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5801 - 5850 of 10000+ citations for 7 hydroxy 1H 1 2 4 triazolo 1 5 a pyrimidin 5 one since 2019

• Non-physiologic interaction of MG53 with insulin receptor and lack of evidence for MG53’s role in controlling insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues

  Kyung Eun Lee, et al., bioRxiv - Physiology 2024

  Quote: ... GAPDH (Cell Signaling Technology, 2118S, 1:5000 dilute) was diluted in 2.5 % (w/v ...
• An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery

  Qin Huang, et al., bioRxiv - Neuroscience 2023

  Quote: ... RCAS1 (1:200 dilution, Cell Signaling Technology, 12290), and TGN46 (1:50 dilution ...
• Mechanical cues of extracellular matrix determine tumor innervation

  Shu-Heng Jiang, et al., bioRxiv - Neuroscience 2024

  Quote: ... Collagen I (#72026, Cell Signaling Technology, 1:200), LOX (17958-1-AP ...
• CTCF/cohesin organize the ground state of chromatin-nuclear speckle association

  Ruofan Yu, et al., bioRxiv - Genetics 2023

  Quote: ... Anti-GAPDH antibody (1:1000, Cell Signaling, 5174); 4 ...
• CTCF/cohesin organize the ground state of chromatin-nuclear speckle association

  Ruofan Yu, et al., bioRxiv - Genetics 2023

  Quote: ... Anti-RAD21 antibody (1:1000, Cell Signaling, 4321s); 3 ...
• HELZ promotes R loop resolution to facilitate DNA double-strand break repair by homologous recombination

  Ramona Haji-Seyed-Javadi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... RPA70 (Cell Signaling # 2267S; 1:120 for IF); CtIP (Millipore # MABE1060 ...
• The proteostasis interactomes of trafficking-deficient K_V11.1 variants associated with Long QT Syndrome and pharmacological chaperone rescue

  Christian L. Egly, et al., bioRxiv - Biochemistry 2024

  Quote: ... Primary anti-KV11.1 antibody (Cell Signaling, 1:2000) was incubated 16 hours at 4 ⁰C ...
• 5-hydroxymethylcytosines regulate gene expression as a passive DNA demethylation resisting epigenetic mark in proliferative somatic cells

  Alex Wei, et al., bioRxiv - Genomics 2023

  Quote: ... 1:3000 anti-ACTB (Cell Signaling Technology, 3700S) overnight in 4°C while shaking ...
• Dynamic mRNA stability changes buffer transcriptional activation during neuronal differentiation and are regulated by RNA binding proteins

  Yuan Zhou, et al., bioRxiv - Molecular Biology 2023

  Quote: ... β-tubulin-III (Cell signaling, Cat# 2128, 1:200), or Synaptophysin (Abcam ...
• Accelerated drug resistant variant discovery with an enhanced, scalable mutagenic base editor platform

  Kristel M. Dorighi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... rabbit anti-pERK (Cell Signaling, 9101, 1:1000), mouse anti-MEK (BD Biosciences ...
• Accelerated drug resistant variant discovery with an enhanced, scalable mutagenic base editor platform

  Kristel M. Dorighi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... rabbit anti-pEGFR (Cell Signaling, 3777, 1:1000), and mouse anti-β-actin (LiCor ...
• Accelerated drug resistant variant discovery with an enhanced, scalable mutagenic base editor platform

  Kristel M. Dorighi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... mouse anti-ERK (Cell Signaling, 9107, 1:1000), rabbit anti-pERK (Cell Signaling ...
• Remote memory engrams are controlled by encoding-specific tau phosphorylation

  Kristie Stefanoska, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-cFos (9F6, Cell Signaling Technologies, 1:500), anti-egr-1 (9F6 ...
• Remote memory engrams are controlled by encoding-specific tau phosphorylation

  Kristie Stefanoska, et al., bioRxiv - Neuroscience 2023

  Quote: ... β3-tubulin (D71G9, Cell Signaling Technologies, 1:400). Immunofluorescence was imaged digitally using an AX70 epifluorescence microscope (Olympus ...
• Instant Assembly of Collagen for Scaffolding, Tissue Engineering, and Bioprinting

  Xiangyu Gong, et al., bioRxiv - Bioengineering 2023

  Quote: ... anti-SOX17 (D1T8M, Cell Signaling Technology, 1:50), anti-CDX2 (D11D10 ...
• Instant Assembly of Collagen for Scaffolding, Tissue Engineering, and Bioprinting

  Xiangyu Gong, et al., bioRxiv - Bioengineering 2023

  Quote: ... anti-CDX2 (D11D10, Cell Signaling Technology, 1:50), anti-Nanog (sc-293121 ...
• Instant Assembly of Collagen for Scaffolding, Tissue Engineering, and Bioprinting

  Xiangyu Gong, et al., bioRxiv - Bioengineering 2023

  Quote: ... anti-OCT4 (#2750, Cell Signaling Technology, 1:200). Secondary antibodies ...
• Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA

  Claire D. James, et al., bioRxiv - Cancer Biology 2023

  Quote: ... phospho-SAMHD1 1/500 (Cell Signaling Technology, 89930) GAPDH 1/10,000 (Santa Cruz ...
• Targetable leukemia dependency on noncanonical PI3Kγ signaling

  Qingyu Luo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-ubiquitin (1:1000; 43124S; Cell Signaling Technology), anti-SPI1 (1:1000 ...
• Targetable leukemia dependency on noncanonical PI3Kγ signaling

  Qingyu Luo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-PDK1 (1:1000; 3062S; Cell Signaling Technology), and anti-β-actin (1:5000 ...
• Targetable leukemia dependency on noncanonical PI3Kγ signaling

  Qingyu Luo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-PAK1 (1:1000; 2602S; Cell Signaling Technology), anti-p-AKT-S473 (1:2000 ...
• Targetable leukemia dependency on noncanonical PI3Kγ signaling

  Qingyu Luo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-SPI1 (1:1000; 2258S; Cell Signaling Technology), anti-ASH2L (1:2000 ...
• Targetable leukemia dependency on noncanonical PI3Kγ signaling

  Qingyu Luo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-AKT (1:1000; 4691S; Cell Signaling Technology), anti-p-PDK1-S241 (1:1000 ...
• Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of Phosphodiesterase 2A

  Sébastien Delhaye, et al., bioRxiv - Animal Behavior and Cognition 2023

  Quote: ... and anti-Ser845-GluR1 (Cell Signaling, 1:1000) were used here ...
• APE1 associates with 60S ribosomes and tRNAs and regulates the expression of IGF2BP1

  Wai Ming Li, Belal Tafech, Chow H. Lee, bioRxiv - Biochemistry 2023

  Quote: ... anti-LAMP1 (D2D11, 1:1000, Cell Signaling Technology); anti-TXN (ab26320 ...
• APE1 associates with 60S ribosomes and tRNAs and regulates the expression of IGF2BP1

  Wai Ming Li, Belal Tafech, Chow H. Lee, bioRxiv - Biochemistry 2023

  Quote: ... anti-fibrillarin (C13C3, 1:1000, Cell Signaling Technology); anti-RPS2 (N2C3 ...
• Cholesterol modulates the human FPN1 iron export function in plasma membrane liquid-ordered microdomains

  Rim Debbiche, et al., bioRxiv - Biochemistry 2023

  Quote: ... rabbit anti-TfR1 (Cell signaling, D7G9X; 1/1000). After three washes with TBST ...
• HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

  Hongbo Ling, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-Beclin-1 (Cell Signaling Technology, #3495, RRID:AB_1903911), anti-p62 (Cell Signaling Technology ...
• Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma

  Feras E. Machour, et al., bioRxiv - Molecular Biology 2023

  Quote: ... γH2AX (Cell Signaling Technology cat.no. 2577, 1:1000), pChk1-S345 (Cell Signaling Technology cat.no ...
• Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

  Zhuxuan Li, et al., bioRxiv - Cancer Biology 2023

  Quote: ... and GAPDH (#2118L, Cell Signaling Technology, 1:500) were detected using the appropriate HRP-conjugated secondary antibodies according to the manufacturer’s instructions.
• ATR promotes mTORC1 activation via de novo cholesterol synthesis in p16-low cancer cells

  Naveen Kumar Tangudu, et al., bioRxiv - Cancer Biology 2023

  Quote: ... HRP-linked (Cell Signaling Technology, 7074; 1:5000).
• Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

  Zhuxuan Li, et al., bioRxiv - Cancer Biology 2023

  Quote: ... KRAS(G12D) (#14429S, Cell Signaling Technology, 1:500), and GAPDH (#2118L ...
• Adaptive epigenetic regulation of neuronal metabolism by a mitochondrial redox signal

  Marius W. Baeken, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-acetylated lysine (9441, Cell Signaling, 1:1000), anti-DNMT3B (67259 ...
• Neural stem cells protect blood-brain barrier integrity via the p38, JNK, and ERK1/2 pathways following intracerebral hemorrhage in rats

  Jing Sun, et al., bioRxiv - Neuroscience 2023

  Quote: ... anti-p38 (Cell Signaling, USA, 1:1000 dilution) and anti-JNK (Cell Signaling ...
• A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

  Veronica Rendo, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit CDKN1A at 1:1,000 (Cell Signaling Technology), and rabbit RBM14 at 1:1,000 (Abcam ...
• Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer

  John D. Mason, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-EGFR (Cell Signaling #4267, 1:1000), rabbit anti-p-EGFR-Tyr1068 (Cell Signaling #3777 ...
• Recruitment of FBXO22 for Targeted Degradation of NSD2

  David Y. Nie, et al., bioRxiv - Biochemistry 2023

  Quote: ... diluted 1:1000 and DRAQ5 (Cell Signaling #4084) diluted 1:2000 in 5% BSA for 1 hour at room temperature with agitation ...
• The YARS Tyrosyl tRNA Synthetase Regulates Senescence Induction and Escape Through the Transcriptional Control of LIN9, a Member of the DREAM Complex

  Hugo Coquelet, et al., bioRxiv - Cancer Biology 2023

  Quote: ... HRP-linked antibody (1/3000, Cell Signaling, 7074), Anti-mouse IgG ...
• CAR T cells recognizing CD276 and Dual-CAR T cells against CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models

  Andrea Timpanaro, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-MycTag (1:1’000; Cell Signaling, #2278S); mouse anti-human FGFR4 (Santa Cruz ...
• Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer

  John D. Mason, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit anti-Akt (Cell Signaling #9272, 1:1000), rabbit anti-p-Akt-Ser473 (Cell Signaling #4060 ...
• EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice

  Emilie Jaune-Pons, et al., bioRxiv - Cancer Biology 2023

  Quote: ... rabbit Vimentin (Cell signaling technology, #5741, 1:400). Sections were washed ...
• Microglial 25-hydroxycholesterol mediates neuroinflammation and neurodegeneration in a tauopathy mouse model

  Danira Toral-Rios, et al., bioRxiv - Neuroscience 2023

  Quote: ... Tmem119 (rabbit polyclonal, 1:250; Cell Signaling, 90840S), P2ry12 (rat monoclonal ...
• Accelerated drug resistant variant discovery with an enhanced, scalable mutagenic base editor platform

  Kristel M. Dorighi, et al., bioRxiv - Molecular Biology 2023

  Quote: ... rabbit anti-MEK (Cell Signaling, 9121, 1:1000), mouse anti-EGFR (MBL ...
• Acetylation-dependent coupling between G6PD activity and apoptotic signaling

  Fang Wu, et al., bioRxiv - Biochemistry 2023

  Quote: ... anti-Fyn (Cell Signaling Technology, #4023; 1:1000), anti-Flag (Sigma-Aldrich ...
• Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

  Marco Leibinger, et al., bioRxiv - Neuroscience 2023

  Quote: ... total CRMP2 (1:1000; Cell Signaling Technology, RRID:AB_2094339), detyrosinated tubulin (1:1000 ...
• The pregnancy-associated protein glycodelin as a potential sex-specific target for resistance to immunotherapy in non-small cell lung cancer

  Sarah Richtmann, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Granzyme B 1:300 (D6e9W, Cell Signaling Technology). The staining was performed in alternating steps ...
• ATF4 Dependent Increase in Mitochondrial-Endoplasmic Reticulum Tethering Following OPA1 Deletion in Skeletal Muscle

  Antentor Hinton Jr., et al., bioRxiv - Biophysics 2023

  Quote: ... Alpha Tubulin (1:1000; Cell Signaling Technology; #2144), and IP3R3 (1:1000 ...
• Mechanical regulation of cell fate transitions underlying colorectal cancer metastasis formation

  Mirjam C van der Net, et al., bioRxiv - Cancer Biology 2023

  Quote: ... Annexin A1 (Cell Signaling, CS32934, 1:400 IHC), ANXA1 (Sigma ...
• NUDC is critical for rod photoreceptor function, maintenance, and survival

  Mary Anne Garner, et al., bioRxiv - Cell Biology 2023

  Quote: ... anti-arrestin (Cell Signaling Technologies [CST], 1:500); anti-transducin (Abcam ...
• Discovery of a Novel Chemotype as DYRK1A Inhibitors against Alzheimer’s disease: Computational Modeling and Biological Evaluation

  Nianzhuang Qiu, et al., bioRxiv - Pharmacology and Toxicology 2023

  Quote: ... anti-APP (1:1000, Cell signaling technology, USA), anti-Presenilin 1 (PS1 ...