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451 - 500 of 10000+ citations for 6 Methyl 5 4 phenyl 1 3 thiazol 2 yl 2 trifluoromethyl nicotinic acid since 2020

• Canonical and noncanonical TGF-β signaling regulate fibrous tissue differentiation in the axial skeleton

  Sade W. Clayton, Ga I Ban, Cunren Liu, Rosa Serra, bioRxiv - Developmental Biology 2020

  Quote: ... pERK1/2 Catalog #9101S (Cell Signaling), ERK1/2 Catalog #4695S (Cell Signaling) ...
• Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/P38 signaling

  Jamie L. Grit, et al., bioRxiv - Genomics 2020

  Quote: ... phospho-ERK1/2 (Cell Signaling #9101), and β-Actin (Cell Signaling #3700) ...
• GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection

  Tomoko Sumitomo, et al., bioRxiv - Microbiology 2020

  Quote: ... Calpain 2 (Rabbit-pAb, Cell Signaling), or serotype 2 capsule (Rabbit ...
• Unbiased and UMI-informed sequencing of cell-free miRNAs at single-nucleotide resolution

  M.A.J. van Eijndhoven, et al., bioRxiv - Genomics 2021

  Quote: ... Argonaute 2 (#2987; Cell Signaling Technology) and β-Actin (sc-47778 ...
• KRAS G12D can be targeted by potent salt-bridge forming inhibitors

  Zhongwei Mao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... pERK1/2 (Cell Signaling Technology, 4370), ERK1/2 (Cell Signaling Technology ...
• KRAS G12D can be targeted by potent salt-bridge forming inhibitors

  Zhongwei Mao, et al., bioRxiv - Cancer Biology 2021

  Quote: ... ERK1/2 (Cell Signaling Technology, 4695), pAKT(Thr308 ...
• SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

  Da-Yuan Chen, et al., bioRxiv - Microbiology 2020

  Quote: ... pSTAT-2 (Cell Signaling Technologies; #4441), STAT2 (Santa Cruz Biotechnology ...
• FGFR Signaling Coordinates the Balance Between Glycolysis and Fatty Acid β-Oxidation in Lymphatic Endothelial Cells

  Hongyuan Song, Jie Zhu, Longhou Fang, Pengchun Yu, bioRxiv - Cell Biology 2020

  Quote: ... ERK1/2 (Cell Signaling Technology, 4695), CPT1A (Abcam ...
• Nutrient Sensing Receptor GPRC6A Regulates mTORC1 Signaling and Tau Biology

  Chao Ma, et al., bioRxiv - Neuroscience 2024

  Quote: ... ERK1/2 (Cell Signaling Tech, #9102S), ERK1/2 pT202/Y204 (Cell Signaling Tech ...
• Small-molecule degraders reduce Aβ production through CAPRIN1-mediated lysosomal degradation of APP in Alzheimer’s iPSC-derived neurons

  Sunghan Jung, et al., bioRxiv - Neuroscience 2023

  Quote: ... Presenilin 2 (Cell Signaling Technology, 9979), BACE1 (Abcam ...
• Calpain-2 mediates SARS-CoV-2 entry and represents a therapeutic target

  Qiru Zeng, et al., bioRxiv - Microbiology 2022

  Quote: ... calpain-2 (Cell Signaling Technology, 2539), ACE2 (R&D Systems ...
• YAP-controlled MHC-I and CXCL10 expression potentiates antitumor immunity independently of IFNγ signaling

  Linyuan Peng, et al., bioRxiv - Cancer Biology 2023

  Quote: ... β2-microglobulin (Cell Signaling Technology, 12851S), TAP1 (Cell Signaling Technology ...
• MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

  Célia Guérin, et al., bioRxiv - Cancer Biology 2023

  Quote: ... ERK1/2-Phospho (Cell Signaling #9101), GAPDH (Santa Cruz #Sc-32233/6c5) ...
• Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors

  Chuankai Chen, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p-ERK1/2 (Cell Signaling, #4376), ERK1/2 (Santa Cruz ...
• Prohibitin 2 is a Key Regulator of T Cell Proliferation and Effector Functions

  Johannes F. Vogt, et al., bioRxiv - Immunology 2024

  Quote: ... p-Erk1/2 (Cell Signaling #9106), a-tubulin (Cell Signaling #2144) ...
• Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors

  Chuankai Chen, et al., bioRxiv - Cancer Biology 2024

  Quote: ... p-MEK1/2 (Cell Signaling, #9121), MEK1 (Cell Signaling ...
• Loss of the Inv(16) Oncogene CBFB::MYH11 Eliminates Leukemia from the Blood and Spleen, but not the Bone Marrow

  Sipra Panda, et al., bioRxiv - Cancer Biology 2024

  Quote: ... BCL-2 (Cell Signaling Technology, MA), and GFP (Invitrogen ...
• The laminin-keratin link shields the nucleus from mechanical deformation and signalling

  Zanetta Kechagia, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit Phospho-Myosin Light Chain 2 (Thr18/Ser19) 1:500 (Cell Signaling, Cat# 3674), rabbit anti-Cytokeratin 8 [EP1628Y] 1:2000 (Abcam ...
• The DCC receptor regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

  Laura Morcom, et al., bioRxiv - Neuroscience 2020

  Quote: ... rabbit anti-phospho p44/42 Mapk (or Erk1/2; 1:250; 9101, Cell Signaling), rabbit anti-Sox9 (1:500 ...
• Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification

  Francesca M. Aloisio, Diane L. Barber, bioRxiv - Cell Biology 2021

  Quote: ... Phospho-p44/42 MAPK Erk1/2 Thr202/Tyr204 (1:1000; #9101; Cell Signaling Technology), Grhl2 (1:1000 ...
• Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification

  Francesca M. Aloisio, Diane L. Barber, bioRxiv - Cell Biology 2021

  Quote: ... Phospho-Myosin Light Chain 2 Thr18/Ser19 E2J8F (1:1000; #95777; Cell Signaling Technology), ERK 1 C-16 (1:1000 ...
• Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington’s disease mouse phenotype

  Jordi Creus-Muncunill, et al., bioRxiv - Neuroscience 2022

  Quote: ... anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (1:1000, #9101, Cell Signaling), anti-p44/42 MAPK (Erk1/2 ...
• Cell-surface PD-L1 expression identifies a sub-population of distal epithelial cells enriched in idiopathic pulmonary fibrosis

  Negah Ahmadvand, et al., bioRxiv - Cell Biology 2022

  Quote: ... F(ab’)2 Fragment (Alexa Fluor® 555 Conjugate Cell Signaling Technologies 1:1000).
• Transient opening of tricellular vertices controls paracellular transport through the follicle epithelium during Drosophila oogenesis

  Jone Isasti-Sanchez, et al., bioRxiv - Developmental Biology 2020

  Quote: ... DSHB) and rabbit anti-phospho-Myosin light chain 2 (1:50; Cell Signaling Technology). Goat secondary antibodies were conjugated with Alexa Fluor 488 ...
• Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome

  Fikri Birey, et al., bioRxiv - Neuroscience 2021

  Quote: ... Phospho-Myosin Light Chain 2 (Ser19) antibody (1:200 dilution, rabbit, Cell Signaling, 3671S), anti-MAP2 antibody (1:10,000 dilution ...
• TGFβ2 regulates human trabecular meshwork cell contractility via ERK and ROCK pathways with distinct signaling crosstalk dependent on the culture substrate

  Haiyan Li, et al., bioRxiv - Cell Biology 2021

  Quote: ... or phospho-myosin light chain 2 (Ser19) (p-MLC [3675] 1:200; Cell Signaling), followed by incubation with Alexa Fluor® 488-conjugated or 594-conjugated secondary antibodies (Invitrogen ...
• Angiocrine IGFBP3 Spatially Coordinates IGF Signaling During Neonatal Cardiac Regeneration

  Shah R. Ali, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-phospho p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling, 9101S, 1:2000), anti-Akt (Cell Signaling ...
• RPTPγ is a redox-regulated suppressor of promigratory EGFR signaling

  Maitreyi S. Joshi, et al., bioRxiv - Systems Biology 2022

  Quote: ... rabbit anti-phospho-ERK-1/2 Thr/Tyr 202/204 (9101, Cell Signaling Technology), mouse anti-ERK1/2 (ab366991 ...
• Langerhans islets induce anti-tumor immunity at the expense of glycemic control and predict chemotherapy response in pancreatic cancer

  Azaz Ahmed, et al., bioRxiv - Cancer Biology 2021

  Quote: ... Phospho-Stat3 (Ser727) (1:200, HIER 2, mouse monoclonal, Cell Signaling Technology, USA; 9136S). The slides were incubated with a secondary antibody (rabbit anti-mouse IgG ...
• Elimination Of Aberrantly Specified Cell Clones Is Independent Of Interfacial Myosin II Accumulation

  Olga Klipa, Fisun Hamaratoglu, bioRxiv - Developmental Biology 2021

  Quote: ... rabbit anti-phospho-Myosin light chain 2 (Ser19) (1:50, Cell Signaling Technology #3671), rabbit anti-Ap (1:1000 ...
• Single Serine on TSC2 Exerts Biased Control over mTORC1 Activation by ERK1/2 but Not Akt

  Brittany L. Dunkerly-Eyring, et al., bioRxiv - Cell Biology 2021

  Quote: ... anti-phospho-p44/42 MAPK (ERK1/2) (Thr202/Tyr204) (Cell Signaling Technology, 1:1000), and anti-p44/42 MAPK (ERK1/2 ...
• P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway

  Zhijia Wang, et al., bioRxiv - Biochemistry 2022

  Quote: ... anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology, 1:4000); anti-p44/42 MAPK (Erk1/2 ...
• Calpain-mediated proteolysis of vimentin filaments is augmented in Giant Axonal Neuropathy (GAN) fibroblasts exposed to hypotonic stress

  Cassandra L. Phillips, et al., bioRxiv - Cell Biology 2022

  Quote: ... rabbit anti-Calpain 2 (Cell Signaling Technology, large subunit M-type, WB 1:1000), and rabbit anti-Calpain 2 (Cell Signaling Technology ...
• Metabotropic NMDA Receptor Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory

  Aliza A. Le, et al., bioRxiv - Neuroscience 2024

  Quote: ... RRID:AB_310282) or rabbit anti-pERK1/2 (Thr202/Tyr204) (1:500; Cell Signaling 4377, AB_331775); Mouse anti-PSD95 (1:1000 ...
• A cellular assay to determine the fusion capacity of MFN2 variants linked to Charcot-Marie-Tooth type 2A

  Chloe Barsa, et al., bioRxiv - Cell Biology 2024

  Quote: ... and rabbit monoclonal anti-Mitofusin-2 (D1E9) (Cell Signaling, 11925, dilution of 1/100).
• Myc controls IL-15-driven expansion and translational machinery of NK cells

  Hanif J. Khameneh, et al., bioRxiv - Immunology 2022

  Quote: ... phospho-ERK1/2 (Thr202/Tyr204; D13.14.4E; XP Rabbit mAb #4370; Cell Signaling, 1:150).
• Cellular mechanisms of heterogeneity in NF2-mutant schwannoma

  Christine Chiasson-MacKenzie, et al., bioRxiv - Cancer Biology 2023

  Quote: ... anti-phospho p44/42 (ERK1/2) rabbit mAb (1:1000; D13.14.4E, Cell Signaling Technology); anti-p44/42 (ERK1/2 ...
• Tumor suppressor let-7 acts as a key regulator for maintaining pluripotency gene expression in Muse cells

  Gen Li, Shohei Wakao, Masaaki Kitada, Mari Dezawa, bioRxiv - Cell Biology 2023

  Quote: ... Phospho-p44/p42 MEK/ERK (ERK1/2; Thr202/Tyr 204) (1:1000, Cell Signaling), p44/p42 MEK/ERK (ERK1/2 ...
• PPARγ controls ESCRT-dependent fibroblast-like synoviocyte exosome biogenesis and Alleviates Chondrocyte Osteoarthritis Mediated by Exosomal ANXA1

  Shuangshuo Jia, et al., bioRxiv - Cell Biology 2023

  Quote: ... p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb (4695, 1:30, Cell Signaling Technology), anti-Hrs (sc-271455 ...
• PPARγ controls ESCRT-dependent fibroblast-like synoviocyte exosome biogenesis and Alleviates Chondrocyte Osteoarthritis Mediated by Exosomal ANXA1

  Shuangshuo Jia, et al., bioRxiv - Cell Biology 2023

  Quote: ... p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb (4695, 1:1000, Cell Signaling Technology), Phospho-p44/42 MAPK (Erk1/2 ...
• Engineering Regionally-Activated Drugs for Neuroscience

  Zhimin Huang, et al., bioRxiv - Bioengineering 2023

  Quote: ... (2) incubate with primary rabbit anti-c-Fos (1:2000, 2250S, Cell Signaling Technology) and chicken antityrosine hydroxylase (1:2000 ...
• Engineering Regionally-Activated Drugs for Neuroscience

  Zhimin Huang, et al., bioRxiv - Bioengineering 2023

  Quote: ... (2) incubate with primary rabbit anti-c-Fos (1:2000, 2250S, Cell Signaling Technology) antibody in PBS with 0.3% Triton-X for 2h at room temperature ...
• E-cadherin-dependent phosphorylation of EGFR governs a homeostatic feedback loop controlling intercellular junction viscosity and collective migration modes

  Chaoyu Fu, et al., bioRxiv - Cell Biology 2023

  Quote: ... Phospho-Myosin Light Chain 2 (Ser19) antibody (3671, Cell Signaling Technologies, diluted 1:50) according to the manufacturer’s instructions ...
• Oseltamivir (Tamiflu), a Commonly Prescribed Antiviral Drug, Mitigates Hearing Loss in Mice

  Emma Sailor-Longsworth, et al., bioRxiv - Neuroscience 2024

  Quote: ... or antibody anti-pERK1/2 (Thr202/Tyr204, 1:400 dilution, 9101, Cell Signaling Technology) and imaged with a confocal microscope (LSM 700 ...
• Dormancy-inducing 3D-engineered matrix uncovers mechanosensitive and drug protective FHL2-p21 signaling axis

  Sadra Bakhshandeh, et al., bioRxiv - Bioengineering 2024

  Quote: ... and anti-phospho-p44/42 MAPK (p-ERK1/2) (1:200, #9101S, Cell Signaling). The secondary antibodies are ...
• Transient proliferation by reversible YAP and mitogen-control of the cyclin D1/p27 ratio

  Katherine R. Ferrick, et al., bioRxiv - Cell Biology 2024

  Quote: ... rabbit phospho-MAPK1/2(Thr202/Tyr204)(1:400, Cell Signaling Technology Cat#4370, RRID:AB_2315112), mouse phospho-S6(235/236)(1:800 ...
• Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

  Mary C. Rominger, et al., bioRxiv - Cancer Biology 2024

  Quote: ... Phospho-p44/42 MAPK (Erk1/2) 1:1000 (Thr202/Tyr204) (Cell Signaling Technology, 4370), AKT 1:1000 (Cell Signaling Technology ...
• Cooperation between oncogenic Ras and p53 stimulates JAK/STAT non-cell autonomously to promote Ras tumor radioresistance

  Yong-Li Dong, et al., bioRxiv - Cancer Biology 2020

  Quote: ... Membranes were probed overnight at 4 °C with anti-pSTAT-3 (Tyr 705) (1:1000, Cell Signaling #9145) or anti-STAT (1:1000 ...
• SIRPα sequesters SHP-2 to promote IL-4/13 signaling and alternative activation of macrophages

  Lei Shi, et al., bioRxiv - Immunology 2021

  Quote: ... and phospho-SHP-2 was detected with an anti-phospho-SHP-2 (Tyr542) antibody (Cell Signaling Technology). Alternatively ...
• TGF-β-driven downregulation of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα⁺ fibroblasts

  Osvaldo Contreras, et al., bioRxiv - Cell Biology 2020

  Quote: ... the inhibitor of MEK1/2/ERK1/2 kinases UO126 (used at 10 μM; 9903, Cell Signaling Technology), Smad3 inhibitor SIS3 (used at 6 μM ...