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751 - 800 of 1760 citations for 2 4 Dimethyl 4' 4 methylpiperazinomethyl benzophenone since 2020

• Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/P38 signaling

  Jamie L. Grit, et al., bioRxiv - Genomics 2020

  Quote: ... phospho-ERK1/2 (Cell Signaling #9101), and β-Actin (Cell Signaling #3700) ...
• GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection

  Tomoko Sumitomo, et al., bioRxiv - Microbiology 2020

  Quote: ... Calpain 2 (Rabbit-pAb, Cell Signaling), or serotype 2 capsule (Rabbit ...
• Unbiased and UMI-informed sequencing of cell-free miRNAs at single-nucleotide resolution

  M.A.J. van Eijndhoven, et al., bioRxiv - Genomics 2021

  Quote: ... Argonaute 2 (#2987; Cell Signaling Technology) and β-Actin (sc-47778 ...
• KRAS G12D can be targeted by potent salt-bridge forming inhibitors

  Zhongwei Mao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pERK1/2 (Cell Signaling Technology, 4370), ERK1/2 (Cell Signaling Technology ...
• KRAS G12D can be targeted by potent salt-bridge forming inhibitors

  Zhongwei Mao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK1/2 (Cell Signaling Technology, 4695), pAKT(Thr308 ...
• SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

  Da-Yuan Chen, et al., bioRxiv - Microbiology 2020

  Quote: ... pSTAT-2 (Cell Signaling Technologies; #4441), STAT2 (Santa Cruz Biotechnology ...
• FGFR Signaling Coordinates the Balance Between Glycolysis and Fatty Acid β-Oxidation in Lymphatic Endothelial Cells

  Hongyuan Song, Jie Zhu, Longhou Fang, Pengchun Yu, bioRxiv - Cell Biology 2020

  Quote: ... ERK1/2 (Cell Signaling Technology, 4695), CPT1A (Abcam ...
• Calpain-2 mediates SARS-CoV-2 entry and represents a therapeutic target

  Qiru Zeng, et al., bioRxiv - Microbiology 2022

  Quote: ... calpain-2 (Cell Signaling Technology, 2539), ACE2 (R&D Systems ...
• Small-molecule degraders reduce Aβ production through CAPRIN1-mediated lysosomal degradation of APP in Alzheimer’s iPSC-derived neurons

  Sunghan Jung, et al., bioRxiv - Neuroscience 2023

  Quote: ... Presenilin 2 (Cell Signaling Technology, 9979), BACE1 (Abcam ...
• Nutrient Sensing Receptor GPRC6A Regulates mTORC1 Signaling and Tau Biology

  Chao Ma, et al., bioRxiv - Neuroscience 2024

  Quote: ... ERK1/2 (Cell Signaling Tech, #9102S), ERK1/2 pT202/Y204 (Cell Signaling Tech ...
• MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

  Célia Guérin, et al., bioRxiv - Cancer Biology 2023

  Quote: ... ERK1/2-Phospho (Cell Signaling #9101), GAPDH (Santa Cruz #Sc-32233/6c5) ...
• YAP-controlled MHC-I and CXCL10 expression potentiates antitumor immunity independently of IFNγ signaling

  Linyuan Peng, et al., bioRxiv - Cancer Biology 2023

  Quote: ... β2-microglobulin (Cell Signaling Technology, 12851S), TAP1 (Cell Signaling Technology ...
• Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors

  Chuankai Chen, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p-ERK1/2 (Cell Signaling, #4376), ERK1/2 (Santa Cruz ...
• Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors

  Chuankai Chen, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p-MEK1/2 (Cell Signaling, #9121), MEK1 (Cell Signaling ...
• Prohibitin 2 is a Key Regulator of T Cell Proliferation and Effector Functions

  Johannes F. Vogt, et al., bioRxiv - Immunology 2024

  Quote: ... p-Erk1/2 (Cell Signaling #9106), a-tubulin (Cell Signaling #2144) ...
• Loss of the Inv(16) Oncogene CBFB::MYH11 Eliminates Leukemia from the Blood and Spleen, but not the Bone Marrow

  Sipra Panda, et al., bioRxiv - Cancer Biology 2024

  Quote: ... BCL-2 (Cell Signaling Technology, MA), and GFP (Invitrogen ...
• Endothelial Rho kinase controls blood vessel integrity and angiogenesis

  Martin Lange, et al., bioRxiv - Developmental Biology 2024

  Quote: ... PAK1/2/3 (Cell Signaling, # 2604S), pLIMK1/2 (Cell Signaling ...
• SIRPα sequesters SHP-2 to promote IL-4/13 signaling and alternative activation of macrophages

  Lei Shi, et al., bioRxiv - Immunology 2021

  Quote: ... and phospho-SHP-2 was detected with an anti-phospho-SHP-2 (Tyr542) antibody (Cell Signaling Technology). Alternatively ...
• TGF-β-driven downregulation of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα⁺ fibroblasts

  Osvaldo Contreras, et al., bioRxiv - Cell Biology 2020

  Quote: ... the inhibitor of MEK1/2/ERK1/2 kinases UO126 (used at 10 μM; 9903, Cell Signaling Technology), Smad3 inhibitor SIS3 (used at 6 μM ...
• TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

  Bruno Silva, Rajika Arora, Claus M. Azzalin, bioRxiv - Cell Biology 2021

  Quote: ... 2 mM EDTA) and incubated with 2 μg of a rabbit monoclonal anti-HA antibody (Cell Signaling, 3724) for 2 h at room temperature ...
• Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice

  Sreeram Vallabhaneni, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-phospho-ERK1/2 (Cell Signaling, CST4370), and anti–β-actin (Sigma) ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... ERK1/2 (#4695S, 1:1000, Cell Signaling), p-STAT3 Y705 (#4370S ...
• Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton

  Wenqing Zhou, et al., bioRxiv - Cell Biology 2020

  Quote: ... anti-Rac1/2/3 (Cell Signaling 2465S) and secondary antibodies anti-rabbit (ThermoFisher SA5-35571) ...
• Injury-induced Erk1/2 signaling enhances Ca²⁺ activity and is necessary for regeneration of spinal cord and skeletal muscle

  Jacqueline B. Levin, Laura N. Borodinsky, bioRxiv - Neuroscience 2021

  Quote: ... pERK1/2 1:50 (Cell Signaling 4377s), SOX2 1:100 (R&D AF2018) ...
• Injury-induced Erk1/2 signaling enhances Ca²⁺ activity and is necessary for regeneration of spinal cord and skeletal muscle

  Jacqueline B. Levin, Laura N. Borodinsky, bioRxiv - Neuroscience 2021

  Quote: ... MEK1/2 1:1000 (Cell Signaling 8727s), and GAPDH 1:10,000 (Sicgen AB0049-20 ...
• Injury-induced Erk1/2 signaling enhances Ca²⁺ activity and is necessary for regeneration of spinal cord and skeletal muscle

  Jacqueline B. Levin, Laura N. Borodinsky, bioRxiv - Neuroscience 2021

  Quote: ... pERK1/2 1:50 (Cell Signaling 4377s), and Xen1 1:100 (deposited to Developmental Studies Hybridoma Bank (DSHB ...
• Inositol depletion regulates phospholipid metabolism and activates stress signaling in HEK293T cells

  Mahmoud Suliman, et al., bioRxiv - Cell Biology 2022

  Quote: ... P44/42 Erk1/2 (#9102, Cell signaling), Phospho-p44/42 MAPK (Erk1/2 ...
• DOK1 and DOK2 regulate CD8⁺ T cell signaling and memory formation without affecting tumor cell killing

  V. Laletin, et al., bioRxiv - Immunology 2021

  Quote: ... Erk-1/2 (Cell Signaling Technology #9102) and β-Actin (Cell Signaling Technology #3700) ...
• DOK1 and DOK2 regulate CD8⁺ T cell signaling and memory formation without affecting tumor cell killing

  V. Laletin, et al., bioRxiv - Immunology 2021

  Quote: ... p-Erk1/2 (Cell Signaling Technology #4377), Erk-1/2 (Cell Signaling Technology #9102 ...
• Glycosyltransferase POMGNT1 deficiency affects N-cadherin-mediated cell-cell adhesion

  Sina Ibne Noor, et al., bioRxiv - Biochemistry 2020

  Quote: ... Rabbit anti-ERK1/2 (#9102, Cell Signaling), 1:1000 ...
• Glycosyltransferase POMGNT1 deficiency affects N-cadherin-mediated cell-cell adhesion

  Sina Ibne Noor, et al., bioRxiv - Biochemistry 2020

  Quote: ... Rabbit anti-MEK1/2 (#9122, Cell Signaling), 1:1000 ...
• The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

  Elisa Avolio, et al., bioRxiv - Cell Biology 2021

  Quote: ... Total ERK1/2 (Cell Signaling Technology #4395), 1:1000 ...
• A molecular clock controls periodically driven cell migration in confined spaces

  Sung Hoon Lee, et al., bioRxiv - Systems Biology 2020

  Quote: ... Myosin Light Chain 2 (Cell Signaling, 8505S), mDia1 (Cell Signaling ...
• Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis

  Benjamin Ng, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-p-ERK1/2 (4370, Cell Signaling), anti-ERK1/2s (4695 ...
• Extracellular Vesicle-Mediated Purinergic Signaling Contributes to Host Microenvironment Plasticity and Metastasis in Triple Negative Breast Cancer

  Suzann Duan, et al., bioRxiv - Cancer Biology 2020

  Quote: ... COX-2 (1:50, Cell Signaling Technologies), and GAPDH (Cell Signaling Technologies ...
• Pseudomonas aeruginosa Stimulates Inflammation and Enhances KSHV-Induced Cell Proliferation and Cellular Transformation through Both LPS and Flagellin

  Ashley Markazi, et al., bioRxiv - Cancer Biology 2020

  Quote: ... phospho-ERK1/2 (4370S, Cell Signaling Technology).
• miR-200 deficiency promotes lung cancer metastasis by activating cancer-associated fibroblasts

  Bin Xue, et al., bioRxiv - Cancer Biology 2020

  Quote: ... pErk1/2 pAb (Cell Signaling Technology, 4370), TTF1 (Nkx2.1 ...
• Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

  Yini Zhu, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho-Erk1/2 (Cell Signaling Technology, 4370), p53 (Cell Signaling Technology ...
• Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function

  Weiyi Xu, et al., bioRxiv - Pharmacology and Toxicology 2022

  Quote: ... anti-ERK1/2 (Cell Signaling Technologies, 9102S), anti-LC3B (Cell Signaling Technologies ...
• Cross-activation of the FGF, TGF-β and WNT pathways constrains BMP4-mediated induction of the Totipotent state in mouse embryonic stem cells

  Thulaj Meharwade, et al., bioRxiv - Developmental Biology 2022

  Quote: ... anti-ERK1/2 (137F5) (Cell Signaling 4695S) lot 28 ...
• Human cytomegalovirus UL7, miR-US5-1 and miR-UL112-3p inactivation of FOXO3a protects CD34⁺ hematopoietic progenitor cells from apoptosis

  Meaghan H. Hancock, et al., bioRxiv - Microbiology 2020

  Quote: ... P-ERK1/2 (Thr202/Tyr204, Cell Signaling), PARP (Cell Signaling) ...
• Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death

  Johanna Lilja, et al., bioRxiv - Cancer Biology 2022

  Quote: ... ERK1/2 (Cat. no. 91025, Cell Signaling), phospho-AKT (Ser473 ...
• PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

  Eyleen Corrales, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Erk1/2 (1:1000; L34F12; Cell Signaling), phospho(Ser473)-AKT (1:2000 ...
• PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma

  Eyleen Corrales, et al., bioRxiv - Cancer Biology 2022

  Quote: ... MEK1/2 (1:1000; L38C12; Cell Signaling), phospho(Thr44/Tyr42)-ERK1/2 (1:1000 ...
• Taxane chemotherapy leads to breast cancer dormancy escape by stromal injury mediated IL-6/MAP2K signaling

  Ramya Ganesan, et al., bioRxiv - Cancer Biology 2022

  Quote: ... rabbit ERK1/2 IgG (Cell Signaling Technology) (cat ...
• Double-targeted knockdown of miR-21 and CXCR4 inhibits malignant glioma progression by suppression of the PI3K/AKT and Raf/MEK/ERK pathways

  Feijiao Liu, Bo Yang, bioRxiv - Cancer Biology 2020

  Quote: ... and phospho-ERK1/2 (Cell Signaling Technology). The protein levels were digitalized using ImageJ 1.48 version (NIH ...
• STAT3 but not STAT5 contributes to the protective effect of electro-acupuncture against myocardial ischemia/reperfusion injury

  Hui-Hui Guo, et al., bioRxiv - Molecular Biology 2020

  Quote: ... Bcl-2 (1:1000, Cell Signaling, #3498), Cyt c (1:1000 ...
• The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation

  Leila Revollo, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti Erk1/2(Cell Signaling Technology, #4695), anti P-selectin (R&D Systems ...
• Activation of proneuronal transcription factor Ascl1 in maternal liver ensures a healthy pregnancy

  Joonyong Lee, et al., bioRxiv - Physiology 2021

  Quote: ... ERK1/2 (Cell Signaling, 9102, 1:2,000), p-ERK1/2 (T202/Y204 ...
• Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

  Melvin Pan, et al., bioRxiv - Cancer Biology 2021

  Quote: ... MEK1/2 (1:500 Cell Signaling Technology), phospho-ERK1/2 (Thr202/Tyr204 ...