CNS tau phosphorylation and myelination during development

  Cody McKee, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-pERK1/2 (1:500, Cell Signaling), anti-pERK1/2 (1:1000 ...
• The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer’s disease

  Felipe C. Ribeiro, et al., bioRxiv - Neuroscience 2023

  Quote: ... ERK1/2 (#9102, 1:1,000; Cell Signaling); phospho-p70S6K1 Thr389 (#9205 ...
• CRIPTO promotes extracellular vesicle uptake and activation of cancer associated fibroblasts

  David W. Freeman, et al., bioRxiv - Cancer Biology 2024

  Quote: ... ERK1/2 (L34F12, Cell Signaling, 1:2000), Vinculin (Clone EPR8185 ...
• Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands

  Lei Wang, et al., bioRxiv - Immunology 2024

  Quote: ... ERK1/2 (4695S, Cell Signaling, 1: 1000), phospho-ERK1/2 (4370S ...
• Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome

  Rosalba Olga Proce, et al., bioRxiv - Neuroscience 2024

  Quote: ... ERK1/2 (Cell Signaling, #4695, 1:500), MNK1 (Cell Signaling ...
• The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds

  Janani Ramachandran, et al., bioRxiv - Developmental Biology 2023

  Quote: ... and then incubated with the following primary antibodies for 2 hours at room temperature in 5% BSA: 1:1000 anti-SMARCC1 (Cell Signaling Technologies cat. #11956T), 1:1000 anti-SMARCA4 (Cell Signaling Technologies cat ...
• Atheroprone Flow Activates SMAD-FOXO1 to drive Endothelial-to-Mesenchymal Transition and Atherosclerosis

  Paul-Lennard Mendez, et al., bioRxiv - Genomics 2024

  Quote: ... SMAD2/3 (SMAD 2/3 XP, Cell Signaling Technology 8685) or isotype control (Rabbit IgG XP ...
• STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation

  Matthew R. Rice, et al., bioRxiv - Biochemistry 2023

  Quote: p-Threonine (Cell Signaling, 9386, 1:1000, 1:10,000, 5% BSA/TBST)
• Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton

  Wenqing Zhou, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-Rac1/2/3 (Cell Signaling 2465S) and secondary antibodies anti-rabbit (ThermoFisher SA5-35571) ...
• Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons

  Nicholas L. Truex, et al., bioRxiv - Immunology 2023

  Quote: ... Primary antibodies were incubated for 2 h in a solution of TBST (0.05%) and LI-COR blocking buffer (5%) containing the following antibodies: anti-ERK1/2 (Cell Signaling Technologies; dilution factor: 1/2000) and streptavidin IRdye680 (LI-COR Biosciences ...
• Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1

  Joyce Wolf van der Meer, et al., bioRxiv - Molecular Biology 2024

  Quote: ... supernatants were transferred to fresh 2 ml tubes and incubated ON at 4°C with either 5 µl α-H2AK119ub1 (D27C4, Cell Signaling Technology #8240), 15 µl α-H3K27me3 (C36B11 ...
• BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas

  Paul Huchedé, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Membranes were blocked with 5% BSA in TBS for 1 hr and then incubated overnight at 4° C with anti-pSMAD1/5/8 (1:1000, Cell Signaling Technology, 13820), anti-SMAD1 (1:1000 ...
• Syndecan-4^-/- mice have smaller muscle fibers, increased Akt/mTOR/S6K1 and Notch/HES-1 pathways, and alterations in extracellular matrix components

  Sissel Beate Rønning, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-RPS6 (1:1000, 5% BSA, #2217, Cell Signaling), anti-HES-1 (1:500 ...
• Syndecan-4^-/- mice have smaller muscle fibers, increased Akt/mTOR/S6K1 and Notch/HES-1 pathways, and alterations in extracellular matrix components

  Sissel Beate Rønning, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-mTOR (1:1000, #2983, 5% BSA, Cell Signaling), anti-Pax-7 (1:500 ...
• Changing the Waddington landscape to control mesendoderm competence

  James R. Valcourt, et al., bioRxiv - Developmental Biology 2020

  Quote: ... phosphorylated SMAD1/5/9 (1:200, Cell Signaling D5B10); phosphorylated-SMAD2 (1:200 ...
• Zebrafish follistatin-like 1b regulates cardiac contraction during early development

  Xin-Xin I. Zeng, et al., bioRxiv - Developmental Biology 2020

  Quote: ... P-Smad1/5/8 (Cell Signaling Technology, 1:100), GFP (anti-Chick ...
• ID1 and CEBPA Coordinate Epidermal Progenitor Cell Differentiation

  Christina Geraldine Kantzer, et al., bioRxiv - Developmental Biology 2022

  Quote: ... phospho-Smad1/5 (Cell Signaling Technology, #9516, 1:1000).
• Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer

  Laura K. Godfrey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p-JUN (#9164, RRID:AB_330892, Cell Signaling Technology, 1:5), p-ERK1/2 (#4376 ...
• Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells

  Tu Nguyen, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-LC3B (1:1000 in 5% BSA, Cell Signaling), and anti-POLDIP2 (1:1000 in 5% BSA ...
• KDM3A and KDM3B Maintain Naïve Pluripotency Through the Regulation of Alternative Splicing

  Caleb M. Dillingham, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-RNAPII (Cell Signaling 14958, 1:1000, lot#5), anti-α-TUBULIN (Cell Signaling 3873 ...
• Adaptive epigenetic regulation of neuronal metabolism by a mitochondrial redox signal

  Marius W. Baeken, et al., bioRxiv - Cell Biology 2023

  Quote: ... and anti-5-methylcytosine (28692, Cell Signaling, 1:200). Cy3-anti-rabbit/Cy2-anti-mouse (Jackson Immunoresearch) ...
• Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

  Suel-Kee Kim, et al., bioRxiv - Neuroscience 2022

  Quote: ... p-SMAD1/5 (9516, Cell Signaling Technology, 1:200), p-SMAD2/3 (8828 ...
• PTPN1 deficiency modulates BMPR2 signaling and induces endothelial dysfunction in Pulmonary Arterial Hypertension

  Md Khadem Ali, et al., bioRxiv - Cell Biology 2022

  Quote: ... pSMAD1/5/9 (Cat # 13820S, Cell Signaling, 1:1000), ID1 (Cat # sc-133104 ...
• Trehalose dimycolate inhibits phagosome maturation and promotes intracellular M. tuberculosis growth via noncanonical SNARE interaction

  Carolina Santamaria, et al., bioRxiv - Microbiology 2024

  Quote: ... rabbit polyclonal anti-Syntaxin 5 (1:1000; Cell Signaling), rabbit monoclonal anti-Syntaxin 6 (1:1000 ...
• Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to early lethality in mice

  Hyung-seok Kim, et al., bioRxiv - Cell Biology 2024

  Quote: ... and anti-pSmad1/5 (1:1000, Cell signaling RRID:AB_491015) antibodies ...
• BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma

  Tianyi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK1/2 (Cell Signaling Technology, 9107, 1:2000), p-ERK1/2 (Cell Signaling Technology ...
• Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1

  Amanda M. Rampersaud, et al., bioRxiv - Developmental Biology 2020

  Quote: ... ERK1/2 (9102, 1:1000, Cell Signaling Technology), phosphorylated ERK1/2 (E10 ...
• Signaling modality within gp130 receptor enhances tissue regeneration

  Ruzanna Shkhyan, et al., bioRxiv - Molecular Biology 2022

  Quote: ... p-ERK 1/2 (cat #9106, Cell Signaling), p-Y416-SRC (cat #1246F ...
• S-Palmitoylation-Dependent Regulation of Cardiomyocyte Rac1 Signaling Activity and Cardiac Hypertrophy

  Matthew J. Brody, et al., bioRxiv - Molecular Biology 2021

  Quote: ... ERK1/2 (Cell Signaling Technology, #9102, 1:500), pan-Ras (Thermo Fisher ...
• Sustained Oxygenation Accelerates Diabetic Wound Healing by Simultaneously Promoting Epithelialization and Angiogenesis, and Decreasing Tissue Inflammation

  Ya Guan, et al., bioRxiv - Bioengineering 2021

  Quote: ... and anti-Erk1/2 (1:1000, Cell signaling).
• Sustained Oxygenation Accelerates Diabetic Wound Healing by Simultaneously Promoting Epithelialization and Angiogenesis, and Decreasing Tissue Inflammation

  Ya Guan, et al., bioRxiv - Bioengineering 2021

  Quote: ... anti-phospho-Erk1/2 (1:500, Cell signaling), and anti-Erk1/2 (1:1000 ...
• Deficiency of cyclin-dependent kinase-like 5 causes spontaneous epileptic seizures in neonatal mice

  Wenlin Liao, Kun-Ze Lee, San-Hua Su, Yuju Luo, bioRxiv - Neuroscience 2020

  Quote: ... glutamate decarboxylase 2 (GAD2; 1:1,000, Cell Signaling), cannabinoid receptor 1 (CB1R ...
• Moderately Inducing Autophagy Reduces Tertiary Brain Injury After Perinatal Hypoxia-Ischemia

  Brian H. Kim, et al., bioRxiv - Neuroscience 2020

  Quote: ... 2) rabbit anti-LC3 (Cell Signaling, 1:200); and 3 ...
• PDGFR dimer-specific activation, trafficking and downstream signaling dynamics

  Madison A. Rogers, Katherine A. Fantauzzo, bioRxiv - Cell Biology 2021

  Quote: ... Erk1/2 (1:1000; 9102; Cell Signaling Technology); phospho-Akt (1:1000 ...
• Marked Synergy by Vertical Inhibition of EGFR signaling in NSCLC Spheroids: SOS1 as a therapeutic target in EGFR-mutated cancer

  Patricia L. Theard, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-ERK1/2 (Cell Signaling 4696; 1:1000), anti-pAKT Ser473 [Cell Signaling 4060 ...
• Marked Synergy by Vertical Inhibition of EGFR signaling in NSCLC Spheroids: SOS1 as a therapeutic target in EGFR-mutated cancer

  Patricia L. Theard, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-pERK1/2 (Cell Signaling 4370; 1:1,000), anti-ERK1/2 (Cell Signaling 4696 ...