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551 - 600 of 10000+ citations for trans 2 2 4 Methoxyphenyl 2 oxoethyl cyclohexane 1 carboxylic acid since 2020

• Addressing Enzymatic-Independent Tumor-Promoting Function of NAMPT via PROTAC-Mediated Degradation

  Xiaotong Zhu, et al., bioRxiv - Biochemistry 2021

  Quote: ... anti-Erk1/2 (Cell signaling technology, cat. no. 4695).
• Hydroxylation of Actin Impairs Cell Motility Through Blocking its’ Histidine Methylation

  Zhenzhen Zi, et al., bioRxiv - Biochemistry 2021

  Quote: ... PHD-2/Egln1 (D31E11) Rabbit mAb (Cell Signaling, 4835s), EGLN3/PHD3 Antibody (Novus Biologicals ...
• SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes

  Yen K. Lieu, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-p-MAPKAPK-2 (MK2; T334) (Cell Signaling, 9595T), anti-α-Tubulin (Cell Signaling ...
• Zfp36l1 and Zfp36l2 balances proliferation and differentiation in the developing retina

  Fuguo Wu, et al., bioRxiv - Developmental Biology 2020

  Quote: ... and rabbit anti-Zfp36l1/2 (Cell signaling 2119,1:100). Secondary antibodies were purchased from Life Sciences.
• The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

  Elisa Avolio, et al., bioRxiv - Cell Biology 2021

  Quote: ... P-ERK1/2 Thr202/Tyr204 (Cell Signaling Technology #4370), 1:2000 ...
• Androgen Receptor promotes renal cell carcinoma (RCC) vasculogenic mimicry (VM) via altering TWIST1 nonsense-mediated decay through lncRNA-TANAR

  Bosen You, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Argonaute-2 (Ago2) (Cell Signaling Technology, #2897, Danvers, MA), IgG (Santa Cruz ...
• Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling

  Hussam Husanie, et al., bioRxiv - Cancer Biology 2022

  Quote: ... monoclonal pSMAD 2/3 (Cell Signaling; 8828, Massachusetts, USA), monoclonal pSMAD 1/5/9 (Cell Signaling ...
• Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1

  Niraj Nag, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti Bcl-2 antibody (Cell Signaling Technology Cat# 15071), anti-caspase 8 antibody (Cell Signaling Technology Cat# 9746) ...
• The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids

  Jennifer Rynne, et al., bioRxiv - Molecular Biology 2022

  Quote: ... Antibodies used were: BRF1/2 (Cell Signaling Technology #2119), GR (Cell Signaling Technology #3660 ...
• Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

  Eleftheria Koropouli, et al., bioRxiv - Neuroscience 2022

  Quote: ... Neuropilin-2 (rabbit polyclonal, Cell Signaling, Cat no. 3366S); Neuropilin-2 (goat polyclonal ...
• PKC-alpha promotes phosphorylation of KRAS suppressing its oncogenic properties

  Tejashree Joglekar, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-p44/42 MAPK (Erk1/2) (Cell Signaling #4696); anti-KRAS (Sigma #WH0003845M1) ...
• Diacylglycerol kinase-ε is S-palmitoylated on cysteine in the cytoplasmic end of its N-terminal transmembrane fragment

  Gabriela Traczyk, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-flotillin-2 (Cell Signaling, cat. No. 3436), donkey anti-sheep IgG-HRP (Jackson ImmunoResearch ...
• Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

  Mingrong Zuo, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-ERK1/2(Thr202/Tyr204) (Cell Signaling Technology #4370S), total-ERK1/2 (Cell Signaling Technology #4696) ...
• Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function

  Chao Chang, et al., bioRxiv - Cell Biology 2023

  Quote: ... rabbit anti-ERK1/2 (Cell Signaling Technology, #9102; RRID:AB_330744), goat polyclonal anti-EPHB2 (R&D Systems ...
• Ellagic acid ameliorates atherosclerosis by targeting the epidermal growth factor receptor

  Ye-Wei Huang, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-ERK1/2 (4696S, Cell Signaling Technology, MA, USA), anti-phospho-ERK1/2 (4370S ...
• Serine arginine-rich splicing factor (SRSF7) cooperates with the histone methyltransferase KMT5a to promote the type I interferon response via transcriptional activation of IRF7

  Haley M. Scott, et al., bioRxiv - Immunology 2023

  Quote: ... or 2 µg of isotype control (IgG, Cell Signaling), 5ul Y701 STAT1 (Cell Signaling) ...
• Copper chelation inhibits TGF-β pathways and suppresses epithelial-mesenchymal transition in cancer

  E. M. Poursani, et al., bioRxiv - Cancer Biology 2022

  Quote: ... p44/42 MAPK (ERK1/2) (9102S, Cell Signaling Technology), MMP-9 (D6O3H ...
• Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells

  Yueyang Wang, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-phospho Myosin Light Chain 2 (Cell Signaling 3671) and secondary antibody anti-rabbit AlexaFluor 488 (Invitrogen A-21441) ...
• Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2

  Ding-Chin Lee, et al., bioRxiv - Evolutionary Biology 2023

  Quote: ... rabbit anti-SARS-CoV-2 envelope (Cell signaling, #74698), rabbit anti-GAPDH (Genetex ...
• Actin polymerization drives lumen formation in a human epiblast model

  Dhiraj Indana, et al., bioRxiv - Developmental Biology 2023

  Quote: ... phospho- myosin light chain 2 (Cell Signaling Technology #3674), Arp2/3 complex (Sigma-Aldrich MABT95) ...
• Viral Insulin/IGF-like Peptides Selectively Activate Host Insulin/IGF Signaling pathways during Grouper Iridovirus Infection

  Aurelien Chuard, et al., bioRxiv - Microbiology 2024

  Quote: ... p44/42 MAPK (Erk1/2) Antibody (Cell Signaling #9102); β-Actin (D6A8 ...
• Braf-mutant Schwann cells divert to a repair phenotype to induce congenital demyelinating neuropathy

  Elise Marechal, et al., bioRxiv - Developmental Biology 2024

  Quote: ... rabbit polyclonal anti-Erk1/2 (#9102; Cell Signaling Technology), rabbit monoclonal anti-Jun (60A8 ...
• Synthetic G protein-coupled receptors for programmable sensing and control of cell behavior

  Nicholas A. Kalogriopoulos, et al., bioRxiv - Synthetic Biology 2024

  Quote: ... p44/42 MAPK (Erk1/2; Cell Signaling Technology #9107), and β-Tubulin (Cell Signaling Technology #86298).
• Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

  Qiwang Xiang, et al., bioRxiv - Molecular Biology 2024

  Quote: ... SARS-CoV-2 Membrane protein (Cell Signaling Technology, 15333S); SARS-CoV-2 Envelope protein (Cell Signaling Technology ...
• Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

  Qiwang Xiang, et al., bioRxiv - Molecular Biology 2024

  Quote: ... SARS-CoV-2 Envelope protein (Cell Signaling Technology, 74698S); furin (Proteintech ...
• Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase

  Erin Skeens, et al., bioRxiv - Biochemistry 2024

  Quote: ... and anti-phospho-ERK1/2 (Cell Signaling cat# 9101) antibodies ...
• Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen and Identifies Co-Treatment Strategies in Estrogen Receptor Positive Breast Cancer

  Rasha T. Kakati, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) (Cell Signaling Technologies), RET (Abcam) ...
• Proteomic analysis reveals complex interactions between PERK/ISR and MAPK1 in translational control in a phenotypic toxin model of Parkinson’s disease expressing PINTAC peptides

  Girish N Nallur, bioRxiv - Systems Biology 2024

  Quote: ... RSK1/2/3 (Cat. No. 9355; Cell Signaling Technology), pRPS6 (Cat ...
• Targeting the Src pathway enhances the efficacy of selective FGFR inhibitors in cancers with FGFR3 alterations

  Nadia Carvalho Lima, et al., bioRxiv - Cancer Biology 2020

  Quote: ... phospho-Erk1/2 T202/Y404 (4370) 1:2000 and Erk1/1 (4695) 1:2000-1:5000 (all from Cell Signaling); and Tubulin (T5168 ...
• Sustained experimental activation of FGF8/ERK in the developing chicken spinal cord reproducibly models early events in ERK-mediated tumorigenesis

  Axelle Wilmerding, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) 1:250 (Cell signaling #9101), rabbit anti-SOX2 1:500 (AB5603 Merck Millipore) ...
• MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis

  Carolyn Sangokoya, Robert Blelloch, bioRxiv - Developmental Biology 2020

  Quote: ... Phospho-p44/42 Erk1/2 Thr202/Tyr204 at 1:1000 dilution (Cell Signaling Technology, 4370), and p44/42 Erk1/2 at 1:1000 dilution (Cell Signaling Technology ...
• Reversal of β-amyloid induced microglial toxicity in vitro by activation of Fpr2/3

  Edward S. Wickstead, et al., bioRxiv - Neuroscience 2020

  Quote: ... or superoxide dismutase 2 (SOD2; rabbit monoclonal, 1:1000, Cell Signaling Technology, Leiden, The Netherlands) in Tris-buffer saline solution containing 0.1% Tween-20 and 5% (w/v ...
• Negative durotaxis: cell movement toward softer environments

  Aleksi Isomursu, et al., bioRxiv - Biophysics 2020

  Quote: ... rbt anti-p-ERK1/2 (T202/Y204) (Cell Signaling Technology, 4370, 1:1000 for WB), ms anti-YAP (Santa Cruz Biotechnology ...
• Kir6.2-containing K_ATP channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer’s-related pathology

  John Grizzanti, et al., bioRxiv - Neuroscience 2022

  Quote: ... 2° antibody conjugated with HRP specific to either (1:3,000) goat anti-rabbit (Cell Signaling) or (1:3,000 ...
• Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

  Jason J. Northey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho-p44/42 MAPK (ERK1/2) (T202/Y204) (Cell Signaling Technology, Cat. #: 9101, 1:200), NFκB p65 (D14E12 ...
• Purinergic receptor P2RY14 cAMP signaling regulates EGFR-driven Schwann cell precursor self-renewal and nerve tumor initiation in neurofibromatosis

  Jennifer Patritti-Cram, et al., bioRxiv - Neuroscience 2021

  Quote: ... P44/42 MAPK (Erk1/2) (137F5) rabbit mAB (1:1000, Cell Signaling Technologies, Cat#: 4695S).
• Biphasic Response of Protein Kinase A to Cyclic Adenosine Monophosphate Triggers Distinct Epithelial Phenotypes

  João Pedro Fonseca, et al., bioRxiv - Systems Biology 2020

  Quote: ... F(ab’)2 Fragment (Alexa Fluor® 488 Conjugate) (Cell Signaling Technology #4412, 1:1000).
• Biphasic Response of Protein Kinase A to Cyclic Adenosine Monophosphate Triggers Distinct Epithelial Phenotypes

  João Pedro Fonseca, et al., bioRxiv - Systems Biology 2020

  Quote: ... anti-p44/42 MAPK (Erk1/2) (L34F12) Mouse mAb (Cell signaling technology ##4696, 1:2000), anti-Phospho-p38 MAPK (Thr180/Tyr182 ...
• Long-term non-invasive drug treatments for adult zebrafish

  Yuting Lu, E. Elizabeth Patton, bioRxiv - Cancer Biology 2021

  Quote: ... total p44/42 MAPK (ERK1/2) primary antibody (1:200, rabbit, Cell Signaling Technologies #9102), and Alexa-fluor 488 secondary antibody (1:1000 ...
• KRAS G12D can be targeted by potent salt-bridge forming inhibitors

  Zhongwei Mao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... slides were incubated with primary antibodies against pERK1/2 (1:200, Cell Signaling Technology, 4370), cleaved Caspase-3 (1:200 ...
• Thrombospondin 2 is a key determinant of fibrogenesis in NAFLD

  Takefumi Kimura, et al., bioRxiv - Molecular Biology 2023

  Quote: ... small mothers against decapentaplegic (SMAD) 2/3 (D7/G7) (Cell Signaling Technology, #8685, 1:1,000), Phospho-Smad2 (Ser465/467)/Smad3 (Ser423/425 ...
• Murine gammaherpesvirus 68 ORF45 stimulates B2 retrotransposon and pre-tRNA activation in a manner dependent on mitogen-activated protein kinase (MAPK) signaling

  Azra Lari, Britt A. Glaunsinger, bioRxiv - Microbiology 2022

  Quote: ... anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) antibody (Cell Signaling #9101, 1:1000), anti-Brf1polyclonal antibody (Bethyl ...
• Ca²⁺-driven cytoplasmic backflow secures spindle position in fertilized mouse eggs

  Takaya Totsuka, Miho Ohsugi, bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-phospho-myosin light chain 2 (Ser19) (pMLC) (1:100, Cell Signaling Technology #3671), for 2 hours ...
• Endosomal LRBA regulates the endo-lysosomal pathway

  Viktória Szentgyörgyi, et al., bioRxiv - Immunology 2024

  Quote: ... mouse monoclonal anti p44/42 MAPK (Erk1/2) (L334F10) antibody (#4696, Cell Signaling, 1:2000), rabbit polyclonal anti phospho-p44/42 MAPK (Erk1/2 ...
• Endosomal LRBA regulates the endo-lysosomal pathway

  Viktória Szentgyörgyi, et al., bioRxiv - Immunology 2024

  Quote: ... mouse monoclonal anti p44/42 MAPK (Erk1/2) (L334F10) antibody (#4696, Cell Signaling, 1:2000), rabbit polyclonal anti phospho-p44/42 MAPK (Erk1/2 ...
• Influence of myosin regulatory light chain and myosin light chain kinase on hair cells of the inner ear

  Ryohei Oya, et al., bioRxiv - Biophysics 2023

  Quote: ... anti-phospho-myosin light chain 2 (3671; Cell Signaling Technology, Danvers, MA, USA; 1:50); Alexa Fluor 488-labeled secondary antibody (Thermo Fisher Scientific ...
• Differentiation signals from glia are fine-tuned to set neuronal numbers during development

  Anadika R. Prasad, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (1:100, Cell Signaling #9101), chicken anti-RFP (1:500 ...
• HD-PTP/PTPN23 hypomorphic mice display lipodystrophy

  Brian A. Davies, et al., bioRxiv - Cell Biology 2022

  Quote: ... total-p42/44 MAPK (ERK1/2) 3A7 mouse monoclonal antibody (1:2000, 9107, Cell Signaling), p-AKT-S473 D9E rabbit monoclonal antibody (1:1000 ...
• Combined KRAS^G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS^G12C-driven cancers by addressing intrinsic and acquired resistance

  Venu Thatikonda, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (1:2000, Cell Signaling Technology #4370) was developed using Opal tyramide signal amplification (TSA ...
• Oncogenic Kras^G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8⁺ T cells dependent manner

  Krishnan K. Mahadevan, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (1:2000, Cell Signaling Technology #4370) was developed using Opal tyramide signal amplification (TSA ...