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851 - 900 of 1737 citations for 5 Methoxypyridine 2 carboxylic acid methyl ester since 2020

• Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression

  Giusy Pizzirusso, et al., bioRxiv - Neuroscience 2024

  Quote: ... 1:1000 anti-Synaptotagmin-2 polyclonal rabbit antibody (#60889, Cell Signaling Technology), 1:1000 anti-GABA-A Receptor beta 3 polyclonal rabbit antibody (#NB300-199 ...
• Diet-induced obesity results in endothelial cell desensitization to VEGF-A and permanent islet vascular dysfunction

  Yan Xiong, et al., bioRxiv - Physiology 2023

  Quote: ... Erk1/2 antibody (rabbit, 1:2000; all from Cell Signaling Technology, USA), and α-tubulin antibody (mouse,1:1000 ...
• Subfamily C7 Raf-like kinases MRK1, RAF26, and RAF39 regulate immune homeostasis and stomatal opening in Arabidopsis thaliana

  Márcia Gonçalves Dias, et al., bioRxiv - Plant Biology 2023

  Quote: ... 1:2,000 rabbit anti-p44/42 MAPK (Erk1/2) (Cell Signaling 9102S); 1:10,000 goat anti-rabbit-IgG (Sigma A0545) ...
• PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

  Maria B. Campaña, et al., bioRxiv - Cell Biology 2023

  Quote: ... phospho-ERK1/2 (Thr202/Tyr204) (1:1000; 9101; Cell Signaling Technology, Inc.); ERK1/2 (1:1000 ...
• Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter

  Marco Di Gioia, et al., bioRxiv - Immunology 2023

  Quote: ... phospho-ERK1/2 (Thr202/Tyr204) (1:1000, Cell Signaling Technology, Cat# 9106), ERK1/2 (1:1000 ...
• Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

  Zhuxuan Li, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (#4370, Cell Signaling Technology, 1:1000), ERK (#9102S ...
• The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids

  Jennifer Rynne, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Precleared lysates were immunoprecipitated with BRF1/2 antibody (#2119, Cell Signaling Technology), Glucocorticoid Receptor antibody (#3660 ...
• Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity

  Dongjoo Kim, et al., bioRxiv - Bioengineering 2022

  Quote: ... FITC conjugated anti-mouse IgG antibody (2 μg/ml, Cell Signaling Technology) was loaded in the first microfluidic channel to differentiate the location of loaded samples in fluorescent image as well as recognize the presence of mouse derived antibodies on PLL slide ...
• Retinoid acid receptor β mechanically regulates the activity of pancreatic cancer cells

  Carlos Matellan, et al., bioRxiv - Bioengineering 2022

  Quote: ... or anti-MLC-2 antibodies (Cell Signaling Technology, 3672S, Rabbit, 1:100) and anti-PAN cytokeratin (Abcam ...
• Copper chelation inhibits TGF-β pathways and suppresses epithelial-mesenchymal transition in cancer

  E. M. Poursani, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Phospho-p44/42 MAPK (pERK1/2)(T202/Y204) (D13.14.4E, Cell Signaling Technology), p44/42 MAPK (ERK1/2 ...
• Breast cancer mutations HER2^V777L and PIK3CA^H1047R activate the p21-CDK4/6 –Cyclin D1 axis driving tumorigenesis and drug resistance

  Xiaoqing Cheng, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell signaling technology, #9101). Secondary antibodies used include anti-rabbit IgG (H+L ...
• Cryptochromes and UBP12/13 deubiquitinases antagonistically regulate DNA damage response in Arabidopsis

  Yuzhao Hu, et al., bioRxiv - Plant Biology 2023

  Quote: ... anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology), anti-actin (MP Biomedicals ...
• Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

  Pavlo Potalitsyn, et al., bioRxiv - Biochemistry 2023

  Quote: ... and IGF-2 Receptor/CI-M6PR (D3V8C) antibody (Cell Signaling, cat.no.14364). Anti-actin (20-33 ...
• Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron

  Da-Yuan Chen, et al., bioRxiv - Microbiology 2023

  Quote: ... An anti-SARS-CoV-2 S antibody (Cell Signaling technologies: clone E5S3V) that showed equivalent immunoreactivity against WT and Omicron spike was used to identify virus-infected cells ...
• Endosome dysfunction leads to gain-of-function TLR7 and human lupus

  Harshita Mishra, et al., bioRxiv - Immunology 2023

  Quote: ... anti-Phospho-p44/42 (ERK1/2) (1:1000, 197G2, 4377T, Cell Signaling), anti-p44/42 (ERK1/2 ...
• Macrophage migration is differentially regulated by distinct ECM components

  Matthew W. Stinson, et al., bioRxiv - Cell Biology 2023

  Quote: ... Phospho-Myosin Light Chain 2 antibody (for immunofluorescence) (Polyclonal, Cell Signaling, #3674); Goat anti-Rabbit IgG Rhodamine Red-X (RRX ...
• Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer

  Amir Hosseini, et al., bioRxiv - Cell Biology 2023

  Quote: ... F(ab’)2 Fragment (Alexa Fluor 647 Conjugate (Cell Signaling Technology, 4410) for 1 hour at room temperature ...
• Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1

  Taoling Zeng, et al., bioRxiv - Cancer Biology 2024

  Quote: ... and anti-MEK1/2 (9122) antibodies were purchased from Cell Signaling Technology; rabbit anti-K-Ras (BS6231 ...
• Drug-Induced p53 Activation Promotes Acinar Cell Identity and Prevents Pancreatic Cancer Initiation

  Jennifer J Twardowski, et al., bioRxiv - Cancer Biology 2024

  Quote: ... rabbit monoclonal anti-p-ERK1/2 (Cell Signaling Technology 4370S, 1:100), rabbit polyclonal anti-p53 (Invitrogen PA5-88098 ...
• Improved protein binder design using beta-pairing targeted RFdiffusion

  Isaac Sappington, et al., bioRxiv - Biochemistry 2024

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology, #9101) 1:10,000 dilution ...
• Viral Insulin/IGF-like Peptides Selectively Activate Host Insulin/IGF Signaling pathways during Grouper Iridovirus Infection

  Aurelien Chuard, et al., bioRxiv - Microbiology 2024

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) Antibody (Cell Signaling #9101); p44/42 MAPK (Erk1/2 ...
• Urban wastewater contains a functional human antibody repertoire of mucosal origin

  Sean Stephenson, et al., bioRxiv - Immunology 2024

  Quote: ... SARS-CoV-2 Spike Protein Serological IgG ELISA Kit (Cell Signaling, #20154C), and SARS-CoV-2 Spike Protein Serological IgA ELISA Kit (Cell Signaling ...
• Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

  Ling Zhou, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... ERK1/2 (4696S) were obtained from Cell Signaling Technology (Boston, MA, USA), against NFE2 (11089-1-AP) ...
• A combination of the geroprotectors trametinib and rapamycin is more effective than either drug alone

  Lisonia Gkioni, et al., bioRxiv - Physiology 2024

  Quote: ... and total ERK1/2 (1:1000, anti-rabbit, Cell Signaling Technology, 4695) in 5% fatty-acid free BSA in TBS-T at 4°C overnight ...
• Cocaine, via ΔFosB, remodels gene expression and excitability in ventral hippocampus

  Andrew L. Eagle, et al., bioRxiv - Neuroscience 2024

  Quote: ... or 2 μg of rabbit polyclonal IgG isotype (3900S, Cell Signaling Technology). Antibody-bound chromatin fragments were isolated with protein G plus/protein A agarose beads (MilliporeSigma) ...
• Rigosertib Reverses Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome

  Levi Legler, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and anti-phospho-ERK 1/2 (Thr202/Tyr204) (#9101) (Cell Signaling Technology). Visualization of the primary antibody binding was performed using the Li-Cor anti-rabbit 680 IRDye system in conjunction with the Li-Cor Odyssey FC ...
• Gestational arsenite exposure alters maternal postpartum heart size and induces Ca²⁺ handling dysregulation in cardiomyocytes

  Nicole Taube, et al., bioRxiv - Pharmacology and Toxicology 2024

  Quote: ... p44/42 MAPK (ERK1/2) (1:1000, Rabbit mAb, Cell Signaling, 9102S), p-p44/42 MAPK (T202/Y204 ...
• Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase

  Erin Skeens, et al., bioRxiv - Biochemistry 2024

  Quote: ... and ERK1/2 using anti-phospho-p38 MAPK (Cell Signaling Cat# 9215), anti-phospho-JNK1/2 (Cell Signaling cat#4668 ...
• Contractile forces direct the chiral swirling of minimal cell collectives

  Ghina Badih, et al., bioRxiv - Cell Biology 2024

  Quote: Rabbit Anti-Phospho-Myosin Light Chain 2 (Ser19) Antibody (Cell Signaling 3671) was used at 1/100 and secondary Goat anti-Rabbit IgG Alexa Fluor 546 antibody (Invitrogen A11035 ...
• The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cells

  Shadi Zahedi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-p44/42 MAP kinase (pERK1/2) (#9101S) (Cell Signaling, Danvers, MA); p44/42 MAP kinase (Erk1/2 ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... or Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology)/Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... or Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology)/Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences ...
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... or Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology)/Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences).
• Uncovering the mechanistic basis of intracellular Raf inhibitor sensitivity reveals synergistic cotreatment strategies

  Ethan G. Stoddard, et al., bioRxiv - Cell Biology 2024

  Quote: ... or Phospho-MEK1/2 (Ser217/221) (41G9) Rabbit mAb (Cell Signaling Technology)/Purified Mouse Anti-MEK1 Clone 25/MEK1 (BD Biosciences).
• PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity

  Florian Wiede, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and p-(Y694) STAT-5 (D47E7) XP® (Cell Signaling Technology Cat# 4322, RRID:AB_10544692) were from Cell Signaling ...
• The novel roles of choline transporter-like 1 and 2 in ethanolamine transport

  Adrian Taylor, et al., bioRxiv - Physiology 2020

  Quote: ... and β-tubulin (Cell signaling; 1:1000 in 5% skim milk in TBS-T) were resolved on an 8% native gel and proteins were transferred onto PVDF membranes (Pall Canada ...
• Role of BMP signaling during early development of the annelid Capitella teleta

  Nicole B. Webster, et al., bioRxiv - Developmental Biology 2021

  Quote: ... and 1:800 rabbit anti-phosphorylated-SMAD1/5/8 (clone 41D10, Cell Signaling Technologies). Secondary antibodies used were as follows ...
• Repeated toxic injuries of murine liver are tolerated through microsteatosis and mild inflammation

  Seddik Hammad, et al., bioRxiv - Systems Biology 2022

  Quote: ... cryosections were incubated for 5 min with Draq5 (Cell Signaling Technology, 4084L, 1:5000). Two tile scans of 9 images each per mouse for quantification were acquired using confocal microscopy (Leica SP8 ...
• Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN

  Masahiro Nogami, et al., bioRxiv - Neuroscience 2021

  Quote: ... The blotted membranes were blocked with 5% nonfat dry milk (Cell Signaling Technology; #9999S) in Tris-buffered saline containing Tween-20 (TBST ...
• Fitm2 is required for ER homeostasis and normal function of murine liver

  Laura M. Bond, et al., bioRxiv - Cell Biology 2022

  Quote: ... Antibodies used include: total eIF2a (Cell Signaling Technology #9722, 1:1000, in 5% BSA), phosphor-Ser51-eIF2a (Cell Signaling Technology #9721 ...
• FBXW7 triggers degradation of WDR5 to prevent mitotic slippage

  Simon Hänle-Kreidler, et al., bioRxiv - Biochemistry 2022

  Quote: ... and cullin-RING E3 ubiquitin ligases with 5 µM MLN4924 (Cell Signaling Technology, 85923) for 5 h prior to cell harvest.
• TRPM2 deficiency protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophages

  Pengyu Zong, et al., bioRxiv - Physiology 2021

  Quote: ... Rabbit polyclonal antibodies to Fyn (Cell Signaling Technology, 4023S, 1:2500 in 5% BSA); Rabbit polyclonal antibodies to Phospho-Src Family (Tyr416 ...
• Dot1L-dependent H3K79 methylation facilitates histone variant H2A.Z exchange at DNA double strand breaks and is required for high fidelity, homology-directed DNA repair

  Nehemiah S. Alvarez, et al., bioRxiv - Molecular Biology 2021

  Quote: ... + 0.5 μL 1M DTT + 5 μL 200X PIC (SimpleChIP Kit #9003, Cell Signaling Technology) and incubated on ice 10 min with mixing every 3 min ...
• ETAS®50 Attenuates SARS-CoV-2 Spike Protein-Induced IL-6 and IL-1β Production by Suppressing p44/42 MAPK and Akt Phosphorylation in Murine Primary Macrophages

  Ken Shirato, Jun Takanari, Takako Kizaki, bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... Cells were co-treated with 5 μM U0126 (Cell Signaling Technology, Danvers, MA, USA) or 20 μM perifosine (Cell Signaling Technology ...
• Impaired clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in a mouse model of Alzheimer’s disease

  Allison R. Fusilier, et al., bioRxiv - Neuroscience 2021

  Quote: ... phospho-GSK3β (Ser9) (1:1000 in 5% BSA and TBST, Cell Signaling Technology, #93360), and GAPDH (1:5000 ...
• iTRVZ: liquid nano-platform for signal integration on the plasma membrane

  Taka A. Tsunoyama, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-VASP (clone 9A2, Cell Signaling Technology: 3132, Lot#: 5, 21 ng/ml), rabbit anti-Akt (Cell Signaling Technology ...
• Hedgehog pathway members Patched and Costal-2 exhibit differences in overgrowth autonomy in Drosophila melanogaster

  Shannon L. Moore, et al., bioRxiv - Developmental Biology 2021

  Quote: ... Other antibodies used were anti-phospho-Smad1/5 (pMad) (rabbit 1:100, Cell Signaling), anti-DIAP1 (mouse ...
• The hepatokine FGL1 regulates hepcidin and iron metabolism during the recovery from hemorrhage-induced anemia in mice

  Ugo Sardo, et al., bioRxiv - Physiology 2023

  Quote: ... Membranes were blocked 1h with 5% of non-Fat dry milk (NFDM, Cell signaling) diluted in TBS-T buffer (10mM Tris-HCl ...
• Ikzf1 association with Foxp3 for Foxp3-dependent gene repression in Treg cells: induction of autoimmunity and tumor immunity by disrupting the association

  Kenji Ichiyama, et al., bioRxiv - Immunology 2023

  Quote: ... whole cell lysates were pre-cleared with 5 μg anti-IgG (Cell Signaling Technology) or 5 μg anti-Ikzf1 (Cell Signaling Technology ...
• Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving calcium-calcineurin-NFAT signaling

  Alison A. Chomiak, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Pre-cleared chromatin was immunoprecipitated with 5 µL of H3K27me3 antibody (Cell Signaling 9733) overnight at 4°C with constant rotation ...