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851 - 900 of 1197 citations for DL Lysine 2 15N DiHCl since 2020

• Thrombospondin 2 is a key determinant of fibrogenesis in NAFLD

  Takefumi Kimura, et al., bioRxiv - Molecular Biology 2023

  Quote: ... small mothers against decapentaplegic (SMAD) 2/3 (D7/G7) (Cell Signaling Technology, #8685, 1:1,000), Phospho-Smad2 (Ser465/467)/Smad3 (Ser423/425 ...
• Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

  Bowen Tan, et al., bioRxiv - Neuroscience 2023

  Quote: ... 2% donkey serum) and then incubated with primary antibody (rabbit anti-c-fos, Cell Signaling, 1:500 for 100-μm sections ...
• Atypical Chemokine Receptor 3 ‘Senses’ CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation

  Christopher T. Schafer, et al., bioRxiv - Biochemistry 2023

  Quote: ... ERK1/2 phosphorylation was detected by probing with anti-phospho-p44/42 (4370, Cell Signaling) and anti-tubulin (T6074 ...
• Combined KRAS^G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS^G12C-driven cancers by addressing intrinsic and acquired resistance

  Venu Thatikonda, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (1:2000, Cell Signaling Technology #4370) was developed using Opal tyramide signal amplification (TSA ...
• Oncogenic Kras^G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8⁺ T cells dependent manner

  Krishnan K. Mahadevan, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (1:2000, Cell Signaling Technology #4370) was developed using Opal tyramide signal amplification (TSA ...
• Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

  Evan J. Underhill, Jared E. Toettcher, bioRxiv - Developmental Biology 2023

  Quote: ... Erk1/2 phosphorylated at Thr202 and Tyr204 rabbit (Cell Signaling Technology, 4370, 1:200 dilution), phospho-Akt at Ser473 rabbit (Cell Signaling Technology ...
• Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis

  Thomas Kehrer, et al., bioRxiv - Microbiology 2022

  Quote: ... Antibodies used for immunostaining of histology slides are: SARS-CoV-2 spike (99423S, Cell Signaling) at a 1:400 dilution ...
• Alterations in the preneoplastic breast microenvironment of BRCA1/2 mutation carriers revealed by spatial transcriptomics

  Anthony Caputo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and 1:200 phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology, 9101S). Primary antibodies used for immunohistochemistry of FFPE tissues were 1:50 COL6 (Rockland ...
• FGF9, a potent mitogen, is a new ligand for integrin αvβ3, and the FGF9 mutant defective in integrin binding acts as an antagonist

  Chih-Chieh Chang, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-phospho-p44/42 MAPK (p-ERK1/2) (Thr-202/Tyr204) (Cell Signaling Technology, USA), rabbit anti-FGFR1 (Cell Signaling Technology ...
• Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral and signaling plasticity in vivo

  Mohamed R. Ahmed, et al., bioRxiv - Neuroscience 2023

  Quote: ... blots were re-probed with a rabbit anti-ERK1/2 antibody (Cell Signaling, cat.# 9102) at 1:1,000 dilution to detect total ERK1/2 ...
• Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning

  George R. Bjorklund, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (RRID:AB_2315112, Cell Signaling Technologies 4370), rabbit anti-ERK2 (RRID:AB_732210 ...
• Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning

  George R. Bjorklund, et al., bioRxiv - Neuroscience 2023

  Quote: ... rabbit anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (RRID:AB_2315112, Cell Signaling Technologies 4370), rabbit anti-ERK2 (RRID:AB_732210 ...
• Influence of myosin regulatory light chain and myosin light chain kinase on hair cells of the inner ear

  Ryohei Oya, et al., bioRxiv - Biophysics 2023

  Quote: ... anti-phospho-myosin light chain 2 (3671; Cell Signaling Technology, Danvers, MA, USA; 1:50); Alexa Fluor 488-labeled secondary antibody (Thermo Fisher Scientific ...
• Fate plasticity of interneuron specification

  Mohammed A. Mostajo-Radji, et al., bioRxiv - Neuroscience 2024

  Quote: Rabbit anti-MAPK (ERK1/2) phosphorylated (T202/Y204) (Cell Signaling # 9101; RRID: AB_331646; 1:100)
• Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity

  Shilpa Singh, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Cells were then incubated with 1 μg/ml DAPI (4,6-diamidino-2-phenylindole, Cell Signaling) for 5 min ...
• Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling

  Peiyuan Chai, et al., bioRxiv - Molecular Biology 2024

  Quote: ... mouse monoclonal anti-p44/42 MAPK (Erk1/2) (Cell Signaling Technology, 4370S, immunoblot 1:500). Secondary antibodies used ...
• Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)

  Ting Zhang, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... or 2 μg control normal Rabbit IgG antibody (antibody 2729; Cell Signaling Technology, Danvers, MA), in the presence of protein G magnetic beads ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... and Phospho-p44/42 MAPK (Erk1/2) D13.14.4E XP®Rabbit mAb (Cell Signaling Technology).
• NOK promotes tumorigenesis through coordinating epidermal growth factor receptor to boost the downstream signaling in breast cancer

  Yinyin Wang, et al., bioRxiv - Cell Biology 2024

  Quote: ... AKT1/2/3 (9272) and SHC (2432) were purchased from Cell Signaling (Danvers, MA, USA). Antibody against phosphotyrosine (4G10 ...
• Astrocyte-derived PEA116 increases adult hippocampal neurogenesis and confers stress resilience

  Carron Charline, et al., bioRxiv - Neuroscience 2024

  Quote: ... Plates were incubated with primary antibodies rabbit anti-ERK1/2 (1/500, Cell Signaling 4695), rabbit anti-p-ERK1/2 (1:500 ...
• Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations

  Wen Yih Aw, et al., bioRxiv - Bioengineering 2024

  Quote: ... and anti-phospho-myosin light chain 2 (Thr18/Ser19) (1:1000, Cell Signaling Technology, #3674). After overnight incubation with primary antibodies ...
• Overexpression of βTrCP1 elicits cell death in cisplatin-induced senescent cells

  Alejandro Belmonte-Fernández, et al., bioRxiv - Cell Biology 2024

  Quote: ... and the supernatants were incubated for 2 hours with anti-βTrCP (#4394, Cell Signaling Technology), anti-NPM1 (GTX57555 ...
• Sensitivity to Vγ9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis

  Astrid Cleven, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Rabbit mAb P44/42 MAPK (Erk 1/2) (137F5) (1:1,000; #4695; Cell Signaling Technology), rabbit mAb Phospho-MAPK (Erk 1/2 Thr202/Tyr204 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... and Phospho-p44/42 MAPK (Erk1/2) D13.14.4E XP®Rabbit mAb (Cell Signaling Technology).
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... and Phospho-p44/42 MAPK (Erk1/2) D13.14.4E XP®Rabbit mAb (Cell Signaling Technology).
• Active Perception during Angiogenesis: Filopodia speed up Notch selection of tip cells in silico and in vivo

  Bahti Zakirov, et al., bioRxiv - Cell Biology 2020

  Quote: ... Embryos were subsequently incubated overnight with anti-phospho-ERK1 /2 antibody (1:250, Cell Signaling; #4370) in blocking buffer ...
• Tumor Suppressor p53 Restrains Cancer Cell Dissemination by Modulating Mitochondrial Dynamics

  Thi Tuyet Trinh Phan, et al., bioRxiv - Molecular Biology 2021

  Quote: ... and phospho-ERK1/2 (Thr202/Tyr204) (4370) were purchase from Cell Signaling Technology (Beverly, MA, USA). Antibodies against MTFP1 (ab198217 ...
• IDENTIFICATION OF A NOVEL BDNF-SPECIFIC CORTICOSTRIATAL CIRCUITRY

  Yann Ehinger, et al., bioRxiv - Neuroscience 2021

  Quote: ... Rabbit anti-Phospho-ERK1/2 antibody (CST 4377) was purchased from Cell Signaling Technology (Danvers, MA). Chicken anti-GFP (A10262) ...
• ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin’s lymphoma and testicular cancer cells

  Daniel Constantin, Christian Widmann, bioRxiv - Cancer Biology 2020

  Quote: ... lot 2) and the one used for immunocytochemistry was from Cell Signaling (CLS D93F6; lot 1). The antibodies against H3K4me3 (Ab8580 ...
• Nanchangmycin regulates FYN, FAK and ERK to control the fibrotic activity of hepatic stellate cells

  Wenyang Li, et al., bioRxiv - Cell Biology 2021

  Quote: ... phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) antibody (1:1000, Cell Signaling Technology, cat# 4370), and goat anti-rabbit IgG secondary antibody (Invitrogen ...
• Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole rat

  Jing Zhao, et al., bioRxiv - Cancer Biology 2020

  Quote: The following antibodies were used in this study: phospho-ERK1/2 (4370, Cell Signaling Technology (CST)) ...
• Silencing of oncogenic KRAS by mutant-selective small interfering RNA

  Bjoern Papke, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Rabbit polyclonal anti-phospho-p44/42 MAPK (pERK1/2) (Thr202/Tyr204) (Cell Signaling Technology Cat #4370), Rabbit polyclonal anti-p44/42 MAPK (ERK1/2 ...
• Dynamics and heterogeneity of Erk-induced immediate-early gene expression

  Siddhartha G. Jena, et al., bioRxiv - Cell Biology 2021

  Quote: ... Primary antibodies used were Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology #9101), c-Fos (Cell Signaling Technology #2250) ...
• Optimized Workflow for Enrichment and Identification of Biotinylated Peptides using Tamavidin 2-REV for BioID and Cell Surface Proteomics

  Kohei Nishino, et al., bioRxiv - Biochemistry 2022

  Quote: ... anti-phospho-ERK1/2 (Thr202/Tyr204) (D13.14.4E) XP rabbit mAb (Cell Signaling Technology, #4370, 1:2,500); anti-α-tubulin (DM1a ...
• A dual mechanism of APC/C inhibition by MAP kinases

  Li Sun, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit polyclonal anti-phospho-p44/42 (detecting activated Pmk1 or Erk1/2) (Cell Signaling Technology; #9101); rabbit polyclonal anti-PSTAIRE (detecting Cdc2 ...
• Purinergic receptor P2RY14 cAMP signaling regulates EGFR-driven Schwann cell precursor self-renewal and nerve tumor initiation in neurofibromatosis

  Jennifer Patritti-Cram, et al., bioRxiv - Neuroscience 2021

  Quote: ... phosphor-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) rabbit (1:1000, Cell Signaling Technologies, Cat#: 8544S); P44/42 MAPK (Erk1/2 ...
• Mechanochemical control of epidermal stem cell divisions by B-plexins

  Chen Jiang, et al., bioRxiv - Cell Biology 2020

  Quote: ... rabbit polyclonal anti-phospho-myosin light chain 2 (Ser19) (1:200, Cell Signaling, cat. no. #3671), rabbit polyclonal anti-phospho-myosin light chain 2 (Thr18/Ser19 ...
• Targeting G_i/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy

  Cancan Lyu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK1/2 (no. 4696) and phospho-ERK1/2T202/Y204 (no. 4370) were from Cell Signaling Technology; GADPH (sc-47724 ...
• RIOK2 drives glioblastoma cell proliferation by modulating MYC through the RNA-binding protein IMP3

  Alexander S. Chen, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Beads were conjugated with 10 μg either anti-IMP3 (#1: MBL, RN009P, #2: Cell Signaling, 57145) or non-specific IgG ...
• Rac1, Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons

  Zouzana Kounoupa, et al., bioRxiv - Neuroscience 2022

  Quote: ... mouse monoclonal anti-Phospho-Myosin light chain 2 (Ser19) (1:200; Cell signaling, Beverly, MA, USA), anti-mouse Phospho RhoA ...
• Independent control over cell patterning and adhesion on hydrogel substrates for tissue interface mechanobiology

  Louis S. Prahl, et al., bioRxiv - Bioengineering 2022

  Quote: ... rabbit anti-phospho-p44/42 MAPK (ERK1/2) (1:200, #4370, Cell Signaling Technologies, RRID: AB_2315112), and rabbit anti-E-cadherin (24E10 ...
• ROS induction as a strategy to target persister cancer cells with low metabolic activity in NRAS mutated melanoma

  Ossia M. Eichhoff, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204, 20G11, Cell Signaling #4376, RRID:AB_331772, dilution 1:1000), Caveolin-1 (E249 ...
• Core material and surface chemistry of Layer-by-Layer (LbL) nanoparticles independently direct uptake, transport, and trafficking in preclinical blood-brain barrier (BBB) models

  Nicholas G. Lamson, et al., bioRxiv - Bioengineering 2022

  Quote: ... F(ab’)2 Fragment (Alexa Fluor® 488 Conjugate) #4412 were purchased from Cell Signaling Technologies. 6 mm biopsy punched were purchased from McKesson ...
• Endogenous μ-opioid – neuropeptide Y Y1 receptor synergy silences chronic postoperative pain

  Tyler S. Nelson, et al., bioRxiv - Neuroscience 2022

  Quote: ... and then incubated with primary rabbit antibody anti-phosphorylated-ERK1/2 antiserum (1:1000, Cell Signaling) at 4 °C for 24h on a shaker ...
• Calpain-mediated proteolysis of vimentin filaments is augmented in Giant Axonal Neuropathy (GAN) fibroblasts exposed to hypotonic stress

  Cassandra L. Phillips, et al., bioRxiv - Cell Biology 2022

  Quote: ... and rabbit anti-Calpain 2 (Cell Signaling Technology, large subunit M-type, E3M6E, IF 1:200). The following secondary antibodies and concentrations were utilized ...
• Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1

  Dymonn Johnson, et al., bioRxiv - Cell Biology 2024

  Quote: ... Primary antibodies used for immunoblotting were: rabbit-p-ERK1/2 (Cell Signaling Technology; T202; 1:2000), rabbit-p-SRC (Cell Signaling Technology ...
• A targetable PREX2/RAC1/PI3Kβ signalling axis confers resistance to clinically relevant therapeutic approaches in melanoma

  Catriona A. Ford, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and phospho-p44/42 MAPK (ERK1/2; ERK1, Thr202/Tyr204/ERK2,Thr185/Tyr187) (#9101, Cell Signaling) was performed on an Agilent Autostainer Link 48 ...
• Multimodal Hox5 activity generates motor neuron diversity

  Ritesh KC, et al., bioRxiv - Developmental Biology 2024

  Quote: ... 200 μg of precleared protein was incubated with 2 μg of anti-HA (Cell Signaling Technology, Cat# 5017 ...
• MAP4K4 regulates biomechanical forces at adherens junctions and focal adhesions to promote collective cell migration

  Lara Elis Alberici Delsin, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit polyclonal anti-phospho-Myosin Light Chain 2 (Ser19) at 1:1000 (Cell Signaling Technology, #3671), rabbit polyclonal anti-Non-Muscle Myosin HC II-A at 1:1000 (Biolegend ...
• MAP4K4 regulates biomechanical forces at adherens junctions and focal adhesions to promote collective cell migration

  Lara Elis Alberici Delsin, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit polyclonal anti-phospho-Myosin Light Chain 2 (Ser19) at 1:500 (Cell Signaling Technology, #3671), rabbit polyclonal anti-α-actinin at 1:400 (USBiological ...