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551 - 600 of 10000+ citations for 2 Chloro 1 1 trifluoromethyl 1 3 4 9 tetrahydro 2H beta carbolin 2 yl ethan 1 one since 2020

• p53 restoration in small cell lung cancer identifies a latent Cyclophilin-dependent necrosis mechanism

  Jonuelle Acosta, et al., bioRxiv - Cancer Biology 2022

  Quote: ... Cleaved Caspase-3 (1:1000,Cell Signaling Technology, 9661S), Cleaved PARP (1:1000,Cell Signaling Technology ...
• Repurposing of the multiciliation gene regulatory network in fate specification of Cajal-Retzius neurons

  Matthieu X Moreau, et al., bioRxiv - Developmental Biology 2022

  Quote: ... rabbit anti-Caspase 3 (Cell Signaling 9664, 1:400), mouse anti-FOP (Abnova H00011116-M01 1:500) ...
• TRPV1-mediated sonogenetic neuromodulation of motor cortex in freely moving mice

  Kevin Xu, et al., bioRxiv - Bioengineering 2022

  Quote: ... or anti-Caspase-3 antibody (Cell Signaling, 1:2500), as well as DAPI mounting medium (Vector) ...
• Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

  Suel-Kee Kim, et al., bioRxiv - Neuroscience 2022

  Quote: ... p-SMAD2/3 (8828, Cell Signaling Technology, 1:200), and TUJ1 (PRB-435P ...
• Tissue-wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression

  Nicole Amberg, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-CASPASE-3 (Cell Signaling, dilution 1:500), rabbit anti-H3K27me3 (Diagenode ...
• Effectors enabling adaptation to mitochondrial complex I loss in Hürthle cell carcinoma

  Raj K. Gopal, et al., bioRxiv - Cancer Biology 2022

  Quote: ... cleaved caspase-3 (Asp175; Cell Signaling #9661S, 1:100), and 4-HNE (Abcam ab46545 ...
• Mechanical cues of extracellular matrix determine tumor innervation

  Shu-Heng Jiang, et al., bioRxiv - Neuroscience 2024

  Quote: ... cleaved caspase 3 (#9661, Cell Signaling Technology, 1:400), CD45 (ab40763 ...
• D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability

  Gergely Rona, et al., bioRxiv - Cell Biology 2024

  Quote: Cleaved Caspase-3 (1:1000, Cell Signaling Technology 9661S)
• Transgenic αβ TCR tonic signaling is leukemogenic while strong stimulation is leukemia-suppressive

  Telmo A. Catarino, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-cleaved-caspase 3 (1:200, 9661, Cell Signaling), Ki67 (1:500 ...
• Exploiting a metabolic vulnerability in brain tumour stem cells using a brain-penetrant drug with safe profile

  Audrey Burban, et al., bioRxiv - Cancer Biology 2024

  Quote: ... anti-Cleaved caspase 3 (1:100, Cell signaling, #D175), anti-SOX2 (1:100 ...
• Overburdened Ferroptotic Stress Impairs Tooth Morphogenesis

  H.S. Wang, et al., bioRxiv - Developmental Biology 2023

  Quote: ... cleaved Caspase 3 (1:200, Cell Signaling Technology, 9664) in blocking buffer (PBS and 2% bovine serum albumin ...
• Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity

  Katharina Bläsius, et al., bioRxiv - Molecular Biology 2023

  Quote: ... α14-3-3pan (1:1000, Cell Signaling Technology, #8312S). The following secondary antibodies were used at the indicated dilutions ...
• The host-directed therapeutic imatinib mesylate accelerates immune responses to Mycobacterium marinum infection and limits pathology associated with granulomas

  Tesia L. Cleverley, et al., bioRxiv - Immunology 2022

  Quote: ... Cleaved Caspase 3 (ASP175) antibody (1:1000, Cell Signaling) and GAPDH (D16H11 ...
• MicroRNA-375 is induced during astrocyte-to-neuron reprogramming and promotes survival of reprogrammed neurons when overexpressed

  Xuanyu Chen, et al., bioRxiv - Neuroscience 2023

  Quote: ... cleaved caspase-3 (rabbit IgG, 1:1000, Cell Signaling), and DCX (guinea pig IgG ...
• APOE4/4 is linked to damaging lipid droplets in Alzheimer’s microglia

  Michael S. Haney, et al., bioRxiv - Neuroscience 2023

  Quote: ... and Caspase-3 (9661, Cell Signaling Technology, 1:500). The secondary antibodies were IgG conjugated to Alexa Fluor 488 (donkey anti-mouse ...
• Targeting the glucose-insulin link in head and neck squamous cell carcinoma induces cytotoxic oxidative stress and inhibits cancer growth

  Simbarashe Mazambani, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Cleaved Caspase-3 (1:1,000; Cell Signaling Technology #9664), and α-actin (1:5,000 ...
• Targeting the glucose-insulin link in head and neck squamous cell carcinoma induces cytotoxic oxidative stress and inhibits cancer growth

  Simbarashe Mazambani, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Cleaved Caspase-3 (1:200; Cell Signaling Technology #9664), Ser473-pAKT (1:500 ...
• Spatially resolved single-cell analysis uncovers protein kinase Cδ-expressing microglia with anti-tumor activity in glioblastoma

  Reza Mirzaei, et al., bioRxiv - Immunology 2023

  Quote: ... Cleaved Caspase-3 (Cell Signaling, 9661, 1:500 dilution), TMEM119 (Abcam ...
• BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss

  Mario A. Shields, et al., bioRxiv - Pathology 2023

  Quote: ... cleaved caspase-3 (Cell Signaling Cat# 9664, 1:1000), Amylase (Cell Signaling #3796 ...
• A primary culture method for the easy, efficient and effective acquisition of oligodendrocyte lineage cells

  Hanki Kim, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-cleaved-caspase-3 (1:200, Cell Signaling, #9664S), anti-Ki67 (1:500 ...
• Analyzing ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets

  Michelle E. Watts, et al., bioRxiv - Cell Biology 2023

  Quote: ... Cleaved Caspase-3 (Cell Signaling Technology 9664S, 1:1000), Actin (Cell Signaling Technology 3700S ...
• Altered liver metabolism post-wean abolishes efficacy of vitamin D for breast cancer prevention in a mouse model

  Sarah M Bernhardt, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Cycle 3 Ki67 (Cell Signaling, 12202, 1:800, 1hr), Cycle 4 Tox1 (Abcam ...
• Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia

  Meghraj S Baghel, et al., bioRxiv - Neuroscience 2024

  Quote: ... cleaved Caspase 3 (1:1000; D3E9; Cell Signaling Technology), Tuj1 (1:500 ...
• Chromatin Remodelling in Damaged Intestinal Crypts Orchestrates Redundant TGFβ and Hippo Signalling to Drive Regeneration

  Mardi Fink, et al., bioRxiv - Molecular Biology 2024

  Quote: ... Rabbit anti-Smad2/3 (Cell Signaling, #8685S, 1:300), Rabbit anti-pSmad2 (Cell signaling ...
• Astrocyte-derived PEA116 increases adult hippocampal neurogenesis and confers stress resilience

  Carron Charline, et al., bioRxiv - Neuroscience 2024

  Quote: ... rabbit anti-Caspase-3 (1:500, Cell Signaling 9661S). Sections were then incubated for 1h15 at room temperature with the corresponding fluorescent secondary antibodies ...
• Removal of the catalytic subunit of DNA-protein kinase in the proximal tubules promotes DNA and tubular damage during kidney injury

  M. Swanson, et al., bioRxiv - Physiology 2024

  Quote: ... cleaved caspase-3 (cat #9661, 1:200; Cell Signaling), and Ki67 (cat #15580 ...
• The pro-apoptotic effect of chronic contractile activity-induced extracellular vesicles on Lewis Lung Carcinoma cells

  Patience O. Obi, et al., bioRxiv - Cancer Biology 2024

  Quote: ... rabbit anti-caspase-3 (9662, Cell Signaling, 1:1000), rabbit anti-cleaved caspase-3 (9661 ...
• Sustained experimental activation of FGF8/ERK in the developing chicken spinal cord reproducibly models early events in ERK-mediated tumorigenesis

  Axelle Wilmerding, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) 1:250 (Cell signaling #9101), rabbit anti-SOX2 1:500 (AB5603 Merck Millipore) ...
• MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis

  Carolyn Sangokoya, Robert Blelloch, bioRxiv - Developmental Biology 2020

  Quote: ... Phospho-p44/42 Erk1/2 Thr202/Tyr204 at 1:1000 dilution (Cell Signaling Technology, 4370), and p44/42 Erk1/2 at 1:1000 dilution (Cell Signaling Technology ...
• Reversal of β-amyloid induced microglial toxicity in vitro by activation of Fpr2/3

  Edward S. Wickstead, et al., bioRxiv - Neuroscience 2020

  Quote: ... or superoxide dismutase 2 (SOD2; rabbit monoclonal, 1:1000, Cell Signaling Technology, Leiden, The Netherlands) in Tris-buffer saline solution containing 0.1% Tween-20 and 5% (w/v ...
• Negative durotaxis: cell movement toward softer environments

  Aleksi Isomursu, et al., bioRxiv - Biophysics 2020

  Quote: ... rbt anti-p-ERK1/2 (T202/Y204) (Cell Signaling Technology, 4370, 1:1000 for WB), ms anti-YAP (Santa Cruz Biotechnology ...
• Kir6.2-containing K_ATP channels are necessary for glucose dependent increases in amyloid-beta and Alzheimer’s-related pathology

  John Grizzanti, et al., bioRxiv - Neuroscience 2022

  Quote: ... 2° antibody conjugated with HRP specific to either (1:3,000) goat anti-rabbit (Cell Signaling) or (1:3,000 ...
• Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

  Jason J. Northey, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho-p44/42 MAPK (ERK1/2) (T202/Y204) (Cell Signaling Technology, Cat. #: 9101, 1:200), NFκB p65 (D14E12 ...
• Purinergic receptor P2RY14 cAMP signaling regulates EGFR-driven Schwann cell precursor self-renewal and nerve tumor initiation in neurofibromatosis

  Jennifer Patritti-Cram, et al., bioRxiv - Neuroscience 2021

  Quote: ... P44/42 MAPK (Erk1/2) (137F5) rabbit mAB (1:1000, Cell Signaling Technologies, Cat#: 4695S).
• Biphasic Response of Protein Kinase A to Cyclic Adenosine Monophosphate Triggers Distinct Epithelial Phenotypes

  João Pedro Fonseca, et al., bioRxiv - Systems Biology 2020

  Quote: ... F(ab’)2 Fragment (Alexa Fluor® 488 Conjugate) (Cell Signaling Technology #4412, 1:1000).
• Biphasic Response of Protein Kinase A to Cyclic Adenosine Monophosphate Triggers Distinct Epithelial Phenotypes

  João Pedro Fonseca, et al., bioRxiv - Systems Biology 2020

  Quote: ... anti-p44/42 MAPK (Erk1/2) (L34F12) Mouse mAb (Cell signaling technology ##4696, 1:2000), anti-Phospho-p38 MAPK (Thr180/Tyr182 ...
• Long-term non-invasive drug treatments for adult zebrafish

  Yuting Lu, E. Elizabeth Patton, bioRxiv - Cancer Biology 2021

  Quote: ... total p44/42 MAPK (ERK1/2) primary antibody (1:200, rabbit, Cell Signaling Technologies #9102), and Alexa-fluor 488 secondary antibody (1:1000 ...
• KRAS G12D can be targeted by potent salt-bridge forming inhibitors

  Zhongwei Mao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... slides were incubated with primary antibodies against pERK1/2 (1:200, Cell Signaling Technology, 4370), cleaved Caspase-3 (1:200 ...
• Differentiation signals from glia are fine-tuned to set neuronal numbers during development

  Anadika R. Prasad, et al., bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (1:100, Cell Signaling #9101), chicken anti-RFP (1:500 ...
• HD-PTP/PTPN23 hypomorphic mice display lipodystrophy

  Brian A. Davies, et al., bioRxiv - Cell Biology 2022

  Quote: ... total-p42/44 MAPK (ERK1/2) 3A7 mouse monoclonal antibody (1:2000, 9107, Cell Signaling), p-AKT-S473 D9E rabbit monoclonal antibody (1:1000 ...
• Murine gammaherpesvirus 68 ORF45 stimulates B2 retrotransposon and pre-tRNA activation in a manner dependent on mitogen-activated protein kinase (MAPK) signaling

  Azra Lari, Britt A. Glaunsinger, bioRxiv - Microbiology 2022

  Quote: ... anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) antibody (Cell Signaling #9101, 1:1000), anti-Brf1polyclonal antibody (Bethyl ...
• Endosomal LRBA regulates the endo-lysosomal pathway

  Viktória Szentgyörgyi, et al., bioRxiv - Immunology 2024

  Quote: ... mouse monoclonal anti p44/42 MAPK (Erk1/2) (L334F10) antibody (#4696, Cell Signaling, 1:2000), rabbit polyclonal anti phospho-p44/42 MAPK (Erk1/2 ...
• Endosomal LRBA regulates the endo-lysosomal pathway

  Viktória Szentgyörgyi, et al., bioRxiv - Immunology 2024

  Quote: ... mouse monoclonal anti p44/42 MAPK (Erk1/2) (L334F10) antibody (#4696, Cell Signaling, 1:2000), rabbit polyclonal anti phospho-p44/42 MAPK (Erk1/2 ...
• Ca²⁺-driven cytoplasmic backflow secures spindle position in fertilized mouse eggs

  Takaya Totsuka, Miho Ohsugi, bioRxiv - Cell Biology 2024

  Quote: ... rabbit anti-phospho-myosin light chain 2 (Ser19) (pMLC) (1:100, Cell Signaling Technology #3671), for 2 hours ...
• Combined KRAS^G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS^G12C-driven cancers by addressing intrinsic and acquired resistance

  Venu Thatikonda, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (1:2000, Cell Signaling Technology #4370) was developed using Opal tyramide signal amplification (TSA ...
• Oncogenic Kras^G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8⁺ T cells dependent manner

  Krishnan K. Mahadevan, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (1:2000, Cell Signaling Technology #4370) was developed using Opal tyramide signal amplification (TSA ...
• Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

  Evan J. Underhill, Jared E. Toettcher, bioRxiv - Developmental Biology 2023

  Quote: ... Erk1/2 phosphorylated at Thr202 and Tyr204 rabbit (Cell Signaling Technology, 4370, 1:200 dilution), phospho-Akt at Ser473 rabbit (Cell Signaling Technology ...
• Alterations in the preneoplastic breast microenvironment of BRCA1/2 mutation carriers revealed by spatial transcriptomics

  Anthony Caputo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and 1:200 phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology, 9101S). Primary antibodies used for immunohistochemistry of FFPE tissues were 1:50 COL6 (Rockland ...
• Influence of myosin regulatory light chain and myosin light chain kinase on hair cells of the inner ear

  Ryohei Oya, et al., bioRxiv - Biophysics 2023

  Quote: ... anti-phospho-myosin light chain 2 (3671; Cell Signaling Technology, Danvers, MA, USA; 1:50); Alexa Fluor 488-labeled secondary antibody (Thermo Fisher Scientific ...
• Fate plasticity of interneuron specification

  Mohammed A. Mostajo-Radji, et al., bioRxiv - Neuroscience 2024

  Quote: Rabbit anti-MAPK (ERK1/2) phosphorylated (T202/Y204) (Cell Signaling # 9101; RRID: AB_331646; 1:100)