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5501 - 5550 of 10000+ citations for 7 Methyl 1 5 dioxo 1 2 3 5 tetrahydro indolizine 6 carbonitrile since 2019

• WNT inhibition creates a BRCA-like state in Wnt-addicted cancer

  Amanpreet Kaur, et al., bioRxiv - Cancer Biology 2020

  Quote: ... BRCA2 (Cell Signaling Technology #10741, 1:1000 dilution), RAD51 (Abcam ab133534 ...
• Genetic editing of CISH enhances T cell effector programs independently of immune checkpoint cell surface ligand expression

  Elisa Arthofer, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and Vinculin (Cell Signaling, Clone EPR8185, 1:5000). Detection of proteins was performed using secondary antibodies conjugated to horseradish peroxidase-HRP and the SuperSignal West Pico Plus chemiluminescent substrate (Thermo Scientific-Pierce).
• Cytidine deaminase protects pancreatic cancer cells from replicative stress and drives resistance to DNA-targeting drugs

  A. Lumeau, et al., bioRxiv - Cancer Biology 2021

  Quote: ... rabbit anti-RPA70 (Cell Signaling #2267, 1:500), rabbit anti-FANCD2 (NOVUSBIO NB100-182 ...
• FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

  Guan-Yu Xiao, Sandra L. Schmid, bioRxiv - Cell Biology 2020

  Quote: ... p-Akt S473 (#4060L, 1:1000, Cell Signaling), Akt (#9272S ...
• Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Male and Female Mice

  Andrea Stojakovic, et al., bioRxiv - Neuroscience 2020

  Quote: ... PP2Ac (1:1000, Cell Signaling Technology, cat. #2038), phospho-PP2Ac (Tyr 307 ...
• PERK Activation by SB202190 Attenuates Amyloidogenesis via TFEB-induced Autophagy-Lysosomal Pathway

  Mihyang Do, et al., bioRxiv - Neuroscience 2021

  Quote: ... or anti-α-synuclein (1:500, Cell Signaling) antibodies for overnight at 4 °C ...
• PERK Activation by SB202190 Attenuates Amyloidogenesis via TFEB-induced Autophagy-Lysosomal Pathway

  Mihyang Do, et al., bioRxiv - Neuroscience 2021

  Quote: ... PERK (1:1000, Cell Signaling, Danvers, MA, USA), p-eIF2α (1:1000 ...
• Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

  Hui Li, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-phospho-Ser473-Akt (1:2000, Cell Signaling), anti-ERK1/2 (1:2000 ...
• Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria

  Marta Vranas, et al., bioRxiv - Biochemistry 2021

  Quote: ... rabbit anti-mitofusin 1 (mAb 13196S, Cell Signaling), rabbit anti-Miro1 (mAb 14016S ...
• Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders

  Pallavi M. Gosavi, et al., bioRxiv - Molecular Biology 2021

  Quote: ... anti-HA (Cell Signaling Technology, 3724S, 1:1,000), anti-FLAG (Cell Signaling Technology ...
• Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders

  Pallavi M. Gosavi, et al., bioRxiv - Molecular Biology 2021

  Quote: ... anti-CRBN (Cell Signaling Technology, 71810, 1:1,000), anti-GAPDH (Santa Cruz Biotechnology ...
• Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders

  Pallavi M. Gosavi, et al., bioRxiv - Molecular Biology 2021

  Quote: ... anti-FLAG (Cell Signaling Technology, 2368S, 1:1000), anti-CRBN (Novus Biologicals ...
• Nerve-mediated amputation-induced stem cell activation primes distant appendages for future regeneration events in axolotl

  Duygu Payzin-Dogru, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-S6 (1:1000, Cell Signaling Technology 2317S), and α-tubulin (1:2000 ...
• Hexapeptide induces M2 macrophage polarization via the JAK1/STAT6 pathway to promote angiogenesis in bone repair

  Xinyun Han, et al., bioRxiv - Biochemistry 2021

  Quote: ... p-STAT6 (1:1000) (Cell Signaling Technology, USA), β-tubulin (1:5000 ...
• Synchronized β cell response to glucose is lost concomitant with loss of islet architecture in Robo deficient islets of Langerhans in vivo

  Melissa T. Adams, et al., bioRxiv - Developmental Biology 2020

  Quote: ... rabbit anti-Glucagon (1:200, Cell Signaling 2760S), rabbit anti-Somatostatin (1:1000 ...
• RIT2 reduces LRRK2 kinase activity and protects against alpha-synuclein neuropathology

  Julia Obergasteiger, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-LC3 1:1000 (Cell Signaling Technologies, 3868), anti-β-actin 1:6000 (Sigma Aldrich ...
• Rabies anterograde monosynaptic tracing reveals organization of spinal sensory circuits

  Sofia Pimpinella, Niccolò Zampieri, bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-PKCγ 1:500 (Cell Signaling Technology), FITC conjugated-IB4 (Sigma ...
• 7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

  Hideaki Tomita, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-TrkB (1:1000; Cell Signaling Technology), rabbit anti-phospho-TrkB (1:1000 ...
• 7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

  Hideaki Tomita, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-MEK (1:1000; Cell Signaling Technology), rabbit anti-phospho-MEK (1:1000 ...
• 7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

  Hideaki Tomita, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-Sox2 (1:200; Cell Signaling Technology), rabbit anti-Pax6 (1:1000 ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-Akt (Cell Signaling 9272, 1:1000), rabbit anti-phospho-ERK1/2 (T202/Y204 ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-FAK (Cell Signaling 3285, 1:1000), rabbit anti-phospho-Pyk2 (Y402 ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-Cofilin (Cell Signaling 5175, 1:1000), rabbit anti-phospho-NR2B (PhosphoSolutions P1516-1472 ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-GluA1 (Cell Signaling 13185, 1:1000), mouse anti-histone H2B (Cell Signaling 2934 ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-Src (Cell Signaling, 2109 1:2000), mouse anti-phospho-Akt (S473 ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-V5 (Cell Signaling 13202, 1:1000), mouse anti-FLAG (Millipore Sigma F1804 ...
• Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling

  Chirag Vasavda, et al., bioRxiv - Neuroscience 2021

  Quote: ... mouse anti-Pyk2 (Cell Signaling 3480, 1:2000), rabbit anti-phospho-Src (Y416 ...
• The E3 ubiquitin ligase HECTD1 contributes to cell cycle progression through an effect on mitosis

  Natalie Vaughan, et al., bioRxiv - Cell Biology 2021

  Quote: ... and PARP (Cell Signaling Technology, #9542, 1/1,000). Secondary antibodies included Goat anti-Mouse IgG HRP (Santa Cruz Biotechnology ...
• Live Imaging Reveals the Cellular Events Downstream of SARM1 Activation

  Kwang Woo Ko, Jeffrey Milbrandt, Aaron DiAntonio, bioRxiv - Neuroscience 2021

  Quote: ... mouse anti-GFP (1:1,000, #2955S, Cell signaling); HRP-conjugated anti-mouse antibody (1:5,000 ...
• Live Imaging Reveals the Cellular Events Downstream of SARM1 Activation

  Kwang Woo Ko, Jeffrey Milbrandt, Aaron DiAntonio, bioRxiv - Neuroscience 2021

  Quote: ... Rabbit-anti-SARM1 (1:1,000, #13022, Cell signaling) and (1:5,000) ...
• A phenotypic rescue approach identifies lineage regionalization defects in a mouse model of DiGeorge syndrome

  Gabriella Lania, et al., bioRxiv - Developmental Biology 2021

  Quote: ... Anti-SLUG (Cell Signaling, #9585, diluted 1:100); Anti-TFAP2A (Hybridoma Bank ...
• Serum Amyloid A promotes Acetaminophen-induced liver injury by damaging sinusoidal endothelial cell and exacerbating platelet aggregation in liver

  Kai You, et al., bioRxiv - Pharmacology and Toxicology 2021

  Quote: ... and Vcam-1 (cat.32653S; Cell Signaling Technology).
• REPTOR/CREBRF encode key regulators of muscle energy metabolism

  Pedro Saavedra, et al., bioRxiv - Physiology 2021

  Quote: ... rabbit anti-pS6K (1:1000, Cell Signaling – 9209), total anti-S6K(18) ...
• REPTOR/CREBRF encode key regulators of muscle energy metabolism

  Pedro Saavedra, et al., bioRxiv - Physiology 2021

  Quote: ... rabbit anti-Akt (1:1000, Cell Signaling – 9272), rabbit anti-pS6K (1:1000 ...
• Mast cell-specific receptor/corticotropin-releasing factor axis regulates alcohol withdrawal-associated headache

  Hyeonwi Son, et al., bioRxiv - Neuroscience 2021

  Quote: ... and anti-β-actin (Cell Signaling, 1:5000)57 ...
• Adult fibroblasts use aggresomes only in distinct cell-states

  Christopher S. Morrow, et al., bioRxiv - Cell Biology 2021

  Quote: ... p38 MAPK (1:1,000; Cell Signaling Technology 8690L), P-p38 MAPK (1:1,000 ...
• Asparagine signals mitochondrial respiration and can be targeted to impair tumour growth

  Abigail S. Krall, et al., bioRxiv - Cancer Biology 2020

  Quote: ... phospho-S1859 CAD (Cell Signaling 70307, 1:500), CAD (Cell Signaling 11933 ...
• Asparagine signals mitochondrial respiration and can be targeted to impair tumour growth

  Abigail S. Krall, et al., bioRxiv - Cancer Biology 2020

  Quote: ... S6 ribosomal protein (Cell Signaling 2217, 1:1000), phospho-S1859 CAD (Cell Signaling 70307 ...
• A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

  Lisa Donker, et al., bioRxiv - Cell Biology 2021

  Quote: ... Cdk1 (POH1, Cell signaling; 9116, 1:250 IF), p130CAS (BD Biosciences ...
• NMNAT promotes glioma growth through regulating post-translational modifications of p53 to inhibit apoptosis

  Jiaqi Liu, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-acetyl-p53 (1:1000, Cell Signaling, 2525), anti-β-actin (1:10,000 ...
• Keratin dynamics govern the establishment of the maternal-fetal interface

  Wallis Nahaboo, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-Cdh11 (rabbit, 1:200, Cell Signaling, 442S), anti-Cdx2 (rabbit ...
• Keratin dynamics govern the establishment of the maternal-fetal interface

  Wallis Nahaboo, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-Kdr (rabbit, 1:100, Cell Signaling, 55B11), anti-Krt-8 (rat ...
• Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting Enteropathy

  Barun Das, et al., bioRxiv - Cell Biology 2020

  Quote: ... Villin-1 (2369S, Cell Signaling Technology, Danvers, MA), Lysozyme (PA5-16668 ...
• Rabaptin5 targets autophagy to damaged endosomes and SCVs by interaction with FIP200 and ATG16L1

  Valentina Millarte, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-FIP200 (12436S, Cell Signaling, 1:1000) was used for Western blot and co-immunoprecipitation ...
• Rabaptin5 targets autophagy to damaged endosomes and SCVs by interaction with FIP200 and ATG16L1

  Valentina Millarte, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-ATG16L1 (8089, Cell Signaling, 1:1000), rabbit anti-MYC (GTX29106 ...
• Rabaptin5 targets autophagy to damaged endosomes and SCVs by interaction with FIP200 and ATG16L1

  Valentina Millarte, et al., bioRxiv - Cell Biology 2021

  Quote: ... rabbit anti-ULK1 (#8054S, Cell Signaling, 1:1000) and rabbit anti ATG13 (#13468S ...
• CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

  Miriam Doepner, et al., bioRxiv - Cancer Biology 2021

  Quote: ... p-CREB (Cell Signaling Technology, #9198, 1:1000), CREB (Cell Signaling Technology ...
• Interferon-Gamma Signaling Promotes Melanoma Progression and Metastasis

  Bo Zhou, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pSTAT1 (Y727, D3B7, 1:2,000; Cell Signaling Technology), STAT3 (124H6 ...
• Loss of BCL-3 sensitises colorectal cancer cells to DNA damage, revealing a role for BCL-3 in double strand break repair by homologous recombination

  Christopher Parker, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and H2ax (1:50, Cell Signaling Technology, #9718). Representative images are shown for each staining.
• Loss of BCL-3 sensitises colorectal cancer cells to DNA damage, revealing a role for BCL-3 in double strand break repair by homologous recombination

  Christopher Parker, et al., bioRxiv - Cancer Biology 2021

  Quote: ... phospho-CHK2 (1:1000, Cell Signaling Technology, #160); α Tubulin (1:10000 ...