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5201 - 5250 of 10000+ citations for 6 METHYL 4 4 NITRO PHENYL 2 OXO 1 2 3 4 TETRAHYDRO PYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER since 2019

• Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics

  Yang Gao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... PLK2 (Cell Signaling Technology, 14821, 1:1000), and GAPDH (Cell Signaling Technology ...
• The protection of Gα_z-null NOD mice from hyperglycemia is sexually dimorphic and only partially β-cell autonomous

  Rachel J. Fenske, et al., bioRxiv - Physiology 2021

  Quote: ... rabbit anti-Ki67 (Cell Signaling - 1:200) and guinea-pig anti-insulin (Abcam - 1:75 ...
• Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

  Aixin Song, et al., bioRxiv - Biochemistry 2021

  Quote: ... PSMB5 (Cell Signaling Technology 12919S, 1:1000); ubiquitin (P4D1 ...
• KANSL1 Deficiency Causes Neuronal Dysfunction by Oxidative Stress-Induced Autophagy

  Katrin Linda, et al., bioRxiv - Neuroscience 2020

  Quote: ... p-mTOR (1:1000; Cell Signaling 2971), GAPDH (1:1000 ...
• Lipidomic profiling of clinical prostate cancer reveals targetable alterations in membrane lipid composition

  Lisa M. Butler, et al., bioRxiv - Cancer Biology 2020

  Quote: ... or pACC1 (Cell Signaling, 3661S; 1:400) was applied and slides incubated overnight at 4°C ...
• SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

  Octavio A. Romero, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-EZH2 5246S (1:1000, Cell Signaling); anti-H3K27ac D5E4 (1:1000 ...
• SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

  Octavio A. Romero, et al., bioRxiv - Cancer Biology 2020

  Quote: ... anti-H3K27ac D5E4 (1:1000, Cell Signaling) anti-H3K27me3 07-449 (1:1000 ...
• RIOK2 drives glioblastoma cell proliferation by modulating MYC through the RNA-binding protein IMP3

  Alexander S. Chen, et al., bioRxiv - Cancer Biology 2020

  Quote: ... and DRAQ7 (1:200, Cell Signaling Technology) to stain nuclear DNA and chromosomes.
• Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression

  Aziz Aiderus, et al., bioRxiv - Cancer Biology 2020

  Quote: ... phospho ERK (1:1000, Cell Signaling #4695), GAPDH (1:5000 ...
• Latent Plasticity of Effector-like Exhausted CD8 T cells contributes to memory responses

  Saravanan Raju, et al., bioRxiv - Immunology 2020

  Quote: ... Anti-TCF-1 antibody (Cell Signaling, C63D9) and detected by Alexa 488-conjugated Donkey anti-rabbit polyclonal IgG (Thermo Fisher ...
• The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity

  Carley Snoznik, et al., bioRxiv - Neuroscience 2021

  Quote: ... anti-PTEN (1:1000; Cell Signaling Technology), anti-DUSP7 (1:1000 ...
• Sex-dependent effects of CYP46A1 overexpression on cognitive function during aging

  María Latorre-Leal, et al., bioRxiv - Animal Behavior and Cognition 2021

  Quote: ... phospho-CREB (Cell Signaling 86B10, 1:1000), ADAM 10 (Abcam ab1997 ...
• Sortilin exhibits tumor suppressor-like activity by limiting EGFR transducing function

  E. Lapeyronnie, et al., bioRxiv - Cancer Biology 2021

  Quote: ... AKT (#4691, 1:1000 dilution, Cell Signaling), lamin b1 (#HPA050524 ...
• Combinatorial Immunotherapies Overcome MYC-Driven Immune Evasion

  Joyce V. Lee, et al., bioRxiv - Cancer Biology 2021

  Quote: ... anti-STAT1 (1:1,000, #9172, Cell Signaling), Anti-Rabbit IgG (1:10,000 ...
• MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

  Dario Zimmerli, et al., bioRxiv - Cancer Biology 2021

  Quote: ... or cGAS (1:200, Cell Signaling, #15102) in PBS–Tween–BSA ...
• The Mammalian Target of Rapamycin (mTOR) Kinase Mediates Haloperidol-Induced Cataleptic Behavior

  Uri Nimrod Ramírez-Jarquín, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-mTOR (1:250, Cell Signaling, #2983), and anti-GFP (Santa Cruz ...
• mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex

  Madeline G. Andrews, et al., bioRxiv - Neuroscience 2020

  Quote: ... p4EBP1 (Cell Signaling Technology, 2855S, 1:500), DEPDC5 (Sigma ...
• Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice

  David V.C. Brito, et al., bioRxiv - Neuroscience 2020

  Quote: ... total-CREB (1:5000, Cell Signaling, #4820), β-Actin (1:1000 ...
• The canonical Wnt signaling pathway is not a promising therapeutic target for PNS regeneration enhancement

  Nikita Mehta, Maia Vardy, Benayahu Elbaz, bioRxiv - Neuroscience 2022

  Quote: ... p75NTR (Cell Signaling Technology, 8238T, 1:250) and MBP (BioRad ...
• 17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice

  Samim Ali Mondal, et al., bioRxiv - Physiology 2022

  Quote: ... phospho-p65 (serine536; Cell Signaling; 1:1000), GAPDH (Abcam ...
• A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding

  Lei Wang, et al., bioRxiv - Neuroscience 2022

  Quote: ... 1 μg/mL leupeptin (Cell Signaling, 9803s), and 1 mM PMSF ...
• Diminished motor neuron activity driven by abnormal astrocytic GLAST glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery

  Emily Welby, Allison D. Ebert, bioRxiv - Neuroscience 2022

  Quote: ... rabbit anti-GFP (1:1000, Cell Signaling). Following 3x washes with 1x TBST ...
• Multiomic deep delve of synthesis and secretion processes in a model peptidergic system

  Soledad Bárez-López, et al., bioRxiv - Neuroscience 2022

  Quote: ... Synapsin (1:1000, Cell Signaling Technology, 2312S) and Tubulin (1:5000 ...
• N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

  Sylvia Varland, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-CUL1 (Cell Signaling, 4995, 1:1000), anti-CUL2 (Abcam ...
• N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

  Sylvia Varland, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-CUL3 (Cell Signaling, 2759, 1:1000), anti-CUL4A (Cell Signaling ...
• N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

  Sylvia Varland, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-CUL4A (Cell Signaling, 2699, 1:1000), anti-CUL4B (Proteintech ...
• Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium

  Natalia Pydyn, et al., bioRxiv - Molecular Biology 2022

  Quote: ... anti-p-AktSer473 (1:1000; Cell Signaling), rabbit anti-IGF1R (1:1000 ...
• ID1 and CEBPA Coordinate Epidermal Progenitor Cell Differentiation

  Christina Geraldine Kantzer, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Cebpa (Cell Signaling Technology, #2295, 1:1000) phospho-Smad1/5 (Cell Signaling Technology ...
• ID1 and CEBPA Coordinate Epidermal Progenitor Cell Differentiation

  Christina Geraldine Kantzer, et al., bioRxiv - Developmental Biology 2022

  Quote: ... Cebpa (Cell Signaling Technology, #2295, 1:500). Antibodies used for immunoblotting are listed below ...
• G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis

  Ewa Bielczyk-Maczynska, et al., bioRxiv - Physiology 2022

  Quote: ... phospho-S6 (Cell Signaling, #2211, 1:1,000). Equal protein loading was verified using antibody against β-actin (Santa Cruz ...
• G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis

  Ewa Bielczyk-Maczynska, et al., bioRxiv - Physiology 2022

  Quote: ... phospho-Akt (Cell Signaling, #4060, 1:1,000), S6 (Cell Signaling ...
• Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

  Tamadher A. Alghamdi, et al., bioRxiv - Physiology 2022

  Quote: ... CD81 (dilution 1:1000; Cell Signaling 10037S), Aldh1a3 (dilution 1:1000 ...
• High-throughput Oligopaint screen identifies druggable regulators of genome folding

  Daniel S. Park, et al., bioRxiv - Genetics 2022

  Quote: ... WAPL (Cell Signaling Technology 77428, 1:1000). The following day ...
• High-throughput Oligopaint screen identifies druggable regulators of genome folding

  Daniel S. Park, et al., bioRxiv - Genetics 2022

  Quote: ... GAPDH (Cell Signaling Technology 5174, 1:2000), GSK3A (Cell Signaling Technology 4337 ...
• High-throughput Oligopaint screen identifies druggable regulators of genome folding

  Daniel S. Park, et al., bioRxiv - Genetics 2022

  Quote: ... GSK3A (Cell Signaling Technology 4337, 1:1000), GSK3B (BD Biosciences 610201 ...
• Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment

  Debolina Ganguly, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-CD45 (1:500, Cell Signaling, 70257), anti-mouse Ly-6G (1:200 ...
• Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells

  Scott M. Emrich, et al., bioRxiv - Immunology 2022

  Quote: ... NFAT1 (1:1000, 4389S, Cell Signaling Technology), NFAT2 (1:1000 ...
• Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells

  Scott M. Emrich, et al., bioRxiv - Immunology 2022

  Quote: ... α-Tubulin (1:5000, 3873S, Cell Signaling Technology), phospho-CREB (Ser133 ...
• In macrophages fatty acid oxidation spares glutamate for use in diverse metabolic pathways required for alternative activation

  Nikki van Teijlingen Bakker, et al., bioRxiv - Immunology 2022

  Quote: ... 1 μg/mL leupeptin (Cell Signaling Technologies), supplemented with 1 mM PMSF ...
• Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells

  Scott M. Emrich, et al., bioRxiv - Immunology 2022

  Quote: ... NFAT2 (1:1000, 8032S, Cell Signaling Technology), α-Tubulin (1:5000 ...
• Aiolos modulates the T_FH and CD4-CTL differentiation programs via reciprocal regulation of the Zfp831/TCF-1/Bcl-6 axis and CD25

  Kaitlin A. Read, et al., bioRxiv - Immunology 2022

  Quote: ... STAT5 (clone (D206Y, Cell Signaling, 1:5000), β-Actin (GenScript ...
• Fat body-specific reduction of CTPS alleviates HFD-induced obesity

  Jingnan Liu, et al., bioRxiv - Cell Biology 2022

  Quote: ... (1:2000, Cell Signaling, Catalogue no.5151).
• The isoforms of pyruvate kinase act as nutrient sensors for the β-cell K_ATP channel

  Hannah R. Foster, et al., bioRxiv - Cell Biology 2022

  Quote: ... or HSP90 (Cell Signaling #4877; 1:1000). Blots were washed for 15 min in TBST four times then incubated for 2 hours at room temperature with an anti-rabbit IgG HRP-linked secondary antibody (Cell Signaling #7074 ...
• Prediction of Resistant Mutations against Upcoming ALK-TKIs, Repotrectinib (TPX-0005) and Ensartinib (X-396)

  Yuta Doi, et al., bioRxiv - Cancer Biology 2022

  Quote: ... ALK (Cell Signaling Technologies, #3791, 1:1000), and α-tubulin (Wako ...
• Fitm2 is required for ER homeostasis and normal function of murine liver

  Laura M. Bond, et al., bioRxiv - Cell Biology 2022

  Quote: ... 1:1000),vinculin (Cell Signaling Technology #4650, 1:1000), ApoB (Abcam ab31992 ...
• Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment

  Debolina Ganguly, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-Arg1(1:500, Cell Signaling, 93668S), anti-Granzyme B (1:500 ...
• Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment

  Debolina Ganguly, et al., bioRxiv - Cancer Biology 2022

  Quote: ... anti-p65 (1:1000, Cell Signaling, 8242), anti-p-p65 (1:1000 ...
• Sugar transporter Slc37a2 regulates bone metabolism via a dynamic tubular lysosomal network in osteoclasts

  Pei Ying Ng, et al., bioRxiv - Cell Biology 2022

  Quote: ... Rab7 (Cell Signaling 95746, 1/2000 dilution), Ctsk (Santa Cruz sc-48353 ...
• Orchestration of alternative splicing regulates bone marrow mesenchymal stem cells fate during aging

  Ye Xiao, et al., bioRxiv - Cell Biology 2022

  Quote: ... FAK (Cell Signaling Technology, 3285, 1:1000), Phospho-FAK (Tyr397 ...
• Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

  Christina Plattner, et al., bioRxiv - Cancer Biology 2022

  Quote: ... phospho-AKT (Cell Signaling, #4060S, 1:1000), phospho-ERK1/2 (Cell Signaling ...