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851 - 900 of 1893 citations for 7 1H Pteridinone 4 amino 2 6 dimethyl 9CI since 2019

• SILAC phosphoproteomics reveals unique signaling circuits in CAR-T cells and the inhibition of B cell-activating phosphorylation in target cells

  Alijah A. Griffith, et al., bioRxiv - Cell Biology 2021

  Quote: ... α-pERK1/2 (T202/Y204) antibody (Cell Signaling cat. 9101, Danvers, MA), α-Erk1/2 (Cell Signaling cat ...
• Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder

  Shinsuke Oda, et al., bioRxiv - Pathology 2021

  Quote: ... Immunostaining for pERK1/2 (Clone D13.14.4E, Cell Signaling Technology, Danvers, MA, USA) and Ki67 (Clone MIB-1 ...
• Oral administration of bacterial Beta cell expansion factor A (BefA) alleviates diabetes in mice with Type 1 and Type 2 diabetes

  Huan Wang, et al., bioRxiv - Biochemistry 2021

  Quote: ... anti-Bcl-2-associated X protein (Bax) (Cell Signaling Technology, USA, # 5023S), anti-B cell lymphoma-2 (Bcl-2 ...
• Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance

  Li Li, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Integrin ß1(D2E5) and Bcl-2 were purchased from Cell Signaling Technology. GFP antibody and HER2/neu Ab-8 (Clone e2-4001 ...
• DNA damage and oxidizing conditions activate p53 through differential upstream signaling pathways

  Tao Shi, et al., bioRxiv - Cell Biology 2020

  Quote: ... pp38MAPK (Thr180/Tyr182) and pATF-2 (Thr71) were from Cell Signaling Technology. Phospho-Histone H2AX (Ser139 ...
• Negative durotaxis: cell movement toward softer environments

  Aleksi Isomursu, et al., bioRxiv - Biophysics 2020

  Quote: ... rbt anti-ERK1/2 (Cell Signaling Technology, 9102, 1:1000 for WB), rbt anti-p-ERK1/2 (T202/Y204 ...
• Melanomagenesis driven by a kinase-dead mutant BRAF lacking codons 600-618

  Megan A. Girtman, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Total MEK1/2 (#4694S) all purchased from Cell Signaling Technology (Davers, MA), BRAF (Santa Cruz Biotechnology ...
• Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

  Parishmita Sarma, et al., bioRxiv - Biochemistry 2022

  Quote: ... and anti-tERK1/2 (1:5000; Cell Signaling Technology, Cat. no. 9102). CXCR7pp2 was synthesized at the Tufts University Core Facility.
• Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington’s disease mouse phenotype

  Jordi Creus-Muncunill, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-p44/42 MAPK (Erk1/2) Antibody (1:1000, #9102, Cell Signaling), anti-C1q [4.8] (1:500 ...
• Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

  Jason J. Northey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p44/42 MAPK (ERK1/2) (Cell Signaling Technology, Cat. #: 9102, 1:1000), phospho-PR (S294 ...
• Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells

  Marianne R. Spalinger, et al., bioRxiv - Microbiology 2020

  Quote: ... incubated with 2 μl anti-PTPN2 antibody (Clone D7T7D, Cell Signaling Technologies) over night ...
• Transferrin-dependent crosstalk between the intestinal tract and commensal microbes contributes for immune tolerance

  Xiaopeng Tang, et al., bioRxiv - Immunology 2020

  Quote: ... anti-total-IκBα (1:2□000 dilution, 4814T, Cell Signaling Technology, USA), anti-phospho-NF-κB p65 (1:1□000 dilution ...
• HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

  Claudio Laquatra, et al., bioRxiv - Biochemistry 2020

  Quote: ... rabbit polyclonal anti-phospho-ERK1/2 was from Cell Signaling (Cat.# 9101); rabbit polyclonal anti-glucose transporter GLUT1 was from Abcam (Cat.# ab652).
• Biased agonists of the chemokine receptor CXCR3 differentially drive formation of G_αi:β-arrestin complexes

  Kevin Zheng, et al., bioRxiv - Biochemistry 2020

  Quote: ... phosphorylated extracellular regulated kinase 1/2 (ERK) (Cell Signaling Technology, Danvers, MA) and total ERK (Millipore ...
• Jak2^V617F Reversible Activation Shows an Essential Requirement for Jak2^V617F in Myeloproliferative Neoplasms

  Andrew Dunbar, et al., bioRxiv - Cancer Biology 2022

  Quote: ... and phospho-44/42 MAPK (Erk1/2) (Cell Signaling 4376, 1:100). Pictures were taken at 100X ...
• Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice

  Florence Njau, et al., bioRxiv - Cell Biology 2019

  Quote: ... Phospho-VEGFR-2 (Tyr1175) Sandwich ELISA Kit was from Cell Signaling Technology. Mouse albumin ELISA kit (Bethyl Lab ...
• Cortical ChAT⁺ neurons co-transmit acetylcholine and GABA in a target- and brain-region specific manner

  Adam J Granger, et al., bioRxiv - Neuroscience 2020

  Quote: ... Session 2 for PSD-95 (rabbit α-PSD95, 3450 Cell Signaling Tech.), Session 3 for VGAT (rabbit α-VGAT ...
• NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

  Carolina Marques, et al., bioRxiv - Cancer Biology 2020

  Quote: ... ERK1/2 (Cell Signaling Technology, #9102, 1:1000; Abcam #ab17942, 1:1000), p-MEK (S217/221 ...
• ATP allosterically stabilizes Integrin-linked kinase for efficient force generation

  Isabel M. Martin, et al., bioRxiv - Biophysics 2021

  Quote: ... phospho-Myosin Light Chain 2 (Thr18/Ser19) (Cell Signaling; 3674; 1:200), Paxillin (BD Transduction Laboratories ...
• MEK1/2 in Rhabdomyosarcoma

  Kenneth A. Crawford, et al., bioRxiv - Cancer Biology 2019

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Cat# 9101), ß-Actin (13E5 ...
• Oxidative Stress and Neuroinflammation in a Rat Model of Co-Morbid Obesity and Psychogenic Stress

  Jose M. Santiago Santana, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-rabbit SOD-2 (1:2000; catalog #13141S; Cell Signaling, Danvers, MA); anti-rabbit GFAP (1:5000 ...
• Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma

  Odessa R. Yabut, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rabbit anti-phospho-Erk1/2 (1:250 dilution; Cat. #: 4370, Cell Signaling); γH2AX (1:100 dilution ...
• Perineuronal net receptor PTPσ regulates retention of memories

  Angelina Lesnikova, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-p44/42 MAPK (Erk1/2) rabbit pAb (Cell Signaling Technology, #9102); anti-p70 S6 kinase rabbit pAb (Cell Signaling Technology ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-phospho-ERK1/2 (T202/Y204) (Cell Signaling 4370, 1:2000), rabbit anti-ERK1/2 (Cell Signaling 4695 ...
• TOP-2 is differentially required for the proper maintenance of cohesin on meiotic chromosomes in C. elegans spermatogenesis and oogenesis

  Christine Rourke, Aimee Jaramillo-Lambert, bioRxiv - Genetics 2021

  Quote: ... rabbit anti-AIR-2 [(1:500) Figure 2B] (Cell Signaling Technology, 2914S), Histone H3 phospho-T3 (1:750 ...
• Venous activation of MEK/ERK drives development of arteriovenous malformation and blood flow anomalies with loss of Rasa1

  Jasper Greysson-Wong, et al., bioRxiv - Developmental Biology 2021

  Quote: Phospho-p44/42 MAPK (ERK1/2) (Thr2020/Tyr204) antibody (Cell Signaling, #9101) staining was performed as previously published (Randlett et al. ...
• A dynamic equilibrium between TTP and CPEB4 controls mRNA stability and inflammation resolution

  Clara Suñer, et al., bioRxiv - Molecular Biology 2021

  Quote: ... Phospho-p44/42 (Erk1/2) (Thr202/Try204) (Cell Signaling Clon E10, 9106); SOCS1 (Abcam Ab9870) ...
• A BTB-Domain Transcription factor Recruits Chromatin Remodelers and a Histone Chaperone during the exit from Pluripotency

  Daniel Olivieri, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Separate membranes were probed with Erk1/2 antibody (Cell Signaling Technology, #9102) or Phospho-Erk1/2 antibody (Cell Signaling Technology ...
• Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt

  Brittany L. Dunkerly-Eyring, et al., bioRxiv - Cell Biology 2021

  Quote: ... and anti-p44/42 MAPK (ERK1/2) (Cell Signaling Technology, 1:1000). Total protein stain used was Revert Total Protein Stain (Licor) ...
• Metformin-mediated mitochondrial protection post-cardiac arrest improves EEG activity and confers neuroprotection and survival benefit

  Muhammad Shoaib, et al., bioRxiv - Neuroscience 2021

  Quote: ... and Total AMPK β1/2 (1:1000; Cell Signaling Technology, Beverly, MA). Detection used anti-rabbit horseradish peroxidase–conjugated secondary antibody (1:2000 ...
• The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids

  Jennifer Rynne, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Precleared lysates were immunoprecipitated with BRF1/2 antibody (#2119, Cell Signaling Technology), Glucocorticoid Receptor antibody (#3660 ...
• Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity

  Dongjoo Kim, et al., bioRxiv - Bioengineering 2022

  Quote: ... FITC conjugated anti-mouse IgG antibody (2 μg/ml, Cell Signaling Technology) was loaded in the first microfluidic channel to differentiate the location of loaded samples in fluorescent image as well as recognize the presence of mouse derived antibodies on PLL slide ...
• Retinoid acid receptor β mechanically regulates the activity of pancreatic cancer cells

  Carlos Matellan, et al., bioRxiv - Bioengineering 2022

  Quote: ... or anti-MLC-2 antibodies (Cell Signaling Technology, 3672S, Rabbit, 1:100) and anti-PAN cytokeratin (Abcam ...
• Copper chelation inhibits TGF-β pathways and suppresses epithelial-mesenchymal transition in cancer

  E. M. Poursani, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Phospho-p44/42 MAPK (pERK1/2)(T202/Y204) (D13.14.4E, Cell Signaling Technology), p44/42 MAPK (ERK1/2 ...
• Breast cancer mutations HER2^V777L and PIK3CA^H1047R activate the p21-CDK4/6 –Cyclin D1 axis driving tumorigenesis and drug resistance

  Xiaoqing Cheng, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell signaling technology, #9101). Secondary antibodies used include anti-rabbit IgG (H+L ...
• Cryptochromes and UBP12/13 deubiquitinases antagonistically regulate DNA damage response in Arabidopsis

  Yuzhao Hu, et al., bioRxiv - Plant Biology 2023

  Quote: ... anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology), anti-actin (MP Biomedicals ...
• Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice

  Ferrol I. Rome, et al., bioRxiv - Physiology 2022

  Quote: ... and 3-hydroxymethylglutaryl-CoA synthase 2 (HMGCS2; Cell Signaling Technology, 20940S; RRID:AB_2798853). All primary antibodies were used as a dilution of 1:1000 ...
• PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

  Maria B. Campaña, et al., bioRxiv - Cell Biology 2023

  Quote: ... phospho-ERK1/2 (Thr202/Tyr204) (1:1000; 9101; Cell Signaling Technology, Inc.); ERK1/2 (1:1000 ...
• Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression

  Giusy Pizzirusso, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1:1000 anti-Synaptotagmin-2 polyclonal rabbit antibody (#60889, Cell Signaling Technology), 1:1000 anti-GABA-A Receptor beta 3 polyclonal rabbit antibody (#NB300-199 ...
• Mitochondrial Raf1 Regulates Glutamine Catabolism

  Ronald L. Shanderson, et al., bioRxiv - Cancer Biology 2024

  Quote: Primary antibodies used: p44/42 (ERK1/2)(L34F12)(4696S, Cell Signaling Technology), Phospho-p44/42 MAPK (ERK1/2)(Thr202/204)(9101S ...
• Mitochondrial Raf1 Regulates Glutamine Catabolism

  Ronald L. Shanderson, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-p44/42 MAPK (ERK1/2)(Thr202/204)(9101S, Cell Signaling Technology),c-Raf (D4B3J ...
• An atlas of epithelial cell states and plasticity in lung adenocarcinoma

  Guangchun Han, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p44/42 MAPK (ERK1/2, rabbit, Cell Signaling Technology, 9102, 1:2000), or S6 (E.573.4 ...
• Bromodomain-containing Protein 4 Regulates Innate Inflammation in Airway Epithelial Cells via Modulation of Alternative Splicing

  Morgan Mann, et al., bioRxiv - Systems Biology 2023

  Quote: ... 2 μg α-RelA antibody (Cell Signaling, Danvers, MA, USA, Cat. # 8242) was added to each extract ...
• Culture conditions greatly impact the levels of vesicular and extravesicular Ago2 and RNA in extracellular vesicle preparations

  Lizandra Jimenez, et al., bioRxiv - Cancer Biology 2023

  Quote: Rabbit anti-Argonaute 2 (cat no. 2897) was purchased from Cell Signaling. Rat anti-Ago2 (cat no ...
• Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints

  Alexa C. Cannon, et al., bioRxiv - Cancer Biology 2023

  Quote: ... PAK 1/2/3 1:1000 (Cell Signaling Technology Cat# 2604, RRID:AB_2160225), Myc-Tag 1:1000 (Cell Signaling Technology Cat# 2276 ...
• Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish

  Nanami Morooka, et al., bioRxiv - Developmental Biology 2023

  Quote: ... rabbit anti-Phospho-p44/42 MAPK (Erk1/2) (1:500, Cell signaling), and mouse anti-RFP (1:500 ...
• Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

  Pavlo Potalitsyn, et al., bioRxiv - Biochemistry 2023

  Quote: ... and IGF-2 Receptor/CI-M6PR (D3V8C) antibody (Cell Signaling, cat.no.14364). Anti-actin (20-33 ...
• Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron

  Da-Yuan Chen, et al., bioRxiv - Microbiology 2023

  Quote: ... An anti-SARS-CoV-2 S antibody (Cell Signaling technologies: clone E5S3V) that showed equivalent immunoreactivity against WT and Omicron spike was used to identify virus-infected cells ...
• Endosome dysfunction leads to gain-of-function TLR7 and human lupus

  Harshita Mishra, et al., bioRxiv - Immunology 2023

  Quote: ... anti-Phospho-p44/42 (ERK1/2) (1:1000, 197G2, 4377T, Cell Signaling), anti-p44/42 (ERK1/2 ...
• Macrophage migration is differentially regulated by distinct ECM components

  Matthew W. Stinson, et al., bioRxiv - Cell Biology 2023

  Quote: ... Phospho-Myosin Light Chain 2 antibody (for immunofluorescence) (Polyclonal, Cell Signaling, #3674); Goat anti-Rabbit IgG Rhodamine Red-X (RRX ...