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4951 - 5000 of 10000+ citations for 7 hydroxy 1H 1 2 4 triazolo 1 5 a pyrimidin 5 one since 2019

• Substance P and adenosine signaling pathways regulate exosomal sorting of miR-21 in colonic epithelial cells

  Sameena Wani, et al., bioRxiv - Cell Biology 2022

  Quote: ... anti-pPKA (1:1,000, 5661S; Cell signaling Technology), anti-TUT7/anti-ZCCHC6 (1:500 ...
• Targeting tau mitigates mitochondrial fragmentation and oxidative stress in amyotrophic lateral sclerosis

  Tiziana Petrozziello, et al., bioRxiv - Neuroscience 2021

  Quote: ... and β-Actin (1:1000; Cell Signaling, MA), overnight at 4°C ...
• MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

  Andrea Toledo, et al., bioRxiv - Neuroscience 2021

  Quote: ... mouse anti-pTyr (Cell Signaling #9411, 1:1000), rabbit anti-panNLGN (Synaptic Systems #129 213 ...
• Phospho-IWS1-dependent U2AF2 splicing is cell-cycle-regulated, promotes proliferation and predicts poor prognosis of EGFR-mutant lung adenocarcinoma

  Georgios I. Laliotis, et al., bioRxiv - Cancer Biology 2021

  Quote: ... IGF-1 (Cell Signaling Technologies, Cat. No. 8917) (20ng/ml) ...
• Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and Atherosclerosis

  Darian Williams, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-phospho-NFκB (Cell Signaling #3033, 1:1000), and anti-HTRA1 (R&D Systems MAB2916 ...
• IFT20 is critical for early chondrogenesis during endochondral ossification

  Hiroyuki Yamaguchi, et al., bioRxiv - Developmental Biology 2021

  Quote: ... anti-GAPDH (Cell Signaling technology; #2118, 1:5,000), anti-GLI1 (R&D systems ...
• YAP/TAZ Maintain the Proliferative Capacity and Structural Organization of Radial Glial Cells During Brain Development

  Alfonso Lavado, et al., bioRxiv - Developmental Biology 2021

  Quote: ... β-Catenin–Alexa-647 (Cell Signaling #4627, 1:100), and S100β (Sigma #52532 ...
• The neurogenic fate of the hindbrain boundaries relies on Notch-dependent asymmetric cell divisions

  Covadonga F Hevia, et al., bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-Taz (1:150; Cell Signaling, D24E4), mouse anti-ZO1 (1:500 ThermoFisher ZO1-1A12) ...
• Self-activation of Wnt signaling in pre-granulosa cells is required for ovarian folliculogenesis

  Okiko Habara, et al., bioRxiv - Developmental Biology 2020

  Quote: ... rabbit anti-FoxO3 (1:500; 12829, Cell Signaling), and rat anti-Ki67 (1:400 ...
• Ciliopathic micrognathia is caused by aberrant skeletal differentiation and remodeling

  Christian Louis Bonatto Paese, et al., bioRxiv - Developmental Biology 2020

  Quote: ... Cleaved Caspase-3 (1:100, Cell Signaling 9661) and Phospho-Histone H3 (1:200 ...
• Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD

  Jaspreet K. Osan, et al., bioRxiv - Microbiology 2020

  Quote: ... acetylated-alpha-tubulin (1:500) (Cell Signaling Technologies) for the staining of ciliated cells ...
• Tsc1 haploinsufficiency leads to Pax2 dysregulation in the developing murine cerebellum

  Ines Serra, et al., bioRxiv - Neuroscience 2021

  Quote: ... or GAPDH (1:1000, mouse, Cell Signaling 97166). Secondary antibodies used were goat anti-Rabbit Immunoglobulins/HRP (1:10000 ...
• Boosting L-type Ca²⁺ channel activity in tuberous sclerosis mitigates excess glutamate receptors

  Farr Niere, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-phospho-S6 (1:1000, Cell Signaling), and mouse anti-tubulin (1:20,000 ...
• Kin17 drives dissociation of Mira from the centrosome in neuroblasts by regulating splicing of Flfl

  Marisa Connell, Yonggong Xie, Rui Chen, Sijun Zhu, bioRxiv - Cell Biology 2021

  Quote: ... and HRP-Rb (Cell Signaling Technology; 1:2000). Blots were visualized with SuperSignal West Pico or Femto PLUS Chemoluminescent Substrate (ThermoFisher Scientific ...
• The consequences of differential origin licensing dynamics in distinct chromatin environments

  Liu Mei, et al., bioRxiv - Molecular Biology 2021

  Quote: ... RPA (1:200, Cell Signaling Technology, Cat#2208). Cells were incubated with secondary Alexa Fluor series antibodies (all 1:500 ...
• Control of ribosomal protein synthesis by Microprocessor complex

  Xuan Jiang, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-NEDD4(1:2000, Cell signaling Technology, 2740), anti-Flag M2(1:2000 ...
• Control of ribosomal protein synthesis by Microprocessor complex

  Xuan Jiang, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-Rps6 (1:500, Cell signaling Technology, 2317), anti-Rps19 (1:300 ...
• Control of ribosomal protein synthesis by Microprocessor complex

  Xuan Jiang, et al., bioRxiv - Molecular Biology 2020

  Quote: ... anti-Myc (1:2500, Cell signaling Technology, 2278), anti-Myc-Tag (Cell signaling Technology ...
• Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -λ

  Manuel Hayn, et al., bioRxiv - Microbiology 2020

  Quote: ... V5-tag (1:1,000, D3H8Q, Cell Signaling Technology), SARS-CoV-2 (COVID-19 ...
• Immunoproteasome deficiency leads to sustained pancreatic injury and delayed recovery from experimental pancreatitis

  Laura L. De Freitas Chama, et al., bioRxiv - Physiology 2020

  Quote: ... and anti-LC3 (1:2000; 2775, Cell Signaling). All membranes were incubated with secondary horseradish peroxidase conjugated antibody (1:10000 ...
• Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Male and Female Mice

  Andrea Stojakovic, et al., bioRxiv - Neuroscience 2020

  Quote: ... GSK3β (1:1000, Cell Signaling Technology, cat. #9832), phospho-GSK3β (Ser9 ...
• Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Male and Female Mice

  Andrea Stojakovic, et al., bioRxiv - Neuroscience 2020

  Quote: ... AMPK (1:1000, Cell Signaling Technology, cat. #2532), Synaptophysin (1:200 ...
• Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Male and Female Mice

  Andrea Stojakovic, et al., bioRxiv - Neuroscience 2020

  Quote: ... GluN2B (1:1000, Cell Signaling Technology, cat. # 14544), phospho-NMDAR 2B (Tyr1472 ...
• Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Male and Female Mice

  Andrea Stojakovic, et al., bioRxiv - Neuroscience 2020

  Quote: ... CDK5 (1:1000, Cell Signaling Technology, cat. #2506), p35/p25 (1:1000 ...
• Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Male and Female Mice

  Andrea Stojakovic, et al., bioRxiv - Neuroscience 2020

  Quote: ... PSD95 (1:1000, Cell Signaling Technology, cat. # 2507), GluA1 (1:1000 ...
• Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Male and Female Mice

  Andrea Stojakovic, et al., bioRxiv - Neuroscience 2020

  Quote: ... GluA1 (1:1000, Cell Signaling Technology, cat. # 13185), phospho-AMPAR 1 (Ser845 ...
• Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Male and Female Mice

  Andrea Stojakovic, et al., bioRxiv - Neuroscience 2020

  Quote: ... Fyn (1:1000, Cell Signaling Technology, cat. # 4023), phosphor-Src (Tyr416 ...
• Morphological and biochemical repercussions of Toxoplasma gondii infection in a 3D human brain neurospheres model

  Paulo Emílio Corrêa Leite, et al., bioRxiv - Neuroscience 2020

  Quote: ... at 1:1000 and SOX2 (Cell Signaling Technology) at 1:200 ...
• Mitophagy antagonism by Zika virus reveals Ajuba as a regulator of PINK1-Parkin signaling, PKR-dependent inflammation, and viral invasion of tissues

  Sanket S. Ponia, et al., bioRxiv - Microbiology 2021

  Quote: ... rabbit anti Mitofusin-1 (#14739S, Cell Signaling Technology), mouse anti MAVS (#ENZ-ABS259-0100 ...
• Telomeric Double Strand Breaks Facilitate Formation of 5’ C-Rich Overhangs in G1 Human Cells

  Christopher B Nelson, et al., bioRxiv - Molecular Biology 2019

  Quote: ... Rabbit Anti-RPA70 (Cell signaling #2267, 1:50), Rabbit Anti-phospho S4/S8 RPA32 (Bethyl A300-245A 1:2000) ...
• A chemical screen identifies a link between lipid metabolism and mRNA translation

  Alba Corman, et al., bioRxiv - Molecular Biology 2020

  Quote: ... PERK (D11A8) (1:500, Cell Signaling Technology, 5683). Protein bands were visualized by chemiluminescence (ECL ...
• Cocaine-dependent acquisition of locomotor sensitization and conditioned place preference requires D1 dopaminergic signaling through a cyclic AMP, NCS-Rapgef2, ERK and Egr-1/Zif268 pathway

  Sunny Zhihong Jiang, et al., bioRxiv - Neuroscience 2020

  Quote: ... anti-pCREB (1:1000, Cell Signaling, Denvers, MA), mouse anti-PSD95 (1:1000 ...
• Dysregulation of NRSF/REST via EHMT1 is associated with psychiatric disorders

  Mouhamed Alsaqati, et al., bioRxiv - Neuroscience 2021

  Quote: ... Sox2 (1:200, 3579, Cell Signaling Technology, USA), NeuN (1:250 ...
• UCHL1 inhibited by A1 astrocytes facilitates aggregates clearance to promote neural stem cells activation after spinal cord injury

  Lu Ding, et al., bioRxiv - Neuroscience 2021

  Quote: ... Tubulin β3 (1:300; Cell Signaling Technology, CST). Post washing in PBS for three times ...
• Purinergic receptor P2RY14 cAMP signaling regulates EGFR-driven Schwann cell precursor self-renewal and nerve tumor initiation in neurofibromatosis

  Jennifer Patritti-Cram, et al., bioRxiv - Neuroscience 2021

  Quote: ... Ki67 (1:200, Cell Signaling Technologies Cat# 12202S), anti-CNPAse (1:250 ...
• Congenital Zika virus infection impairs corpus callosum development

  Raissa R. Christoff, et al., bioRxiv - Neuroscience 2021

  Quote: ... rabbit anti-Caspase3 1:300 (Cell signaling 9664); anti-IBA1 1:1000 (Wako 019-19741 ...
• Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling

  Diep Nguyen, et al., bioRxiv - Biochemistry 2020

  Quote: ... anti-MEK antibody (1:250) (Cell Signaling, #9122), anti-ERK antibody (1:1000 ...
• Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling

  Diep Nguyen, et al., bioRxiv - Biochemistry 2020

  Quote: ... anti-ERK antibody (1:1000) (Cell Signaling, #9102), or anti-GST antibody (1:1000 ...
• Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling

  Diep Nguyen, et al., bioRxiv - Biochemistry 2020

  Quote: ... anti-ERK antibody (1:1000) (Cell Signaling, #9102), or anti-B-Raf antibody (1:2000 ...
• Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling

  Diep Nguyen, et al., bioRxiv - Biochemistry 2020

  Quote: ... anti-MEK antibody (1:1000) (Cell Signaling, #9122), anti-ERK antibody (1:1000 ...
• Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolism

  Wenqing Wang, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-AMPK (Cell Signaling Technology, 2532s, 1:50), anti-pAMPK (Cell Signaling Technology ...
• Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolism

  Wenqing Wang, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-pAMPK (Cell Signaling Technology, 2535s, 1:50). Secondary antibodies were ...
• A genetic compensatory mechanism regulated by c-Jun and Mef2d modulates the expression of distinct class IIa HDACs to ensure peripheral nerve myelination and repair

  Sergio Velasco-Aviles, et al., bioRxiv - Cell Biology 2021

  Quote: ... c-Jun (Cell Signaling Technology, rabbit 1:1000), GAPDH (Sigma- Aldrich ...
• Multiple viral microRNAs regulate interferon release and signaling early during infection with Epstein-Barr virus

  Mickaël Bouvet, et al., bioRxiv - Microbiology 2020

  Quote: ... anti-rabbit HRP (Cell signaling, #7074S, 1:20000). The membranes were scanned using the ChemiDoc Imaging sytem (Bio-Rad ...
• IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

  Caterina Prelli Bozzo, et al., bioRxiv - Microbiology 2020

  Quote: ... IFITM3 (α-IFITM3 Cell Signaling #59212S, 1:1000) SARS Spike CoV-2 (SARS-CoV-1/-2 (COVID-19 ...
• IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition

  Caterina Prelli Bozzo, et al., bioRxiv - Microbiology 2020

  Quote: ... IFITM2 (α-IFITM2 Cell Signaling #13530S, 1:1000), IFITM3 (α-IFITM3 Cell Signaling #59212S ...
• Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics

  Yang Gao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... and GAPDH (Cell Signaling Technology, 2118, 1:5000) antibodies were employed.
• Fast Transport of RNA Granules by Direct Interactions with KIF5A/KLC1 Motors Prevents Axon Degeneration

  Yusuke Fukuda, et al., bioRxiv - Cell Biology 2020

  Quote: ... rabbit anti-pan actin (1:1000; Cell Signaling), mouse anti-Myc (1:500 ...
• Systematic expression profiling of dprs and DIPs reveals cell surface codes in Drosophila larval peripheral neurons

  Yupu Wang, et al., bioRxiv - Neuroscience 2021

  Quote: Rabbit anti-HA (1:1000, Cell Signaling C29F4)
• Bassoon controls synaptic vesicle pools via regulation of presynaptic phosphorylation and cAMP homeostasis

  Carolina Montenegro-Venegas, et al., bioRxiv - Neuroscience 2021

  Quote: ... Italy) pSer9Syn1 (WB: 1:1000, # 2311S, Cell Signaling), PKAα cat (C-20 ...