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9851 - 9900 of 10000+ citations for 7 CHLORO 1 METHYL 1H PYRAZOLO 4 3 B PYRIDINE since 2019

• Interstrand Crosslinks in Donor DNA Boost Gene Editing in Human Cells

  Hannah I. Ghasemi, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Phospho-Chk2 (1:1000) was detected using #2661 from Cell Signaling. GFP was detected using #A11122 from ThermoFisher (1:2000).
• In vivo KRAS G12D/V degradation mediated by CANDDY using a modified proteasome inhibitor

  Satoshi Imanishi, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... Erk1/2 (p44/42 MAPK) (1:1000, #4695; Cell Signaling Technology), p-Akt (1:2000 ...
• Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

  Capria Rinaldi, et al., bioRxiv - Systems Biology 2022

  Quote: ... rabbit anti-Rab11 (Cell Signaling Technology, #5589, 1:100 for IF), rabbit anti-GM130 (Cell Signaling Technology ...
• Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

  Capria Rinaldi, et al., bioRxiv - Systems Biology 2022

  Quote: ... rabbit anti-GM130 (Cell Signaling Technology, #12480, 1:3200 for IF), rabbit anti-LC3A/B (Cell Signaling Technology ...
• Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

  Capria Rinaldi, et al., bioRxiv - Systems Biology 2022

  Quote: ... rabbit anti-Rab7 (Cell Signaling Technology, #9367, 1:100 for IF), rabbit anti-Rab11 (Cell Signaling Technology ...
• Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

  Capria Rinaldi, et al., bioRxiv - Systems Biology 2022

  Quote: ... mouse anti-GAPDH (Cell Signaling Technology, #97166, 1:1000 for WB). AlexaFluor secondary antibodies (ThermoFisher ...
• Inhibiting circRNA Cdr1as expression in the ILPFC of adult male C57BL/6J mice impairs fear extinction memory

  Esmi Lau Zajaczkowski, et al., bioRxiv - Neuroscience 2022

  Quote: ... Rabbit IgG (1:4000 Cell Signaling Technology, #2729S, Ref: 11/2016) was used as a control to visualise background staining caused by non-specific IgG binding ...
• Neuron-specific protein expression at striatal excitatory synapses

  Yi-Zhi Wang, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-Shank2 (1:1000, Cell Signaling Technology, Cat # 12218, RRID:AB_2797848), rabbit anti-Shank3 (1:1000 ...
• Neuron-specific protein expression at striatal excitatory synapses

  Yi-Zhi Wang, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-GAPDH (1:2000, Cell Signaling Technology, Cat # 2118, RRID:AB_561053), rabbit anti-Shank1 (1:1000 ...
• The Respiratory Syncytial Virus M2-2 protein is targeted for proteasome degradation and inhibits translation and stress granules assembly

  Orlando Bonito Scudero, et al., bioRxiv - Microbiology 2023

  Quote: ... anti-Phospho-4E-BP1 rabbit (#2855 – Cell Signaling, 1:1000 WB), anti-4E-BP1 rabbit (#9452 – Cell Signaling ...
• Activation of β2-adrenergic receptors in microglia alleviates neuropathic hypersensitivity in mice

  Elisa Damo, Amit Agarwal, Manuela Simonetti, bioRxiv - Neuroscience 2022

  Quote: ... rabbit-anti-p-JNK (1:100, cat # 4668, Cell Signaling Technology), guinea pig-anti-GFAP (1:1000 ...
• Activation of β2-adrenergic receptors in microglia alleviates neuropathic hypersensitivity in mice

  Elisa Damo, Amit Agarwal, Manuela Simonetti, bioRxiv - Neuroscience 2022

  Quote: ... rabbit-anti-p-p38 (1:300, cat # 9212, Cell Signaling Technology), mouse-anti-p-JNK (1:200 ...
• Activation of β2-adrenergic receptors in microglia alleviates neuropathic hypersensitivity in mice

  Elisa Damo, Amit Agarwal, Manuela Simonetti, bioRxiv - Neuroscience 2022

  Quote: ... mouse-anti-p-JNK (1:200, cat # 9255, Cell Signaling Technology), rabbit-anti-p-JNK (1:100 ...
• RHINO restricts MMEJ activity to mitosis

  Alessandra Brambati, et al., bioRxiv - Molecular Biology 2023

  Quote: ... phospho-Chk1 (Ser345, 2348 S; Cell Signaling Technology; 1: 1000 dilution), phospho-RPA32 (S4/S8 ...
• RHINO restricts MMEJ activity to mitosis

  Alessandra Brambati, et al., bioRxiv - Molecular Biology 2023

  Quote: ... phospho-H2AX (S139, 9718 S; Cell Signaling Technology; 1: 1000 dilution), phospho-H3 (S10 ...
• RHINO restricts MMEJ activity to mitosis

  Alessandra Brambati, et al., bioRxiv - Molecular Biology 2023

  Quote: ... phospho-H3 (S10, 9718 S; Cell Signaling Technology; 1: 10000 dilution), phospho-Chk1 (Ser345 ...
• Calcium signals tune AMPK activity and mitochondrial homeostasis in dendrites of developing neurons

  Akane Hatsuda, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-phospho-AMPKα (Thr172) (1:1000, Cell Signaling Technology, 2535); rabbit anti-MFF (1:3000 ...
• A shift in the mechanisms controlling hippocampal engram formation during brain maturation

  Adam I. Ramsaran, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-β-actin (1:1000, Cell Signaling Technology, cat# 4967) overnight at 4 °C or for 1 h at room temperature ...
• Endothelial Histone Deacetylase 1 Activity Impairs Kidney Microvascular NO Signaling in Rats fed a High Salt Diet

  Luke S. Dunaway, et al., bioRxiv - Physiology 2023

  Quote: ... or phospho-S1176 (1:500, 9571L, Cell Signaling Technology, Danvers, MA) followed by incubation with goat anti-mouse or goat anti-rabbit secondary antibody (1:1000 ...
• Disease-associated astrocyte epigenetic memory promotes CNS pathology

  Hong-Gyun Lee, et al., bioRxiv - Immunology 2024

  Quote: ... and rabbit IgG polyclonal isotype control (Cell Signaling, 2975S, 1:100). Cross-links were reversed in 100 µL of 0.1% SDS and 300 mM NaCl in 1X TE at 63°C for 4-5 hours ...
• Endoplasmic reticulum stress signaling actively contributes to therapy resistance in colorectal cancer

  Daisuke Sasaki, et al., bioRxiv - Cancer Biology 2024

  Quote: ... mouse anti-β-actin antibody (#3700, 1:2000, Cell Signaling Technology), PARP1 antibody (sc74470 ...
• Antibody targeting of surface PSGL-1 glycoprotein leads to lymphoma apoptosis and tumorigenesis inhibition

  João L. Pereira, et al., bioRxiv - Cancer Biology 2024

  Quote: ... For phosphorylated-ERK (1:1000 dilution; cat. no. 9101S, Cell Signaling) hybridization ...
• The Notch1/Delta-like-4 axis is crucial for the initiation and progression of oral squamous cell carcinoma

  Christian T. Meisel, et al., bioRxiv - Cancer Biology 2024

  Quote: ... polyclonal rabbit anti-Notch1 (D1E11) (dilution 1:100; 3608S; Cell Signaling), polyclonal rabbit anti-Runx1 (dilution 1:100 ...
• Persister cancer cells are characterized by H4K20me3 heterochromatin that defines a low inflammatory profile

  Valentina Ramponi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... mouse anti-Histone H3 (96C10) Antibody (1:500, Cell Signaling, #3638), mouse anti-γ-Tubulin Antibody clone GTU-88 (1:5000 ...
• Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20^Slp1 under stress

  Li Sun, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit monoclonal anti-phospho-p38 (Cell Signaling Technology; #4511; 1:1,000); rabbit polyclonal anti-PSTAIRE (detecting Cdc2 ...
• Microglia are involved in regulating histamine dependent and non-dependent itch transmissions with distinguished signal pathways

  Yuxiu Yang, et al., bioRxiv - Neuroscience 2022

  Quote: ... and rabbit-anti-c-Fos (1:500, Cell Signaling, Catalogue #2250). After rinse for three times for at least 30 minutes with TBS buffer ...
• A Drosophila model of diabetic neuropathy reveals a crucial role of proteasome activity in the glia

  Mari Suzuki, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-Akt (pan) (C67E7) (Cell Signaling Technology Cat# 4691, 1:2000); anti-Actin (Developmental Studies Hybridoma Bank Cat# jla20 ...
• MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice

  Houjian Zhang, et al., bioRxiv - Neuroscience 2022

  Quote: ... MOB1 (1:1000; Cell signaling Tec., Cat. No. 13730, RRID: AB_2783010), p MOB1 (1:1000 ...
• MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice

  Houjian Zhang, et al., bioRxiv - Neuroscience 2022

  Quote: ... MAP4K4 (1:500; Cell Signaling Tec., Cat. No. 3485, RRID: AB_2140972), MINK1 (1:500 ...
• MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice

  Houjian Zhang, et al., bioRxiv - Neuroscience 2022

  Quote: ... Vinculin (1:5000, Cell Signaling Tec., Cat. No. 13901, RRID: AB_2728768) was used as loading control ...
• MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice

  Houjian Zhang, et al., bioRxiv - Neuroscience 2022

  Quote: ... MAP4K4 (1:500, Cell Signaling Tec., Cat. No. 3485, RRID: AB_2140972), MAP4K6 (1:500 ...
• Identification of regulatory elements in primary sensory neurons involved in neuropathic pain

  Kimberly E. Stephens, et al., bioRxiv - Neuroscience 2022

  Quote: ... and anti-β-actin antibody (1:1000; Cell Signaling, Cat# 4970S). Targets were detected after incubation with a goat anti-rabbit secondary antibody horseradish peroxidase conjugated (1:10,000 ...
• Cell-type-specific whole-genome landscape of ΔFOSB binding in nucleus accumbens after chronic cocaine exposure

  Szu-Ying Yeh, et al., bioRxiv - Neuroscience 2022

  Quote: ... and non-immune rabbit IgG (2729, Cell Signaling, 1:100 dilution). The nuclei-bound beads were washed with antibody buffer and incubated with antibody buffer containing guinea pig anti-rabbit secondary antibody (ABIN101961 ...
• Regenerating axolotl retinas regrow diverse cell types with modulation by Notch signaling and reconnect to the brain

  Anastasia S. Yandulskaya, et al., bioRxiv - Neuroscience 2022

  Quote: Primary antibodies used: rhodopsin (1:400, rabbit, #8710, Cell Signaling Technologies), β-III-tubulin (1:500 ...
• RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia

  M McMillan, et al., bioRxiv - Neuroscience 2022

  Quote: ... Primary antibody (rabbit anti-m6A antibody 1:500, Cell Signaling #56593) was added to blocking solution ...
• Disrupting ACE2 Dimerization Mitigates the Infection by SARS-COV-2

  Jiaqi Zhu, Yue Su, Young Tang, bioRxiv - Molecular Biology 2022

  Quote: ... Myc-Tag (9B11) Mouse mAb (1:1,000, Cell Signaling Technology, MA) and GAPDH (D16H11 ...
• Microglial TNFα orchestrates brain phosphorylation during the sleep period and controls homeostatic sleep

  Maria J Pinto, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-phospho MARK family activation loop (1:1000, Cell Signaling, 4836), anti-vinculin (1:5000 ...
• Mapping PTBP splicing in human brain identifies targets for therapeutic splice switching including SYNGAP1

  Jennine M. Dawicki-McKenna, et al., bioRxiv - Molecular Biology 2022

  Quote: ... and anti-mouse-HRP (Cell Signaling Technology #7076S, 1:5000 dilution) were used ...
• Mapping PTBP splicing in human brain identifies targets for therapeutic splice switching including SYNGAP1

  Jennine M. Dawicki-McKenna, et al., bioRxiv - Molecular Biology 2022

  Quote: ... mouse anti-GAPDH (D4C6R) (Cell Signaling Technology #97166S, 1:1000 dilution) and mouse anti-ATP5F1 (as above ...
• Phosphoprotein Phosphatase Activity Positively Regulates Oligomeric Pyrin to Trigger Inflammasome Assembly in Phagocytes

  Haleema S. Malik, et al., bioRxiv - Immunology 2022

  Quote: ... rabbit-anti-mouse monoclonal PP2A (1:1000 dilution, #2038, Cell Signaling), and rabbit-anti-mouse GSDMD (1:1000 dilution ...
• PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth

  Abigail H. Cleveland, et al., bioRxiv - Neuroscience 2022

  Quote: Primary antibodies used were: H3K27me3 diluted 1:200 (Cell Signaling, #9733), pRB diluted 1:3000 (Cell Signaling ...
• P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway

  Zhijia Wang, et al., bioRxiv - Biochemistry 2022

  Quote: ... anti-p44/42 MAPK (Erk1/2) (Cell Signaling Technology, 1:4000). Manufacturers provide validation for all antibodies.
• Obesity Disrupts Pituitary UPR Leading to NAFLD

  Qingwen Qian, et al., bioRxiv - Physiology 2022

  Quote: ... and Lamin A/C (Cell Signaling, Cat No. 4777, 1:500), followed by 1 hr incubation with fluorescent-conjugated secondary antibodies at RT for 1hr ...
• The role of Limch1 alternative splicing in skeletal muscle function

  Matthew S. Penna, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-Histone H3 (1: 2,000, catalog number D1H2: 4499, Cell Signaling), and anti-mLIMCH1 (1:400 ...
• Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium

  Natalia Pydyn, et al., bioRxiv - Molecular Biology 2022

  Quote: ... rabbit anti-p-IGF1RTyr1135/1136/IRTyr1150/1151 (1:1000; Cell Signaling), rabbit anti-IR (1:1000 ...
• NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

  Ruolin Zhang, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-ß-III- tubulin (1:300, Cell signaling technology, catalog 5568S) or anti-Nestin (1:250 ...
• The anatomy of transcriptionally active chromatin loops in Drosophila primary spermatocytes using super-resolution microscopy

  Madeleine L. Ball, et al., bioRxiv - Molecular Biology 2022

  Quote: ... 1:500 and rabbit anti-RPol-PSer2/5 (47355, Cell Signaling); 1:500 ...
• RSV-induced Expanded Ciliated Cells Contribute to Bronchial Wall Thickening

  Sattya N. Talukdar, et al., bioRxiv - Microbiology 2022

  Quote: ... anti-E-cadherin rabbit monoclonal (1:200) (3195S, Cell Signaling Technologies), anti-MUC5B rabbit monoclonal (1:500 ...
• Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

  Chikako Okubo, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit monoclonal anti-phospho-AKT (Ser473) (1:50, Cell Signaling Technology), rabbit polyclonal anti-p70S6K (1:50 ...
• JAK/STAT signaling promotes the emergence of unique cell states in ulcerative colitis

  Grzegorz Maciag, et al., bioRxiv - Cell Biology 2024

  Quote: ... anti-Phospho-S6 (1:10,000; D57.2.2E monoclonal rabbit; Cell Signaling 4858) and anti-a-Tubulin (1:10,000 ...