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2201 - 2250 of 4145 citations for 7 chloro 5 methylpyrazolo 1 5 A pyrimidine since 2019

• Maintaining structural and functional homeostasis of the Drosophila respiratory epithelia requires stress-modulated JAK/STAT activity

  Xiao Niu, et al., bioRxiv - Cell Biology 2022

  Quote: ... Alexa488-conjugated goat-anti-mouse (used at 1:500, Jackson Immunoresearch, Dianova, Hamburg, Germany), Alexa488-conjugated goat-anti-rabbit (used at 1:500 ...
• Aberrant activation of Wnt/β-Catenin signaling pathway drives the expression of poor prognosis-associated microRNAs in adrenocortical cancer with a major impact on miR-139-5p and its host gene PDE2A

  Justine Cristante, et al., bioRxiv - Cancer Biology 2023

  Quote: ... or with HRP Goat anti-mouse IgG (1:5000, Jackson Immunoresearch, #115-035-062). The membrane was washed as previously mentioned and the antigen-antibody complex was revealed by Clarity Enhanced Chemiluminescence Blotting Substrate (Bio-Rad ...
• AGAP1-associated endolysosomal trafficking abnormalities link gene-environment interactions in a neurodevelopmental disorder

  Sara A. Lewis, et al., bioRxiv - Genetics 2023

  Quote: ... Neuronal membranes were visualized with 1:100 goat α HRP-Alexa 647 (Jackson ImmunoResearch) added with secondary antibody ...
• Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics

  Iris. A. Unterweger, et al., bioRxiv - Developmental Biology 2023

  Quote: Secondary antibodies included: donkey-anti-goat 488 (1:200, Jackson Immunoresearch, 705-545-147), donkey-anti-rat-cy3 (1:500 ...
• Mechanical forces at the kidney filtration barrier govern spatial orientation of podocyte processes on capillaries

  David Unnersjö-Jess, et al., bioRxiv - Cell Biology 2023

  Quote: ... donkey anti-mouse antibody coupled with Cy3 (Jackson ImmunoResearch 715-165-150 1:50), goat anti-guinea pig secondary antibody coupled with Alexa-488 (Abcam ab150185 1:50).
• Re-evaluating the nuclear staining on pathological sections in Alzheimer's disease

  Hualin Fu, et al., bioRxiv - Neuroscience 2023

  Quote: ... donkey anti-rabbit Alexa-488 secondary antibody (Jackson ImmunoResearch 711-545-152, 1:400), and donkey anti-mouse Alexa-488 secondary antibody (Jackson ImmunoResearch 715-545-150 ...
• Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A

  Alice Bochel, et al., bioRxiv - Biophysics 2023

  Quote: ... fluorochrome-conjugated secondary antibodies at a ratio of 1:200 (Jackson ImmunoResearch Laboratories, Invitrogen) for 30 min at RT in blocking buffer ...
• Loss of TREM2 exacerbates parenchymal amyloid pathology but diminishes CAA in Tg-SwDI mice

  Rui Zhong, et al., bioRxiv - Neuroscience 2023

  Quote: ... followed by fluorescently conjugated secondary antibodies in 1:2 (primary:secondary) molar ratios (Jackson ImmunoResearch). After active labeling ...
• Engram cell connectivity as a mechanism for information encoding and memory function

  Clara Ortega-de San Luis, et al., bioRxiv - Neuroscience 2023

  Quote: ... and anti-guinea pig AlexaFluor AffiniPure 647 (1:800, Jackson ImmunoResearch, 106-605-003). To detect ArchT-EYFP and ChR2-EYFP ...
• Tissue-specific knockout in Drosophila neuromuscular system reveals ESCRT’s role in formation of synapse-derived extracellular vesicles

  Xinchen Chen, et al., bioRxiv - Neuroscience 2023

  Quote: ... donkey anti-rabbit secondary antibody conjugated with Cy5 or Alexa488 (1:400, Jackson ImmunoResearch) and rabbit polyclonal anti-GFP antibody conjugated with Alexa 488 (1:400 ...
• LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension

  Jochen Steppan, et al., bioRxiv - Physiology 2023

  Quote: ... AffiniPure goat anti-rabbit IgG (H + L)-HRP conjugate (Jackson ImmunoResearch, 111035144; 1:2500).
• PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation

  Maria B. Campaña, et al., bioRxiv - Cell Biology 2023

  Quote: ... and horseradish peroxidase-conjugated goat anti-mouse IgG (1:20,000; 115035003; Jackson ImmunoResearch Inc.). Quantifications of signal intensity were performed with ImageJ software (version 1.53t ...
• Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

  Matteo Gentili, et al., bioRxiv - Systems Biology 2024

  Quote: ... 1:1800 donkey anti-rabbit antibody (Jackson ImmunoResearch Labs Cat# 711-006-152, RRID:AB_2340586) disulfide-linked to Alexa Fluor 647 (Thermo Fisher Scientific A10277 ...
• An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery

  Qin Huang, et al., bioRxiv - Neuroscience 2023

  Quote: ... and goat anti-mouse 647 nm (1:500 dilution, 115-605-062, Jackson ImmunoResearch) were applied.
• Olfactory ensheathing cells are hybrid glial cells that promote neural repair

  Patricia E. Phelps, et al., bioRxiv - Neuroscience 2023

  Quote: ... and incubated with donkey anti-goat 488 (1:100; Jackson Immunoresearch, #705-545-0030). Sections were then incubated in rabbit polyclonal anti-Blbp (Suppl ...
• Progressive degeneration in a new Drosophila model of Spinocerebellar Ataxia type 7

  Alyson L. Sujkowski, et al., bioRxiv - Neuroscience 2023

  Quote: ... Secondary antibody: peroxidase-conjugated anti-mouse (1:5000, Jackson Immunoresearch, West Grove, PA, USA). For direct blue staining ...
• VLP-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice

  Ana Barajas, et al., bioRxiv - Immunology 2023

  Quote: ... washed and incubated with Donkey anti-mouse IgG Fc antibody (Jackson ImmunoResearch, 1:10000) for one hour at RT ...
• Positive selection analyses identify a single WWE domain residue that shapes ZAP into a super restriction factor

  Serina Huang, et al., bioRxiv - Microbiology 2023

  Quote: ... and secondary antibody 1:20,000 goat anti-mouse HRP (Jackson ImmunoResearch, West Grove, PA), or 1:20,000 goat anti-rabbit HRP (Thermo Fisher Scientific ...
• Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling

  Naoto Soya, et al., bioRxiv - Biophysics 2023

  Quote: ... F(ab’)₂ Fragment Goat anti-Mouse IgG (1:1000, Jackson ImmunoResearch, #115-036-003).
• Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord

  Donghang Zhang, et al., bioRxiv - Neuroscience 2023

  Quote: ... and CyTM3 goat anti-rabbit IgG (1:500, Jackson ImmunoResearch, Cat#: 111-165-003). Images were obtained using a Zeiss AxioImager Z.2 (Guangzhou ...
• LINE-1 retrotransposon activation intrinsic to interneuron development

  Gabriela O. Bodea, et al., bioRxiv - Genomics 2023

  Quote: ... Alexa Fluor 488 donkey anti-mouse (Jackson ImmunoResearch, Cat# 715-546-150, 1:1000) and Alexa Fluor 647 donkey anti-rabbit (Jackson ImmunoResearch ...
• Neurotransmitter signaling specifies sweat gland stem cell fate through SLN-mediated intracellular calcium regulation

  Juliana Remark, et al., bioRxiv - Developmental Biology 2023

  Quote: ... Secondaries and dilutions are as follows: Donkey anti-rabbit Cy3 (1:400, Jackson ImmunoResearch), Donkey anti-rabbit A488 (1:800 ...
• Impaired transitioning of the FXR ligand binding domain to an active state underlies a PFIC5 phenotype

  Annika Behrendt, et al., bioRxiv - Physiology 2024

  Quote: ... followed by staining at 1:250 with goat anti-rabbit-IgG-FITC (Jackson ImmunoResearch) and DAPI at 1:20.000 ...
• Dynein directs prophase centrosome migration to control the stem cell division axis in the developing C. elegans epidermis

  Cátia Carvalho, et al., bioRxiv - Cell Biology 2023

  Quote: ... incubated with goat polyclonal anti-mouse IgG (Jackson ImmunoResearch 115-035-044, 1:10000) or anti-rabbit IgG (Jackson ImmunoResearch 111-035-003 ...
• Qualitative Observations of Transgenically Individualized Serotonergic Fibers in the Mouse Telencephalon

  Justin H. Haiman, et al., bioRxiv - Neuroscience 2023

  Quote: ... AlexaFluor 594-conjugated donkey anti-rat IgG (1:500; Jackson ImmunoResearch #712-585-150), and AlexaFluor 647-conjugated donkey anti-guinea pig IgG (1:500 ...
• Regions of Inflammation in mouse asthma correspond to regions of heme-free soluble guanylyl cyclase and can be tracked by marked expression of heme-oxygenase-1

  Mamta Sumi, et al., bioRxiv - Immunology 2023

  Quote: ... and donkey anti-rabbit (Texas red, Jackson Immunoresearch, 711-076-152, 1:200 dilution). Stained sections were then mounted ...
• Ventral hippocampal interneurons govern extinction and relapse of contextual associations

  Anthony F. Lacagnina, et al., bioRxiv - Neuroscience 2023

  Quote: ... or 1:500 donkey anti-chicken Alexa Fluor 488 (Jackson ImmunoResearch; 703-545-155) in 1x PBST for 2 h at room temperature ...
• Revealing intact neuronal circuitry in centimeter-sized formalin-fixed paraffin-embedded brain

  Ya-Hui Lin, et al., bioRxiv - Neuroscience 2024

  Quote: ... 2% v/v normal goat serum (Jackson ImmunoResearch, 005-000-121, 1:500 dilution), and 0.1% w/v Triton X-100 in 1×PBS at 4 °C for 24 hours ...
• Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in Drosophila larvae

  Suguru Takagi, et al., bioRxiv - Neuroscience 2024

  Quote: goat Cy5-conjugated anti-HRP (123-175-021, 1:300, Jackson ImmunoResearch Laboratories Inc.)
• The Rubicon-WIPI axis regulates exosome biogenesis during aging

  Kyosuke Yanagawa, et al., bioRxiv - Cell Biology 2024

  Quote: ... and HRP-conjugated goat anti–mouse IgG (Jackson ImmunoResearch, 115–035-003, 1:5000). The following antibodies were used for immunofluorescence ...
• Linear ubiquitin chains remodel the proteome and influence the levels of hundreds of regulators in Drosophila

  Oluwademilade Nuga, et al., bioRxiv - Cell Biology 2024

  Quote: ... HRP-conjugated secondary antibodies were used at 1:5000 and were from Jackson ImmunoResearch.
• Multi-parametric MRI can detect enhanced myelination in the Gli1^-/- mouse brain

  Choong H. Lee, et al., bioRxiv - Bioengineering 2024

  Quote: ... the secondary antibody used was goat anti-chicken (IgG 488, Jackson ImmunoResearch, 1:1000). Slides were imaged and acquired at 20x on Confocal Zeiss LSM 800 Fluorescence Microscope using Zeiss Zen blue software ...
• Suppression of astrocyte BMP signaling improves fragile X syndrome molecular signatures and functional deficits

  James Deng, et al., bioRxiv - Neuroscience 2024

  Quote: ... Appropriate secondary antibodies were used (1:500, donkey anti-goat Alexa 488, Jackson ImmunoResearch 705-545-147 ...
• PARP14 mediated SQSTM1/p62 cysteine ADP-ribosylation is counteracted by the SARS-CoV-2 macrodomain

  David Kubon, et al., bioRxiv - Molecular Biology 2024

  Quote: ... goat anti-mouse IgG (H+L) Cy3 (115-165-003, Jackson Immunoresearch, 1:250).
• Classification of psychedelic drugs based on brain-wide imaging of cellular c-Fos expression

  Farid Aboharb, et al., bioRxiv - Neuroscience 2024

  Quote: ... and then by fluorescently conjugated secondaries in 1:2 primary:secondary molar ratios (Jackson ImmunoResearch). Following active labeling ...
• Potentiation of the M₁ muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in Mecp2^+/- mice

  Mackenzie Smith, et al., bioRxiv - Neuroscience 2024

  Quote: ... followed by fluorescently conjugated secondaries in 1:2 primary: secondary molar ratio (Jackson ImmunoResearch). After active labeling ...
• The prevalent NR2E3 c.932G>A mutation induces aberrant splicing that can be rescued using splice-shifting antisense oligonucleotides

  Yehezkel Sztainberg, et al., bioRxiv - Genomics 2024

  Quote: ... Secondary antibodies: goat anti-rabbit HRP (1:5,000; Jackson ImmunoResearch Labs 111-036-047), goat anti-mouse HRP (1:5,000 ...
• Integrin-deficient T cell leukemia accumulates in the central nervous system

  Samantha Y. Lux, et al., bioRxiv - Immunology 2024

  Quote: ... Alexa Fluor 647 AffiniPure Donkey Anti-Rabbit IgG (H+L) 1:1000 (Jackson ImmunoResearch), Cy3 Affinipure Donkey anti-Rabbit IgG (H+L ...
• Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in the Alzheimer’s disease

  Hualin Fu, et al., bioRxiv - Cell Biology 2024

  Quote: ... donkey anti-rabbit Alexa-594 secondary antibody (Jackson ImmunoResearch 711-585-152, 1:400), and donkey anti-mouse Alexa-488 secondary antibody (Jackson ImmunoResearch 715-545-150 ...
• Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in the Alzheimer’s disease

  Hualin Fu, et al., bioRxiv - Cell Biology 2024

  Quote: ... donkey anti-rabbit Alexa-488 secondary antibody (Jackson ImmunoResearch 711-545-152, 1:400), donkey anti-rabbit Alexa-594 secondary antibody (Jackson ImmunoResearch 711-585-152 ...
• Transformation of an olfactory placode-derived cell into one with stem cell characteristics by disrupting epigenetic barriers

  Ghazia Abbas, et al., bioRxiv - Molecular Biology 2024

  Quote: ... and donkey anti-mouse-Cy3 secondary antibody (Jackson Immunoresearch, 715-165-150, 1:100), was performed on two separate transfections to confirm Sox2 expression ...
• Disparate requirements for RAD54L in replication fork reversal

  Mollie E. Uhrig, et al., bioRxiv - Cell Biology 2024

  Quote: ... HRP-conjugated goat anti-rabbit or goat anti-mouse IgG (Jackson ImmunoResearch; 1:10,000) were used as secondaries ...
• BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas

  Paul Huchedé, et al., bioRxiv - Cancer Biology 2024

  Quote: ... membranes were incubated with the appropriate HRP-conjugated secondary antibody (1:20.000, Jackson ImmunoResearch). HRP-conjugated β-Actin antibody (1:25.000 ...
• Sde Proteins Coordinate Ubiquitin Utilization and Phosphoribosylation to Promote Establishment and Maintenance of the Legionella Replication Vacuole

  Kristin M. Kotewicz, et al., bioRxiv - Microbiology 2024

  Quote: ... and donkey anti-mouse Alexa Fluor 488 (Jackson ImmunoResearch, Cat# A-11012, 1:500). Hoescht 33342 (Life Technologies ...
• The Mettl3 epitranscriptomic writer amplifies p53 stress responses

  Nitin Raj, et al., bioRxiv - Cancer Biology 2021

  Quote: ... peroxidase Affinipure goat anti- rabbit IgG (H+L) (Jackson ImmunoResearch, 111-035-144, 1:5,000), or peroxidase Affinipure goat anti-mouse IgG (H+L ...
• ATP triggers macropinocytosis that internalizes and is regulated by PANX1

  Andrew K.J. Boyce, et al., bioRxiv - Cell Biology 2020

  Quote: ... and the secondary antibody was Alexa647 AffiniPure donkey anti-rabbit IgG (1:600; Jackson ImmunoResearch).
• EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells

  Irini Topalidou, et al., bioRxiv - Cell Biology 2019

  Quote: ... and incubated with rhodamine anti-rabbit secondary antibody (1:1000, Jackson Immunoresearch #111-025-144), Alexa Fluor 488 anti-rabbit secondary antibody (1:1000 ...
• EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells

  Irini Topalidou, et al., bioRxiv - Cell Biology 2019

  Quote: ... and Rhodamine Ret-X anti mouse secondary antibody (1:1000, Jackson Immunoresearch #715-295-150) at room temperature for 1 hour ...
• Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells

  Rashmi J. Kumar, et al., bioRxiv - Cell Biology 2020

  Quote: ... and FITC Goat Anti Rabbit IgG (H+L) (1:500, Jackson ImmunoResearch, 111-095-144). Images were acquired using the GE IN CELL 2200 high through-put imaging system at 40x magnification.
• A septin GTPase scaffold of dynein-dynactin motors triggers retrograde lysosome transport

  Ilona A. Kesisova, et al., bioRxiv - Cell Biology 2020

  Quote: ... F(ab’)2 fragment affinity-purified secondary antibodies (1:200) were purchased from Jackson ImmunoResearch Laboratories and included donkey anti-mouse ...